Clinical trials: Cue-reactivity
Cannabis Use Disorders
Stress and Marijuana Cue-elicited Craving and Reactivity
The purpose of this study is to explore the interaction between stress and marijuana cues, in hopes that it may lead to the development of new treatments for marijuana dependence.
- Trial name
- NCT00613405
- Testing
- Stress + cue exposure, No stress + cue exposure
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Medical University of South Carolina
Physiological Reactivity to Cues
Physiological Reaction After Food Intake
The goal of this clinical trial is to clarify the normal response of the body after food intake. Therefore, participants will wear three wearables for two weeks and document their food intake via an app- and picture-based…
- Trial name
- NutriPulse (NCT06548165)
- Testing
- Wearable
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Cannabis Use Disorder, Cannabis Use Disorders
Effect of Semaglutide on Cannabis Use in Adults With Cannabis Use Disorder
The HASHTAG Study is investigating whether the medicine semaglutide can help adults with cannabis use disorder (CUD) reduce their cannabis use. Participants will be randomly assigned to receive either semaglutide or a placebo.
- Conditions
- Cannabis Use Disorder, Cannabis Use Disorders, Cannabis Abuse, Cannabis Dependence
- Trial name
- HASHTAG (NCT07523633)
- Testing
- semaglutide
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Anders Fink-Jensen, MD, DMSci
Obesity, Childhood
Resilience to the Effects of Advertising in Children
Strong empirical evidence shows food marketing promotes excess energy intake and obesity. Yet, not all children are susceptible to its effects and this variability is poorly understood.
- Trial name
- REACH (NCT05073185)
- Where
- United States
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- Penn State University
Opioid Use Disorder
Effect of Music on Cue Reactivity for Patients With Opioid Use Disorder
This research is being performed to understand the role of music in people's opioid cravings, opioid use, and recovery. Music affects individuals in so many ways, and can trigger strong good and bad emotions.
- Trial name
- NCT06948890
- Testing
- Music intervention, Silence
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Brigham and Women's Hospital
Alcohol Use Disorder
Brain Connectivity Between Networks Implied in Inhibition and Cue-reactivity in Alcohol Use Disorder
Research about patients with alcohol use disorder has shown that task-related brain activation patterns as well as resting-state connectivity (measured with functional magnetic resonance imaging) change with clinical parameters…
- Trial name
- NIQA (NCT05843435)
- Testing
- Go-Nogo-task during functional magnetic resonance imaging, Resting-state functional magnetic resonance imaging
- Where
- Switzerland
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Bern
Alcohol Use Disorder, Trauma, Psychological
Adverse Childhood Experiences in Substance-related Disorders
Aversive childhood experiences (ACE) and their relation to the development of an alcohol use disorder will be measured with fMRI.
- Trial name
- NCT03758053
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Cocaine Dependence, Alcohol Dependence
10 Days of Theta Burst Stimulation as a Tool to Treat Cocaine Dependence
The goal of this double-blind sham controlled study is to evaluate the effeicacy of continuous theta burst stimulation to the frontal pole as a tool to decrease drug cue reactivity and improve treatment outcomes in…
- Trial name
- NCT03238859
- Testing
- Real cTBS
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder
Clinical and Mechanistic Effects of Psilocybin in Alcohol Addicted Patients
Effects of serotonin 2A/1A receptor stimulation by psilocybin on alcohol addicted patients: a randomized double-blind placebo-controlled study
- Trial name
- NCT04141501
- Testing
- Psilocybin
- Where
- Switzerland
- Volunteers
- 37 people
- Sponsor
- University of Zurich
Alcohol Dependence
Neurofeedback & Alcohol Dependence
The study aims to examine whether the neurofeedback method (based on functional magnetic resonance imaging [fMRI]) can help patients with alcohol dependence to control their urges to drink alcohol and thus to remain abstinent.
- Trial name
- NCT02486900
- Testing
- fMRI-based neurofeedback
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- Cardiff University
Nicotine Addiction, Smoking Cessation
Extinction Updating in Reconsolidation
Smoking occurs in approximately 21% of the US population, is responsible for an annual mortality rate of approximately 438,000 citizens, and has an associated healthcare economic burden of $167 billion.
- Trial name
- NCT02154685
- Testing
- Retrieval-Extinction, Non-Retrieval Extinction
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Opioid Use Disorder, Tobacco Use Disorder
Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use Disorder
This pilot study will evaluate the use of deep transcranial magnetic stimulation (Deep TMS) to help adults with opioid use disorder (OUD) who are receiving medications for opioid use disorder (MOUD) such as buprenorphine or…
- Trial name
- NCT07770555
- Testing
- Deep TMS System With H4 Coil
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Payel Roy
Smokers
Effect of Behavioral Training on Physiological Responses to Smoking Cues, Affect and Cortisol
This study is ancillary. Participants will be recruited as part of a separate clinical trial on effects of two intensive behavioral training programs that evaluates feasibility and efficacy of a behavioral treatment that includes…
- Trial name
- physio (NCT01362101)
- Testing
- Mindfulness behavioral intervention (MT),cognitive behavioral intervention (CBT)
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- A. Eden Evins
Alcohol Use Disorder (AUD), Alcoholism
Cue Effects in Human Addiction: Pavlovian to Instrumental Transfer
Individuals with substance use disorders (SUD) have to cope with drug-related cues and contexts, which can affect instrumental drug seeking as shown with Pavlovian to instrumental transfer (PIT) paradigms in animals and humans.
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders, Smoking, Tobacco
- Trial name
- ReCoDe (NCT05992272)
- Testing
- fMRI imaging (BOLD), sMRI (structure), Trier Social Stress Test
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Prader-Willi Syndrome
Stress and Brain Response Using MEG in PWS
Individuals with Prader-Willi Syndrome (PWS) have increased hunger and food seeking behaviour, as well as learning (cognitive) challenges.
- Trial name
- NCT04032639
- Where
- 2 sites in Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Tobacco Use Disorder, Nicotine Dependence
Efficacy and Neural Correlates of Personalized Treatment With Transdermal Nicotine Replacement
This study involves the use of personalized nicotine patch dosing as a treatment strategy for smokers who cannot quit smoking after 2 weeks of using the standard nicotine patch dose.
- Trial name
- iT-NRT (NCT02439944)
- Testing
- Nicotine patch, Nicotine mouthspray
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Centre for Addiction and Mental Health
Tobacco Dependence
Establishing the Effect of Flavor on the Addictive Potential of Electronic Cigarettes
The current study aims to establish proof-of-concept that neural cue-reactivity can serve as an early, objective marker of electronic cigarette (ECIG) addictive potential.
- Trial name
- NCT03905928
- Testing
- Nicotine Containing ECIG with tobacco flavor, Nicotine Containing ECIG with Strawberry Vanilla Flavor
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Alcohol Use Disorder, Alcoholism
Effect of Social Isolation on the Role of Pavlovian Mechanisms for Control Over Alcohol Use
During the first funding period (1st FP) we investigated the impact of acute and chronic stress (Trier Social Stress Test, TSST) on Pavlovian-to-instrumental transfer (PIT).
- Conditions
- Alcohol Use Disorder, Alcoholism, Stress Reaction, Ostracism
- Trial name
- ReCoDe (NCT06256952)
- Testing
- PIT paradigm, social exclusion (Cyberball task), Saliva samples
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Tobacco Use Disorder, Nicotine Dependence
Beta-Adrenergic Modulation of Drug Cue Reactivity
This study is designed to investigate the effects of a beta-adrenergic antagonist (Propranolol; 40 mg IR) and nicotine patch (14 mg) administered alone and in combination on neurobiological and behavioral responses to smoking…
- Conditions
- Tobacco Use Disorder, Nicotine Dependence, Cigarette Smoking
- Trial name
- NCT05587361
- Testing
- Propranolol, Nicotine Patch
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Obesity
To Predict Weight Loss Response to Liraglutide (Saxenda®), From fMRI-based Determination of Food Cue Reactivity
The study is a single center, randomized, double blind, placebo controlled; parallel-group repeated measures design. Subjects will be randomly assigned to either Saxenda® or placebo group after baseline assessments.
- Trial name
- NCT03795701
- Testing
- Saxenda®
- Where
- 2 sites in United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Texas Tech University