Clinical trials: Cryopreservation
Fertility
Testicular Tissue Viability After Cryopreservation
we will use testicular tissue from patient who underwent orchidectomy due to medical reasons and test the viability of the tissue after cryopreservation and de-freezing.
- Trial name
- NCT01262495
- Testing
- cryopreservation
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- Hadassah Medical Organization
Prostate Cancer
AMNIOX CORD Study - Radical Prostatectomy With and Without Cryopreserved Umbilical Cord Allograft
This study aims at evaluating if placement of CLARIX® CORD 1K during robotic prostatectomy decreases the time to achieve complete erectile and urinary function after the surgery.
- Trial name
- NCT04263025
- Testing
- Cryopreserved Umbilical Cord Allograft, Robot-Assisted Radical Prostatectomy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Hackensack Meridian Health
Multiple Sclerosis
Outpatient Hematopoietic Grafting in Multiple Sclerosis Employing Autologous Peripheral Blood Stem Cells
Multiple sclerosis (MS) is a chronic, inflammatory, debilitating disease that causes destruction of central nervous system (CNS) myelin, with varying degrees of axonal damage.
- Trial name
- NCT02674217
- Testing
- Hematopoietic stem cell transplantation
- Volunteers
- 1,000 people
- Sponsor
- Centro de Hematología y Medicina Interna
Malaria, Vivax
VAC069: A Study of Blood-stage Controlled Human P. Vivax Infection
This is a clinical study to assess the safety and feasibility of Plasmodium vivax (P. vivax) controlled blood-stage human malaria infection (CHMI), by inoculation using a newly created source of P. vivax malaria-infected blood.
- Trial name
- NCT03797989
- Testing
- P. vivax infected inoculum (parasitised red blood cells)
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Frozen Embryo Transfer (FET), Assisted Reproductive Techniques
Direct Warming Frozen Embryo Transfer Outcomes in Assisted Reproductive Technology
The goal of this clinical trial is to evaluate whether the direct warming method for frozen embryo transfers (FET) can improve live birth and pregnancy outcomes in women aged 18-45 undergoing IVF treatments.
- Conditions
- Frozen Embryo Transfer (FET), Assisted Reproductive Techniques, In Vitro Fertilization (IVF), Cryopreservation of Embryos
- Trial name
- DW-FET-RCT (NCT06741748)
- Testing
- Direct Warming Method, Conventional Multi-step Thawing Method
- Where
- 3 sites in Hong Kong, United Kingdom
- Volunteers
- 578 people
- Sponsor
- Chinese University of Hong Kong
Fertility Disorders, Turner Syndrome
The Danish TURNER Cryopreservation Study
The goal of this clinical trial is to investigate if cryopreservation of ovarian tissue in girls with Turner syndrome can improve their fertility and lead to increased number of liveborn babies of Turner syndrome mothers.
- Conditions
- Fertility Disorders, Turner Syndrome, Premature Ovarian Failure
- Trial name
- DANTE (NCT05740579)
- Testing
- laparoscopic cryopreservation of one ovary
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Delayed Graft Function
Propensity Score Matched Comparison of HMP vs. SCS in Kidney Transplantation
Hypothermic machine perfusion (HMP) is considered superior to static cold storage (SCS) in kidney transplantation, but the true benefit in the real-world experience remains incompletely understood.
- Trial name
- HMP (NCT04359173)
- Where
- Austria
- Volunteers
- 347 people
- Sponsor
- Medical University Innsbruck
End Stage Liver DIsease, Liver Failure
Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver Transplantation
This is a prospective, multi-center, controlled, randomized, pivotal study to evaluate the safety and effectiveness of the VitaSmart™ Liver Machine Perfusion System by comparing clinical outcomes in patients undergoing liver…
- Trial name
- NCT05045794
- Testing
- VitaSmart™Liver Machine Perfusion System, Static cold storage
- Where
- 15 sites in United States
- Volunteers
- 228 people
- Sponsor
- Bridge to Life Ltd.
Liver Diseases, Kidney Diseases
Clinical Trial of New Hypothermic Oxygenated Perfusion System Versus Static Cold Storage
With the present study the investigators will evaluate the benefit of end-ischemic HOPE on ECD grafts (livers and kidneys) as compared to SCS.
- Trial name
- NCT03837197
- Testing
- Kidney-Hypothermic oxygenated, Liver-Hypothermic oxygenated
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- University of Bologna
Organ Transplant, Ischemic Reperfusion Injury
PERTRIAL - Perla® Preservation Solution
Perla® is a Cold Preservation Solution, with purpose to wash out, preserve during transport liver and kidney grafts in optimal conditions from the donor to the recipient.
- Trial name
- NCT05194306
- Testing
- Perla® Cold Preservation solution
- Where
- Spain
- Volunteers
- 11 people
- Sponsor
- Advanced Life Solutions
Cancer, Effects of Chemotherapy
Ovarian Tissue Cryopreservation in Females Undergoing Procedures That Will Potentially Lead To Loss of Ovarian Function
The purpose of this study is to retrieve and cryopreserve ovarian tissue from females undergoing a treatment that may lead to irreversible loss of ovarian function.
- Conditions
- Cancer, Effects of Chemotherapy, Unspecified Complication of Bone Marrow Transplant, Auto Immune Disease
- Trial name
- NCT01993732
- Testing
- Retrieval and Cryopreservation
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Medical College of Wisconsin
Infertility
The PrISICE Clinical Trial (Pre-Implantation Screening and Investigation on the Cryopreservation of Embryos)
The trial objective is to determine whether the deferred transfer of embryos following cryopreservation at the blastocyst stage following pre-implantation genetic screening (PGS-FET) improves live birthrates compared to both the…
- Trial name
- PrISICE (NCT03371745)
- Testing
- Trophectoderm biopsy, Cryopreservation, Embryo Transfer
- Where
- 3 sites in United States
- Volunteers
- 32 people
- Sponsor
- Yale University
Infertility
Vitrification and Slow Freezing for Cryopreservation of Blastocyst
Improvement in the treatment of infertility by Assisted Reproductive Techniques (ART) allows single embryo transfer to be applied without compromising pregnancy rates after the first in vitro fertilization (IVF) or Intra…
- Trial name
- NCT02068924
- Testing
- Slow freezing versus vitrification
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Fertility Issues
Testicular Tissue Cryopreservation (TTC)
The "Testicular Tissue Cryopreservation" study is open to a subset of patients facing disease or treatment regimens that could lead to infertility (gonadotoxic therapies).
- Trial name
- TTC (NCT06387498)
- Testing
- Testicular tissue biopsy and cryopreservation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Pediatric Cancer
Ovarian Tissue Cryopreservation in Post Pubertal (OTC-Post Pubertal)
The purpose of this study is to safely remove ovarian tissue in pediatric patients, who are at risk for infertility from their medical treatment, for freezing for future restoration of fertility and hormone function.
- Trial name
- NCT05309746
- Testing
- Laparoscopic surgery
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Erin Rowell
Anxiety, Infertility, Female
Stress and Fertility: How to Lower Stress When Trying to Conceive
Psychological stress and its sources differ among the population and can be reduced in various ways. The practice of yoga has been shown to be an effective stress reducing agent.
- Trial name
- NCT03031990
- Testing
- In-person yoga for fertility group, Online yoga for fertility group, In person discussion only group
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Fertility Centers of Illinois
Acute Myeloid Leukemia
Minimal Residual Disease Evaluation on Cryopreserved Ovarian Fragments in Younger Patients Treated for Acute Myeloid Leukemia
Cryopreservation of ovarian cortex represents an option for fertility preservation in patients diagnosed with acute myeloid leukemia and requiring allogeneic stem cell transplantation.
- Trial name
- FERTILAM (NCT04679285)
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Lille
COVID19, ARDS
REgulatory T Cell infuSion fOr Lung Injury Due to COVID-19 PnEumonia
To assess the safety and efficacy of CK0802 in treatment of patients with COVID-19 induced moderate-to-severe PNA-ARDS.
- Trial name
- RESOLVE (NCT04468971)
- Testing
- CK0802
- Where
- 5 sites in United States
- Volunteers
- 45 people
- Sponsor
- Cellenkos, Inc.
Ovarian Autotransplantation Using Cryopreserved Ovarian Tissue in Women Treated for Cancer
Human Ovarian Autotransplantation
Chemotherapy can cause permanent damage to a woman's ovaries. Women who are cancer survivors may find that they are not able to produce female hormones, and they may not be able to have a child.
- Trial name
- NCT01403675
- Testing
- Ovarian autotransplantation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Samuel Kim, MD
Trauma, Bleeding
Frozen Platelets in the Treatmentof Traumatic or Vascular Bleeding
Primarily due to its logistical advantages The Netherlands Armed Forces (NLAF) have been successfully using deep frozen (-80°C) platelets (DTC) for the treatment of (massive) bleeding trauma patients in austere environments since…
- Trial name
- MAFOD (NCT05502809)
- Testing
- Deep-frozen platelets
- Volunteers
- 158 people
- Sponsor
- Alrijne Ziekenhuis Leiderdorp