Clinical trials: Cryopreservation
Fertility
Oocyte Cryopreservation
The purpose of this investigation is to offer the opportunity for young women to cryopreserve (freeze) their oocytes (eggs) for use with IVF at a later point in time.
- Trial name
- egg freezing (NCT01232972)
- Testing
- vitrification of oocytes
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant
RATIONALE: Ondansetron may help lessen or prevent nausea and vomiting in patients undergoing stem cell transplant. PURPOSE: This phase II trial is studying how well ondansetron works in preventing nausea and vomiting in patients…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT00795769
- Testing
- ondansetron, survey administration, management of therapy complications
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Fred Hutchinson Cancer Center
Gender Dysphoria, Adolescent
Fertility Preservation for Transfeminine Adolescents Via Semen Cryopreservation or Testicular Sperm Extraction
The goal of this observational cohort study is to identify and predict parameters for successful testicular sperm extraction (TESE) procedures or semen cryopreservation more accurately and to evaluate the decision making process…
- Trial name
- TESE (NCT06400199)
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Malignancy, Fertility
Ovarian Tissue Freezing For Fertility Preservation
The purpose of this study is to offer an alternative method to women who wish to preserve the possibility of fertility, as well as to learn more about the ability of human eggs to survive and function after long term storage in…
- Trial name
- NCT00902720
- Testing
- Tissue sample storage
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Fertility Preservation
Ovarian Tissue Cryopreservation for Fertility Preservation in Girls and Women
This study will compare efficacy of ovarian tissue freezing using slow-freeze versus vitrification methods.
- Trial name
- NCT05434936
- Testing
- Oophorectomy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Baylor College of Medicine
Infertility, Female, Deferred Childbearing
Investigational Oocyte Cryopreservation for Medical and Non Medical Indications
This is a prospective study to assess the long term benefits and outcomes of the existing oocyte cryopreservation methods for fertility preservation in women with a potential medical or non medical risk of loss of fertility
- Trial name
- NCT04616417
- Testing
- Investigational Oocyte Cryopreservation
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Ovarian Hyperstimulation Syndrome
Luteal Antagonist Versus Conventional Treatment in Women With Severe Early Ovarian Hyperstimulation Syndrome (OHSS)
The study aims to compare the novel method of GnRH antagonist administration in the luteal phase versus conventional treatment in IVF patients who develop severe early ovarian hyperstimulation syndrome and have all their embryos…
- Trial name
- NCT02392520
- Testing
- cetrorelix (cetrotide)
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eugonia
Ovarian Hyperstimulation Syndrome, Infertility Drugs
Transfer of Fresh Versus Frozen/Thawed Embryos in IVF Cycles Where GnRH Agonist is Utilized for Oocyte Maturation.
It has been suggested that in IVF cycles where GNRH agonist is utilized for final oocyte maturation in patients at risk of ovarian hyperstimulation, pregnancy rates are reduced.
- Conditions
- Ovarian Hyperstimulation Syndrome, Infertility Drugs, Female
- Trial name
- NCT00365027
- Testing
- Delayed embryo transfer
- Sponsor
- HaEmek Medical Center, Israel
Malaria, Plasmodium Falciparum Malaria
Safety and Protective Efficacy of Intravenous Immunization With Cryopreserved Plasmodium Falciparum Sporozoites Under Chemoprophylaxis
TÜCHMI-002 is a single center, randomized, placebo-controlled, double-blinded, PfSPZ Challenge dose finding trial with two chemoprophylactic regimens and subsequent controlled human malaria infection (CHMI).
- Trial name
- NCT02115516
- Testing
- PfSPZ Challenge
- Where
- Germany
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Lysosomal Storage Disease, Metachromatic Leukodystrophy
A Safety and Efficacy Study of Cryopreserved OTL-200 for Treatment of Metachromatic Leukodystrophy (MLD)
OTL-200 is autologous CD34+ cells transduced with lentiviral vector containing human arylsulfatase A (ARSA) complementary deoxyribonucleic acid (cDNA) used for the treatment of MLD.
- Trial name
- NCT03392987
- Testing
- OTL-200
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Orchard Therapeutics
Oocyte Cryopreservation
Oocyte Cryopreservation Registry (HOPE Registry)
Phase IV, prospective multicenter, observational Registry will track cycle outcomes for subjects who are thawing frozen oocytes for subsequent use through in vitro fertilization (IVF) and embryo transfer (ET)
- Trial name
- NCT00699400
- Where
- 15 sites in United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- EMD Serono
Hepatocellular Injury, Liver Transplant Disorder
Hypothermic Oxygenated (HOPE) Versus Normothermic Machine Perfusion (NMP) in Human Liver Transplantation
The common practice of conventional cold storage (CCS) organ preservation has changed little since the initial introduction of the original University of Wisconsin (UW) organ preservation solution in the late 1980s.
- Trial name
- HOPE-NMP (NCT04644744)
- Testing
- Hypothermic oxygenated perfusion (HOPE), Normothermic machine perfusion (NMP)
- Where
- 4 sites in Germany
- Volunteers
- 213 people
- Sponsor
- Charite University, Berlin, Germany
Breast Cancer
Risk of Infertility Related to Adjuvant Chemotherapy for Early Breast Cancer: Oocyte/Embryo Cryopreservation
The aim of the study is to perform a French multicenter prospective interventional study in order to assess the feasibility and safety of ovarian hyperstimulation for oocyte / embryo cryopreservation in young women with breast…
- Trial name
- CHACRY (NCT02871167)
- Testing
- Controlled ovarian hyperstimulation (COH), Oocyte/embryo freezing
- Where
- 28 sites in France
- Volunteers
- 140 people
- Sponsor
- Centre Oscar Lambret
Infertility
Vitrification Versus Slow Cooling of Human Cleavage Stage Embryos
Human embryos can be preserved for later transfers by freezing. Traditionally the slow cooling method has been used. About 70% of the embryos remain fully intact after thawing.
- Trial name
- NCT00886431
- Testing
- embryo vitrification
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Fertility Preservation
Follicular Flushing Versus Direct Aspiration in Transabdominal Oocyte Retrieval
The goal of this observational study is to learn whether rinsing the egg sacs (follicles) during egg collection helps doctors collect more eggs in women with low egg reserve.
- Trial name
- NCT07877025
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Centrum Clinic IVF Center
Aneurysm of the Abdominal Aorta
Use of Sentinel Cells for the Development of Molecular Tests to Control the Quality of Cryopreservation
The aim is to set up tools that will serve as quality tracers for cryopreservation procedures. To meet this objective, we have chosen to develop reference samples (sentinel cells) that, in the medium term, can be used as controls…
- Trial name
- NCT01904825
- Sponsor
- Centre Hospitalier Universitaire Dijon
Fertility Disorders, Childhood Cancer
Cryopreservation of Prepubertal Testicular Tissue for Preservation of Fertility in Young Boys With Cancer
Prepubertal boys treated for cancer are at risk of infertility as a result of their treatment. At present there are no options to preserve fertility in these boys.
- Trial name
- NCT06063551
- Testing
- Testicular Biopsy
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh
Plasmodium Falciparum
A Clinical Trial to Evaluate Plasmodium Falciparum 7G8 and NF54 Challenge Strains (PfSPZ) in a Head-to-head Comparative Study - (ECG-CHMI)
A comparison of Malaria events (symptoms and signs of malaria) experienced by subjects infected with PfSPZ Challenge (NF54) vs. PfSPZ Challenge (7G8).
- Trial name
- ECG-CHMI (NCT04203186)
- Testing
- atovaquone-proguanil
- Volunteers
- healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Basal Cell Carcinoma, Squamous Cell Carcinoma
Does Cryofixation of Skin Specimens Affect Quality of Subsequent Formalin Fixed Paraffin Embedded H and E Histology
This prospective study of 60 slides of basal and squamous cell carcinomas of the skin aims to determine whether: 1. The process of cryofixation prior to generating formalin fixed paraffin embedded (FFPE) H\&E sections alters the…
- Trial name
- NCT01540695
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Frozen Embryo Transfer (FET)
Cryopreserved Pre-embryo Transfer in a Cytokine-rich Medium Versus Hyaluronic Acid
This multicenter, randomized, double-blind study compares a GM-CSF-enriched embryo transfer medium with a hyaluronic acid-enriched medium in women undergoing single frozen embryo transfer.
- Trial name
- CSF-EG (NCT07869576)
- Testing
- Cytokine-rich embryo transfer medium, Hyaluronic acid-enriched embryo transfer medium
- Volunteers
- 610 people
- Sponsor
- Vida Recoletas Sevilla