Clinical trials: Cross Infection
Mechanical Ventilation
Lung Microbiota and VAP Development (PULMIVAP)
Ventilator-associated pneumonia (VAP) refers to a lower respiratory tract nosocomial infection acquired >48h after being intubated in Intensive Care Units.
- Trial name
- PULMIVAP (NCT04849039)
- Where
- Italy
- Volunteers
- 700 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Neisseria Gonorrhoeae Infection
Study to Assess Gonorrhoeae Immune Responses Induced by a N. Meningitidis Vaccine
The purpose of this study is to test whether the group B meningitis vaccine (brand name Bexsero™) induces immune responses against the bacteria that causes gonorrhea.
- Trial name
- 4CMenB (NCT04094883)
- Testing
- Meningococcal Group B Vaccine
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Hidradenitis Suppurativa, Quality of Life
Impact of Hidradenitis Suppurativa on Quality of Life Functions
The goal of this study is to get a better understanding of the impact of Hidradenitis Suppurativa (HS) on the quality of life of patients with this condition.
- Trial name
- NCT03288337
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Montefiore Medical Center
Coronavirus
Exploring Vaccine Confidence and Uptake of Potential COVID-19 Vaccines
The COVID-19 pandemic has highlighted deleterious US health inequities. Specifically, African Americans, Latinos, and Native Americans have and continue to shoulder a greater burden of COVID-19 infections and deaths in the US.
- Trial name
- NCT04731870
- Testing
- Survey research
- Where
- United States
- Volunteers
- 632 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Pneumonia Ventilator Associated
Early-onset Ventilator-associated Pneumonia in Adults: Comparison of 8 Versus 15 Days of Antibiotic Treatment
The duration of treatment of community acquired pulmonary infection varies between 5 and 14 days according to the authors (22), or even 3 days with new drugs having long half-life (2).
- Trial name
- NCT01559753
- Testing
- Augmentin, Ceftriaxone, Cefotaxime, netilmycin, tobramycin, compare 8 to15 days of antibiotic treatment
- Volunteers
- 225 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Ventilator Associated Pneumonia, Covid19
Incidence of VAP in Patients With Severe COVID-19
Combined retrospective and prospective cohort study to evaluate the incidence of microbiologically confirmed VAP in mechanically ventilated patients with COVID-19.
- Trial name
- CoV-AP (NCT04766983)
- Testing
- bronchoalveolar lavage
- Where
- Italy
- Volunteers
- 323 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Malaria
Immune Parameters in the Cord Blood of Newborns Exposed to Malaria in the Womb
This study, conducted by the Malaria Research and Training Center at the University of Bamako, Mali, and the NIAID, will examine how exposure to the malaria parasite in the womb affects the developing immune system of newborns.
- Trial name
- NCT00772642
- Where
- Mali
- Volunteers
- 120 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bacterial Colonization
Bacterial Colonization on Nails Covered With a Methacrylic Coating
In the research, the investigators will monitor the bacterial colonization of nails coated with a methacrylic coating
- Trial name
- NCT06831305
- Testing
- Comparison of microbiological sampling on natural nails, Comparison of microbiological sampling on methacrylic nails
- Where
- Slovenia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Ventilator Associated Pneumonia
Role of Oral Chlorhexidine Gel in Prevention of Ventilator Associated Pneumonia
The purpose of this study is to determine if oral mucosal application of chlorhexidine gel will prevent the development of ventilator associated pneumonia in children.
- Trial name
- NCT00597688
- Testing
- Chlorhexidine gel
- Where
- India
- Volunteers
- 86 people
- Sponsor
- All India Institute of Medical Sciences
Surgery
Operating Room Air Filtration/Sterilization
Determine whether operating room air filtration and sterilization with the ActivePure system reduces a composite of serious surgical site infections, infection-related complications, and death within 30 days after surgery.
- Trial name
- ORACLE (NCT04610294)
- Testing
- Functioning Aerus air filtration/sterilization, Deactivated Aerus air filtration/sterilization
- Where
- United States
- Volunteers
- 66,273 people
- Sponsor
- The Cleveland Clinic
Ventilator-Associated Pneumonia (VAP), Inha'le'd
Inhaled Colistin to Prevent Ventilator-Associated Pneumonia in Patients With Acute Brain Injury
Ventilator associated pneumonia is the most common manifestation of hospital acquired infections in ICU. The incidence of ventilator-associated pneumonia in patients receiving mechanical ventilation is as high as 20% -71%, which…
- Trial name
- NCT06819462
- Testing
- Inhaled colistin, Inhaled 0.9% sodium chloride
- Where
- China
- Volunteers
- 444 people
- Sponsor
- Southeast University, China
Ventilator Associated Pneumonia
Diagnostic Stewardship for Ventilator Associated Pneumonia
The goal of this pragmatic cluster-randomized crossover trial is to test if less unnecessary antibiotics are prescribed when the lab reports respiratory culture test results in a specific way for patients who have respiratory…
- Trial name
- NCT05989269
- Testing
- Modified lab reporting
- Where
- 3 sites in United States
- Volunteers
- 161 people
- Sponsor
- University of Maryland, Baltimore
Ventilator Associated Pneumonia
Antimicrobial Stewardship For Ventilator Associated Pneumonia in Intensive Care
Increasing emergence of multidrug resistant (MDR) bacteria worldwide is now considered one of the most urgent threats to global health.
- Trial name
- ASPIC (NCT05124977)
- Testing
- Antimicrobial Stewardship, Standard management
- Where
- France
- Volunteers
- 590 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilator-Associated Pneumonia
Oropharyngeal Care With Colostrum, Chlorohexidine and Sodium Bicarbonate in Preventing Ventilator-associated Pneumonia in Preterm Neonates
comparing the effect of oral care with colostrum, chlorohexidine and sodium bicarbonate in prevention of ventilator-associated pneumonia in preterm neonates.
- Trial name
- NCT07482007
- Testing
- Oropharyngeal Care with Colostrum, Chlorhexidine Oral Care, Sodium Bicarbonate oral care
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
HIV Infections
A Randomized, Controlled, Cross-Over Trial of Safety of Vaginal Use of Carraguard by HIV-Infected Women
Randomized, controlled, double-blinded, cross-over trial of 60 HIV-infected women recruited from general medical clinics, family planning clinics, groups/organizations working with persons living with AIDS to assess product…
- Trial name
- NCT00213044
- Testing
- Carraguard (PC-515)
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Population Council
Hospital-Acquired Infection, Influenza
Nosocomial Influenza Surveillance 2018 - 2022
Hospital-acquired influenza is associated with significant morbidity and mortality in hospitalized patients notably elderly patients. Furthermore, it is also associated with a large economic impact for the hospitals.
- Trial name
- NOSOGRIPPE (NCT03413228)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Hospices Civils de Lyon
Adenovirus Infection
Posoleucel (ALVR105) for the Treatment of Adenovirus Infection in Pediatric and Adult Participants Receiving Standard of Care Following Allogeneic Hematopoietic Cell Transplantation
This study will assess the safety and efficacy of Posoleucel for the treatment of adenovirus (AdV) infection in pediatric and adult allo-HCT recipients receiving standard of care (SoC).
- Trial name
- NCT05179057
- Testing
- Posoleucel
- Where
- 47 sites in United States, Canada and 4 more
- Volunteers
- 57 people
- Sponsor
- AlloVir
Ventilator Associated Pneumonia ( VAP)
Clinical Outcomes of Inhaled Amikacin in Ventilator Associated Pneumonia
Article: Clinical Outcomes of Inhaled Amikacin in Ventilator-Associated Pneumonia: A group randomized controlled,add-on trial English:Patients in intensive care units often need ventilators to breathe.
- Trial name
- RCT (NCT07369336)
- Testing
- Amikacin (Inhalation), Standard-of-Care Intravenous Antibiotics
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Postgraduate Medical Institute, Lahore
Hospital Acquired Pneumonia (HAP), Cardiovascular and Respiratory Disease
Long-term Alterations of Host-microbiome Interactions and Cardiovascular and Respiratory Diseases Progression After Pneumonia
The HOMI-LUNG - HAP study is part of the HOMI-LUNG project, funded by the Horizon Europe program. The "HOMI-LUNG" project is an international, interdisciplinary project that aims to better understand the causal links between…
- Trial name
- HOMI-LUNG-HAP (NCT06602934)
- Testing
- Blood samples, Oropharyngeal swabs, ECG
- Where
- 5 sites in France
- Volunteers
- 300 people
- Sponsor
- Nantes University Hospital
Ventilator Associated Pneumonia ( VAP)
VAP Identification by AI
Ventilator-associated pneumonia (VAP) is the most frequent infection in the intensive care setting. For VAP there is currently no reliable diagnostic criteria.
- Trial name
- AI-VAP (NCT06917521)
- Where
- Switzerland
- Volunteers
- 76 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona