Clinical trials: Crohn Disease (CD)
Ulcerative Colitis, Crohn's Disease
Long-term Safety With Vedolizumab Intravenous (IV) in Pediatric Participants With Ulcerative Colitis (UC) or Crohn's Disease (CD)
The purpose of this study is to determine the safety profile of long-term vedolizumab IV treatment in pediatric participants with UC or CD.
- Trial name
- NCT03196427
- Testing
- Vedolizumab
- Where
- 23 sites in United States, France and 5 more
- Volunteers
- 59 people
- Sponsor
- Takeda
Crohn's Disease
A Study of Abatacept in Patients With Active Crohn's Disease
The purpose of this clinical research study is to learn if abatacept can improve signs and symptoms of active Crohn's Disease in patients who have not had an adequate response to other therapies.
- Trial name
- NCT00406653
- Testing
- abatacept
- Where
- 101 sites in United States, Australia and 15 more
- Volunteers
- 451 people
- Sponsor
- Bristol-Myers Squibb
Crohn Disease
Identification of Factors ASsociaTed With a Delayed Diagnosis in Crohn's Disease
The goal of this observational study is to determine the factors associated with a delayed diagnosis and/or an immediately complicated disease for CD patients.
- Trial name
- FAST (NCT06250361)
- Testing
- Questionnaire completion
- Volunteers
- 600 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Crohn Disease
The Crohn's Disease Exclusion Diet With Early Dairy Introduction vs Partial Enteral Nutrition for Crohn's Disease
This study aims to evaluate a novel diet for adult Crohn's disease patients (The Crohn's Disease Exclusion Diet - CDED). Some of the patients in this study will receive the CDED combined with partial enteral nutrition (PEN)…
- Trial name
- CD-EDEN (NCT05606419)
- Testing
- CDED+PEN, CDED+dairy
- Where
- Greece
- Volunteers
- 44 people
- Sponsor
- Evangelismos Hospital
Crohn's Disease, Active, Crohn's Disease (CD)
Tailored Anti-Inflammatory American Diet for Patients With Crohn's Disease
The purpose of this study is to test the effect of an anti-inflammatory diet tailored for patients living in the United States with Crohn's Disease (CD) on clinical symptoms and disease inflammation and to identify biomarkers of…
- Conditions
- Crohn's Disease, Active, Crohn's Disease (CD), Diet Interventions
- Trial name
- NCT07671872
- Testing
- Catered Anti-Inflammatory Diet, Diet Guidance for Usual Diet
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- University of Miami
Crohn Disease (CD), Ulcerative Colitis (UC)
the REMONO-CD and the REMONO-UC Studies
Infliximab was the first-in-class anti-TNF agent approved for treating patients with IBD, both for Crohn's disease (CD)1 and ulcerative colitis (UC)2.
- Trial name
- REMONO (NCT07564609)
- Where
- 18 sites in France
- Volunteers
- 420 people
- Sponsor
- University Hospital, Clermont-Ferrand
Crohn Disease (CD), Intestinal Stricture
Endoscopic Stricturotomy Versus Balloon Dilation for Small Bowel Fibrotic Strictures in Crohn's Disease
This multicenter, open-label, randomized controlled trial aims to compare the safety and immediate effectiveness of endoscopic stricturotomy (ES) and endoscopic balloon dilation (EBD) for the treatment of small bowel fibrotic…
- Conditions
- Crohn Disease (CD), Intestinal Stricture, Intestinal Fibrosis
- Trial name
- NCT07833332
- Testing
- Endoscopic Stricturotomy, Endoscopic Balloon Dilation
- Where
- China
- Volunteers
- 244 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC)
A Phase 2 Study to Evaluate Therapies for Inflammatory Bowel Disease
This is a Phase 2, multicenter, platform study in adult participants with IBD (moderately to severely active Crohn's Disease or Ulcerative Colitis).
- Conditions
- Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC), Crohn's Disease
- Trial name
- ASCEND-IBD (NCT07113522)
- Testing
- MT-501, MT-201
- Where
- 66 sites in United States, Canada and 3 more
- Volunteers
- 140 people
- Sponsor
- Mirador Therapeutics, Inc.
Ileocolic Crohn Disease, Kono S Anastomosis
The Remeasure Trial
Aim of the present study is to compare a stapled, functional end-to-end, ileo-colic anastomosis with removal of the mesentery vs the manual, functional end-to-end, ileo-colic Kono-S anastomosis with mesentery preservation, in…
- Conditions
- Ileocolic Crohn Disease, Kono S Anastomosis, Resection of the Mesentery
- Trial name
- NCT07164209
- Testing
- Excision of the mesentery: the mesentery is fully dissected and excised to the limit of macroscopic "fat wrapping", where mesenteric fat is inflamed and extends beyond its normal anatomical distribut, Kono S Anastomosis
- Where
- Italy
- Volunteers
- 73 people
- Sponsor
- Azienda Ospedaliera Ordine Mauriziano di Torino
Autoimmune Diseases, Inflammatory Bowel Diseases
Chronic Inflammatory Disease, Lifestyle and Treatment Response
Chronic inflammatory diseases (CID) - including inflammatory bowel diseases (Crohn's disease and ulcerative colitis), rheumatic conditions (rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis), inflammatory skin…
- Conditions
- Autoimmune Diseases, Inflammatory Bowel Diseases, Crohn Disease (CD), Colitis, Ulcerative (UC)
- Trial name
- BELIEVE (NCT03173144)
- Testing
- Primary exposure variable, Other (exploratory) exposure variables
- Where
- 3 sites in Denmark
- Volunteers
- 233 people
- Sponsor
- University of Southern Denmark
Crohn's Disease
An Observational Study to Assess Change in Disease Activity and Adverse Events in Adolescent and Adult Participants With Moderate to Severe Active Crohn's Disease (CD) in Japan
Crohn's disease (CD) is an incurable chronic inflammatory disorder of the gastrointestinal tract. This study will assess how safe and effective upadacitinib is in treating moderately to severely active CD in real world.
- Trial name
- NCT06023030
- Where
- 104 sites in Japan
- Volunteers
- 240 people
- Sponsor
- AbbVie
Crohn Disease
ProteIn Nutrition in Crohn's Disease
Muscles are essential for good quality of life. The investigators have shown that when children with Crohn's disease eat protein, only very little of it enters the muscles, leading to poor muscle growth and fatigue.
- Trial name
- PINC (NCT05572008)
- Testing
- Protein nutrition in paediatric Crohn's disease
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Crohn Disease (CD)
Impact of Advanced Crohn's Disease Therapies on Sleep Quality
The goal of this observational study is to measure changes in sleep quality before and after starting treatment with advance therapy in adult with Crohn disease.
- Trial name
- NCT07649408
- Testing
- Wearable activity and sleep tracker
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Shmuel Kivity, MD
CD - Crohn's Disease
Comparison of the Therapeutic Effects of Balloon Assisted Enteroscopy Assisted Narrow Incision and Balloon Dilation in the Treatment of Crohn's Disease Small Intestinal Stenosis
This study is designed as a controlled trial to evaluate the efficacy of balloon-assisted enteroscopy-guided radial incision therapy for the treatment of stricturing small bowel Crohn's disease.
- Trial name
- CD stenosis (NCT07409376)
- Testing
- stricture incision, balloon dilation, No Interventions
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Inflammatory Bowel Disease
Multi-Center African-American Inflammatory Bowel Disease Study (MAAIS)
The investigators are doing the research to discover genes that cause Inflammatory Bowel Disease (IBD) specifically in the African American population.
- Trial name
- MAAIS (NCT01169194)
- Where
- United States
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
MASH, PSC
A Microdose Trial Investigating Binding of [68Ga]Ga-DOTA-CYS-ATH001 in Healthy Subjects and Different Patient Groups.
The goal of this clinical trial is to use positron emission tomography (PET) to evaluate and compare the binding of the novel tracer [68Ga]Ga-DOTA-Cys-ATH001 in the liver and/or gastrointestinal tract between healthy volunteers…
- Conditions
- MASH, PSC, Fibrostenotic Crohn's Disease, Healthy Volunteers
- Trial name
- NCT06562361
- Testing
- [68Ga]Ga-DOTA-Cys-ATH001
- Where
- 3 sites in Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Antaros Medical
Inflammatory Bowel Disease (IBD), Crohn's Disease (CD)
Observational, Real World Study Of Inflectra In Patients With Inflammatory Bowel Disease
This is a prospective, observational, multicenter study conducted in adult patients with ulcerative colitis (UC) or Crohn's disease (CD).
- Conditions
- Inflammatory Bowel Disease (IBD), Crohn's Disease (CD), Ulcerative Colitis (UC)
- Trial name
- ONWARD (NCT03801928)
- Testing
- Inflectra
- Where
- 15 sites in United States, Canada
- Volunteers
- 118 people
- Sponsor
- Pfizer
Crohn Disease
Biomarkers of Intestinal Mucosal Healing in Crohn's Disease (P08143)
This study will evaluate biomarkers that reflect changes in gut mucosal status during therapy with infliximab and determine whether changes in the levels of the selected biomarkers can be used to predict endoscopically assessed…
- Trial name
- NCT01349920
- Testing
- Infliximab
- Volunteers
- 15 people
- Sponsor
- Merck Sharp & Dohme LLC
Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC)
Anal Human Papillomavirus in Inflammatory Bowel Disease Study
This is an observational cohort study with two time points (baseline and after at least 6 months of treatment with a non-corticosteroid immunosuppressive agent for inflammatory bowel disease (IBD)).
- Conditions
- Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC), Crohn's Disease (CD), Anal Human Papillomavirus
- Trial name
- AnalHPV&IBD (NCT01364896)
- Testing
- Venous blood samples, anal swab samples, vaginal swab samples, high resolution anoscopy (HRA), anal biopsy samples
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Pittsburgh
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Crohn Disease (CD)
Eating Disorders in Patients With IBD
Inflammatory bowel diseases (IBD) may influence eating habits and lead some patients to adopt restrictive dietary behaviours to control gastrointestinal symptoms.
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Crohn Disease (CD), Ulcerative Colitis (UC), ARFID
- Trial name
- NCT07610694
- Where
- Italy
- Volunteers
- 355 people
- Sponsor
- Federico II University