Clinical trials: Critically Ill Surgical Patients
Malnutrition
Trial of Continuous Versus Interrupted Feeding for Intubated Intensive Care Unit Patients
Surgical patients fed up until the point of surgery will have safe delivery of more calories compared to a group whose feeding is held at midnight prior to surgery.
- Trial name
- NCT01383980
- Testing
- Continuous Tube Feedings
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Oregon Health and Science University
Sarcopenia, Muscle Weakness
Effects of Mobility Dose in Surgical Intensive Care Unit Patients
The primary aim of this study is to assess if the mobility dose that patients receive in the surgical intensive care unit (SICU) predicts adverse discharge disposition (primary endpoint), and muscle wasting diagnosed by bedside…
- Conditions
- Sarcopenia, Muscle Weakness, Critical Illness
- Trial name
- MQS (NCT03196960)
- Where
- 3 sites in United States, Germany and 1 more
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
Polysomnographic Sleep Characteristics
Sleep in Critically Ill Patients on Mechanical Ventilation in ICU
15 patients with sepsis, 15 patients with COPD and 15 surgical patients will undergo polysomnographic sleep monitoring up to 24 hours in order to define if there are common sleep features within the groups
- Trial name
- NCT02434341
- Where
- Denmark
- Volunteers
- 33 people
- Sponsor
- University of Southern Denmark
Critical Illness, Intensive Care Patients
IMMUNOREA - Immunological and Inflammatory Determinants Associated With the Prognosis of Intensive Care Patients
This is a prospective observational physiopathological study aimed at evaluating the immunological and inflammatory determinants associated with the prognosis of patients admitted to intensive care units (ICU).
- Conditions
- Critical Illness, Intensive Care Patients, Critical Illness Requiring Intensive Care - Sepsis, Critical Illness Requiring Intensive Care - Acute Brain Injury
- Trial name
- IMMUNOREA (NCT07345169)
- Where
- France
- Volunteers
- 540 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neurocognitive Disorders, Surgery-Complications
Cerebrolysin in Prevention of Postoperative Delirium in Cardiac Surgery
Postoperative delirium (POD) and postoperative neuropsychological dysfunction are frequently noted in critically ill patients undergoing elective or emergency surgery and treated in the intensive care unit (ICU).
- Conditions
- Neurocognitive Disorders, Surgery-Complications, Critical Illness, Brain Damage
- Trial name
- Cereb-POD (NCT05864677)
- Testing
- Cerebrolysin
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Lublin
Mortality
Effectness of Treatment With Mechanical Insufflation-Exsufflation
Patients defined with impaired cough function as maximum expiratory pressure (MEP) < 60cmH2O. Collected the patients in our surgical ICU who are able to reach 6-8CC/IBW under pressure support mode for 24 hours and MEP < 60cmH2O.
- Trial name
- NCT04149873
- Testing
- MIE
- Where
- Taiwan
- Volunteers
- 240 people
- Sponsor
- Chimei Medical Center
Adult ICU Patients, Pain, Acute
Incidence of Inadequate Pain Treatment in Ventilated Critically Ill Surgical Patients
In SICU, Siriraj hospital there were no protocols place for the management of pain. All decisions were made according the attending physicians.
- Trial name
- NCT03641911
- Where
- Thailand
- Volunteers
- 118 people
- Sponsor
- Mahidol University
Cardiac Output
Non-invasive Cardiac Output Monitoring (esCCO™) in Critically Ill Patients Within ICU
Evaluation of a non-invasive technique to measure cardiac output (esCCO™) with the "clinical goldstandard" of the transcardiopulmonal thermodilution technique (PiCCO®).
- Trial name
- NCT02682615
- Where
- Germany
- Sponsor
- University Hospital Schleswig-Holstein
Cardiac Surgery Patients, Blood Glucose
Glucose Control by eMPC Algorithm in Peri- and Postoperative Period in Cardiac Surgery Patients
Randomized controlled trial to compare blood glucose control by the model predictive control algorithm with variable sampling rate (eMPC) with routine glucose management protocol (RMP) in peri- and postoperative period in cardiac…
- Trial name
- NCT00444171
- Testing
- insulin infusion rate controled by computer algorithm, insulin infusion rate guided by in-house glucose management protocol
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Charles University, Czech Republic
CGM, Intensive Care (ICU)
Evaluate the Performance of the Dexcom G7 Continuous Glucose Monitoring (CGM) System in Critically Ill Patients Undergoing Major Abdominal Surgery and Solid Organ Transplantation Which Require Blood Glucose Monitoring for Intensive Insulin Therapy.
Main objective: The goal is to to determine the accuracy of Dexcom G7 Continuous glucose monitor system in critically ill patients, undergoing major abdominal surgery and solid organ transplantation, in the intensive care unit.
- Conditions
- CGM, Intensive Care (ICU), Liver Transplant Surgery, Solid Organ Transplantation
- Trial name
- DREAM-ICU (NCT07611721)
- Testing
- Continuous glucose monitor
- Where
- Czechia
- Volunteers
- 62 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Sepsis, ARDS
Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit
As medicine advances, many lives can be saved in the intensive care unit. However, when multiple organ failure occurs, the mortality rate of patients increases dramatically.
- Conditions
- Sepsis, ARDS, Liver Failure, Renal Failure
- Trial name
- NCT00808691
- Testing
- Critical care
- Where
- Taiwan
- Volunteers
- 124 people
- Sponsor
- National Taiwan University Hospital
Protein Malnutrition
Comparison of Clinical Outcomes According to High-protein Provision in Critically Ill Patients After Abdominal Surgery
Protein malnutrition in critically ill patients is a global concern due to its association with prolonged hospital stays, and higher morbidity rates.
- Trial name
- NCT06458387
- Testing
- Active protein supplementation, Conventional protein supplementation
- Where
- South Korea
- Volunteers
- 152 people
- Sponsor
- Seoul St. Mary's Hospital
Critical Illness
Blood Glucose Control Over an Extended Glucose Control Range in Postoperative Cardiac Surgery Patients in the Intensive Care Unit
Hyperglycaemia is commonly found in critically ill patients. Clinical studies demonstrated that tight blood glucose control in medical and surgical ICU patients results in a significant better outcome for the patients.
- Trial name
- Aldea_02 (NCT00882427)
- Testing
- enhanced model predictive control algorithm (eMPC)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- B. Braun Melsungen AG
Sepsis, Heart Failure
Mean Systemic Filling Pressure Continuous Diuretics Critical Care Patients
Within clinical settings observation of hemodynamic changes (e.g. mean systemic filling pressure, cardiac output) in critically ill patients with a clinical indication for deresuscitation with intravenous diuretic therapy.
- Conditions
- Sepsis, Heart Failure, Heart Diseases, Septic Shock
- Trial name
- NCT03395951
- Testing
- Diuretics
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Oncologic Complications, Anemia
Liberal Versus Restrictive Transfusion Threshold in Oncologic surgerY
Anemia is common in oncology. Up to three-quarters of cancer patients are exposed to an episode of anemia. In oncology surgery, perioperative bleeding is a major risk factor for anemia.
- Trial name
- LIBERTY1 (NCT04506125)
- Testing
- Haemoglobin 9.5 g/dL, Haemoglobine 7.5g/dL
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Brest
Critical Illness, Hyperglycemia
Tight Glycemic Control in Critical Care Patients
The purpose of this study is to evaluate the impact of tight control of serum glucose levels with an intensive insulin treatment in patients hospitalized in an intensive care unit with medical and surgical patients.
- Conditions
- Critical Illness, Hyperglycemia, Insulin Resistance
- Trial name
- NCT00096421
- Testing
- Tight control of blood glucose levels, Conventional control of glucose levels
- Where
- Colombia
- Volunteers
- 504 people
- Sponsor
- Hospital Pablo Tobón Uribe
Sepsis
Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS): A New Horizon for Surgical Critical Care and Induced Frailty
The purpose of this study is to define the natural history and causes of chronic critical illness (CCI) in surgical intensive care patients who have had sepsis.
- Trial name
- NCT02711709
- Testing
- Frailty Measurements, Modified Minnesota Leisure Time Activities, Computed tomography morphometrics
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Florida
Critical Illness, Surgical Procedure, Unspecified
Preoperative Fasting vs. Not Fasting in Critically Ill Patients
The goal of this clinical trial is to learn if fasting or not fasting before a procedure has an effect on recovery in those who are critically ill.
- Conditions
- Critical Illness, Surgical Procedure, Unspecified, Pulmonary Aspiration, Fasting
- Trial name
- FEEDS (NCT06751043)
- Testing
- Fasting, Not fasting
- Where
- 19 sites in United States
- Volunteers
- 1,072 people
- Sponsor
- Massachusetts General Hospital
Coronary Artery Disease
Intravenous Fish Oil in Critically Ill Cardiac Patients
A large body of evidence has accumulated showing that n-3 PUFAs exert extensive cardiac effects. The development of commercial solutions of FO opens perspectives for therapeutic applications in patients with acute cardiac…
- Trial name
- FO-cardiac (NCT00516178)
- Testing
- Fish oil emulsion, Saline
- Where
- 2 sites in Switzerland
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Fungal Prophylaxis, Candida Infection
Antifungal Prophylaxis in Intensive Care Unit (ICU) Patients
Purpose. Oral chemoprophylaxis has been advocated to reduce the incidence of Candida colonization and infection. However, Candida prophylaxis in intensive care unit (ICU) is still a matter of debate. Methods.
- Conditions
- Fungal Prophylaxis, Candida Infection, Critical Illness, Surgery
- Trial name
- NCT01495039
- Testing
- Nystatin
- Where
- Italy
- Volunteers
- 99 people
- Sponsor
- Policlinico Hospital