Clinical trials: Cross Infection
Ventilator Associated Pneumonia, Respiratory Tract Infection
Candida in the Respiratory Tract Secretions of Critically Ill Patients and The Efficacy of Antifungal Treatment
The purpose of the study is to determine whether the effect of treating Candida spp. isolated in the respiratory tract secretions of patients with a clinical suspicion of ventilator associated pneumonia (VAP) on clinical outcomes…
- Trial name
- CANTREAT (NCT00934934)
- Testing
- Normal Saline, anidulafungin
- Where
- 6 sites in Canada
- Volunteers
- 61 people
- Sponsor
- Daren K. Heyland
Sepsis
Establishment of Early Diagnosis and Monitoring Model for Sepsis Patients
In recent years, although the clinical treatment of sepsis has been greatly improved, it is still an important cause of death in ICU patients, and seriously threatens human health.
- Trial name
- EDAMMFS (NCT04974411)
- Testing
- infection, sepsis
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Genital Herpes
Randomized Trial to Evaluate Suppressive Effect of High-Dose Acyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2
The purpose of the research study is to evaluate the effectiveness of high-dose acyclovir compared to valacyclovir for reduction of asymptomatic genital shedding in persons with genital herpes.
- Trial name
- NCT00362297
- Testing
- acyclovir, valacyclovir
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Washington
Ventilator-associated Pneumonia
B Lymphocyte Populations in the Pulmonary Microenvironment of Patients Under Mechanical Ventilation With or Without VAP (Ventilator-Associated Pneumonia)
Diagnosis of VAP relies on a set of non-specific clinical, biological, and imaging criteria. Understanding host-pathogen interactions and the mechanisms of deregulations leading to infection of pulmonary tissue appears essential.
- Trial name
- OLYMPE (NCT07436780)
- Where
- France
- Volunteers
- 75 people
- Sponsor
- University Hospital, Limoges
Nosocomial Infection
Glutamine to Improve Outcomes in Cardiac Surgery
Patients undergoing heart surgery with a heart-lung machine (termed cardiopulmonary bypass) are at an increased risk of having abnormal "inflammation" in their body after surgery.
- Trial name
- GLADIATOR (NCT01704430)
- Testing
- Glutamine, Maltodextrin
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Alberta
HIV Dementia
Ferumoxytol-enhanced Brain MRI in HIV-associated Neurocognitive Disorders
The purpose of this study is to describe the radiologic findings on brain MRI after ferumoxytol administration in HIV-infected patients with cognitive impairment.
- Trial name
- NCT01665846
- Testing
- Ferumoxytol
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Hawaii
Corneal Ulcers
Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Refractory Corneal Infection
This study will evaluate the Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes with Corneal Infection.
- Trial name
- NCT02068430
- Testing
- Riboflavin 0.1%, UV-X™ Illumination System
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Stephen Trokel
Ventilated Patient in Intensive Care
Variation in Viscoelastic Properties of Pulmonary Mucus in Patients Undergoing Mechanical Ventilation
Ventilator-associated pneumonia (VAP) is defined as an infection of the lung parenchyma in patients undergoing invasive mechanical ventilation for at least 48 hours.
- Trial name
- RHEOREA (NCT07490028)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Intercommunal Aix-Pertuis
Nosocomial Pneumonia
High-dose Inhaled NO Therapy for the pREvenvention of NP After Cardiac Surgery Under CPB
The primary aim of this single-center, prospective, randomized, controlled, study is to test the hypothesis that inhalation of NO 200 ppm prevents the development of nosocomial pneumonia in patients at risk after cardiac surgery…
- Trial name
- NCT06261827
- Testing
- 200-ppm NO
- Where
- Russia
- Volunteers
- 160 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Ventilator Associated Pneumonia
Air-impingement Manipulation to Clear Subglottic Secretion to Prevent VAP in Prolonged Intubated Patients
Ventilator-associated pneumonia (VAP) is the most frequent infection occurring in patients who are admitted to the ICU. The accumulation of respiratory secretions in the subglottic space is a well-proven cause of VAP.
- Trial name
- NCT02632539
- Testing
- Manual air-impingement operation, subglottic secretion drainage
- Volunteers
- 220 people
- Sponsor
- Beijing Chao Yang Hospital
Men Who Have Sex With Men and Transgender Women
Study to Evaluate the Feasibility of Integrating the Point-of-care Testing for Sexually Transmitted Infections and HIV Into Community-based Clinics for MSM and TGW in Thailand
This will be a prospective study that will enroll up to 2000 MSM and TG from community-based clinics in Bangkok, Chonburi, Chiang Mai, and Songkhla.
