Clinical trials: Cryopreservation
Subfertility
Endometrial Scratching for Cryopreserved Embryo Transfer
Endometrial injury performed in a cycle preceding the one for embryo transfer is associated with an increased implantation and pregnancy rate when carried out during the month preceding that of ovulation induction and fresh…
- Trial name
- NCT02093442
- Testing
- Endometrial injury
- Where
- Brazil
- Volunteers
- 62 people
- Sponsor
- University of Sao Paulo
Corneal Wound Healing
Sutureless Cryopreserved Amniotic Membrane Graft (ProKera) and Wound Healing After Photorefractive Keratectomy
The purpose of this study is to evaluate the effect of ProKera on corneal wound healing after photorefractive keratectomy (PRK) in terms of re-epithelialization, pain, adverse effects, visual recovery, refractive accuracy, and…
- Trial name
- NCT00915759
- Testing
- ProKera, Bandage contact lens
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Venous Leg Ulcer, Venous Stasis Ulcer
Evaluation of Bilayered Cellular Matrix (OrCel) for the Treatment of Venous Ulcers
This study was designed to evaluate the clinical benefits and safety of OrCel in the treatment of venous ulcers. OrCel and standard care were compared to standard care alone.
- Trial name
- NCT00270946
- Testing
- Bilayered Cellular Matrix (OrCel)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Ortec International
Fertility Issues, Reproductive Issues
The Stanford Egg Freezing Study
The purpose of this study is to see if the investigators can obtain non-inferior clinical outcomes (similar numbers of oocytes) using the Cardinal protocol, a cost-conscious, low-intensity egg freezing protocol, compared to other…
- Trial name
- NCT05842070
- Testing
- Low-Intensity Egg Freezing Protocol, High-Intensity Egg Freezing Protocol
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Stanford University
Kidney Transplant; Complications, Kidney Failure
Normothermic Machine Perfusion (NMP) Versus Static Cold Storage (SCS) in Human Kidney Transplantation
Due to organ shortage in kidney transplantation (KT) several strategies have been implemented in an attempt to increase donor pool utilization, including transplantation of extended criteria donor (ECD) allografts.
- Conditions
- Kidney Transplant; Complications, Kidney Failure, Graft Dysfunction
- Trial name
- NMP-DBD (NCT05031052)
- Testing
- End-ischemic normothermic oxygenated machine perfusion, Static cold storage
- Where
- 4 sites in Germany
- Volunteers
- 194 people
- Sponsor
- Charite University, Berlin, Germany
Spermatogenesis and Semen Disorders, DNA Double Strand Break
Effects of Procyanidine on Semen Parameters and DNA Fragmentation Index During Cryopreservation of Abnormal Human Semen Samples
Cryopreservation is the storage of biological material at subzero temperatures at which biochemical processes of cell metabolism and the biochemical reactions that lead to cell death are slowed, interrupted or stopped.Many…
- Trial name
- NCT03451682
- Testing
- procyanidine
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Aristotle University Of Thessaloniki
Hypoproliferative Thrombocytopenia
Study on the Safety and Efficacy of Cryopreserved Platelets in Hypoproliferative Thrombocytopenic Patients
The purpose of this study is to study the safety and efficacy of pooled buffy-coat derived platelets which had been frozen with dimethyl sulphoxide (DMSO), in the prevention of bleeding for patients with hypoproliferaitve…
- Trial name
- NCT05067608
- Testing
- Control arm receiving normal (never before frozen) platelets as per current clinical practice, Treatment arm receiving cryopreserved platelets
- Where
- Singapore
- Volunteers
- 17 people
- Sponsor
- Singapore General Hospital
Oxidative Stress
Oxidative Stress in Testicular Tissue Before and After Cryopreservation
The absence of sperms in ejaculated semen, is the most severe form of male-factor infertility and is present in approximately 5 % of all investigated infertile couples.
- Trial name
- NCT03621995
- Testing
- Malondialdehyde and Catalase level measurement
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Assiut University
Organ Transplant
Trial to Compare the SherpaPak™ Device vs Cold Storage
The Investigator's are doing this study to see which method of organ preservation leads to better outcomes for donated hearts. There are two methods of organ preservation. The first method is the use of cold storage.
- Trial name
- SherpaPak (NCT05194514)
- Testing
- SherpaPak™ Device, Cold Storage
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Thrombocytopenia
Phase 1 Safety Study of Dimethyl Sulfoxide Cryopreserved Platelets
This study is to evaluate the safety of intravenous (IV) infusion of dimethyl sulfoxide (DMSO) cryopreserved platelets (CPP) in participants with World Health Organization (WHO) Grade 2 bleed in spite of receiving a transfusion…
- Trial name
- NCT02078284
- Testing
- CPP, LSP
- Where
- 4 sites in United States
- Volunteers
- 28 people
- Sponsor
- U.S. Army Medical Research and Development Command
Multiple Myeloma, Lymphomas
Impact of DMSO Concentrations on Hematopoietic Recovery After Autologous HSC Transplantation.
The main aim of the study was to evaluate the clinical impact of different DMSO concentrations in cryopreservation mixture (5%, 7.5%, 10%) on reconstitution of hematopoiesis after autologous hematopoietic stem cell…
- Conditions
- Multiple Myeloma, Lymphomas, Leukemias
- Trial name
- DMSOconc3 (NCT02452099)
- Testing
- Cryopreservation of HSCs using 5% DMSO concentration, Cryopreservation of HSCs using 7,5% DMSO concentration, Cryopreservation of HSCs using 10% DMSO concentration
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Infertile Females or Females With Ovarian Insufficiency
Ovarian Tissue Transplantation
Chemotherapy and radiation therapy for the treatment of cancer can compromise fertility. Ovarian tissue cryopreservation is an experimental strategy offered at The University of Pennsylvania to preserve future fertility (protocol…
- Trial name
- NCT01870752
- Testing
- Transplantation of previously cryopreserved ovarian tissu
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Transplant; Failure, Heart
Non-ischaemic Heart Preservation Versus Standard Cold Storage in Human Heart Transplantation
The overall aim of this study is to compare a new state-of-the-art ex-vivo organ preservation method with standard ischemic cold static storage of donor hearts in adult cardiac transplantation.
- Trial name
- NIHP2 (NCT04066127)
- Testing
- Non-ischemic heart preservation (NIHP), Standard ischemic cold static storage (SCS)
- Where
- Sweden
- Volunteers
- 66 people
- Sponsor
- Region Skane
Chronic Myelogous Leukemia/Other Leukemia, Acute Leukemias
Providing Access to Cord Blood Units for Transplants
Background: Cord blood banks have been set up to collect and store umbilical cord blood for transplants. These transplants are used to treat different types of cancer.
- Conditions
- Chronic Myelogous Leukemia/Other Leukemia, Acute Leukemias, MDS/MPS, Multiple Myeloma
- Trial name
- NCT01479582
- Testing
- Access to unlicensed cord blood units
- Sponsor
- National Cancer Institute (NCI)
Fertility
Effect of Oocyte Vitrification on Fertilization Rate, Embryo Quality and Development
Indications for oocyte (egg) vitrification (fast freezing) include the preservation of reproductive competence of young cancer patients who need chemotherapy, pelvic radiation, or surgical removal of ovaries for treatment.
- Trial name
- NCT01422395
- Testing
- Freezing
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Main Line Fertility Center
Hematologic Malignancy, Acute Leukemia
Study to Characterize Mismatched to Fully HLA-Matched Ossium HPC, Marrow and Living Donor Transplantation in Patients With Hematologic Malignancies
Prospective, multi-center open label study of HLA-partially to fully matched allogeneic cryopreserved deceased donor bone marrow transplantation and living donor transplantation for patients with hematologic malignancies.
- Conditions
- Hematologic Malignancy, Acute Leukemia, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
- Trial name
- NCT07710781
- Testing
- Ossium HPC, Marrow, Standard of care living donor - Haplo Related, Standard of care living donor - Mismatched Unrelated
- Volunteers
- 300 people
- Sponsor
- Ossium Health, Inc.
Infertility
Cryopreserved-thawed Embryo Transfer With or Without Gonadotropin Releasing Hormone Agonist
Traditionally, the use of GnRH-a suppression was considered essential for adequate endometrial hormonal modulation in cryopreserved-thawed embryo transfer cycles.
- Trial name
- NCT02736032
- Testing
- Embryo transfer, Serum Estradiol and Progesterone levels, GnRH agonist
- Where
- 3 sites in Egypt
- Volunteers
- 310 people
- Sponsor
- Cairo University
Breast Cancer
Safety of Ovarian Stimulation With Letrozole and Gonadotropins in Breast Cancer Patients
Breast cancer patients are commonly treated with drugs that eggs present in the ovary and may reduce their chance for getting pregnant.
- Trial name
- NCT00504699
- Testing
- Ovarian stimulation in vitro fertilization cryopreservation
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- New York Medical College
Osteo Arthritis Knee
"Ready-to-use" Intra-articular Formulation of Mesenchymal Stromal Cells
The goal of this clinical trial is to compare a newly developed off-the-shelf cryopreserved "ready to inject" Mesenchymal Stem Cell (MSC) product with the usual MSC preparation the investigators have used in knee osteoarthritis…
- Trial name
- PANLAR-II (NCT05751564)
- Testing
- "Ready to inject" Umbilical cord-derived Mesenchymal Stromal Cell (MSC) product, Resuspended Umbilical cord-derived Mesenchymal Stromal Cell (MSC) product
- Volunteers
- 60 people
- Sponsor
- Universidad de los Andes, Chile
Infertility
Frozen Embryo Transfer (FET) in Natural Cycles or in Natural Cycles Controlled by Human Chorionic Gonadotropin (hCG) Administration
The rational of the study is to assess the implantation, pregnancy and live birth rates after the transfer of frozen- thawed embryos in natural cycles with spontaneous Luteinizing Hormone (LH)/Progesterone rise or in natural…
- Trial name
- FRET (NCT00809107)
- Testing
- HCG
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel