Clinical trials: Crosslinking
Myopia, Myopic Astigmatism
Laser In-situ Keratomileusis With Crosslinking Compared to Conventional LASIK in Patients With High Myopia
The objectives of this study are to evaluate the safety and efficacy of a treatment regimen for high myopia and myopic astigmatism: LASIK followed by crosslinking performed with the KXL Crosslinking-System and VibeX Xtra…
- Conditions
- Myopia, Myopic Astigmatism, Crosslinking, Corneal Ectasia
- Trial name
- NCT03913338
- Testing
- LasikXtra, LASIK
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Clinic Frankfurt
Guided Bone Regeneration, Bone Augmentation
Lateral GBR Using Two Types of Membrane With a Combination of Allograft-xenograft
Bone width is critical for successful implant placement, as thin bone increases the risk of bone loss. Various augmentation techniques-especially guided bone regeneration (GBR)-are effective in restoring bone volume using grafts…
- Trial name
- NCT07525128
- Testing
- Lateral Guided bone regeneration
- Where
- Lebanon
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Keratoconus
Comparative Analysis of the Visual Performance After TICL Implantation in Patients With Stable Keratoconus
To report on 4-year postoperative safety, efficacy, stability and predictability outcomes(to evaluate the visual, refractive, contrast sensitivity, defocus curve and aberrometric data preoperation, and compare with a similar…
- Trial name
- TICL (NCT02833649)
- Testing
- Toric Implantable collamer Lens
- Where
- Iran
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Bone Loss
Lateral Ridge Augmentation Using Cross-linked or Non-cross-linked Collagen Membrane
The objective of the present trial is to test clinically, radiographically and histologically , in a lateral alveolar ridge augmentation model (without simultaneous implant placement) the efficiency in supporting bone formation…
- Trial name
- NCT04402671
- Testing
- non-cross-linked porcine skin collagen membrane, glutaraldehyde cross-linked bovine collagen membrane
- Where
- Lebanon
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Facial Aging, Skin Aging
Hyaluronic Acid Crosslinking Clinical Study
This prospective observational case series aims to evaluate the clinical efficacy, safety, and patient satisfaction associated with hyaluronic acid dermal fillers with different degrees of divinyl sulfone (DVS) crosslinking.
- Conditions
- Facial Aging, Skin Aging, Facial Volume Loss, Facial Rhytides
- Trial name
- HACS (NCT07744464)
- Testing
- Hyaluronic Acid Dermal Fillers
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Antony de Paula Barbosa
Osteoarthritis, Arthritis
Marathon and Enduron Polyethylene at Long-Term Follow-up
The purpose of the study is to determine whether crosslinked Marathon and standard Enduron polyethylene liners show differences in survivorship due to wear-related revisions at minimum 14-year follow-up and every 5 years after.
- Conditions
- Osteoarthritis, Arthritis, Joint Diseases, Musculoskeletal Diseases
- Trial name
- NCT02508428
- Testing
- Hip Replacement with crosslinked Marathon polyethylene, Hip Replacement with noncrosslinked Enduron polyethylene
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Anderson Orthopaedic Research Institute
Alveolar Bone Resorption
Lateral Ridge Augmentation Around Implants
The rehabilitation of dentoalveolar defects and tooth loss has seen remarkable advancements over time. Extraction of tooth leads to reduction in physiologic dimension of bone and it is imperative to evaluate the site before…
- Trial name
- NCT04197128
- Testing
- Resorbable Collagen membrane with bone graft for augmentation, Ribose cross linked collagen matrix for augmentation
- Where
- India
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Keratoconus, Keratoconus, Unstable
Epi-On Corneal Crosslinking for Keratoconus
Epithelium-On Corneal Crosslinking for Keratoconus.
- Trial name
- NCT03245853
- Testing
- Riboflavin 5'-Phosphate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Comprehensive EyeCare of Central Ohio
Dermal Filler, Volume Deficiency of the Midface
An Interventional Study to Evaluate the Safety and Performance of Crosslinked Hyaluronic Acid Hydrogel
The aim of this interventional, pre-market, double- blinded, controlled, two stages study is to evaluate the performance and safety of Crosslinked Hyaluronic Acid (CLHA) Hydrogel (with and without Lidocaine) for the Treatment of…
- Trial name
- NCT05853224
- Testing
- Crosslinked Hyaluronic Acid (CLHA) Hydrogel with and without Lidocaine
- Where
- Italy
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Biopolimeri Srl
Keratoconus
Treatment of Keratoconus With Advanced Corneal Crosslinking
The purpose of this study was to determine whether mechanical compression of the cornea during corneal crosslinking for keratoconus using a sutured rigid contact lens can improve the optical outcomes of the treatment.
