Clinical trials: Crohn Disease (CD)
Crohn's Disease
USTekinumab in Fistulising Perianal Crohn's Disease (USTAP)
Phase IV Trial design : Multicentre, randomized, double-blind, placebo-controlled study Population : Moderate to severe Crohn's disease with at least one active perianal fistula track Investigational treatment : Group 1…
- Trial name
- USTAP (NCT04496063)
- Testing
- Ustekinumab
- Where
- 20 sites in France
- Volunteers
- 33 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Inflammatory Bowel Diseases, Crohn Disease (CD)
Early Inflammatory Bowel Disease Progression
The purpose of this study is to assess the capacity of the gut microbial composition and function to predict the course of IBD during the first year after diagnosis.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- PRO-IBD (NCT06756100)
- Where
- Chile
- Volunteers
- 140 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Ulcerative Colitis (UC), IBD (Inflammatory Bowel Disease)
Ex Vivo Comparison Of Combination Versus Single Therapeutic Pathway Inhibition In Human Intestinal Mucosa From Patients With Inflammatory Bowel Disease
The purpose of this study is to evaluate whether simultaneously targeting three inflammatory pathways (TL1A, IL-23, and α4β7) produces a stronger anti-inflammatory effect in intestinal tissue from patients with Inflammatory Bowel…
- Conditions
- Ulcerative Colitis (UC), IBD (Inflammatory Bowel Disease), Crohn Disease (CD)
- Trial name
- NCT07824726
- Testing
- Collection of 8 additional intestinal mucosal biopsies during standard-of-care endoscopy for subsequent ex vivo testing, Collection of an additional 2 mL blood sample
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- PhoenixLAB srls
IBD (Inflammatory Bowel Disease), Crohn Disease (CD)
Individualizing Anti-TNF Therapy in Patients With Inflammatory Bowel Disease
This observational study aims to identify genes that may affect how patients with inflammatory bowel disease respond to anti-TNF treatment and why some patients lose response to treatment over time.
- Conditions
- IBD (Inflammatory Bowel Disease), Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- NCT07644117
- Testing
- This is an observational study with no intervention. Patients will receive anti- TNF therapy as part of their standard care
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Shmuel Kivity, MD
Inflammatory Bowel Disease (IBD), Crohn&Amp;#39;s Disease (CD)
Evaluating the Shift From Intravenous to Subcutaneous Vedolizumab for Inflammatory Bowel Disease
The goal of this retrospective study is to learn about dosing patterns in patients starting subcutaneous vedolizumab administration and patient outcomes after starting subcutaneous administration.
- Conditions
- Inflammatory Bowel Disease (IBD), Crohn&Amp;#39;s Disease (CD), Ulcerative Colitis (UC)
- Trial name
- NCT07123350
- Testing
- Patient switched from IV vedolizumab to subcutaneous vedolizumab as part of normal patient care
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Vanderbilt University Medical Center
Crohn's Disease (CD), Ulcerative Colitis (UC)
Upadacitinib for Refractory IBD in Asian Children and Elderly: Age-Stratified Analysis
This single-center, retrospective study aims to evaluate the effectiveness and safety of upadacitinib (UPA) in Asian pediatric patients with refractory Crohn's disease (CD) and elderly patients with refractory ulcerative colitis…
- Conditions
- Crohn's Disease (CD), Ulcerative Colitis (UC), Refractory Crohn's Disease, Refractory Ulcerative Colitis
- Trial name
- UPA-AGE (NCT06922331)
- Testing
- Upadacitinib
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
CD - Crohn's Disease
Intestinal Response Patterns to Microbial Signals
A cohort of CD patients (total n=300) and a cohort of controls (healthy individuals and family members of CD patients, total n=200) will be recruited.
- Trial name
- NCT03872622
- Testing
- Blood tests, intestinal biopsies, stool samples, environmental exposure questionnaire and FFQ questionnaire
- Where
- Israel
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Crohn's Disease
An Observational Study to Assess Change in Disease Activity and Adverse Events In Adult Participants With Moderate to Severe Active Crohn's Disease (CD)
Crohn's disease (CD) is an incurable chronic inflammatory disorder of the gastrointestinal tract. This study will assess how safe and effective risankizumab is in treating moderately to severely active CD in real world.
- Trial name
- APPRISE (NCT05841537)
- Where
- 154 sites in Austria, Canada and 9 more
- Volunteers
- 1,019 people
- Sponsor
- AbbVie
Ulcerative Colitis (UC), IBD (Inflammatory Bowel Disease)
The Prospective Improved Vitamin D Study for Inflammatory Bowel Disease Patients
The aim of this clinical trial is to gain a better understanding of the effect of Vitamin D supplementation on disease activity and overall health. The main questions it aims to answer are: 1.
- Conditions
- Ulcerative Colitis (UC), IBD (Inflammatory Bowel Disease), Crohn Disease (CD)
- Trial name
- PIVD (NCT07177157)
- Testing
- Vitamin D3 (Cholecalciferol)
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Terry Ponich
Crohn Disease (CD)
Evaluation of the Acceptability and Therapeutic Maintenance After Substitution of Ustekinumab With a Biosimilar
In a population of adult patients followed for Crohn's disease, who had previously agreed to replace Stelara® with a biosimilar of ustekinumab (Uzpruvo®) and were followed over a period of 12 months under usual medical practice…
- Trial name
- NCT07077681
- Where
- 11 sites in France
- Volunteers
- 246 people
- Sponsor
- EG Labo
Ulcerative Colitis, Crohn's Disease
A Long-Term Extension Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis (UC) or Crohn's Disease (CD)
The main aim of this study is to learn about medical problems (adverse events) if vedolizumab subcutaneously (SC) is given to a child or teenager with UC or CD for a long time.
- Trial name
- NCT06405087
- Testing
- Vedolizumab SC, No Intervention
- Where
- 47 sites in United States, Belgium and 12 more
- Volunteers
- 70 people
- Sponsor
- Takeda
Crohn Disease (CD), Perianal Crohns Disease
Regenerative Endoscopy in Refractory Perianal Crohn's Disease
Perianal fistulizing Crohn's disease (pCD) represents a severe phenotype of Crohn's disease, affecting approximately 20-30% of patients and resulting in chronic drainage, recurrent sepsis, impaired continence, and reduced quality…
- Trial name
- REPAIR-pCD (NCT07652632)
- Testing
- Autologous Mechanical Tissue Stromal Vascular Fraction (tSVF) Injection
- Where
- 2 sites in India
- Volunteers
- 50 people
- Sponsor
- Asian Institute of Gastroenterology, India
Inflammatory Bowel Disease (IBD), Crohn Disease (CD)
PROactive and Early Infliximab Monitoring and OPTimization in Inflammatory Bowel Disease
Infliximab (IFX) is a Food and Drug administration (FDA)-appoved monoclonal antibody medication targeting tumor necrosis factor (TNF) widely used in inflammatory bowel disease (IBD) to treat intestinal inflammation and improve…
- Conditions
- Inflammatory Bowel Disease (IBD), Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- PROMPT-IBD (NCT06758024)
- Testing
- Infliximab
- Where
- Chile
- Volunteers
- 72 people
- Sponsor
- Pontificia Universidad Catolica de Chile
CD
Changing the coUrse of cRohn's Disease With an Early Use of Adalimumab
This is a prospective, longitudinal, multicenter study conducted in a cohort of patients with early CD. This study will not change the patient/physician relationship.
- Trial name
- CURE (NCT03306446)
- Testing
- Start adalimumab in monotherapy
- Where
- 23 sites in Belgium, France
- Volunteers
- 203 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Ulcerative Colitis (UC), Ulcerative Colitis (Disorder)
A Phase I Study to Evaluate the Safety/Tolerability of BDHK-2009 Tablets in Healthy Adult
A Phase 1, 2-part, randomised, double-blind, placebo-controlled, FIH study to determine the safety, tolerability, and PK of single, ascending oral doses (SAD) of BDHK-2009 (Part 1) and multiple oral doses (Part 2) of BDHK-200 in…
- Conditions
- Ulcerative Colitis (UC), Ulcerative Colitis (Disorder), Ulcerative Colitis Acute, IBD (Inflammatory Bowel Disease)
- Trial name
- NCT07632573
- Testing
- BDHK-2009 Tablets
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Benethera (Shaoxing) Biotechnology Co., Ltd.
Crohn's Disease
Study About the Effect of Doxycycline and Acetylcystein in the Treatment of CD-associated Fistulae
The investigators will study whether local instillation of Doxycycline and Acetylcystein results in fistula closure in CD patients.
- Trial name
- NCT01012726
- Testing
- Colonoscopy
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Gerhard Rogler
Crohn Disease, Ultrasound Therapy; Complications
Correlation of Cross Sectional Imaging and Small Intestinal Contrast Ultrasonography in Known Crohn's Disease
Small intestinal contrast ultrasound (SICUS) is a modality of intestinal ultrasound (IUS) which does not require any parenteral administration of contrast agent but requires ingestion of around 500 ml of polyethylene glycol…
- Conditions
- Crohn Disease, Ultrasound Therapy; Complications, Computed Tomography, Magnetic Resonance Imaging
- Trial name
- CACTUS-CD (NCT06125678)
- Testing
- Small intestinal contrast enhanced ultrasound followed by Computed tomography/Magnetic resonance enterography
- Where
- India
- Volunteers
- 407 people
- Sponsor
- Asian Institute of Gastroenterology, India
Ulcerative Colitis (UC), Indeterminate Colitis
CEDUR - German IBD Registry
The CEDUR registry systematically collects real-world data on inflammatory bowel disease (IBD) patients in Germany. The registry aims to assess quality of care, disease activity, treatment effectiveness, safety, and…
- Conditions
- Ulcerative Colitis (UC), Indeterminate Colitis, Crohn Disease (CD)
- Trial name
- CEDUR (NCT07319442)
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- ImmunoRegister gUG
Crohn Disease (CD)
The Utility of Hand-held Ultrasound Devices to Detect Bowel Wall Inflammatory Activity in Crohn's Disease
One of the major obstacles in implementing intestinal ultrasound services for inflammatory bowel disease (IBD) patients relates to the costs of acquiring ultrasound (US) machines.
- Trial name
- NCT06686589
- Testing
- Intestinal ultrasound
- Volunteers
- 150 people
- Sponsor
- Sheba Medical Center
Crohn's Disease
A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease
Crohn's disease (CD) is a long-lasting condition causing inflammation that can affect any part of the gut. The purpose of this study is to evaluate the efficacy and safety of TAK-279 versus placebo in participants with moderately…
- Trial name
- NCT06233461
- Testing
- TAK-279
- Where
- 201 sites in United States, Australia and 23 more
- Volunteers
- 268 people
- Sponsor
- Takeda