Clinical trials: Current Episode Depressed
Major Depressive Disorder, Major Depressive Disorder, Recurrent, Unspecified
Escitalopram, Placebo and tDCS in Depression: a Non-inferiority Trial
Major depressive disorder (MDD) is a common psychiatric condition, mostly treated with antidepressant drugs, which are limited for issues such as refractoriness and adverse effects.
- Conditions
- Major Depressive Disorder, Major Depressive Disorder, Recurrent, Unspecified, Major Depressive Disorder, Single Episode, Unspecified
- Trial name
- ELECT-TDCS (NCT01894815)
- Testing
- Escitalopram oxalate, transcranial direct current stimulation
- Where
- 2 sites in Brazil
- Volunteers
- 245 people
- Sponsor
- University of Sao Paulo
Major Depressive Disorder
Single IV Dose of GLYX-13 in Patients With Treatment-Resistant Depression
The purpose of this study is to determine whether GLYX-13 reduces depression score in patients with treatment-resistant depression.
- Trial name
- NCT01234558
- Testing
- GLYX-13
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Naurex, Inc, an affiliate of Allergan plc
Bipolar I Disorder, Current Episode Depressed
Creatine Monohydrate as Adjuvant Therapy for Bipolar Depression
The purpose of this study is to determine whether creatine monohydrate is effective as an adjuvant treatment for bipolar depression.
- Trial name
- NCT01655030
- Testing
- creatine monohydrate
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Sao Paulo
Major Depressive Disorder (MDD)
Genomics Used to Improve DEpression Decisions
Evaluate the impact of GeneSight Psychotropic on response to psychotropic treatment as judged by the mean change in the 17-item Hamilton Depression (HAM-D17) score from baseline to end of Week 8 of the study.
- Trial name
- GUIDED (NCT02109939)
- Testing
- GeneSight Psychotropic
- Where
- 61 sites in United States
- Volunteers
- 1,398 people
- Sponsor
- Assurex Health Inc.
Bipolar Disorder I or II With a Major Depressive Episode
ALTO-100 in Bipolar Disorder With Depression (BD-D)
The purpose of this study is to assess antidepressant efficacy differences between ALTO-100 and placebo during the Double-Blind period in patients with bipolar disorder I or II with current major depressive episode, when used…
- Trial name
- NCT06656416
- Testing
- ALTO-100
- Where
- 68 sites in United States, United Kingdom
- Volunteers
- 200 people
- Sponsor
- Alto Neuroscience
Bipolar I Disorder, Mania
A Cariprazine Study in the Prevention of Relapse in Bipolar I Disorder Patients Whose Current Episode is Manic or Depressive, With or Without Mixed Features
1) To evaluate the efficacy and safety of cariprazine at a target dose of 3.0 mg/day compared with placebo in prevention of relapse in patients with bipolar I disorder whose current episode (i.e.
- Conditions
- Bipolar I Disorder, Mania, Depression
- Trial name
- NCT03573297
- Testing
- Cariprazine
- Where
- 108 sites in United States, Bulgaria and 9 more
- Volunteers
- 901 people
- Sponsor
- AbbVie
Bipolar II Disorder, Most Recent Episode Major Depressive, Current Depressive Episode
Accelerated Intermittent Theta-Burst Stimulation (aiTBS) in Treatment-Resistant Depression of Bipolar II Disorder
The purpose of this study is to investigate the effectiveness of accelerated intermittent theta-burst transcranial magnetic stimulation (aiTBS) in inducing anti-depressant responses in individuals with treatment-resistant…
- Conditions
- Bipolar II Disorder, Most Recent Episode Major Depressive, Current Depressive Episode, Treatment Resistant Depression
- Trial name
- NCT05849402
- Testing
- Active Comparator: Active aiTBS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Stanford University
MDD, Severe Depression
At-Home tDCS as Maintenance Therapy
The primary purpuse of this pilot study is to find out whether a home-based transcranial direct current stimulation (tDCS) program is feasible and well tolerated as maintenance therapy and whether there are early signs that it…
- Conditions
- MDD, Severe Depression, Major Depressive Episode
- Trial name
- MaintenanceDC (NCT07269964)
- Testing
- tDCS
- Where
- 2 sites in Germany
- Volunteers
- 30 people
- Sponsor
- Technical University of Munich
Depression, Major Depressive Disorder
Single Session of tACS in a Depressive Episode
Purpose: Investigating the effects of non-invasive transcranial alternating current stimulation (tACS) on healthy participants and participants with mood disorders.
- Conditions
- Depression, Major Depressive Disorder, Premenstrual Dysphoric Disorder, Depressive Episode
- Trial name
- SSDE (NCT03449979)
- Testing
- XCSITE100 Stimulator tACS
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Moderate Depression, Severe Depressive Episode Without Psychotic Symptoms
A Randomized Clinical Trial Comparing Active Versus Sham T-PEMF Headband Treatment for Depression
An 8-week, two-armed, randomized-controlled trial that examines the antidepressant effect of treatment with transcranial pulsed electromagnetic fields (T-PEMF) in patients diagnosed with moderate to severe depression using using…
- Conditions
- Moderate Depression, Severe Depressive Episode Without Psychotic Symptoms, Recurrent Depressive Disorder, Current Episode Moderate, Recurrent Depressive Disorder, Current Episode Severe Without Psychotic Symptoms
- Trial name
- NCT06005103
- Testing
- Treatment with MoodHeadBand (T-PEMF treatment)
- Where
- Denmark
- Volunteers
- 117 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Schizophrenia, Schizotypal Disorder
Feasibility of a Novel Process-based Treatment for Patients With Psychosis
The purpose of this single-arm feasibility study is to develop and pilot test a novel process-based and modular group therapy approach for patients with acute psychotic symptoms in an inpatient setting.
- Conditions
- Schizophrenia, Schizotypal Disorder, Delusional Disorder, Brief Psychotic Disorder
- Trial name
- PROBAS (NCT04874974)
- Testing
- Metacognitive and Defusion Training
- Where
- Germany
- Volunteers
- 37 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Depression
Transcranial Direct Current Stimulation (tDCS) Cost-utility-analysis in Medical Care on Depressive Episode With One Drug Therapy Failure.
The purpose of this study is to determine the transcranial direct current stimulation (tDCS) cost-utility in the depression therapy.
- Trial name
- DISCO (NCT03758105)
- Testing
- tDCS associated with usual care, Usual care
- Where
- 12 sites in France
- Volunteers
- 214 people
- Sponsor
- Nantes University Hospital
Depressive Disorder, Major, Depression
Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder
Evidence exists supporting the ability of genetic variations to influence patient drug response and side effects. Previous studies utilizing an open-label design have shown significant improvement in major depressive disorder…
- Conditions
- Depressive Disorder, Major, Depression, Depressive Disorder
- Trial name
- NCT02466477
- Testing
- GeneSight Psychotropic (GEN), Enhanced-GeneSight Psychotropic (E-GEN), Treatment as Usual (TAU)
- Where
- 14 sites in Canada
- Volunteers
- 542 people
- Sponsor
- Assurex Health Inc.
Major Depressive Disorder, Suicidal Ideation
Paliperidone and Lithium in the Treatment of Suicidality - Treatment Indication and Epigenetic Regulation
The study aims to use a combined clinical and translational approach to identify an efficient pharmacotherapy for the acute management of suicidality and the epigenetic regulation associated with the treatment.The primary…
- Trial name
- AFSP (NCT01134731)
- Testing
- paliperidone, lithium
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Alabama at Birmingham
Depression
Treating Depression With Transcranial Direct Current Stimulation (tDCS)
The purpose of this study is to see if transcranial direct current stimulation may improve the symptoms of depression.
- Trial name
- NCT00481988
- Testing
- transcranial direct current stimulation, iomed phoresor transcranial direct current stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder
Efficacy and Safety of GLYX-13 in Subjects With Inadequate/Partial Response to Antidepressants
GLYX-13 is a NMDA receptor glycine site partial agonist being studied in subjects with major depressive disorder (depression) who have responded inadequately to another antidepressant drug during the current episode.
- Trial name
- NCT01684163
- Testing
- GLYX-13 5 mg/kg, GLYX-13 10 mg/kg
- Where
- 26 sites in United States
- Volunteers
- 369 people
- Sponsor
- Naurex, Inc, an affiliate of Allergan plc
Depression - Major Depressive Disorder
Efficacy and Safety of Transcranial Alternating Current Stimulation (tACS) in Adolescents With First-episode Depression Who Are Drug-naive: A Randomized, Double-blind, Controlled Pilot Study
To evaluate the efficacy of tACS treatment.To determine whether tACS can accelerate symptom remission, improve clinical response rates, and facilitate the recovery of emotional and cognitive functions through standardized…
- Trial name
- NCT07185464
- Testing
- tACS
- Where
- China
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Depression
Comparison of the Efficacy of Transcranial Direct Current Stimulation at Home Versus in Hospital Settings in Patients With Depressive Episodes
Transcranial direct current stimulation (tDCS) is a neuromodulation method that modulates brain activity using low-intensity electrical current.
- Trial name
- CAPUCINOO (NCT07490379)
- Testing
- Distribution of study questionnaires, tDCS sessions (D1-D10), Monitoring tDCS appropriation
- Where
- 6 sites in France
- Volunteers
- 66 people
- Sponsor
- Nantes University Hospital
Mild Cognitive Impairment, Major Depressive Disorder, Recurrent, In Remission
Prevention of Alzheimer's Disease With CR Plus tDCS in Mild Cognitive Impairment and Depression (PACt-MD)
This 7-year randomized controlled trial will compare the efficacy of non-invasive brain stimulation (trans-cranial Direct Current Stimulation - tDCS) combined with cognitive remediation (CR) versus sham ("placebo") tDCS combined…
- Conditions
- Mild Cognitive Impairment, Major Depressive Disorder, Recurrent, In Remission, Major Depressive Disorder, Single Episode, in Full Remission
- Trial name
- PACt-MD (NCT02386670)
- Testing
- tDCS + CR
- Where
- 5 sites in Canada
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Depressive; Episode, Major, Recurrent Depressive Disorder, Current Episode Moderate
Efficacy of Edupression.Com® in Depressive Patients
The aim of the study is to investigate the efficacy and adherence of the digital self-help programme edupression.com®.
- Conditions
- Depressive; Episode, Major, Recurrent Depressive Disorder, Current Episode Moderate, Recurrent Depressive Disorder, Current Episode Mild
- Trial name
- eFICASY (NCT04839822)
- Testing
- edupression.com®, Health tips, Surveys
- Where
- Austria
- Volunteers
- 250 people
- Sponsor
- Medical University of Vienna