Clinical trials: Crohn Disease of Intestine
Crohn's Disease
A Study to Assess the Effectiveness of Second-Line Therapy of Upadacitinib and Risankizumab in Adult Participants With Crohn's Disease in a Real-World Setting
Crohn's disease (CD) is an incurable chronic inflammatory disorder of the gastrointestinal tract. This study will evaluate the second line effectiveness of upadacitinib and risankizumab in Crohn's Disease (CD) in a real-world…
- Trial name
- CROHNOS (NCT07073079)
- Where
- 25 sites in Italy
- Volunteers
- 250 people
- Sponsor
- AbbVie
Inflammatory Bowel Diseases, Crohn Disease
The PRognostic Effect of Environmental Factors in Crohn's and Colitis
The PREdiCCt Study: This is a major study that is now being launched. This is the first study of its kind and is specifically directed toward understanding how environmental factors and the gut microorganisms influence IBD flare…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- PREdiCCt (NCT03282903)
- Where
- 41 sites in United Kingdom
- Volunteers
- 2,629 people
- Sponsor
- University of Edinburgh
Crohn´s Disease
The Role of IL-23-Responsive Immune Cell Subsets in Post-Operative Recurrence in Patients With Crohn's Disease.
Inflammatory Bowel Diseases (IBDs), including ulcerative colitis and Crohn's disease (CD), constitute a group of debilitating chronic diseases that profoundly impact patient quality of life and incurs large costs in terms of…
- Trial name
- DIVE-23 (NCT06006039)
- Where
- 2 sites in Canada, Netherlands
- Volunteers
- 40 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Crohn's Disease, Ulcerative Colitis
The Influence of 5-Aminosalicylates on Thiopurine Metabolite Levels
The purpose of this study is to determine the influence of different 5-aminosalicylate concentrations on the metabolism of azathioprine or 6-mercaptopurine in patients with inflammatory bowel disease.
- Conditions
- Crohn's Disease, Ulcerative Colitis, Inflammatory Bowel Disease
- Trial name
- NCT00167882
- Testing
- 5-aminosalicylate (Pentasa, Ferring)
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Amsterdam UMC, location VUmc
Crohn Disease, Ulcerative Colitis
Changes in Faecal Calprotectin Levels and Participation-related Scores Following Three Weeks of Inpatient Rehabilitation
For many people affected by inflammatory bowel disease (IBD), their quality of life and their ability to participate in their professional and social lives are severely restricted.
- Trial name
- NCT05500040
- Testing
- Multimodal Rehabilitation
- Where
- Austria
- Volunteers
- 226 people
- Sponsor
- Pensionsversicherungsanstalt
Crohn Disease (CD), Cryptoglandular Perianal Fistula
A Study Comparing Transperineal Ultrasound, Magnetic Resonance Imaging, Endoscopic Ultrasound, and Examination Under Anesthesia to Detect and Classify Perianal Fistulas in Patients With Crohn's Disease or Fistulas of Unknown Cause
The goal of this study is to learn how well different imaging tests detect and describe perianal fistulas in adults with Crohn's disease or fistulas with no known cause (cryptogenic).
- Trial name
- TRANSIT CD (NCT07794410)
- Testing
- Transperineal Ultrasound (TPUS), Magnetic Resonance Imaging (MRI), Endoscopic Ultrasound (EUS)
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Asian Institute of Gastroenterology, India
Crohn's Disease
TOward a Better Understanding of the autoPhagy Machinery for the Identification of Potential Novel Biomarkers and Therapeutic Targets in Crohn's Disease - TOPIC Study
Crohn's disease (CD) belongs to chronic inflammatory bowel diseases (IBD) affecting over 2 million individuals in the North America and 3.2 million in Europe with an increasing incidence rate in newly industrialized countries…
- Trial name
- TOPIC (NCT06244849)
- Testing
- Blood samples, Stool simple, Ileocolonic biopsies
- Where
- 2 sites in France
- Volunteers
- 170 people
- Sponsor
- Hospices Civils de Lyon
Inflammatory Bowel Diseases, Crohn Disease
Utility of Random Biopsies in Patients With Inflammatory Bowel Disease
The proposed study is a multicenter parallel group clinical trial that will include 821 evaluable patients per group who will be randomly assigned to either high definition white light colonoscopy (HDWLC) with targeted biopsies…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- URBI (NCT06560021)
- Testing
- Biopsy strategy
- Where
- 21 sites in United States
- Volunteers
- 1,642 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Crohn's Disease
Urinary Prostaglandin E Metabolite (PGE-M), A Metabolite of Prostaglandin E2 (PGE2): A Novel Biomarker of Crohn's Disease Activity
The purpose of this study is to determine whether urinary PGE-M levels correlate with Crohn's disease activity and to compare how well urinary PGE-M correlates with other non-invasive biomarkers of disease activity such as…
- Trial name
- NCT00496548
- Testing
- Fecal calprotectin, Urinary PGE-M Level
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Vanderbilt University Medical Center
Inflammatory Bowel Diseases, Crohn Disease
Effects of an Intermittent Reduced Calorie Diet on Crohn's Disease
The purpose of this study is to see how an Intermittent Calorie Reduced Diet (IRCD) that mimics fasting (also known as a fasting mimicking diet, FMD) effects inflammation in patients with mild to moderate Crohn's disease (CD).
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Diet Modification
- Trial name
- NCT04147585
- Testing
- Intermittent Reduced Calorie Diet (IRCD)
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Stanford University
Crohn's Disease
One Year Study of Rifaximin Delayed Release (DR) in Crohn's Disease
The primary objective is to determine the efficacy of rifaximin DR also referred to as Extended Intestinal Release (EIR) tablets vs.
- Trial name
- NCT02240108
- Testing
- Rifaximin EIR
- Where
- 78 sites in United States
- Volunteers
- 81 people
- Sponsor
- Bausch Health Americas, Inc.
Crohn Disease
Surgically Resected Crohn's Disease Patients: Prognostic Factors for Re-operation and New Score Building
The project will consist of a multicentre, prospective, observational study with a total duration of 24 months. Clinical, endoscopic and ultrasound data will be collected in a dedicated database (on IG-IBD Register), which will…
- Trial name
- POCD2017 (NCT03150238)
- Testing
- observation of prognostic factors for relapse
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- Istituto Clinico Humanitas
Crohn's Disease
Infliximab, Regulatory T Cells, IL2 and Crohn's Disease
Crohn's disease is an inflammatory (swelling and soreness) disorder of the digestive tract. Affected patients suffer from abdominal pains, diarrhea (sometimes bloody), weight loss.
- Trial name
- NCT01266785
- Testing
- Infliximab
- Where
- United States
- Sponsor
- Oregon Health and Science University
Peripheral Vascular Access in Pediatric Patients, Peptic Ulcer
The Effect of Vascular Imaging Devices on Success Rates of Peripheral Vascular Access in Pediatric Patients
The study was designed as a prospective, observational study. Pediatric patients under 18 years of age scheduled for peripheral vascular access placement during day-case surgery or non-operating room anesthesia (NORA) will be…
- Conditions
- Peripheral Vascular Access in Pediatric Patients, Peptic Ulcer, Cataract, Crohn's Disease
- Trial name
- NCT07315711
- Where
- 6 sites in Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Sibel Seçkin Pehlivan
Crohn Disease, Bowel Cleansing
DWI MR-enterography Without or With Bowel Cleansing to Assess Intestinal Inflammatory Activity in the Follow-up of Crohn's Disease
Since 2009, many studies tend to prove the effectiveness of diffusion-weighted MR-enterography in the assessment of inflammatory activity in IBD compared to standard MR-enterography, with the emergence of new radiological scores…
- Conditions
- Crohn Disease, Bowel Cleansing, Apparent Diffusion Coefficient
- Trial name
- ENTEDIF (NCT05354609)
- Testing
- MR-enterography
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Crohn Disease
Non-invasive Approaches to Identify the Cause of Fatigue in Inflammatory Bowel Disease Patients.
Crohn's disease (CD) presents with severe symptoms, but fatigue is a very predominant symptom that negatively impacts upon quality of life.
- Trial name
- IBD Fatigue (NCT03670693)
- Testing
- Muscle strength and fatigue assessment, Dual-energy X-ray absorptiometry (DEXA scan), Supine cardiorespiratory fitness assessment
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Crohn's Disease
Imuran (Azathioprine) Dose-Ranging Study in Crohn's Disease
The purpose of this study is to identify an optimal weight based dose of azathioprine that is safe and effective in the treatment of subjects with active Crohn's disease requiring treatment with corticosteroids, and for…
- Trial name
- NCT00098111
- Testing
- azathioprine
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Massachusetts General Hospital
Crohn Disease
Efficacy Classification Prediction of the Effects of Acupuncture on Abdominal Pain in Patients With Crohn's Disease
Machine learning algorithms are applied to discover gut flora markers that predict the clinical efficacy of acupuncture, so as to screen the appropriate population for acupuncture and optimise the allocation of healthcare…
- Trial name
- NCT06352164
- Testing
- Acupuncture treatment
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Crohn Disease, Rectal Fistula
A Study Using Artificial Intelligence to Identify Adults With Complex Perianal Fistulas Associated With Crohn's Disease
Natural Language Processing and machine learning are examples of artificial intelligence tools. This study will check if these tools correctly identify people with Crohn's disease with complex perianal fistulas from their medical…
- Trial name
- INTUITION-CPF (NCT04844593)
- Where
- 3 sites in Spain
- Volunteers
- 32 people
- Sponsor
- Takeda
Crohn Disease
Mesenteric Sparing for the Prevention of Recurrent Crohn's Disease
The purpose of this study is to determine if taking an increased sampling of mesentery (fatty tissue next to the intestine) and lymph nodes at the time of the subject's ileocolic resection prevents a 4-6 month recurrence of…
- Trial name
- NCT03172143
- Testing
- Mesenteric Sparing Ileocolic Resection, High Ligation Ileocolic Resection
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
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