Clinical trials: Crohn's Diseases
Healthy
Safety, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of Ascending Doses BCD-261 in Healthy Subjects
The goal of this clinical trial is to investigate the safety, tolerability, pharmacodynamics, pharmacokinetics, and immunogenicity of BCD-261 after single subcutaneous injection at ascending doses and proposed therapeutic doses…
- Trial name
- NCT06715540
- Testing
- BCD-261, dose 1, BCD-261, dose 2, BCD-261, dose 3
- Where
- Russia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Biocad
Crohn Disease (CD)
The Microbial Impact on Intestinal Fibrosis and the Associated Immune Microenvironment in Crohn's Disease
The goal of this study is to find out if there is a direct connection between an imbalance of gut bacteria and the development of scar tissue in the gut by identifying important bacterial proteins found in scarred gut tissue.
- Trial name
- NCT06720961
- Testing
- Collection of surgical specimen, Collection of stool sample
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Inflammatory Bowel Diseases, Psychosocial Impairment
Evaluation of Quality of Life and Psychosocial Status in Children With Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a chronic condition that affects the psychosocial status and physical activities of children and their parents in many ways.
- Trial name
- NCT06270277
- Testing
- Pediatric Quality of Life Inventory (PedsQL), Strengths and Difficulties Questionnaire (SDQ)
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Crohn Disease, Ulcerative Colitis
Endoscopic Ultrasound Determines Disease Activity in Crohn's Disease And Ulcerative Colitis
Although Crohn's disease and ulcerative colitis are the main subtypes of inflammatory bowel disease, they differ substantially in disease behavior, prognosis, and treatment paradigm.
- Trial name
- EUSIBD (NCT03863886)
- Testing
- Endoscopic ultrasound catheter (UM-2R/3R, Olympus)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Crohn's Disease, Ulcerative Colitis
Proteomic Analysis of Crohn's Disease Macrophages in Response or Not to AIEC
The M2iSH laboratory showed with two previous clinical trials that Crohn's Disease (CD) macrophages present i) a defect to control Adherent-Invasive Escherichia coli (AIEC) infection related to polymorphisms associated with CD…
- Trial name
- ROMAN (NCT03404557)
- Testing
- Proteomic analysis
- Where
- France
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Ulcerative Colitis, Crohn's Disease
Threonine Requirement in IBD Adults and Healthy Adult Controls
The daily requirement of threonine, an essential amino acid, will be evaluated in healthy adult males and in adult males with Crohn's Disease or ulcerative colitis using the indicator amino acid oxidation (IAAO) method.
- Conditions
- Ulcerative Colitis, Crohn's Disease, Healthy
- Trial name
- NCT02423460
- Testing
- Threonine
- Where
- Canada
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Inflammatory Bowel Disease, Colitis, Ulcerative
Biomarkers in Inflammatory Bowel Diseases
Ulcerative colitis (UC) and Crohn's disease (CD) are chronic relapsing inflammatory bowel diseases (IBD). At the time of diagnosis it is not possible to predict the course of the disease, which can range from a few flares in a…
- Conditions
- Inflammatory Bowel Disease, Colitis, Ulcerative, Crohn Disease
- Trial name
- NCT02612103
- Where
- Denmark
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Line Elberg Godskesen
Inflammatory Bowel Disease, Crohn's Disease
SSAT 054: Non Genetic Factors in the Pathogenesis of IBD in Twins
This study aims to investigate the role of non-genetic factors in the pathogenesis of inflammatory bowel disease.An exploratory study to investigate differences between the epigenome, microbiota and functional immunology in twins…
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT02383953
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- St Stephens Aids Trust
Crohn Disease
Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult
The pathogenesis of Crohn Disease (CD) is unknown, but there is evidence show that the inadequate immune response or overreaction of the immune system against food antigens or components of the commensal flora involve it.
- Trial name
- EN (NCT02056418)
- Testing
- enteral nutrition, corticosteroid
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Crohn Disease
PMA-Zeolite-Clinoptilolite Effects in Crohn Disease
This pilot study aims to evaluate the safety and efficacy of PMA-zeolite when used in patients with uncontrolled CD (Crohn´s disease).
- Trial name
- NCT04370535
- Testing
- cellulose, PMA-zeolite
- Where
- 3 sites in Slovenia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ciim Plus, d.o.o.
Lymphocytic Enteritis (Disorder), Healthy Volunteers
Evaluation of the Lymphocyte Subpopulations in the Normal Mucosa of the Upper Digestive Tract
The macro and microscopic findings of the upper gastrointestinal tract are useful in the differential diagnosis of digestive diseases such as Crohn's or celiac diseases.
- Trial name
- GUTproject (NCT05084807)
- Testing
- Endoscopy
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital Mutua de Terrassa
Crohn's Disease, Olfactogustatory Perception
Olfactogustatory Perception, Eating Behaviour and Inflammation in Crohn's Disease
This study will improve our understanding of the mechanisms underlying anorexia in persons with Crohn's disease flare-ups. The practical spin-off from this research is potentially very important for the management of nutritional…
- Trial name
- Smell&Crohn (NCT02859675)
- Testing
- triangular test, blood sampling, Questionnaires
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
IBD, Crohn Disease
Volatile Organic Compounds (VOCs) in Active Inflammatory Bowel Disease
Inflammatory Bowel Disease (IBD) are chronic diseases of the gut comprising Crohn's Disease (CD) and Ulcerative Colitis (UC). The symptoms of IBD consist of diarrhea, abdominal discomfort, weight loss, fatigue and rectal…
- Conditions
- IBD, Crohn Disease, Ulcerative Colitis
- Trial name
- VOC (NCT04827368)
- Testing
- Breath Test
- Where
- United States
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis)
Study of Single and Multiple Ascending Doses of CM551 in Healthy Participants
This is a randomized, double-blind, placebo-parallel controlled phase I study to evaluate the safety and tolerability of single and multiple doses of CM551 in healthy participants
- Trial name
- NCT07900945
- Testing
- CM551
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Keymed Biosciences Co.Ltd
Inflammatory Bowel Diseases
Study of an Environmental Risk Factor in Crohn's Disease
Inflammatory bowel disease (IBD) are lifelong chronic diseases affecting the gastrointestinal tract. The precise etiology and the different actors participating to the pathophysiological process leading to the disease development…
- Trial name
- EVICTION (NCT04960826)
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Rheumatoid Arthritis, Osteoarthritis
FolateScan in Autoimmune Disease
This study will gather information on the safety of FolateScan and the ability of FolateScan to detect inflammation in the joints and other organs in people with arthritis (rheumatoid arthritis and osteoarthritis), systemic lupus…
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Multiple Sclerosis, Crohn's Disease
- Trial name
- NCT00588393
- Testing
- FolateScan (Technetium Tc 99mEC20)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Crohn Disease
Myoelectric GutPrint-Crohn's Disease
A feasibility study for assessing and recording myoelectric activity in patients for early detection of flare in patients with Crohn's disease and differentiating the myoelectric signals from Crohn's disease patients in remission…
- Trial name
- Gutcheck-CD (NCT03774485)
- Testing
- G-Tech Gutcheck Myoelectric recording device
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Stanford University
IBD and Renal Involement, Chronic Kidney Disease
Renal Dysfunction in Patients With Inflammatory Bowel Disease and the General Population (NEPHRO-IBD)
The NEPHRO-IBD study is a multicenter prospective observational study designed to evaluate the prevalence of renal dysfunction and renal complications in adult patients with inflammatory bowel disease (IBD) compared with…
- Conditions
- IBD and Renal Involement, Chronic Kidney Disease, Inflamatory Bowel Disease (Crohn's and Ulcerative Colitis)
- Trial name
- NEPHRO-IBD (NCT07593352)
- Testing
- Prospective assessment of the prevalence of kidney disease and/or renal complications in patients with IBD/the general population based on routine laboratory test and abdominal ultrasound.
- Where
- Poland
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Państwowy Instytut Medyczny Ministerstwa Spraw Wewnętrznych i Administracji
Inflammatory Bowel Disease, Crohn's Disease
The Role of Gut Microbiome in Predicting Comorbidities and Complications in Children With Inflammatory Bowel Disease
Background: Bacteria and other microorganisms that live in the intestines (the gut microbiome) play an important role in a person s health. The gut microbiome helps to regulate the immune system and control inflammation.
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT05652491
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Crohn Disease, Spondyloarthritis
Identification of Fecal Microbiota Biomarkers of Spondyloarthritis in Patients Suffering From Crohn's Disease.
The MICROSPA project aims to compare gut microbiota, serum cytokines, and PBMC of patients suffering from Crohn's disease (CD) associated or not to spondylarthritis (SpA).
- Trial name
- MICROSPA (NCT03983473)
- Testing
- Microbiota Sequencing
- Where
- 2 sites in France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France