Clinical trials: Cutaneous Squamous Cell Carcinoma in Situ
Facial isSCC
Study to Evaluate Safety, Efficacy of Intralesional Injection of STP705 in Adults With Facial isSCC
Open label, dose escalation to evaluate safety.
- Trial name
- isSCC (NCT05421013)
- Testing
- STP705
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Sirnaomics
Actinic Keratosis, Bowen's Disease
Clinical Study Assessment of SR-T100 Topical Gel Against Actinic Keratosis
To evaluate the efficacy of SR-T100 gel by observing the lesion size (length x width x height) of human cutaneous squamous cell carcinoma in situ (Actinic Keratosis and Bowen's Disease) reduced at least 75%.
- Trial name
- AK (NCT02085395)
- Testing
- SR-T100 ® Gel
- Where
- Taiwan
- Volunteers
- 27 people
- Sponsor
- G&E Herbal Biotechnology Co., LTD
Cancer
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
This is a phase III, randomized, double-blind, placebo-controlled, multicenter study of the clinical response to fentanyl sublingual spray as a treatment for breakthrough cancer pain.
- Trial name
- NCT00538850
- Testing
- Fentanyl sublingual spray
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- INSYS Therapeutics Inc
Head and Neck Squamous Cell Carcinoma, Breast Cancer
A Study of Tremelimumab and IV Durvalumab Plus Poly-ICLC in Subjects With Biopsy-accessible Cancers
This is an open-label, multicenter, Phase 1/2 study of the CTLA-4 antibody, tremelimumab, and the PD-L1 antibody, durvalumab (MEDI4736), in combination with the tumor microenvironment (TME) modulator poly-ICLC, a TLR3 agonist, in…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Breast Cancer, Sarcoma, Merkel Cell Carcinoma
- Trial name
- NCT02643303
- Testing
- Durvalumab, Tremelimumab, Poly-ICLC
- Where
- 7 sites in United States
- Volunteers
- 58 people
- Sponsor
- Ludwig Institute for Cancer Research
Melanoma, Squamous Cell Carcinoma of the Head and Neck
Treatment of Solid Tumors With Intratumoral Hiltonol® (Poly-ICLC)
The purpose of this study is to test the safety of a course of injections containing Poly-ICLC in patients with advanced solid tumors that can be easily and safely reached with a needle.
- Conditions
- Melanoma, Squamous Cell Carcinoma of the Head and Neck, Squamous Cell Carcinoma of the Skin, Sarcoma of the Skin
- Trial name
- Hiltonol (NCT01984892)
- Testing
- Poly-ICLC
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Nina Bhardwaj
Facial Cutaneous Squamous Cell Carcinoma in Situ
Evaluating the Use of Photodynamic Therapy to Treat Facial Cutaneous Squamous Cell Carcinoma in Situ (isSCC)
The goal of this clinical trial is to test how safe and effective it is to treat early form of cancer cells found in the upper skin layer of the face, using a light-sensitive cream used in combination with a light source.
- Trial name
- NCT06159842
- Testing
- Aminolevulinic Acid 20% Topical Solution with Blue Light
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- The Center for Clinical and Cosmetic Research
Bowen's Disease, Cutaneous Squamous Cell Carcinoma in Situ
Open Label, Dose Escalation Study for the Safety and Efficacy of STP705 in Adult Patients With isSCC
This is an open label, dose escalation study to evaluate the safety and efficacy of intralesional injection of STP705 in adult patients with Cutaneous Squamous Cell Carcinoma in situ (isSCC, Bowen's disease).
- Trial name
- NCT04293679
- Testing
- STP705
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Sirnaomics
Squamous Cell Carcinoma
An Open-Label Safety Study of API 31510 in a Topical Cream for in Situ Cutaneous Squamous Cell Carcinoma (SCCIS)
The purpose of this study is to determine the safety and tolerability of pharmaceutical compound 31510 in a topical cream when applied to in situ cutaneous squamous cell carcinoma and to obtain preliminary efficacy data for the…
- Trial name
- NCT00652080
- Testing
- API 31510
- Where
- 5 sites in United States
- Volunteers
- 35 people
- Sponsor
- BPGbio
Basal Cell Carcinoma of Skin, Cutaneous Squamous Cell Carcinoma (CSCC)
Impact of Preoperative High-Frequency Ultrasound Cutaneous Lesion Extent Assessment on Excision Margin Positivity in Head and Neck Skin Cancer, and the Relationship Between Preoperative Assessment Methods, Inadequate Excision Margins, and Tumor Recurrence
Non-melanoma skin cancers (NMSC), particularly basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), are the most common malignancies in Caucasians, with the majority of tumors located in the head and neck due…
- Conditions
- Basal Cell Carcinoma of Skin, Cutaneous Squamous Cell Carcinoma (CSCC), Cutaneous Squamous Cell Carcinoma in Situ (CSCCis), Cutaneous Squamous Cell Carcinoma of the Head and Neck
- Trial name
- HFUS-CLEAR (NCT07361666)
- Testing
- High-Frequency Ultrasound, Dermoscopy
- Where
- Poland
- Volunteers
- 400 people
- Sponsor
- Państwowy Instytut Medyczny Ministerstwa Spraw Wewnętrznych i Administracji
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma
In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors
This phase I trial evaluates the safety and effectiveness of in situ immunomodulation with CDX-301, radiotherapy, CDX-1140 and Poly-ICLC (Cohort A) and these with intravenous (IV) pembrolizumab and subcutaneous (SC) tocilizumab…
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Prognostic Stage IV Breast Cancer AJCC v8, Unresectable Breast Carcinoma
- Trial name
- NCT04616248
- Testing
- Anti-CD40 Agonist Monoclonal Antibody CDX-1140, Poly ICLC, Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Southern California
Cutaneous Squamous Cell Carcinoma in Situ (CSCCis)
Safety, Tolerability, and Efficacy Study of CLL442 in Patients With Cutaneous Squamous Cell Carcinoma in Situ (SCCis)
The purpose of this first in human and proof of concept study is to characterize the safety, tolerability and initial efficacy of CLL442 in patients with Squamous Cell Carcinoma in situ (SCCis) to enable further clinical…
- Trial name
- NCT03333694
- Testing
- Cutaneous Cream application
- Where
- 8 sites in United States, Australia and 1 more
- Volunteers
- 40 people
- Sponsor
- Novartis Pharmaceuticals
Carcinoma, Squamous Cell
Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Cutaneous Squamous Cell Carcinoma In Situ
The purpose of this study is to determine whether the topical application of PEP005 is safe and effective for the treatment of cutaneous squamous cell carcinoma in situ (SCCIS, Bowen's disease).
- Trial name
- NCT00329121
- Testing
- PEP005
- Where
- 3 sites in Australia
- Volunteers
- 24 people
- Sponsor
- Peplin
Squamous Cell Carcinoma
Photodynamic Therapy for Treatment of Cutaneous Squamous Cell Carcinoma in Situ
This pilot study will evaluate the effectiveness of using photodynamic therapy for treatment of cutaneous squamous cell in situ (SCCis). Our hypothesis is that PDT will be effective for treating SCCis.
- Trial name
- NCT03025724
- Testing
- Levulan Kerastick, blue light source, participant satisfaction survey
- Volunteers
- 40 people
- Sponsor
- Rhode Island Hospital
Squamous Cell Carcinoma
Combination 5-FU / Calcipotriene Cream for SCCIS/SCC
The study will determine if calcipotriene and 5-fluorouracil (5-FU) creams when combined can treat SCCIS and superficially invasive SCC (but not deeply invasive or high-risk cutaneous SCC).
- Trial name
- NCT04839731
- Testing
- Combination topical 5-fluorouracil 5% / calcipotriene 0.005% cream, Nourivan Base Cream
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Non-melanomatous Skin Cancer
Photodynamic Therapy in Treating Patients With Skin Cancer
RATIONALE: Photodynamic therapy uses light and drugs that make cancer cells more sensitive to light to kill tumor cells. Photodynamic therapy using aminolevulinic acid cream may be effective in treating patients with skin cancer.
- Trial name
- NCT00002963
- Testing
- aminolevulinic acid hydrochloride, conventional surgery
- Where
- United States
- Sponsor
- Roswell Park Cancer Institute
Squamous Cell Carcinoma (Skin), Squamous Cell Carcinoma in Situ
Hair Regrowth Following Partial Thickness Removal of SSCIS
Participants are being approached to participate in this study because they are undergoing surgery for a skin cancer known as squamous cell carcinoma in situ (SCCIS) on the scalp.
- Conditions
- Squamous Cell Carcinoma (Skin), Squamous Cell Carcinoma in Situ, Alopecia
- Trial name
- NCT07809191
- Testing
- Partial Thickness Excision
- Volunteers
- 15 people
- Sponsor
- The Cooper Health System
Squamous Cell Carcinoma
Dose-Ranging Safety and Efficacy Study of Topical Creams Containing API 31510 for the Treatment of in Situ Cutaneous Squamous Cell Carcinoma
The purpose of this study is to determine the safety and tolerability of pharmaceutical compound 31510 in a topical cream when applied to in situ cutaneous squamous cell carcinoma and to obtain preliminary efficacy data for the…
- Trial name
- NCT00605709
- Testing
- API 31510 Topical Cream
- Sponsor
- BPGbio
Squamous Cell Carcinoma of the Skin, Squamous Cell Carcinoma
Drug Screening of Cutaneous Lesions of Squamous Cell Carcinoma
This research study is studying the effect of different drugs as possible treatments for squamous cell carcinoma (SCC).
- Trial name
- SCC (NCT06782399)
- Testing
- Microdevice
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Oliver Jonas
Wound Healing After MMS Surgery, BCC - Basal Cell Carcinoma
Effectiveness and Safety of X A-DERM™ Microsurfaced Acellular Dermal Matrix for Wound Healing After MOHS Surgery
The goal of this single-arm clinical trial is to learn about the effectiveness and safety of the X A-DERM™ mADM in promoting wound healing and improving scar formation after MMS surgery for removing BCC, SCC, or MIS lesions on…
- Conditions
- Wound Healing After MMS Surgery, BCC - Basal Cell Carcinoma, SCC - Squamous Cell Carcinoma, Melanoma In Situ
- Trial name
- NCT06919809
- Testing
- A microsurfaced ADM (acellular dermal matrix)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- McGuire Institute
Cutaneous Squamous Cell Carcinoma
Evaluating the Use of Photodynamic Therapy to Treat Facial Cutaneous Squamous Cell Carcinoma in Situ (SCCis)
The goal of this clinical trial is to test how safe and effective it is to treat early form of cancer cells found in the upper skin layer of the face, using a light-sensitive gel used in combination with a light source.
- Trial name
- NCT06577311
- Testing
- Aminolevulinic acid hydrochloride 10% topical gel with Red Light
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Center for Clinical and Cosmetic Research