Clinical trials: Crohn Disease of Intestine
Crohn's Disease
Oral Administration of AlequelTM for Patients With Inflammatory Bowel Disease (IBD)
Oral administration of Alequel, a mixture of proteins derived from the patient's bowel will be tested in patients with inflammatory bowel disease.
- Trial name
- NCT02185183
- Testing
- Alequel
- Volunteers
- 22 people
- Sponsor
- Hadassah Medical Organization
Crohn's Disease
Single and Repeat Dose Pharmacokinetic Study of GSK1605786 in Healthy Chinese Subjects
This is an open-label, parallel group, single and repeat dose pharmacokinetic (PK) study in healthy male and female subjects. This study will confirm the PK and safety profile in Chinese subjects.
- Trial name
- NCT01827631
- Testing
- GSK1605786 capsule
- Where
- China
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Crohn's Disease, Rheumatoid Arthritis
An ObserVatIonal STudy of the Effectiveness of AdaLimumab on Health and Disability Outcomes in New Zealand Patients With Immune-Mediated InflammaTorY Diseases (VITALITY)
For public health purposes disability is becoming increasingly important as an outcome measure. Despite this, there are few data on the effectiveness of adalimumab on disability outcomes in patients with immune-mediated…
- Conditions
- Crohn's Disease, Rheumatoid Arthritis, Psoriasis
- Trial name
- VITALITY (NCT02451839)
- Volunteers
- 168 people
- Sponsor
- AbbVie
Rheumatoid Arthritis, Spondyloarthritis
The Norwegian Drug Monitoring Study
Infliximab and other TNF-inhibitors have revolutionised the treatment of several immunological inflammatory diseases. Still, more than half of the patients either do not respond sufficiently to infliximab therapy or loose…
- Conditions
- Rheumatoid Arthritis, Spondyloarthritis, Ankylosing Spondylitis, Crohn Disease
- Trial name
- NOR-DRUM (NCT03074656)
- Testing
- Therapeutic drug monitoring, Standard care
- Where
- 21 sites in Norway
- Volunteers
- 611 people
- Sponsor
- Diakonhjemmet Hospital
Crohn Disease, Inflammatory Bowel Diseases
Effect of Acupuncture on Patients With Crohn's Disease in Remission
To observe the therapeutic effect of acupuncture on Crohn's disease in remission and its influence of brain functional activity
- Trial name
- NCT04211129
- Testing
- acupuncture
- Where
- 2 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Crohn Disease, Insomnia
CBT-I for Sleep, Pain, and Inflammation in Crohn's Disease
People with Crohn's disease often suffer from sleep problems. Long term, sleep problems may lead to more flares of Crohn's disease or other complications.
- Conditions
- Crohn Disease, Insomnia, Sleep Disturbance, Pain
- Trial name
- SPIN (NCT05034159)
- Testing
- Cognitive Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Crohn Disease (CD)
The Microbial Impact on Intestinal Fibrosis and the Associated Immune Microenvironment in Crohn's Disease
The goal of this study is to find out if there is a direct connection between an imbalance of gut bacteria and the development of scar tissue in the gut by identifying important bacterial proteins found in scarred gut tissue.
- Trial name
- NCT06720961
- Testing
- Collection of surgical specimen, Collection of stool sample
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Crohn's Disease, Ulcerative Colitis
Improving Treatment of Inflammatory Bowel Diseases Through Better Understanding Infliximab Drug and Antibody Levels
The purpose of this study is to develop a predictive model that will allow optimized dosing of infliximab for individual patients
- Trial name
- OPTIMIZE (NCT01787786)
- Sponsor
- University of Western Ontario, Canada
Crohn Disease
Biomarkers of Intestinal Mucosal Healing in Crohn's Disease (P08143)
This study will evaluate biomarkers that reflect changes in gut mucosal status during therapy with infliximab and determine whether changes in the levels of the selected biomarkers can be used to predict endoscopically assessed…
- Trial name
- NCT01349920
- Testing
- Infliximab
- Volunteers
- 15 people
- Sponsor
- Merck Sharp & Dohme LLC
Crohn Disease
A Pilot Study of FMT on CD Patients With AIEC
The goal of this pilot study is to test whether Fecal Microbiota Transplant (FMT) would be an effective antibacterial treatment for managing Adherent-invasive Escherichia coli (AIEC) colonization in Crohn's disease (CD) patients.
- Trial name
- NCT05611866
- Testing
- Fecal Microbiota Transplantation
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Crohn's Disease, Ileitis
Evaluate PF-00547659 On Cerebrospinal Fluid Lymphocytes In Volunteers With Crohn's Disease Or Ulcerative Colitis Who Failed Or Did Not Tolerate Anti-TNFs
Study is designed to show a lack of effect on white blood cells circulating in the spinal fluid.
- Conditions
- Crohn's Disease, Ileitis, Ileo-colonic and Colonic Crohn's Disease, Granulomatous Colitis
- Trial name
- TOSCA (NCT01387594)
- Testing
- lumbar puncture
- Where
- 9 sites in Austria, Belgium and 3 more
- Volunteers
- 49 people
- Sponsor
- Shire
Inflamatory Bowel Disease, Crohn Disease (CD)
Non-nutritive Sweeteners in Inflammatory Bowel Disease
This study will focus on the commonly used non-nutritive sweetener (NNS) sucralose (2 sachets/day resulting in daily dose: sucralose 2.5mg/kg) and its role in changing the gut microbiota in humans with IBD, compared to healthy…
- Trial name
- NCT07769437
- Testing
- Sucralose (non-nutritive sweetener)
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Crohn's Disease
Clinical Course of Korean Crohn's Disease Cohort
In the past decade, the incidence and prevalence of CD (Crohn's disease) has continued to increase in Korea. Previous studies have indicated that Asian IBD (inflammatory bowel disease) patients differ from those of Western…
- Trial name
- NCT01554007
- Testing
- Observation study
- Where
- 9 sites in South Korea
- Volunteers
- 2,000 people
- Sponsor
- Kyunghee University Medical Center
Inflammatory Bowel Diseases, Ulcerative Colitis
Predictors of Prognosis in IBD Patients
A study of clinical characteristics and potential prognostic factors in inflammatory bowel disease
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT05653011
- Testing
- Endoscopic biopsy
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Bundang Hospital
Crohn's Disease
An Audit of Patients With Crohn's Disease Treated With Infliximab (P06066)
The aim of this study is to quantify how infliximab therapy is being used in the UK and the consequent impact on health care resources, which will help to inform budget holders and payers on the costs associated with the…
- Trial name
- NCT00988832
- Testing
- Infliximab
- Volunteers
- 380 people
- Sponsor
- Merck Sharp & Dohme LLC
Crohn's Disease, Obesity or Overweight
Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight
The main purpose of this study is to evaluate the efficacy and safety of mirikizumab and placebo compared with mirikizumab and concomitantly administered tirzepatide in adult participants with moderately to severely active CD and…
- Trial name
- COMMIT-CD (NCT06937099)
- Testing
- Mirikizumab, Tirzepatide
- Where
- 183 sites in United States, Austria and 20 more
- Volunteers
- 290 people
- Sponsor
- Eli Lilly and Company
Inflammatory Bowel Disease (IBD)
SC12267 (4SC-101) for Treatment of Patients With Inflammatory Bowel Disease
This is an exploratory, open-label, uncontrolled, multi-center, 1-arm study conducted at 16 sites in Bulgaria, Germany and Romania. A total of ca.
- Trial name
- ENTRANCE (NCT00820365)
- Testing
- SC12267 (4SC-101)
- Where
- 16 sites in Bulgaria, Germany and 1 more
- Volunteers
- 34 people
- Sponsor
- 4SC AG
Crohn's Disease, Ulcerative Colitis
Medico-economic Evaluation of the Therapeutic Drug Monitoring of Anti-TNF-α Agents in Inflammatory Bowel Diseases
Since their appearance more than a decade ago, anti-tumor necrosis factor (TNF) inhibitors have demonstrated beneficial activity in the treatment of inflammatory bowel diseases (IBD).
- Trial name
- ATAIM (NCT02508012)
- Testing
- Immuno monitoring
- Where
- France
- Volunteers
- 260 people
- Sponsor
- University Hospital, Montpellier
Crohn Disease
An Efficacy and Safety Study of Anti-TNF Monoclonal Antibody in Patients With Fistulizing Crohn's Disease
The purpose of this study is to evaluate the effectiveness and safety of anti-TNF chimeric monoclonal antibody (cA2) compared to placebo in the treatment of patients with fistulizing Crohn's disease.
- Trial name
- NCT00269841
- Testing
- Infliximab 10 mg/kg, Infliximab 5 mg/kg
- Volunteers
- 94 people
- Sponsor
- Centocor, Inc.
Fibrostenotic Crohn's Disease
A Study of PALI-2108 in Healthy Volunteers, Patients With Ulcerative Colitis, and Patients With Fibrostenosing Crohn's Disease
This is a Phase 1b, open-label, exploratory study designed to evaluate the pharmacodynamic effects of PALI-2108, a phosphodiesterase-4 (PDE4) inhibitor, in patients with fibrostenotic Crohn's disease (FSCD).
- Trial name
- NCT07428096
- Testing
- PALI-2108
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Palisade Bio
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