Clinical trials: Cryopreservation
Cryopreservation, Human Spermatozoa Parameters
Hypotaurine Supplementation Benefits in Cryopreservation
Although it is widely used, slow freezing can induce strong functional and nuclear spermatic alterations reducing the chances of pregnancy.
- Conditions
- Cryopreservation, Human Spermatozoa Parameters, Hypotaurine Supplementation, Spermatozoa DNA Alterations
- Trial name
- HYPOTAURINE (NCT04011813)
- Testing
- Hypotaurine : antioxidant and osmoregulator
- Volunteers
- 33 people
- Sponsor
- University Hospital, Clermont-Ferrand
Ovarian Tissue Cryopreservation, Vitrification
Assessing the Technique of Ovarian Tissue Cryopreservation by Vitrification in Vietnam
Ovarian tissue cryopreservation (OTC) is a new approach on fertility preservation for young female patients with cancer. It is now used by many IVF centers in the world.
- Trial name
- NCT04666376
- Testing
- evaluation of the effectiveness of vitrification technique on ovarian tissue quality
- Where
- Vietnam
- Volunteers
- 43 people
- Sponsor
- Mỹ Đức Hospital
Infertility
A Pilot Study Analyzing Reproductive Results After IUI Using Vitrified Human Sperm
The aim of this study is to assess the evaluate the effectiveness of vitrified donor semen in intrauterine insemination treatments.
- Trial name
- BIOKIBANK (NCT06243913)
- Testing
- IUI with vitrified sperm from donor:
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Clínica EUGIN
Acute Biphenotypic Leukemia, Acute Lymphoblastic Leukemia in Remission
Donor Umbilical Cord Blood Transplant With or Without Ex-vivo Expanded Cord Blood Progenitor Cells in Treating Patients With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, or Myelodysplastic Syndromes
This randomized phase II trial studies how well donor umbilical cord blood transplant with or without ex-vivo expanded cord blood progenitor cells works in treating patients with acute myeloid leukemia, acute lymphoblastic…
- Conditions
- Acute Biphenotypic Leukemia, Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia in Remission, Chronic Myelogenous Leukemia
- Trial name
- NCT01690520
- Testing
- Cyclophosphamide, Cyclosporine, Ex Vivo-Expanded Cord Blood Progenitor Cell Infusion
- Where
- 8 sites in United States
- Volunteers
- 163 people
- Sponsor
- Nohla Therapeutics, Inc.
Infusion Reactions
Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation
This study will evaluate the safety of infusion of the investigational cord blood units by carefully documenting all infusion-related problems.
- Trial name
- NCT01656603
- Testing
- unlicensed CBU
- Where
- 71 sites in United States
- Volunteers
- 9,999 people
- Sponsor
- New York Blood Center
Cellular Injury and Post-Cryogenic Recovery, Cryogenic Cellular Stress
Evaluation of In-Vitro Cryo Therapeutic Protocols on Human Cell Samples (TWH-CRYO-001)
This laboratory-based study evaluates the effects of controlled cryogenic preservation on human cell samples using Truway Health's in-vitro cryo therapeutic methodology.
- Conditions
- Cellular Injury and Post-Cryogenic Recovery, Cryogenic Cellular Stress, Cold-Induced Cellular Injury, Thermal Injury Response
- Trial name
- CRYO-IVT (NCT07321028)
- Testing
- Standard Laboratory Cryopreservation Procedure, Enhanced Laboratory Cryopreservation Procedure, Normothermic Cell Culture Control
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Truway Health, Inc.
Cancer, Risk of Premature Ovarian Failure
Cryopreservation of Ovarian Tissue
The study hopes to contribute to the development of technologies of ovarian tissue freezing-thawing and in vitro maturation of immature eggs such that a person at risk for premature ovarian failure might be able to conceive a…
- Conditions
- Cancer, Risk of Premature Ovarian Failure, Fertility Preservation
- Trial name
- NCT01558544
- Testing
- surgery to remove ovaries or high dose chemotherapy
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Weill Medical College of Cornell University
Satisfaction Survey, Fertility Perservation
Survey of Patients Who Received Fertility Preservation Counseling and Underwent Testicular Tissue Cryopreservation Prior to Gonadotoxic Treatment During Childhood or Peripuberty
Chemotherapy and radiotherapy can lead to spermatogonial stem cell depletion in pre- and peripubertal boys, potentially resulting in infertility during adulthood A testicular biopsy is considered a safe procedure performed in…
- Trial name
- QUALIFERT (NCT07140549)
- Testing
- Survey using a questionnaire.
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Fertility Preservation
Oocyte Cryopreservation
The specific aim of this study is to further develop methods of oocyte cryopreservation and evaluate their impact on reproductive outcomes.
- Trial name
- NCT01696786
- Testing
- Oocyte cryopreservation
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Thrombocytopenia, Primary Thrombocytopenia,Unspecified
Protocol for the Infusion of Buffy Coat-derived Cryopreserved Platelets in Patients With Severe Thrombocytopenia
The increasing need for blood components and the increasingly careful donor selection procedures, make the availability of blood components very reduced, in particular for platelets that are currently administered preferably…
- Conditions
- Thrombocytopenia, Primary Thrombocytopenia,Unspecified, Thrombocytopenia Chemotherapy Induced
- Trial name
- MICE (NCT02032134)
- Testing
- Transfusion of Pooled Platelets Cryopreserved In DMSO
- Where
- Italy
- Volunteers
- 5 people
- Sponsor
- Napolitano Mariasanta
Acute Leukemia, Acute Lymphoblastic Leukemia
A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies
The goal of this clinical trial is to determine the safety and feasibility of allogeneic transplantation with bone marrow from a deceased donor in patients with acute and chronic leukemias, myelodysplastic syndrome, and certain…
- Conditions
- Acute Leukemia, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Acute Biphenotypic Leukemia
- Trial name
- NCT05589896
- Testing
- Ossium HPC Marrow, Bone Marrow Transplant, Pre-transplant conditioning - Myeloablative (MAC), Pre-transplant conditioning - Reduced Intensity (RIC)
- Where
- 9 sites in United States
- Volunteers
- 12 people
- Sponsor
- Ossium Health, Inc.
Fertility, Male Cancer
Outcomes for Patients Who Preserved Their Fertility as Part of Cancer Treatment at the Center for the Study and Preservation of Eggs and Sperm: MaPreservFerti
Improvements in diagnostic methods and cancer treatments have led to a steady increase in survival rates. The 5-year survival rate for men diagnosed with cancer between the ages of 15 and 39 has exceeded 81%.
- Conditions
- Fertility, Male Cancer, Oncofertility
- Trial name
- MaPreservFerti (NCT07601451)
- Testing
- Patient self-assessment form
- Where
- France
- Volunteers
- 950 people
- Sponsor
- Hospices Civils de Lyon
in Vitro Activation, Dormant Follicle
In Vitro Activation of Dormant Follicles for Patients With Primary Ovarian Insufficiency
In this study, the investigators used the newly developed technique i.e. in vitro activation of dormant follicles (IVA) to promote ovarian follicle growth much more efficiently than natural, in vivo process for women with Primary…
- Conditions
- in Vitro Activation, Dormant Follicle, Primary Ovarian Insufficiency, Ovarian Resistance Syndrome
- Trial name
- IVADFPOI (NCT02322060)
- Testing
- Ovariotomy, Activate dormant follicles, Ovary tissue transplantation
- Where
- China
- Volunteers
- 35 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Lysosomal Storage Diseases, Metachromatic Leukodystrophy
OTL-200 in Patients With Late Juvenile Metachromatic Leukodystrophy (MLD)
OTL-200 is a cryopreserved dispersion for infusion containing autologous CD34+ cell enriched population that contains haematopoietic stem and progenitor cells (HSPC) transduced ex vivo using a lentiviral vector encoding the human…
- Trial name
- NCT04283227
- Testing
- OTL-200
- Where
- Italy
- Volunteers
- 6 people
- Sponsor
- Orchard Therapeutics
Adenosine Deaminase Severe Combined Immune Deficiency
Gene Therapy for Adenosine Deaminase Severe Combined Immune Deficiency Using Peripheral Blood and EFS ADA Vector
The aim of this study is to assess the safety and efficacy of autologous transplantation of hematopoietic stem cells (CD34+ cells) from mobilized peripheral blood (mPB) of ADA-deficient SCID infants and children following human…
- Trial name
- NCT05432310
- Testing
- A cryopreserved formulation of autologous mPB CD34+ hematopoietic stem and progenitor cells transduced ex vivo with the EFS-ADA lentiviral vector encoding the human ADA enzyme
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Osteonecrosis Due to Drugs, Jaw
Human Amniotic Membrane (hAM) for Stage II Maxillomandibular Osteonecrosis Management
This study aims to demonstrate, during the first standard surgical management of patients with stage II MRONJ, the effect of the implantation of a cryopreserved hAM on the maxillomandibular bone, on the healing of the oral mucosa.
- Trial name
- amniOST (NCT05664815)
- Testing
- Human Amniotic Membrane, Conventional/Standard treatment
- Where
- 5 sites in France
- Volunteers
- 66 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Ovarian Tissue Transplantation
Autograft of Human Ovarian Tissue : Efficiency and Safety
Ovarian tissue cryopreservation is a new technique for female fertility preservation. One way to restore fertility is autotransplantation of ovarian tissue.
- Trial name
- CAROLéLISA (NCT02184806)
- Testing
- orthotopic graft, heterotopic graft
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Venous Leg Ulcer
Subjects With Non-Healing Venous Leg Ulcers Treated With Standard Care Plus Cryopreserved Human Umbilical Cord (TTAX01)
It is hypothesized that application at 4-week intervals of the human umbilical cord tissue TTAX01 to the surface of a well debrided, nonhealing venous leg ulcer (VLU) will result in a high proportion of wounds showing complete…
- Trial name
- NCT03818828
- Testing
- TTAX01, Profore Compression Therapy, Cadexomer Iodine dressing
- Where
- 6 sites in United States
- Volunteers
- 31 people
- Sponsor
- BioTissue Holdings, Inc
Malaria,Falciparum, Parasitemia
Study in Blood Stage Malaria Infection After DVI of Cryopreserved P. Falciparum (NF54 Strain) Sporozoites
This is a single-centre, open-label, Phase Ib study designed to assess if intravenous injection of approximately 3200 P. falciparum (NF54 strain) sporozoites can be safely administered to achieve blood-stage parasitaemia with a…
- Conditions
- Malaria,Falciparum, Parasitemia, Protozoan Infections, Parasitic Disease
- Trial name
- NCT04310085
- Testing
- Artemether-Lumefantrine 20 Mg-120 Mg Oral Tablet, PfSPZ-DVI Challenge
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Clinical Pregnancy, Live Birth
Efficacy Study of Segmentation of PGD Treatment
A single centre observational study into the segmentation of preimplantation genetic diagnosis (PGD) treatment by comparing cumulative pregnancy rates following cryopreservation of all genetically transferable embryos after PGD…
- Trial name
- NCT02133950
- Testing
- elective cryopreservation of available embryos after PGD, PGD and elective fresh embryo transfer plus cryopreservation of supernumerary available embryos after PGD
- Where
- Belgium
- Volunteers
- 252 people
- Sponsor
- Universitair Ziekenhuis Brussel