Clinical trials: Crystalloid Solution
Intensive Care
Crystalloid Versus Hydroxyethyl Starch Trials
The aim of this study is to determine whether patients in the Intensive Care Unit who receive fluid resuscitation with either hydroxyethyl starch (a synthetic colloid solution) or saline (a salt solution), have an increased rate…
- Trial name
- CHEST (NCT00935168)
- Testing
- 6% Hydroxy-ethyl starch (130/0.4), Saline
- Where
- Australia
- Volunteers
- 7,000 people
- Sponsor
- The George Institute
Shock, Septic
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis: A Pilot Feasibility Study
The objective of this pilot study is to assess overall feasibility prior to embarking on a larger randomized pragmatic trial comparing the clinical effectiveness of fluid resuscitation with NS versus LR for pediatric patients…
- Trial name
- PRoMPT BOLUS (NCT03340805)
- Testing
- Lactated Ringer, Normal saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's Hospital of Philadelphia
Metabolomics
Metabolomics of Intraoperative Saline and Balanced Crystalloid Infusion
Different crystalloids, namely 0.9% saline and balanced crystalloid may result in different metabolomic profile among surgical patients.
- Trial name
- NCT04137042
- Testing
- Saline, Balanced crystalloid
- Where
- Taiwan
- Volunteers
- 56 people
- Sponsor
- National Taiwan University Hospital
Sepsis
Mechanistic Inflammatory Sub-study Embedded Within the Albumin vs Balanced Crystalloid Trial
MIS-ABC Sepsis is a sub-study looking to understand how the immune response in patients with infection changes during the early stages of the illness, as well as after intravenous fluid treatment.
- Trial name
- MIS-ABC Sepsis (NCT04963569)
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Edinburgh
Aortic Valve Disease, Coronary Artery Disease
Intermittent Cold Blood vs Crystalloid Cardioplegia in Aortic Valve Surgery
Controversies still exists concerning the overall clinical effects of blood-based vs. crystalloid- based cardioplegic solution for myocardial protection during cardiac arrest. Both techniques are used world-wide.
- Trial name
- NCT00257777
- Testing
- Myocardial protection techniques
- Where
- Norway
- Volunteers
- 350 people
- Sponsor
- Oslo University Hospital
Lumbar Fusion Surgery, Elderly Patients
Clinical Impact of Different Crystalloid Solution on Early Biomarkers of Kidney Injury After Lumbar Fusion Surgery in Elderly Patients
This study aims to compare the effects of sodium acetate Ringer's solution versus sodium lactate Ringer's solution on early postoperative renal function indicators, renal injury biomarkers, and acute kidney injury (AKI) in…
- Conditions
- Lumbar Fusion Surgery, Elderly Patients, Sodium Acetate Ringer's Solution, Sodium Lactate Ringer's Solution
- Trial name
- NCT07542353
- Testing
- Sodium Acetate Ringer's Solution (Group A), Sodium Lactate Ringer's Solution (Group B)
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Xianping Wu
Sepsis
Feasibility of 5% Albumin Compared With Balanced Crystalloid, as Intravenous Fluid Resuscitation in Adult Patients With Sepsis, Presenting as an Emergency to Hospital
The aim of this research study is to compare two different fluids (Human Albumin Solution (HAS) and Balanced Crystalloid that are given via a drip to patients with severe infection (sepsis).
- Trial name
- ABC Sepsis (NCT04540094)
- Testing
- Human albumin, Balanced crystalloid solution
- Where
- 15 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Edinburgh
HEALTHY
Bioimpedance Spectroscopy in Humans During Acute Fluid Volume Expansion With Different Crystalloid Solutions
The objective of the study is to identify a pattern of bioimpedance in humans during acute food changes. As a part of this study the investigators will be administering sodium bromide in oder to measure extracellular water via…
- Trial name
- NCT01930578
- Testing
- Treatment with 0.9% normal saline, Treatment with D5+ 0.45 saline, Treatment with D5
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Shock
Crystalloids for AKI in Shock Patients
Fluid resuscitation is important in shock therapy, but the choice of fluids, especially the choice of crystalloid is under debate.
- Trial name
- NCT03188614
- Testing
- Fluid resuscitation
- Volunteers
- 40 people
- Sponsor
- Southeast University, China
Cardiac Diseases
The Use of Colloid Versus Crystalloid in Post-operative Pediatric Cardiac Patients for Fluid Resuscitation
The purpose of the study is to help determine if either crystalloid solution or colloid solution is more advantageous as a resuscitative fluid in post-operative pediatric cardiac patients.
- Trial name
- NCT00464126
- Testing
- 5% albumin, crystalloid
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Vanderbilt University Medical Center
Sepsis, Septic Shock
The Effect of Fluid Resuscitation With 0.9% Sodium Chloride Versus Balanced Crystalloid Solution on Renal Function of Sepsis Patients
The high chloride content of 0.9%sodium chloride (0.9%NaCl) leads to adverse pathophysiological effects in both animals and healthy human volunteers.
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT03277677
- Testing
- Normal saline, Ringer's Acetate
- Where
- Thailand
- Volunteers
- 116 people
- Sponsor
- Chulalongkorn University
Septic Shock, Fluid Resuscitation
Bicarbonated Ringer's Solution Versus Lactated Ringer's Solution in Patients With Septic Shock
In this prospective randomized controlled trial, investigators aim to study the effects and safety of bicarbonated Ringer's solution in patients with septic shock compared with lactated ringer's solution, and provide evidence for…
- Conditions
- Septic Shock, Fluid Resuscitation, Crystalloid Solution, Intensive Care Unit
- Trial name
- NCT04449757
- Testing
- Bicarbonated Ringer's solution, Lactated Ringer's solution
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Zhongnan Hospital
Sepsis, Intra-Abdominal Infections
Gelaspan vs Crystalloid Therapy in Sepsis
The goal of this randomized clinical trial is to evaluate whether balanced gelatin solution is more effective and safe than balanced crystalloid solution for perioperative fluid management in adults with sepsis undergoing…
- Trial name
- SPACES (NCT07172451)
- Testing
- Balanced Gelatin Solution, Acetate Ringer's Solution
- Where
- 9 sites in China
- Volunteers
- 318 people
- Sponsor
- Shanghai Zhongshan Hospital
Septic Shock Hyperdynamic
Acetated Ringer's Solution Versus Saline in Patients With Septic Shock
The primary aim of this trial is to compare the effect of acetated ringer's solution with that of saline for therapy on the incidence and development of major adverse renal events among septic shock patients.
- Trial name
- NCT04507672
- Testing
- Fluid resuscitation
- Volunteers
- 2,000 people
- Sponsor
- Southeast University, China
Sepsis, Acute Kidney Injury
Comparison of Balanced Crystalloids and Normal Saline in Septic Patients
In this prospective randomized controlled trial, investigators attempt to study the effects of acetated Ringer's solution on the prognosis and renal function of patients with sepsis in intensive care unit compared with normal…
- Conditions
- Sepsis, Acute Kidney Injury, Septic Shock, Sepsis, Severe
- Trial name
- NCT03685214
- Testing
- 0.9% saline, lactated Ringer's solution
- Where
- China
- Volunteers
- 500 people
- Sponsor
- ZhiYong Peng
Volume Expansion, Fluid Responsiveness
Ability of Changes in Analgesia Nociception Index to Assess the Stroke Volume Effects of a Volume Expansion of 250ml of Crystalloid in the Operating Room
Volume expansion is the cornerstone of perioperative hemodynamic optimization. The main objective of volume expansion is to increase and maximize stroke volume. Hemodynamic changes have an impact on the autonomic nervous system.
- Trial name
- REVANI (NCT04223414)
- Testing
- Analgesia Nociception Index (ANI)
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Bordeaux
Fluid and Electrolyte Imbalance
Volume Kinetics of Fluid Resuscitation in Early Sepsis
The recommended volume resuscitation for patients with early sepsis-induced hypoperfusion is at least 30 ml/kg of crystalloid administered within the first three hours.
- Trial name
- NCT06499701
- Testing
- Ringer's Lactate
- Where
- 2 sites in Romania
- Volunteers
- 13 people
- Sponsor
- Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu
Diabetic Ketoacidosis
Intravenous Fluids in Adults With Diabetic Ketoacidosis in the Emergency Department
Diabetes mellitus is a common chronic disease. It is estimated that up to 40% of adults may develop diabetes in their lifetime. Patients with poorly controlled blood sugars often visit the emergency department for treatment of…
- Trial name
- BRISK-ED (NCT04926740)
- Testing
- Ringer's lactate
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Acute Kidney Injury
The Effect of the Hydroxyethyl Starch on Kidney Injury in Pediatric Cardiac Surgery
The investigator will evaluate the influence of colloid administration on postoperative acute kidney injury in pediatric patients undergoing cardiac surgery under cardiopulmonary bypass.
- Trial name
- NCT02599155
- Testing
- Crystalloid, Colloid
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Cirrhosis With Sepsis
Comparison of Colloid (20% Albumin) Versus Crystalloid (Plasmalyte) for Fluid Resuscitation in Cirrhotics With Sepsis Induced Hypotension.
Consecutive cirrhotics who present to emergency department of Institute of Liver \& Biliary Sciences with documented or suspected sepsis induced hypotension will be randomized to receive either human albumin infusion over 3 hours…
- Trial name
- NCT02721238
- Testing
- 20% Albumin, Plasmalyte
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India