- Trial name
- NCT03580512
- Where
- 6 sites in Thailand
- Volunteers
- 2,000 people
- Sponsor
- Thai Red Cross AIDS Research Centre
Hiv, HIV Infections
HIV HOspital TEsting: Bringing the Hidden to Light in the Hospital Setting
This study aims to evaluate the prevalence of previously undiagnosed HIV infection in the hospital setting (across various medical or surgical departments) among individuals exhibiting at least one HIV indicator condition…
- Conditions
- Hiv, HIV Infections, AIDS
- Trial name
- HIV-HOTE (NCT06282328)
- Testing
- HIV test
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Castagna Antonella
Pneumonia, Ventilator-Associated
Comparison Between Two Methods of Oral Care on the Incidence of VAP
Patients on ventilator are in high risk to develop ventilator associated pneumonia (VAP). This acquired infection significantly increases morbidity and mortality of these patients.
- Trial name
- NCT00521677
- Testing
- Sage oral care, Traditional oral care
- Where
- Israel
- Volunteers
- 108 people
- Sponsor
- HaEmek Medical Center, Israel
Human Papillomavirus Infection
Anal HPV Infection and Risk for Anal High-grade Squamous Intraepithelial Lesion Among Thai MSM With Acute HIV Infection
1. To determine the prevalence and incidence of anal HSIL and associated risk factors among MSM who initiate ART during AHI.
- Trial name
- NCT03032575
- Testing
- SEARCH010/RV254
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Thai Red Cross AIDS Research Centre
Ventilator Associated Pneumonia
Ventilator Associated Pneumonia Care Bundle Prevention on Internship Students' Knowledge and Clinical Performance
The goal of this clinical trial is to determine the effect of a self-instructional module regarding ventilator-associated pneumonia care bundle prevention on internship students' knowledge and clinical performance in pediatric…
- Trial name
- NCT06090019
- Testing
- Routine PICU nursing care for children on mechanical ventilator., Self-instructional module for VAP care bundle prevention
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Postoperative Peritonitis
Duration of Antibiotic Therapy in the Treatment of Severe Postoperative Peritonitis Admitted in ICU
The investigators purpose is to demonstrate that a short antibiotic therapy (8 days) for postoperative peritonitis brings an increased number of antibiotic-free days over a 28 days period when compared to conventional (15 days)…
- Trial name
- DURAPOP (NCT01311765)
- Testing
- Duration of antibiotic therapy limited to 8 days
- Where
- France
- Volunteers
- 244 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilator Associated Pneumonia, Morality
Endotracheal Tube Cuff Pressure Measurement
The effect of endotracheal cuff pressure measurement technique for preventing ventilatory associated pneumonia.
- Conditions
- Ventilator Associated Pneumonia, Morality, Trauma, Brain, Endotracheal Aspiration
- Trial name
- NCT04397952
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bagcilar Training and Research Hospital
Traumatic Brain Injury, Deep Vein Thrombosis
Traumatic Brain Injury Associated Radiological DVT Incidence and Significance Study
Whilst deep vein thrombosis (DVT) is common following traumatic brain injury (TBI), optimal timing and safety of pharmacological prophylaxis is uncertain. Paradoxically the harm associated with the occurrence of is also unclear.
- Conditions
- Traumatic Brain Injury, Deep Vein Thrombosis, Acute Lung Injury, Ventilator Associated Pneumonia
- Trial name
- TARDIS (NCT03937947)
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- NHS Lothian
Nosocomial Infection
New Dosages of Inflammatory Markers for the Early Diagnosis of Nosocomial Bacterial Infections of the Newborn
This study aims to evaluate new dosage of inflammatory markers or new inflammatory markers for the diagnosis of nosocomial bacterial infection.
- Trial name
- NOSODIAG (NCT00701948)
- Where
- 2 sites in France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Strasbourg, France
Exposome, Non-communicable Diseases (NCD)
Analysis of the Influence of the Exposome in Patients With Non-communicable Diseases
It is well documented that factors such as obesity, a sedentary lifestyle, and comorbidities-including hypertension, diabetes, and dyslipidemia-increase the risk of developing non-communicable diseases (NCDs).
- Conditions
- Exposome, Non-communicable Diseases (NCD), Non-communicable Disease Risk Factors
- Trial name
- EXPOSOME (NCT07879378)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche