Clinical trials: Cycloserine
Height Phobia
D-Cycloserine-Enhancer of One-Session Treatment for Phobia of Heights
The study will determine the effects of D-Cycloserine (DCS) on fear reduction in patients diagnosed with phobia of heights (acrophobia) undergoing one session of three hours of virtual reality exposure therapy (VRET) or in vivo…
- Trial name
- NCT01037101
- Testing
- In Vivo Exposure Therapy, Virtual Reality Exposure Therapy, D-Cycloserine
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- CAMC Health System
Social Anxiety Disorder
Dose Timing of D-Cycloserine to Augment CBT for Social Anxiety Disorder
The purpose of this study is to examine the efficacy of 50 mg of d-cycloserine in comparison to placebo (a pill containing no medication) for improving the effectiveness of cognitive-behavioral therapy (CBT) in reducing symptoms…
- Trial name
- NCT02066792
- Testing
- D-Cycloserine, Cognitive Behavioral Therapy
- Where
- 3 sites in United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Jasper A. Smits
Schizophrenia
Glutamate, Learning, and Working Memory
Impairments in plasticity and working memory in schizophrenia have been hypothesized to reflect dysfunction at the N-methyl-D-aspartate glutamate receptor (NMDAR).
- Trial name
- NCT02769936
- Testing
- D-cycloserine
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Nicotine Dependence, Smoking Cessation
D-cycloserine (DCS) Pretreatment + CBT + Nicotine Replacement Therapy for Smoking Cessation (DCS)
1. Compare the relative efficacy of ten weeks of once weekly 250 mg D-cycloserine (DCS) vs. placebo (both in conjunction with cognitive behavioral therapy (CBT) and nicotine replacement therapy (NRT) on reducing cigarette smoking…
- Trial name
- DCS (NCT01842334)
- Testing
- Cognitive Behavioral Therapy, Nicotine Replacement Therapy
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Motor Activity
Repeated iTBS Cycloserine Motor Plasticity
Repetitive transcranial magnetic stimulation (rTMS) is a modality for probing and altering brain function in humans non-invasively.
- Trial name
- NCT05081986
- Testing
- Transcranial Magnetic Stimulation, Cycloserine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Cycloserine, Healthy Volunteer
The Effect of D-cycloserine on Emotional Processing
To investigate the effects of N-methyl-D-aspartate (NMDA) partial agonist DCS on emotional processing, memory and stress tasks
- Trial name
- NCT03961464
- Testing
- d-cycloserine
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Healthy Individuals
The Influence of Glutamate on Memory in Humans
The hippocampus is particularly laden with n-methyl-d-aspartate (NMDA) receptors, and is at the same time one of the most important sites in declarative memory.
- Trial name
- NCT00980408
- Testing
- Sugar pill, Glutamic Acid, Memantine
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Smoking Cessation, Harm Reduction
Assisting Smokers to Switch to an e-Cigarette by Accelerating Learning of Adaptive Habits Using D-cycloserine
This study will evaluate the effects of a reward devaluation strategy, which has been researched in the past, combined/augmented with the medication d-cycloserine in assisting smokers to switch from combustible cigarette (CC) to…
- Trial name
- NCT05994703
- Testing
- d-cycloserine, Juul e-cigarette
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Autistic Disorder, Asperger's Disorder
D-Cycloserine and Social Skills Training in Autism Spectrum Disorders
The purpose of this study is to determine the effectiveness of D-cycloserine for improving social impairment in child with pervasive developmental disorders (PDD).
- Conditions
- Autistic Disorder, Asperger's Disorder, Pervasive Developmental Disorder NOS
- Trial name
- NCT01086475
- Testing
- D-cycloserine
- Where
- 2 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Indiana University
Anxiety Disorders
Medication Enhanced Rapid Therapy
The purpose of this research study is to determine whether taking a one-time dose of a combination of putatively learning-enhancing medications can improve treatment response to a brief learning-based psychotherapy for public…
- Trial name
- MERiT (NCT02099825)
- Testing
- d-cycloserine and mifepristone
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Obsessive-compulsive Disorder
D-Cycloserine Augmentation of Therapy for Pediatric Obsessive-Compulsive Disorder
Cognitive-behavioral therapy (CBT) has proven efficacy for treatment of pediatric obsessive-compulsive disorder (OCD). Yet, CBT does not help all children and those who benefit often remain symptomatic upon treatment completion.