- Trial name
- NCT02425150
- Testing
- Corneal reshaping/crosslinking (CRXL), Corneal Crosslinking (CXL)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Umeå University
Myopia, Corneal Crosslinking
Advanced Cross Linking for Low-grade Myopia
To evaluate the improvement in myopic refractive error and the corneal endothelial safety with a corneal crosslinking treatment regimen for mild myopia.
- Trial name
- PiXLO2 (NCT03197272)
- Testing
- PiXL
- Where
- Sweden
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Umeå University
Postprandial Hyperglycemia
Comparison of Different Types of Resistant Starch
This study is to determine whether different types of resistant starch have different effects on blood glucose in healthy adults.
- Trial name
- NCT00930956
- Testing
- Resistant Starch
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Kansas State University
Keratoconus, Corneal Ectasia
Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal Ectasia
Corneal collagen crosslinking (CXL) has been demonstrated as an effective method of reducing progression of both keratoconus and corneal ectasia after surgery, as well as possibly decreasing the steepness of the cornea in these…
- Trial name
- NCT04905108
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Cornea and Laser Eye Institute
Aging Problems
Safety and Performance of DKL Crosslinked Sodium Hyaluronate 26 Dermal Filler for Cheek Augmentation
This is a pivotal, prospective, active-controlled, randomized, double blinded (blinded evaluator and subject), intra-individual split-face comparison, non-inferiority study of DKL crosslinked sodium hyaluronate 26 versus Juvederm…
- Trial name
- NCT05021926
- Testing
- DKL crosslinked sodium hyaluronate 26, Juvéderm Voluma™ with lidocaine (Allergan, Inc)
- Where
- Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dr. Korman Laboratories Ltd.
Bone Healing, Augmentation
Healing After Augmentation of Alveolar Ridge Using Collagen Membrane
One of the prerequisites for successful prosthetic implant therapy of patients is achieving the initial stability of the embedded implant, which largely depends on the width alveolar ridge, at the place of its installation.
- Conditions
- Bone Healing, Augmentation, Augmentation, Alveolar Ridge
- Trial name
- NCT06885983
- Testing
- implant placement, Guided bone regeneration
- Where
- Serbia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Sinus Lift, Graft Materials
Transcrestal Sinus Lift With OSSIX Bone vs BIOSS Collagen
Primary: Histologically analyse the quality of bone regeneration after graft material insertion in severely resorbed maxilla. Secondary: Radiological analysis of the volume of the bone regenerations with the shirnkage rate of the…
- Conditions
- Sinus Lift, Graft Materials, Transcrestal Approach
- Trial name
- TSL (NCT07041411)
- Testing
- maxillary sinus elevation through transcrestal approach using OSSIX® Bone
- Where
- Italy
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Studio Odontoiatrico Associato Dr. P. Cicchese e L. Canullo
Socket Preservation
Sticky Bone vs Xenograft With Cross-linked Hyaluronic Acid in Socket Preservation
The present study aimed to evaluate clinical and radiographic outcomes of sticky bone in comparison to crosslinked hyaluronic acid mixed with xenograft in alveolar ridge preservation.
- Trial name
- NCT06983015
- Testing
- sticky bone, xenograft mixed with cross-linked hyaluronic acid
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Vocal Fold Palsy, Vocal Cord Paralysis
A Histological Study Evaluating Silk Voice and Crosslinked Hyaluronic Acid
The primary study goal is to evaluate the histological characteristic of Silk Voice to evaluate the potential for Silk Voice to deliver long-term results to patients.
- Conditions
- Vocal Fold Palsy, Vocal Cord Paralysis, Vocal Cord Atrophy
- Trial name
- NCT04315415
- Testing
- Silk Voice
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Sofregen Medical, Inc.
Pterygium of Conjunctiva and Cornea
Recurrence Rate of Mini-SLET vs. Limbal-Conjunctival Autograft in Primary Pterygium Excision
To study the efficacy and safety of amniotic membrane transplantation as an adjunctive therapy after surgical excision of primary pterygium and compare the clinical outcomes with conjunctival autograft
- Trial name
- NCT03363282
- Testing
- Pterygium Excision
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Osteogenesis Imperfecta
Urinary Biomarkers of OI Pathobiology
Osteogenesis imperfecta (OI) is a rare inherited disorder that causes bones to break easily. Individuals with osteogenesis imperfecta break bones often and may have other problems, including hearing loss, dental problems, pain…
- Trial name
- NCT02531087
- Where
- 7 sites in United States, Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine