Clinical trials: Current Major Depressive Disorder
Major Depressive Disorder, Bipolar Affective Disorder, Currently Depressed, Moderate
The Role of Negr1 In Modulating Neuroplasticity in Major Depression (RONIN)
Patients belonging to Group 1 (Major Depression) and 2 (Bipolar Disorder) will be tested with psychometric and functional scales at baseline (T0) and after 4 weeks of pharmacological therapy (T1), to evaluate clinical and…
- Trial name
- RONIN (NCT06131268)
- Testing
- Venlafaxine
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Mild Cognitive Impairment, Major Depressive Disorder, Recurrent, In Remission
Prevention of Alzheimer's Disease With CR Plus tDCS in Mild Cognitive Impairment and Depression (PACt-MD)
This 7-year randomized controlled trial will compare the efficacy of non-invasive brain stimulation (trans-cranial Direct Current Stimulation - tDCS) combined with cognitive remediation (CR) versus sham ("placebo") tDCS combined…
- Conditions
- Mild Cognitive Impairment, Major Depressive Disorder, Recurrent, In Remission, Major Depressive Disorder, Single Episode, in Full Remission
- Trial name
- PACt-MD (NCT02386670)
- Testing
- tDCS + CR
- Where
- 5 sites in Canada
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Depression
Major Depressive Disorder (MDD)
The purpose of this study is to assess the effectiveness of systematic screening for depression in high-risk patient participants in everyday clinical practice.
- Trial name
- NCT01662817
- Testing
- Intervention, Control
- Where
- Spain
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Major Depression
Modulation of Cognitive Control by Transcranial Direct Current Stimulation
Insufficient cognitive control over emotional distracters is characteristic for major depressive disorder (MDD). Hypoactivation of the dorsolateral prefrontal cortex (dlPFC) is associated with this deficit.
- Trial name
- NCT01652391
- Testing
- Transcranial direct current stimulation (tDCS); DC-STIMULATOR (NeuroConn GmbH, Ilmenau, Germany)
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Antenatal Depression, Major Depressive Disorder
Pilot Study of Personalized Aperiodic Transcranial Alternating Current Stimulation in Antenatal Depression (PandA-tACS)
The purpose of this study is to develop the safety, feasibility, and tolerability of a personalized transcranial alternating current stimulation (tACS) approach in antenatal depression.
- Conditions
- Antenatal Depression, Major Depressive Disorder, Major Depressive Disorder in Pregnancy, Healthy Controls
- Trial name
- PandA-tACS (NCT06979154)
- Testing
- tACS (aperiodic)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Major Depressive Disorder
Transcranial Alternating Current Stimulation (tACS) on Serotonin-1A Receptor in Depression
This study will apply a comprehensive tools that integrates neuroimaging, psychological evaluation, and sleep monitoring through 18F-MPPF PET/MR, neuropsychological tests, and polysomnography (PSG) to explore the neurobiological…
- Trial name
- NCT06211140
- Testing
- tACS, Control
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Clinical Trial
tDCS as Adjunctive Therapy to Cognitive Stimulation in Medical Students With Depression
Major depressive disorder (MDD) is a major public health problem, it negatively affects cognition and cognitive deficits affect information processing speed, attention, memory, executive function and working memory.
- Trial name
- NCT06562387
- Testing
- transcranial direct current stimulation, cognitive stimulation
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico
Current Major Depressive Disorder, Healthy
Evaluating Brain Responses to Facial Expressions in Major Depressive Disorder
This study will evaluate emotional processing biases in the brain while viewing facial expressions in adults with current or remitted major depressive disorder and healthy volunteers.
- Conditions
- Current Major Depressive Disorder, Healthy, Remitted Major Depressive Disorder
- Trial name
- NCT00071123
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Stress Reaction, Stress Related Disorder
Research on the Effects of Combined Neurostimulation Protocols on Stress
The study examines the effects of the combined use of two different non-invasive brain stimulation (NIBS) techniques targeting the DLPFC on stress reactivity and recovery.
- Conditions
- Stress Reaction, Stress Related Disorder, Major Depressive Disorder
- Trial name
- NCT03722095
- Testing
- active tDCS, iTBS
- Where
- Belgium
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University Ghent
Major Depressive Disorder, Schizophrenia
Disorder-tailored Transcranial Direct Current Stimulation (tDCS) of the Prefrontal Cortex
Major depressive disorder (MDD) is a common, recurrent, and frequent chronic disorder. Among others, deficient cognitive control over emotional distraction is a central characteristic of MDD (Ochsner \& Gross 2005; Disner et al.
- Trial name
- MRSDC1 (NCT02715128)
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Depression, Major Depressive Disorder
Single Session of tACS in a Depressive Episode
Purpose: Investigating the effects of non-invasive transcranial alternating current stimulation (tACS) on healthy participants and participants with mood disorders.
- Conditions
- Depression, Major Depressive Disorder, Premenstrual Dysphoric Disorder, Depressive Episode
- Trial name
- SSDE (NCT03449979)
- Testing
- XCSITE100 Stimulator tACS
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Major Depressive Disorder, Unipolar Depression
Transcranial Direct Current Stimulation (tDCS) As Treatment for Major Depression
Major depressive disorder (MDD) is a common, recurrent, and frequent chronic disorder. Treatment is often challenging; an estimated 20-40% of patients do not benefit sufficiently from existing antidepressant interventions…
- Conditions
- Major Depressive Disorder, Unipolar Depression, Depression
- Trial name
- DepressionDC (NCT02530164)
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- Germany
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Major Depressive Disorder
Remotely Non-invasive Brain Stimulation and Videogame to Alleviate Depression
Major depressive disorder (MDD) is a common, recurrent, and frequent chronic disorder. Treatment is often challenging; up to 40% of patients do not benefit sufficiently from existing antidepressant interventions including trials…
- Trial name
- NCT04953208
- Testing
- active tDCS, cognitive and emotional control video game
- Where
- 3 sites in Germany, Israel and 1 more
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Mor Nahum
Major Depressive Disorder, Loneliness
Treating Loneliness In The Older Adult With Depression With tDCS
High loneliness is prevalent among older adults and is a significant risk factor for major depression and low recovery rates in patients. Current interventions for loneliness are limited.
- Trial name
- NCT06658795
- Testing
- Transcranial direct current stimulation (tDCS) on the Left DLPFC, Transcranial direct current stimulation (tDCS) on the right VLPFC
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Guangzhou Psychiatric Hospital
Major Depressive Disorder
Impact of tDCS on Emotional Processing in Major Depression
Background: transcranial direct current stimulation (tDCS) is an innovative treatment for major depression. However, its mechanisms of action are still unclear.
- Trial name
- EmoStim (NCT02793258)
- Testing
- transcranial direct current stimulation
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Anodal Stimulation tDCS, Major Depression
Effects of tDCS on Cognitive Control and Emotion Regulation in Depressed Patients
Deficient cognitive control (CC) and the use of dysfunctional emotion regulation strategies (ERS) are both central characteristics of major depression.
- Conditions
- Anodal Stimulation tDCS, Major Depression, Cognitive Control, Emotion Regulation
- Trial name
- NCT03039387
- Testing
- anodal transcranial direct current stimulation
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Traumatic Brain Injury, Major Depressive Disorder
Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive…
- Conditions
- Traumatic Brain Injury, Major Depressive Disorder, Bipolar Disorder, Schizophrenia
- Trial name
- NCT04296604
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital