Clinical trials: Cue-reactivity
Internet Gaming Disorder
Retrieval-extinction Paradigm on Internet Gaming Disorder
The overall aim of this experimental study is to apply the new paradigm of substance addiction intervention to the study of Internet gaming disorder(IGD) subjects' intervention.
- Trial name
- NCT04180839
- Testing
- gaming-related retrieval-extinction, nongaming-related retrieval-extinction
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Normal University
Nicotine Dependence, Smoking
The Effect of Exercise on Acute Nicotine Withdrawal
The primary aim of this project is to test the effect of exercise on acute nicotine withdrawal. Acute nicotine withdrawal is characterized by a complex array of symptoms associated with increased risk of relapse among individuals…
- Conditions
- Nicotine Dependence, Smoking, Sleep Disorders, Intrinsic
- Trial name
- NicEx (NCT01047930)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Alcohol Dependence
Safety and Pharmacodynamic Study of GET 73 in Alcohol Dependent
Examination of the effect of GET 73 on alcohol pharmacokinetics and pharmacodynamics (intoxication and sedation)and safety profile in alcohol-dependent individuals.To evaluate whether GET 73, as compared to placebo, results in…
- Trial name
- SPAD (NCT01842503)
- Testing
- GET 73, inactive ingredients capsule
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Laboratorio Farmaceutico Ct S.r.l.
Nicotine Dependence, Smoking Cue Reactivity
Concurrent PET D2/D3 Receptor Imaging and fMRI Smoking Cue Reactivity in Smokers
This trial aims to determine whether dopamine D3 receptors are elevated in smokers versus nonsmokers and whether correlations exist between D3 receptor binding potential (BP) and functional MRI (fMRI) reactivity to smoking cues…
- Conditions
- Nicotine Dependence, Smoking Cue Reactivity, Relapse to Smoking
- Trial name
- NCT01784016
- Testing
- [11C]-PHNO
- Where
- 3 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mclean Hospital
Marijuana Dependence
Pregnenolone and Marijuana Dependence
The cannabinoid delta 9-tetrahydrocannabinol (THC) is the primary psychoactive component of marijuana. THC is believed to be a significant factor in the addictive potential associated with marijuana use.
- Trial name
- NCT02439814
- Testing
- Pregnenolone
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medical University of South Carolina
Methamphetamine Use Disorder
The Effects of Suvorexant on Sleep, Stress, and Cue-reactivity in Methamphetamine Use Disorder
The purpose of this study is to determine the effects of SUVO on sleep, stress, and cue reactivity/craving and to evaluate the preliminary safety and side effects profile of suvorexant (SUVO)
- Trial name
- NCT05711862
- Testing
- suvorexant (SUVO)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- The University of Texas Health Science Center, Houston
Nicotine Dependence
Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use
Oral nicotine pouches (ONPs) are non-combustible nicotine products that may reduce cigarette craving and smoking cue-induced brain activity, supporting their potential as harm-reduction tools for adults who smoke cigarettes.
- Trial name
- NCT07698470
- Testing
- Oral Nicotine Pouch, Smoking Cue Reactivity Task
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Obesity and Overweight
Effects of Antagonizing the Ghrelin Receptor on Brain Food Cue Reactivity in Obesity
The naturally occurring peptide hormone liver-expressed antimicrobial peptide 2 (LEAP2) in an antagonist/inverse agonist towards the ghrelin receptor.
- Trial name
- LEAP2fMRI (NCT06845033)
- Testing
- LEAP2 infusion
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Alcoholism
Single-dose of Nalmefene to Modulate Neural Alcohol Cue Reactivity
The aim of this study is to use functional Magnetic Resonance Imaging (fMRI) to measure neural reactivity to alcohol-related and emotional cues in alcohol dependent subjects following a single dose of the opioid receptor…
- Trial name
- NALCUE (NCT02372318)
- Testing
- Nalmefene
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Heavy Drinking
Targeted Extinction of Drug Cues During Sleep - Olfactory Cue Reactivity Task
The study aims to utilise olfactory stimulation in addition to the visual stimulation in cue reactivity tasks to enhance precision in measuring alcohol based cues in individuals diagnosed with heavy drinking.
- Trial name
- TEDDS_OCRT (NCT05189379)
- Testing
- Non-Alcoholic Odour, Alcoholic Odour, Non-Alcoholic Images
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Social Phobia
The Use of Quetiapine (Seroquel) in the Treatment of Social Phobia: Public Speaking Environment
This is a pilot study that will focus on the collection of preliminary data to determine the efficacy of quetiapine for individuals with social phobia.
- Trial name
- NCT00407199
- Testing
- quetiapine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Minnesota
Obesity, Childhood, Eating Behavior
Study of Brain, Reward, and Kids' Eating
Children from rural communities are at greater risk for obesity than children from more urban communities. However, some children are resilient to obesity despite greater exposure to obesogenic influences in rural communities…
- Trial name
- BRAKE (NCT05456516)
- Testing
- Food Rating
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cannabis Use Disorder, Cue-reactivity
Semaglutide for the Treatment of Cannabis Use Disorder
The goal of this pilot study is to learn about the effects of semaglutide on brain reactivity to cannabis-related cues in adults with cannabis use disorder. The main questions it aims to answer are: 1.
- Trial name
- S-CUD (NCT07879612)
- Testing
- semaglutide
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Cannabis
Transcranial Magnetic Brain Stimulation to Reduce Cannabis Use in Heavy Cannabis Users
The growing legalization of cannabis across the U.S. is associated with increases in cannabis use, and accordingly, an increase in the number of individuals with cannabis use problems, including cannabis use disorder (CUD).
- Trial name
- iCURE (NCT05401929)
- Testing
- iTBS
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Duke University
Alcohol Dependance
Cortical rTMS as a Tool to Change Brain Reactivity to Alcohol Cues
The goal of this investigation is to determine if, in heavy alcohol users, a single session of transcranial magnetic brain stimulation (TMS) over a brain region involved in craving (medial prefrontal cortex) and a brain region…
- Trial name
- ARC4 (NCT02939313)
- Testing
- medial prefrontal cortex, dorsolateral prefrontal cortex
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cocaine-Related Disorders
Neurocircuit Strategy to Decrease Cocaine Cue Reactivity
The overarching goal of this project is to examine the effect of combining theta burst stimulation (TBS) and N-acetylcysteine (NAC) on cocaine craving and brain response to cocaine-related images.
- Trial name
- COCA (NCT04155632)
- Testing
- N-acetylcysteine, Theta-burst stimulation (TBS)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Tobacco Dependence
Effects of Yoga and Cardiovascular Exercise on Smoking Motivation
The overall purpose of this pilot study is to examine effects of Hatha yoga and cardiovascular exercise on craving, mood, cue reactivity, and smoking behavior.
- Trial name
- NCT01423578
- Testing
- Hatha Yoga (HY), Cardiovascular Exercise (CE), Smoking Cessation Counseling
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Heavy Drinking
Exploring the Effects of Brief Mindfulness Training With Vagal Nerve Stimulation on Alcohol Cue Reactivity Among Young Adult Heavy Drinkers
The present study will assess the acceptability and feasibility of a brief intervention designed to help young heavy drinkers reduce their alcohol consumption.
- Trial name
- NCT07516873
- Testing
- Active RAVANS, Brief Mindfulness-Based Intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Cambridge Health Alliance
Alcohol Dependence
Aripiprazole Effects on Alcohol Reactivity and Consumption
The purpose of this study is to determine whether aripiprazole (marketed dopamine stabilizer) is effective in reducing of alcohol craving compared to placebo.
- Trial name
- NCT00183235
- Testing
- aripiprazole (up to 15 mg/day) for 8 days
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Binge-Eating Disorder, Overweight
CHARGE: Controlling Hunger and ReGulating Eating
The objectives of this proposed study are: 1) to evaluate feasibility and acceptability of a novel intervention, Regulation of Cues (ROC), and Cognitive Behavior Therapy (CBT), and 2) to evaluate the efficacy of both treatments…
- Conditions
- Binge-Eating Disorder, Overweight, Obesity
- Trial name
- CHARGE (NCT03678766)
- Testing
- Regulation of Cues (ROC), Cognitive Behavior Therapy (CBT)
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- University of California, San Diego