Clinical trials: Crohn Disease of Intestine
Crohn's Disease
Open Label Extension Study to Protocol C2/13/DR-6MP-02
The open label extension study (Protocol C2/13/DR-6MP-02 EXT) is designed to evaluate the clinical efficacy and safety of 80 mg DR-6MP test formulation for an additional 12 weeks in subjects who already completed 12 weeks of…
- Trial name
- OLE (NCT01433432)
- Testing
- 80 mg DR-6MP
- Sponsor
- Teva GTC
Crohn Disease
Oral Administration of MB-102 Versus Dual Sugar Testing for Gut Permeability
The objectives of the study are to evaluate the safety and tolerability of oral administration of MB-102, and to evaluate the use of MB-102 as a means of measuring gut permeability in normal participants (n=10) and in those with…
- Trial name
- NCT03962998
- Testing
- Lactulose/Rhamnose solution, MB-102
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- MediBeacon
Spondyloarthritis, Crohn Disease
Characterization of the Intestinal Microbiota in Patients With Inflammatory Bowel Disease and/or Spondyloarthritis and Study of the Impact of an Anti-TNF Alpha Therapy
Spondyloarthritis and inflammatory bowel diseases are common diseases, frequently met together in overlap syndromes. Their physiopathology remains puzzling.
- Conditions
- Spondyloarthritis, Crohn Disease, Ulcerative Colitis
- Trial name
- MIST (NCT03359642)
- Testing
- blood sample, stool samples, food questionnaire
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Bordeaux
Crohn's Disease
Trial of Growth Hormone Therapy in Pediatric Crohn's Disease
The purpose of this study is to determine whether taking a growth hormone (GH) drug called somatropin causes the intestine of a person with Crohn's Disease (CD) to heal faster when compared to a person with Crohn's Disease that…
- Trial name
- NCT00109473
- Testing
- growth hormone, cortecosteroid
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Crohn Disease
Immune Modulation by Parenteral Fish Oil in Patients With Crohn's Disease
To evaluate the effects of infusion of a Fish oil-based lipid emulsion on TNF-α production and other relevant immune functions. A soybean oil emulsion, rich in the omega-6 polyunsaturated fatty acid linoleic acid, will serve as…
- Trial name
- NCT02349594
- Testing
- Omegaven 10%, Intralipid 20%
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Radboud University Medical Center
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Frailty
Immune Aging and Advanced Therapy Outcomes in Older Adults With IBD
The goal of this observational study is to learn whether signs of immune aging and frailty can help predict the balance of benefits and risks of advanced therapies in adults aged 60 years or older with inflammatory bowel disease…
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Frailty, Immunosenescence
- Trial name
- NCT07828886
- Volunteers
- 300 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Crohns Disease, Bile Acid Malabsorption
Colesevelam for the Treatment of Bile Acid Malabsorption in Patients With Crohn's Disease
The purpose of this study is to assess the efficacy of cholestagel to reduce the frequency of soft and liquid stools per day in patients with CD in clinical remission with symptoms of BAM and to assess the improvement in stool…
- Trial name
- COBAM (NCT01203254)
- Testing
- Colesevelam
- Where
- 6 sites in Germany
- Volunteers
- 34 people
- Sponsor
- Florian Beigel
Crohn's Disease
Certolizumab Pegol for Treatment of Adult Greek Patients With Moderate to Severe Crohn's Disease Who Failed Infliximab
An open-label multi-center single-cohort study to assess the safety and efficacy of certolizumab pegol for the treatment of signs and symptoms of active Crohn's disease in Greek patients who have previously responded to…
- Trial name
- NCT00307931
- Testing
- Certolizumab pegol
- Where
- 5 sites in Greece
- Volunteers
- 16 people
- Sponsor
- UCB Pharma
Crohn's Disease
Pilot Study of Stem Cell Transplantation for Children and Young Adults With Refractory Crohn's Disease.
This is a study for people with Crohn's Disease (CD) that are not responsive to standard treatment. CD is a chronic disease with an auto-immune component that goes away and relapses over the years and causes lifelong impairment…
- Trial name
- NCT02225795
- Testing
- Hematopoietic stem cell transplantation
- Sponsor
- TriStar Health
Crohn's Disease, Ulcerative Colitis
Proteomic Analysis of Crohn's Disease Macrophages in Response or Not to AIEC
The M2iSH laboratory showed with two previous clinical trials that Crohn's Disease (CD) macrophages present i) a defect to control Adherent-Invasive Escherichia coli (AIEC) infection related to polymorphisms associated with CD…
- Trial name
- ROMAN (NCT03404557)
- Testing
- Proteomic analysis
- Where
- France
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Crohn's Disease
A Study to Assess Efficacy, Safety and Tolerability of the Anti-IL-13 Monoclonal Antibody QAX576 in the Treatment of Perinanal Fistulas in Patients Suffering From Crohn's Disease
Test safety and efficacy and of a novel IL-13 AB in the treatment of perianal fistulas Trial with medicinal product
- Trial name
- NCT01316601
- Testing
- QAX567
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Gerhard Rogler
Inflammatory Bowel Diseases, Crohn Disease
Conventional vs Biologic Therapy in Pediatric IBD
This combined retrospective-prospective cohort study aims to evaluate the effectiveness, safety, and adverse events of conventional versus biologic therapy in children and adolescents with inflammatory bowel disease at Assiut…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT07818473
- Volunteers
- 100 people
- Sponsor
- Assiut University
Crohn Disease Haemorrhagic Rectocolitis
Study of the Impact of a Physical Activity Programme on the Quality of Life of Patients With Inflammatory Bowel Disease
Regular physical activity at a mild to moderate intensity can control inflammation in general and intestinal inflammation in particular during IBD.
- Trial name
- APMICI (NCT05099653)
- Testing
- physical activity
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Raincy Montfermeil Hospital Group
Crohn's Disease
Retrospective Data Analysis in Crohn's Disease
The purpose of this study is to identify prognostic parameters about efficacy of Mesalazine in recently diagnosed patients with Morbus Crohn by retrospective data collection.
- Trial name
- Crohn 2 (NCT01363427)
- Where
- 16 sites in Germany
- Volunteers
- 161 people
- Sponsor
- Ferring Pharmaceuticals
Intestinal Disease, Inflammatory Bowel Disease
Comparison of Capso Vision SV-1 to PillCam SB2 in the Evaluation of Subjects With Suspected Small Bowel Disease
The purpose of this study is to compare the clinical findings involving the small bowel obtained with the Capso Vision Video Capsule Device to those results obtained with the PillCam SB2.
- Conditions
- Intestinal Disease, Inflammatory Bowel Disease, Crohn Disease, Ulcer
- Trial name
- NCT01787825
- Testing
- PillCam SB2 capsule, CapsoCam SV-1
- Where
- 7 sites in United States, Canada
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Capso Vision, Inc.
Crohn's Disease
Intra-erythrocyte Dexamethasone Versus Placebo in Patients With Steroid-dependent Crohn's Disease
Primary objective: Assessment of the efficacy of EryDex vs PLACEBO in maintaining patients with steroid-dependent Crohn's disease in clinical remission throughout 12 months without oral steroids. Secondary objectives: 1.
- Trial name
- Crodex (NCT01277289)
- Testing
- Dexamethasone
- Where
- 8 sites in Italy, Romania and 1 more
- Volunteers
- 51 people
- Sponsor
- Quince Therapeutics S.p.A.
Crohn's Disease
Oral Budesonide vs. Oral Mesalazine in Active Crohn's Disease (CD)
The purpose of this study is to determine whether mesalazine or budesonide is more active in the treatment of active Crohn's disease.
- Trial name
- NCT00300118
- Testing
- budesonide, mesalazine
- Where
- Germany
- Volunteers
- 311 people
- Sponsor
- Dr. Falk Pharma GmbH
Crohn's Disease, Ulcerative Colitis
Effect of Iron and Vitamin E Supplementation on Disease Activity in Patients With Either Crohn's Disease or Ulcerative Colitis
Hypothesis:In patients with ulcerative colitis and Crohn's disease diagnosed with mild or moderate anaemia: 1. iron supplementation will increase disease activity and oxidative stress 2.
- Conditions
- Crohn's Disease, Ulcerative Colitis, Mild or Moderate Anaemia
- Trial name
- NCT00152841
- Testing
- Iron supplement 300-600 mg/day, Vitamin E 800IU
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Crohn's Disease
Single Ascending Dose Study of Oral CPSI-2364 (Semapimod)
This study will be conducted in healthy male or female subjects using a double-blind, randomized, placebo-controlled, single-dose design.
- Trial name
- NCT00950105
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Bowel Disease, Crohn Disease
Development of New Diagnostic Tools in Capsule Endoscopy
Patients participating to this study will provide images and videos of capsule endoscopy to train, tune and evaluate technological bricks of artificial intelligence solutions, in order to improve diagnostic performances of the…
- Conditions
- Bowel Disease, Crohn Disease, Celiac Disease, Chronic Diarrhea
- Trial name
- NOCE (NCT06152289)
- Where
- France
- Volunteers
- 10,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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