Clinical trials: Critically Ill Patients
Sleep Disturbance
Impact of a Multifaceted Intervention of Environment Control in the ICU to Optimize Quantity and Quality of Sleep
In critically ill patients, sleep and circadian rhythms are markedly disturbed, including sleep deprivation and disruption, as well as altered sleep architecture, and loss of normal oscillations of Melatonin and Cortisol.
- Trial name
- NCT05694052
- Testing
- Multifaceted Intervention of environment control
- Where
- Chile
- Volunteers
- 56 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Critical Illness
Blood Glucose Control With A Software-Algorithm In Intensive Care Unit (ICU) Patients
Hyperglycemia is common in critically ill patients and associated with an adverse outcome. Recently, large randomized controlled trials have demonstrated that tight glycaemic control (TGC) reduces morbidity and mortality in this…
- Trial name
- Aldea _01 (NCT00735163)
- Testing
- enhanced model predictive control algorithm (eMPC)
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- B. Braun Melsungen AG
Critical Illness, Multiple Organ Failure
Adding a Gastrointestinal Subscore to SOFA2 for Mortality Risk Assessment in the ICU: The SOFA2-GIS Study
The goal of this observational study is to learn whether adding a gastrointestinal (GI) component to a widely used organ failure score improves the prediction of death risk in critically ill adults treated in the intensive care…
- Conditions
- Critical Illness, Multiple Organ Failure, Gastrointestinal Diseases, Mortality
- Trial name
- SOFA2-GIS (NCT07586254)
- Where
- Turkey (Türkiye)
- Volunteers
- 800 people
- Sponsor
- Ozkul Yilmaz Colak
Peripheral Perfusion
Assessment of Peripheral Perfusion in the Critically Ill Patient
The purpose of this study is to evaluate PPI as a surrogate for clinical signs of peripheral perfusion in patients in septic shock and after cardiac surgery.
- Trial name
- CRTPPI (NCT02771002)
- Testing
- Peripheral Perfusion index by Carescape Patientenmonitor
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Nutrition Therapy, Critical Illness
Efficacy and Safety of SmofKabiven Extra Nitrogen for Parenteral Nutrition in Patients Receiving Intensive Care
The aim of this clinical trial is to assess the efficacy and safety of the investigational product SmofKabiven extra Nitrogen in patients requiring parenteral nutrition (PN) to achieve the target protein dose.
- Trial name
- NCT05257031
- Testing
- SmofKabiven extra Nitrogen
- Where
- Russia
- Volunteers
- 56 people
- Sponsor
- Fresenius Kabi
Muscle Weakness or Atrophy, Mechanical Ventilation Complication
NMES Role to Prevent Respiratory Muscle Weakness in Critically Ill Patients and Its Association to Changes in Myokines.
Particularly, muscle respiratory wasting will occur early (18 to 69 hours) in up to 60% of patients with mechanical ventilation (MV), leading rapidly to diaphragmatic weakness, which is associated with prolonged MV use, longer…
- Conditions
- Muscle Weakness or Atrophy, Mechanical Ventilation Complication, Electrical Stimulations
- Trial name
- NCT05536531
- Testing
- Neuromuscular electrical stimulation (NMES)
- Where
- Chile
- Volunteers
- 32 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Neurocognitive Disorders, Surgery-Complications
Cerebrolysin in Prevention of Postoperative Delirium in Cardiac Surgery
Postoperative delirium (POD) and postoperative neuropsychological dysfunction are frequently noted in critically ill patients undergoing elective or emergency surgery and treated in the intensive care unit (ICU).
- Conditions
- Neurocognitive Disorders, Surgery-Complications, Critical Illness, Brain Damage
- Trial name
- Cereb-POD (NCT05864677)
- Testing
- Cerebrolysin
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Lublin
Critically Ill Patients Admitted in ICU
Severe Hypoxemia : Prevalence, Treatment and Outcome
Hypoxemia is usually observed during ICU stay. Nevertheless, the prevalence of hypoxemia among patients admitted in ICU is not well known, in partly due to a lack of a consensual definition.
- Trial name
- NCT02722031
- Where
- France
- Volunteers
- 1,694 people
- Sponsor
- French Society for Intensive Care
Critical Illness, Surgery
Gastric US in ICU Patient
This is a case series study using gastric ultrasound in critically ill patients to quantify gastric residual volumes to compare the efficacy of different NPO protocols.
- Conditions
- Critical Illness, Surgery, Aspiration Pneumonia
- Trial name
- NCT05526105
- Testing
- Gastric Ultrasound
- Where
- United States
- Sponsor
- Dartmouth-Hitchcock Medical Center
Critical Illness, Adult
A Study in Critically Ill Patients Investigating Tolerability and Efficacy of Low-volume Pharmaconutrition (Intestamin)
The aim of the study is to assess the efficacy and tolerability of the low-volume supplement. The investigators randomized critically ill patients to receive Intestamin plus Fresubin or Fresubin alone.
- Conditions
- Critical Illness, Adult, Sepsis, Systemic Inflammatory Response Syndrome
- Trial name
- Intestamin (NCT01167075)
- Testing
- Fresubin Original, Intestamin plus Fresubin Original
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- Hannover Medical School
Ischemic Stroke, Ischaemic Stroke With Coma
Decision Aid Feasibility Trial for Families of Critically Ill Stroke Patients
Severe strokes, including large artery acute ischemic stroke and intracerebral hemorrhage, continue to be the leading cause of death and disability in adults in the U.S.
- Conditions
- Ischemic Stroke, Ischaemic Stroke With Coma, Intracerebral Hemorrhage, Hemorrhagic Stroke
- Trial name
- NCT04143113
- Testing
- Decision Aid
- Where
- 2 sites in United States
- Sponsor
- University of Massachusetts, Worcester
Shock, Septic
NOrepinephrine and VasoprEssin Versus Norepinephrine aLone in Critically Ill Patients With Septic Shock
Sepsis, a systemic host response to the invasion of a pathogenic microorganism, may progress to severe sepsis, wherein the patient experiences acute dysfunction in at least one organ system, and further develop into septic shock…
- Trial name
- NOVEL (NCT02454348)
- Testing
- Vasopressin, Norepinephrine
- Where
- United States
- Sponsor
- University of Arkansas
COVID-19, Critical Illness
Risk of Venous Thromboembolism in Critically Ill Patients With Severe COVID-19
Severe COVID-19 patients at a high risk of venous thromboembolism. We studied patients in 2 intensive care units of university hospitals in Barcelona and Badalona, Spain.
- Conditions
- COVID-19, Critical Illness, Venous Thromboembolism, Venous Thromboses
- Trial name
- NCT04374617
- Testing
- Duplex ultrasound and Computed Tomography Angiography
- Where
- 3 sites in Spain
- Volunteers
- 230 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Central Venous Catheter Thrombosis, Critical Illness
Daily Ultrasound-screening for CVC-related Thrombosis
The central venous catheters (CVC) related thrombosis is an issue of importance to ICU clinicians.This study conducts the daily ultrasound-screening for CVC-related thrombosis (DUCT).Its aim is to evaluate the characteristic and…
- Conditions
- Central Venous Catheter Thrombosis, Critical Illness, Ultrasonography
- Trial name
- DUCT (NCT03327376)
- Testing
- ultrasound-screening
- Where
- China
- Volunteers
- 1,262 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Linezolid, Antioxidant
Efficacy of Intravenous N-Acetylcysteine in Preventing Linezolid-Induced Thrombocytopenia in Critically Ill Patients
Study the effect of acetylcysteine on decreasing the incidence of LIT in critically ill patients. Study the impact of acetylcysteine on the time to onset of LIT and the time to recovery of platelets.
- Conditions
- Linezolid, Antioxidant, Thrombocytopenia, Critical Illness
- Trial name
- NCT05944458
- Testing
- N acetyl cysteine
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Helwan University
Critically Ill, Intensive Care Unit
High Protein Formula on Enteral Feeding in Clinical Improvement and Malnutrition at Intensive Care Unit Patients
Effectiveness of Early Enteral Feeding With High Protein Polymeric Formula Versus Oligomeric Formula Versus 5% Dextrose Solution in Clinical Improvement and Malnutrition on Intensive Care Unit Patients Background : Critically ill…
- Trial name
- NCT04150978
- Testing
- High Protein Polymeric Formula, Oligomeric Formula, 5% Dextrose
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Hasanuddin University
Acute Circulatory Failure
Assessment of Agreement Between Two Measurement Methods of Left Ventricular Outflow Tract (LVOT) Velocity Time Integral (VTI)
Acute circulatory failure (ACF) is a common cause of admission in intensive care unit (ICU). Echocardiography is a widespread tool nowadays for the initial assessment and the hemodynamic monitoring.
- Trial name
- AUTO-VTI (NCT04360304)
- Testing
- Echocardiographic exam
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Nutritional Deficiency
Nutritional Management in Respiratory Critically Ill Patients -an Observational Study in Mainland China
The important role of nutritional management in the treatment of ICU patients has been paid more and more attention. Reasonable nutritional management can improve the nutritional status of patients, reduce the risk of…
- Trial name
- NM-in-RCIP (NCT04958447)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- China-Japan Friendship Hospital
Pressure Sores, Intensive Care
The Effect of Antioxidants on the Immune Response and Wound Healing in Critically Ill Patients
The purpose of this study is to investigate whether the addition of omega-3 and antioxidants to nutritional support in critically ill patients in the intensive care unit influences the immune and anti-inflammatory systems and so…
- Trial name
- NCT00487097
- Testing
- Eicosapentanoic acid, docosahexaenoic acid
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Rabin Medical Center
Critical Illness, Near-Death Experience
Incidence of Episodes of (Dis)Connected Consciousness Among Emergency Patients Admitted in the Resuscitation Room
This observational study aims to describe the incidence of episodes of disconnected consciousness (including near-death experience (NDE)) and episodes of connected consciousness in patients admitted to the resuscitation room, who…
- Conditions
- Critical Illness, Near-Death Experience, Consciousness, Loss of, Quality of Life
- Trial name
- NCT06362525
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Liege