Clinical trials: Critically Ill Patients
Pre-Eclampsia, Critical Illness
Homocysteine in Critically Ill Preeclampsia
Preeclampsia is a disorder characterized by the new onset of hypertension and proteinuria typically presenting after 20 weeks of gestation.
- Trial name
- NCT06413576
- Testing
- homocysteine measurement
- Where
- 2 sites in Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Bacterial Infections
Pharmacokinetics of Colistin in Critically-ill Patients With AKI Who Receive SLED
Colistin was developed in the 1960s and preliminary pharmacokinetic studies were performed at that time. Dosing recommendations, on the basis of these pharmacokinetic studies, are listed in the drug's product information.
- Trial name
- NCT05586438
- Testing
- Colistin Sulfomethate
- Where
- Thailand
- Volunteers
- 13 people
- Sponsor
- Mahidol University
Acute Kidney Disease, Acute Kidney Injury
Impact of Different CRRT Modalities, Dosing Strategies, and Timing on Kidney Recovery and Prolonged Kidney Dysfunction
KARMA study is a hospital-based research study looking at how different ways of delivering kidney support therapy (CRRT) affect patients who are critically ill.
- Trial name
- KARMA (NCT07052617)
- Testing
- Continuos renal replacement therapy
- Volunteers
- 2,500 people
- Sponsor
- Croatian Society for Organ Support
Gastroparesis
Methylnaltrexone vs Erythromycin for Facilitating Gastric Emptying Time in Critically Ill Patients
42 patients admitted in ICU with intolerance to enteral feeding (GRV more than 250 ml) are recruited. All patients enter a primary acetaminophen absorption test study as baseline.
- Trial name
- NCT01117376
- Testing
- Erythromycin, Methylnaltrexone
- Where
- Iran
- Volunteers
- 42 people
- Sponsor
- Shiraz University of Medical Sciences
Evidence-Based Nursing, Critically Ill Patient
Enhancing Critical Thinking Competency and Nursing Quality in Critically Ill Patient Care
The EBN-based nutritional management protocol effectively enhances junior nurses' specialized critical thinking competency and improves patient nutritional outcomes and satisfaction, demonstrating its potential to optimize…
- Conditions
- Evidence-Based Nursing, Critically Ill Patient, Training
- Trial name
- NCT06997614
- Testing
- Conventional group, evidence-based nursing group
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Taizhou Hospital
End of Life Care, Critical Illness
Palliative Care Protocol for Adult Patients Hospitalized in Critical Care Units.
The goal of this clinical trial is to determine the effectiveness of a palliative care protocol in improving the quality of care of adult patients at high risk of dying hospitalized in the critical care unit.
- Conditions
- End of Life Care, Critical Illness, Palliative Care
- Trial name
- NCT06483958
- Testing
- palliative care protocol
- Where
- Chile
- Volunteers
- 248 people
- Sponsor
- University of Chile
Ventilator Associated Pneumonia, Corona Virus Infection
Epidemiology and Outcome of Ventilator-associated Pneumonia Among Critically Ill COVID-19 Patients
The aim of this study is to determine the risk factors for development of ventilator-associated pneumonia (VAP) and to identify the prognostic factors of VAP among Coronavirus Disease 2019 (CoViD-19) patients.
- Trial name
- NCT04372576
- Testing
- Assessment of ventilator-associated pneumonia criteria
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Semmelweis University
COVID-19, Critical Illness
Recovery of Patients From COVID-19 After Critical Illness
Patients who are critically ill with COVID-19 requiring life support in an intensive care unit (ICU) have increased risk of morbidity and mortality.
- Trial name
- NCT04401254
- Where
- 29 sites in Australia
- Volunteers
- 536 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Acute Kidney Injury, Metabolic Acidosis
Sodium Bicarbonate for Critically Ill Patients With Metabolic Acidosis and Acute Kidney Injury
The study investigates whether sodium bicarbonate is able to reduce the occurrence of major adverse kidney events on day 90 (MAKE90) in critically ill patients with metabolic acidosis and acute kidney injury (AKI).
- Conditions
- Acute Kidney Injury, Metabolic Acidosis, Critical Illness
- Trial name
- ESCALATE (NCT07464431)
- Testing
- Sodium Bicarbonate 8.4% Solution for Injection, Balanced crystalloid solution
- Where
- Germany
- Volunteers
- 660 people
- Sponsor
- Universität Münster
Acute Kidney Injury
Continuous Venovenous Hemodiafiltration Versus Sustained Low-efficiency Hemodialysis for Critically Ill Patients With Acute Kidney Injury in Intensive Care Unit
The investigators conducted a comparison trial between SLED and CRRT in critically ill patients to evaluate the outcome for all cause mortality at 30 day .
- Trial name
- NCT02879201
- Testing
- Slow efficiency dialysis
- Where
- Thailand
- Volunteers
- 27 people
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Sepsis, Septic Shock
Intravenously Administered M6229 in Critically Ill Sepsis Patients
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality is high and survivors frequently suffer from long-term sequelae.
- Conditions
- Sepsis, Septic Shock, Critical Illness
- Trial name
- HistoSeps (NCT05208112)
- Testing
- M6229
- Where
- 2 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- A.P.J. Vlaar
Colonic Neoplasms, Rectal Neoplasms
Endoscopically Assisted Colostomy With Colopexy for Critically Ill Patients Without General Anesthesia or Laparotomy
Indications for colostomy are rectal or anal cancer, diverticular disease, radiation enteritis, complex perirectal fistulas, anorectal trauma, severe incontinence, motility and functional disorders.
- Conditions
- Colonic Neoplasms, Rectal Neoplasms, Fecal Incontinence
- Trial name
- EACC (NCT02308631)
- Testing
- ENDOSCOPICALLY ASSISTED COLOSTOMY WITH COLOPEXY
- Where
- Brazil
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Colistin
Evaluation of Pharmacokinetic and Pharmacodynamic Properties of Intravenous Colistimethate Sodium
Colistin is a polymixin antibiotic used in the treatment of multidrug-resistant gram-negative infections. Given the limited use of colistin and previous challenges with laboratory assays to determine plasma concentrations, there…
- Trial name
- NCT02288429
- Testing
- colistimethate sodium
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Critical Illness Polyneuropathies
Role of Anabolic Steroids on Intensive Care Unit-Acquired Weakness
The researchers intend to investigate possible anabolic effects of bi-weekly exogenous testosterone administration during intensive care unit (ICU) stay for up to 8 weeks.
- Trial name
- RAS-ICU (NCT03038919)
- Testing
- Testosterone cypionate, Standard nutrition and physical therapy at ICU
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Emergency Gastrointestinal Surgery, Mortality Within 30 Days
Construction and Validation of a Prediction Model for All - Cause Mortality Within 30 Days After Surgery in Critically Ill Patients Undergoing Emergency Gastrointestinal Surgery
Gastrointestinal surgeries are crucial for treating digestive tract diseases. However, they often lead to high postoperative infection rates due to long durations, bacterial translocation, weakened immunity, and reduced…
- Trial name
- EGS-30MP (NCT06787157)
- Testing
- Prediction Model Construction
- Volunteers
- 900 people
- Sponsor
- Quan Wang
Critical Illness
Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients
This pilot study will study the impact of critical illness and ICU processes of care on the trajectory and development of frailty.
- Trial name
- FORECAST (NCT04605029)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Dr. John Muscedere
Nutrition Disorders, Neurologic Disorder
The Effects of Enteral Whey Protein Supplement on Serum Albumin Level in Acute Critically Ill Neurological Patients
The incidence of malnutrition in patients with severe neurological diseases is approximately 37%, among which hypoproteinemia is a common manifestation.
- Trial name
- NCT04361357
- Testing
- whey protein
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Xuanwu Hospital, Beijing
Sepsis
Beta-Lactam InfusioN Group Study
The purpose of this study is to find out whether continuous infusion of beta-lactam antibiotics or intermittent infusion or beta-lactam antibiotics, offers more health advantages to patients or if there is no difference.
- Trial name
- BLING III (NCT03213990)
- Testing
- Continuous infusion, Intermittent infusion
- Where
- 103 sites in Australia, Belgium and 5 more
- Volunteers
- 7,203 people
- Sponsor
- The George Institute
Endotracheal Tube, Tracheostomy
Safety of Mechanical Insufflation-exsufflation and Hypertonic Saline
Conventional catheter suctioning of respiratory tract secretions is a mandatory procedure in intubated patients. Poor tolerance, pain and other, sometimes severe, lung and cardiovascular complications may occur during suctioning.
- Trial name
- SMASH (NCT03940118)
- Testing
- Catheter secretion suctioning, Secretion suctioning + hypertonic saline, Ins-exsufflation
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Hospital San Carlos, Madrid
Hemodynamics, Blood Pressure Monitoring
Non-Invasive Blood Pressure Monitoring in ICU Patients Using the DARE Device
This study tests a new non-invasive device called DARE to monitor blood pressure in patients in intensive care. It compares the device's readings to standard invasive methods and also looks at how well it measures other vital…
- Conditions
- Hemodynamics, Blood Pressure Monitoring, Intensive Care Units, Critical Illness
- Trial name
- NCT07052123
- Testing
- MultiSense® Non-Invasive Hemodynamic Monitoring Device
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Centre Hospitalier de Saint-Denis