Clinical trials: Crohn Disease (CD)
Crohn Disease (CD), Ulcerative Colitis (UC)
Research for the Precision Medicine in the Treatment of Inflammatory Bowel Disease
This study aims to establish an integrated cohort of patients with inflammatory bowel disease (IBD) from Seoul National University Hospital, Seoul National University Boramae Medical Center, and Seoul National University Bundang…
- Conditions
- Crohn Disease (CD), Ulcerative Colitis (UC), IBD (Inflammatory Bowel Disease)
- Trial name
- PREDICT (NCT07166588)
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Seoul National University Hospital
Inflammatory Bowel Disease (IBD), Crohn's Disease
A Study in Adults With Ulcerative Colitis (UC) or Crohn's Disease (CD) Receiving Vedolizumab in Real-World Practice in Poland
The primary reason of this study is to observe current treatment options in participants receiving Vedolizumab, intravenous (IV) or subcutaneous (SC), for IBD in Poland.
- Conditions
- Inflammatory Bowel Disease (IBD), Crohn's Disease, Ulcerative Colitis
- Trial name
- VARIETY (NCT05384080)
- Where
- 11 sites in Poland
- Volunteers
- 165 people
- Sponsor
- Takeda
Crohn Disease, Intestinal Tuberculosis
MRI Differentiating Gut TB and Crohn's
It is clinically challenging to differentiate Crohn's disease from gut tuberculosis especially in regions endemic of tuberculosis infection.
- Trial name
- NCT03096379
- Testing
- Magnetic resonance imaging
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The University of Hong Kong
Crohn's Disease
Nine-Weeks Treatment With 683699 In Subjects With Moderately-To-Severely Active Crohn's Disease
This study will evaluate the effectiveness and safety of the investigational drug 683699 in treating subjects with moderately to severely active CD (Crohn's Disease).
- Trial name
- NCT00101946
- Testing
- 683699
- Where
- 19 sites in United States, Canada
- Volunteers
- 17 people
- Sponsor
- GlaxoSmithKline
Exacerbation of Ulcerative Colitis, Ulcerative Colitis, Active Severe
Manipulating the Microbiome in IBD by Antibiotics and FMT
the etiology of Inflammatory Bowel Diseases (IBD) is closely associated with the gut microbiome. The results of previous studies on the effectiveness of antibiotics and fecal macrobiota transplantation (FMT) are contradicting.
- Conditions
- Exacerbation of Ulcerative Colitis, Ulcerative Colitis, Active Severe, Crohn's Colitis
- Trial name
- FMT (NCT02033408)
- Testing
- AB (antibiotics), CS (corticosteroids) Only
- Where
- 12 sites in Canada, Finland and 4 more
- Volunteers
- 28 people
- Sponsor
- Shaare Zedek Medical Center
Pediatric Inflammatory Bowel Disease
Impact of Therapeutic Strategies in the Pediatric Inflammatory Bowel Disease: a Population Based Study (1988-2011).
Crohn's disease (CD) and ulcerative colitis (UC) are chronic Inflammatory Bowel Disease (IBD) and may affect all segments of the digestive tract.
- Trial name
- Inspired (NCT02392221)
- Where
- 2 sites in France
- Volunteers
- 966 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Crohn's Disease
Oral Budesonide vs. Oral Mesalazine in Active Crohn's Disease (CD)
The purpose of this study is to determine whether mesalazine or budesonide is more active in the treatment of active Crohn's disease.
- Trial name
- NCT00300118
- Testing
- budesonide, mesalazine
- Where
- Germany
- Volunteers
- 311 people
- Sponsor
- Dr. Falk Pharma GmbH
Small Bowel Crohn's Disease
Combined [18F]-FDG PET-MRI in Diagnostics and Surveillance of Small Bowel Crohn's Disease
Patients with suspected small bowel Crohn's disease (CD) are assessed with PET-MRE using 18-fluorodeoxyglucose ([18F]-FDG) tracer.
- Trial name
- CD-PET (NCT06796959)
- Where
- Finland
- Volunteers
- 35 people
- Sponsor
- Turku University Hospital
Crohn's Disease
The Efficacy of Enteral Nutrition in Fill of the Treatment Blank Period of the Postoperative Maintain Remission Medication for Crohn's Disease (CD)
Crohn's disease(CD) is a agnogenic disease which has a lifelong relapse tendency even after surgery treatment.So maintain remission medications were routinely given to patients after surgery.But maintain remission medications,as…
- Trial name
- NCT01823042
- Testing
- azathioprine+enteral nutrition, Azathioprine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jinling Hospital, China
Crohn Disease (CD)
Clostridium Butyricum in Stenosing Crohn's Disease
Crohn's disease is a condition of unknown etiology with an immune-mediated pathogenesis. The subgroup of Crohn's disease with a stricturing phenotype represents a particular challenge for clinicians, as currently no effective…
- Trial name
- AUTOCD (NCT07263880)
- Testing
- Clostridum Butyricum Capsule, Trehalose
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- San Giovanni Addolorata Hospital
Crohn Disease (CD), Crohn Disease
Cranberry and Gut Health in Crohn's Disease
This study is investigating whether a cranberry-based dietary supplement, rich in polyphenols and fiber, can enhance gut health in individuals with Crohn's disease.
- Trial name
- NCT07170462
- Testing
- Cranberry powder
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Ana Maldonado-Contreras
Crohn Disease
Safety and Efficacy of EcoActive on Intestinal Adherent Invasive E. Coli in Patients With Inactive Crohn's Disease
This study will evaluate the safety of oral administration of EcoActive to patients with inactive Crohn's disease and how it affects the levels of AIEC in stool.
- Trial name
- NCT03808103
- Testing
- Bacteriophage preparation
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Intralytix, Inc.
IBD (Inflammatory Bowel Disease), Ulcerative Colitis (UC)
Assessing Interventions of Diet in IBD
In this study, we are trying to learn how certain diets affect people with inflammatory bowel disease (IBD). We want to understand what makes it hard or easy for them to stick to different eating plans, like intermittent fasting…
- Conditions
- IBD (Inflammatory Bowel Disease), Ulcerative Colitis (UC), Crohn Disease (CD)
- Trial name
- AID-IBD (NCT06773182)
- Testing
- Intermittent Fasting Intervention, Mediterranean Diet Intervention, Low FODMAP Diet Intervention
- Where
- 2 sites in Canada
- Volunteers
- 45 people
- Sponsor
- McMaster University
Crohn Disease (CD)
TNFi Plus Low-Dose Upadacitinib vs TNFi Intensification in Crohn's Disease With Suboptimal Response
This multicenter, randomized, controlled trial aims to evaluate the efficacy and safety of standard-dose tumor necrosis factor inhibitor (TNFi) plus low-dose upadacitinib compared with TNFi dose intensification in patients with…
- Trial name
- CD (NCT07510191)
- Testing
- Upadacitinib, Infliximab Dose Intensification, Adalimumab Dose Intensification
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Crohn's Disease, Ulcerative Colitis (UC)
A Blood and Tissue Sample Collection Study of Patients Who Have Inflammatory Bowel Disease, Who Have Been Treated With Adalimumab and Who Developed Hepatosplenic T-Cell Lymphoma
To collect and store blood and biopsy samples obtained from CD or UC patients exposed to adalimumab and diagnosed with Hepatosplenic T-cell Lymphoma (HSTCL), for the purpose of identifying potential biomarkers and genetic…
- Conditions
- Crohn's Disease, Ulcerative Colitis (UC), Hepatosplenic T-Cell Lymphoma
- Trial name
- HSTCL (NCT02087878)
- Where
- Italy
- Sponsor
- AbbVie
Crohn's Disease
COMMIT (Combination Of Maintenance Methotrexate-Infliximab Trial)
The primary objective is to compare the efficacy and safety of infliximab plus methotrexate to infliximab alone for the long-term control of signs and symptoms of Crohn's disease (CD) in patients with symptoms that are persistent…
- Trial name
- NCT00132899
- Testing
- Methotrexate
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- University of Western Ontario, Canada
Crohn&Amp;#39;s, Crohn&Amp;#39;s Disease (CD)
A Double-Blind, Randomized, Placebo-Controlled Phase II Clinical Trial to Evaluate the Safety and Efficacy of L2-01 in Subjects With Crohn's Disease
This clinical trial is testing a new treatment called L2-01 in patients with Crohn's Disease, a condition that causes ongoing inflammation of the digestive tract.
- Trial name
- NCT07010926
- Testing
- L2-01 adipose-derived mesenchymal stem cells (MSC)
- Volunteers
- 120 people
- Sponsor
- EL3 Bio, LLC.
Inflammatory Bowel Disease
Johns Hopkins Crohn's Disease and Ulcerative Colitis Study
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a idiopathic, chronic and frequently disabling inflammatory disorder of the intestines characterized by a dysregulated mucosal…
- Trial name
- NCT01169207
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Crohn's Disease
A Phase II Study of H021 Enteric-coated Tablets for Moderately to Severely Active Crohn's Disease
This study employs a multicenter, randomized, double-blind, placebo-controlled, parallel-group, continuous treatment design to evaluate the efficacy, safety, PPK characteristics, and PD effects of H021 Enteric-coated Tablets…
- Trial name
- NCT07677514
- Testing
- H021 Enteric-coated Tablets Low-dose Group, H021 Enteric-coated Tablets High-dose Group
- Where
- 24 sites in United States, China
- Volunteers
- 156 people
- Sponsor
- Jiangsu Carephar Pharmaceutical Co., Ltd.
Crohn Disease (CD), IBD (Inflammatory Bowel Disease)
Abdominally Targeted Management Exercises for Crohn's Disease Patients (TAME-CD)
The goal of this clinical trial is to learn if abdominally targeted exercises can assist to manage disease activity in Crohn disease (CD) patients.
- Trial name
- NCT06917443
- Testing
- Abdominally targeted exercises, General exercises
- Where
- Israel
- Volunteers
- 42 people
- Sponsor
- Shmuel Kivity, MD