- Trial name
- NCT00864123
- Testing
- Cognitive-behavioral therapy, D-cycloserine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Phobic Disorders
D-Cycloserine to Enhance Cognitive Behavioral Therapy (CBT) for Acrophobia
The purpose of this study is to investigate the utility of post-session administration of D-cycloserine to enhance fear extinction in a sample of people with acrophobia who will be treated with CBT.
- Trial name
- NCT01102803
- Testing
- Individual Cognitive Behavioral Therapy (CBT), D-Cycloserine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Southern Methodist University
Fear
Effect of D-cycloserine on Extinction of Fear Conditioning
This study will evaluate whether the drug D-cycloserine (DCS) can improve a type of learning called classical conditioning, in which the brain learns to associate neutral stimuli with stimuli that elicit emotional or…
- Trial name
- NCT00352586
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Chronic Obstructive Pulmonary Disease
Understanding the Importance of Plasticity in the Brain Mechanisms of Dyspnoea Perception
Dyspnoea is the uncomfortable shortness of breath that debilitates millions of patients with lung disease, heart failure and cancer. It is often very difficult to treat.
- Trial name
- NCT01985750
- Testing
- d-cycloserine
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Motor Activity
Cycloserine rTMS Plasticity Augmentation
Transcranial magnetic stimulation (rTMS) is an investigational and therapeutic modality that impacts the connection strength between neurons by delivering patterned energy.
- Trial name
- NCT03432689
- Testing
- Transcranial Magnetic Stimulation, Cycloserine
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Obsessive-compulsive Disorder
D-cycloserine Augmentation of Cognitive Behavioral Therapy (CBT) for Pediatric Obsessive-compulsive Disorder (OCD)
The investigators are conducting a randomized double-blind placebo-controlled study to assess the efficacy of d-cycloserine augmentation of cognitive-behavioral therapy for the treatment of pediatric obsessive compulsive…
- Trial name
- NCT01411774
- Testing
- Cognitive-behavioral therapy, d-cycloserine
- Where
- 2 sites in United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Fibromyalgia
iTBS-DCS in Fibromyalgia
Background \& Rationale: Fibromyalgia is characterized by widespread pain, fatigue, mood and anxiety as well as cognitive complaints.
- Trial name
- NCT05395494
- Testing
- D-Cycloserine, iTBS repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Canada
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Post Traumatic Stress Syndrome
The Effects of D-cycloserine on Stimulus Generalization of Conditioned Fear Healthy Controls.
PROJECT SUMMARY: PTSD is a debilitating psychiatric condition precipitated by exposure to extreme, or life threatening, trauma with an estimated lifetime prevalence between 8% and 9% in U.S. adults.
- Trial name
- DCS (NCT01733030)
- Testing
- Seromycin
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Alcohol Dependence
Glycine and Oral D-Cycloserine in Alcoholic Patients and Healthy Subjects
Question #1: Will glycine ameliorate cognitive deficits? Hypothesis #1: Based on positive findings conducted with glycine and milacemide, a glycine prodrug, in schizophrenia and dementia, we expect that glycine will ameliorate…
- Trial name
- NCT00635102
- Testing
- D-Cycloserine PO and Glycine IV
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Yale University
Obsessive-Compulsive Disorder
Translational Approach to the Understanding and Treatment of Obsessive-Compulsive Disorder (OCD). Can D-Cycloserine Enhance and Stabilize the Treatment-response in Relapsed and Non-responding OCD-patients?
In this randomized controlled trial (RCT) the investigators experimentally test if patients with Obsessive-Compulsive Disorder (OCD) who have received treatment with exposure and response prevention (ERP), but either relapsed or…
- Trial name
- NCT02656342
- Testing
- D-Cycloserine
- Where
- 14 sites in Norway
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital