Clinical trials: Cystic Fibrosis Related Diabetes
Cystic Fibrosis-related Diabetes
EnVision CF Multicenter Study of Glucose Tolerance in Cystic Fibrosis
Cystic Fibrosis Related Diabetes has been identified by the CF community as one of the top ten priorities for CF research. In CF clinical decline due to dysglycemia begins early, prior to diagnosis of diabetes and increases…
- Trial name
- NCT03650712
- Testing
- Oral glucose tolerance test, Continuous glucose monitoring, Dexa scan
- Where
- 4 sites in United States
- Volunteers
- 317 people
- Sponsor
- Katie Larson Ode
Type 1 Diabetes, Type 2 Diabetes
ACCESS 2: AI for pediatriC diabetiC Eye examS Study 2
The purpose of this study is to determine if use of a nonmydriatic fundus camera using autonomous artificial intelligence software at the point of care increases the proportion of underserved youth with diabetes screened for…
- Conditions
- Type 1 Diabetes, Type 2 Diabetes, Cystic Fibrosis-related Diabetes
- Trial name
- ACCESS2 (NCT05463289)
- Testing
- Point of Care Autonomous AI diabetic retinopathy exam
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Johns Hopkins University
Cystic Fibrosis-related Diabetes, Cystic Fibrosis
SGLT2 Inhibitor Therapy in Cystic Fibrosis-related Diabetes
This will be a placebo-controlled, randomized, double blind, crossover study with a 4 week wash out period. Collect pilot data on the safety, tolerability, and feasibility of empagliflozin therapy in overweight/obese patients…
- Trial name
- NCT06149793
- Testing
- Empagliflozin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota
Cystic Fibrosis-related Diabetes
Bionic Pancreas in CFRD
This multi-center randomized controlled trial (RCT) will compare efficacy and safety endpoints using the insulin-only configuration of the iLet Bionic Pancreas System (BP) versus a control group using their usual care insulin…
- Trial name
- NCT06449677
- Testing
- iLet Bionic Pancreas System (BP), Usual Care (UC)
- Where
- 16 sites in United States
- Volunteers
- 150 people
- Sponsor
- Jaeb Center for Health Research
Prediabetes, Cystic Fibrosis (CF)
CGM Dynamic Index for Predicting Prediabetes in Cystic Fibrosis
The primary objective of this pilot study is to develop a CGM-based model to predict the progression from prediabetes to diabetes in individuals with cystic fibrosis.
- Conditions
- Prediabetes, Cystic Fibrosis (CF), Cystic Fibrosis-related Diabetes
- Trial name
- NCT06642610
- Testing
- CGM Dynamic Index (CDI)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Indiana University
Pancreatic Insufficiency, Cystic Fibrosis-related Diabetes
Dorzagliatin in Pancreatic Insufficient Cystic Fibrosis
This study is designed to determine the pharmacokinetic and pharmacodynamic response of dorzagliatin 50 mg twice daily following 7-day administration in individuals with pancreatic insufficient cystic fibrosis and abnormal…
- Trial name
- NCT06995651
- Testing
- Dorzagliatin
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Michael R. Rickels, MD, MS
Cystic Fibrosis Related Diabetes
Glucose Metabolism in Cystic Fibrosis Related Diabetes (CFRD)
The study aims to test whether use of CFTR modulators (ETI) improves fasting and post prandial glycemia by enhancing disposition index (DI) in individuals with CFRD with CFTR +ve mutation (at least one copy of F508del) on CFTR…
- Trial name
- NCT07102043
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Cystic Fibrosis-related Diabetes, Cystic Fibrosis
Continuous Glucose Monitoring and OGTT Screen for Cystic Fibrosis Related Diabetes in Cystic Fibrosis
Cystic Fibrosis (CF) related diabetes (CFRD) is a unique form of diabetes mellitus, different from type 1 diabetes and type 2 diabetes.
- Trial name
- NCT06560463
- Testing
- Access to Dexcom G7 CGM Data
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical College of Wisconsin
Cystic Fibrosis Related Diabetes, Cystic Fibrosis (CF)
Verapamil Effect in Cystic Fibrosis-related Dysglycemia
The investigators are conducting a pilot open-label pre/post interventional trial in adolescents and adults with cystic fibrosis (CF) and abnormal glucose tolerance or early CF-related diabetes mellitus (CFRD) to assess the…
- Conditions
- Cystic Fibrosis Related Diabetes, Cystic Fibrosis (CF), Abnormal Glucose Tolerance
- Trial name
- NCT07688070
- Testing
- Verapamil Hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Rhode Island Hospital
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
FEED-Cystic Fibrosis (FEED-CF)
The goal of this study is to determine the extent to which excess dietary sugars serve as a precipitating factor in glucose intolerance in adults with cystic fibrosis (CF), a population at especially high risk for a unique form…
- Trial name
- FEED-CF (NCT05766774)
- Testing
- Low-added sugar, high-fat diet, High-added sugar, high-fat CF diet
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Emory University
Obesity and Obesity-related Medical Conditions, Diabetes
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research…
- Conditions
- Obesity and Obesity-related Medical Conditions, Diabetes, Atherosclerotic Disease, Heart Failure
- Trial name
- VALD (NCT07083557)
- Testing
- Endothelial cell collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bettina Mittendorfer
Cystic Fibrosis-related Diabetes, Cystic Fibrosis
Metformin for People With CFRD on CFTR Modulator Therapy to Improve Ion Channel Function
The purpose of this study is to assess the efficacy of metformin to improve airway ion channel function in those with CF-related diabetes (CFRD)
- Trial name
- NCT04530383
- Testing
- Metformin Hydrochloride
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kansas Medical Center
Cystic Fibrosis Related Diabetes
Genetic Modifiers of Cystic Fibrosis Related Diabetes
This research is being done to find the genes and other factors that are responsible for differences among persons with cystic fibrosis.
- Trial name
- NCT01113216
- Where
- 3 sites in United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cystic Fibrosis-related Diabetes
Measurement of Beta Cell Death in Individuals With Cystic Fibrosis
This study evaluates the feasibility of using differentially methylated insulin DNA, a biomarker of beta cell death, in determining the time course of beta cell death and development of diabetes in people with cystic fibrosis.
- Trial name
- NCT03713437
- Testing
- Measurement of differentially methylated insulin DNA
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Nebraska
Cystic Fibrosis-related Diabetes
Closed-loop for People Living With Cystic Fibrosis Related Diabetes
The main objective of this study is to determine whether closed-loop glucose control is superior to standard insulin therapy with continuous glucose monitoring (CGM) in young people (≥16 years) and adults with cystic fibrosis…
- Trial name
- CL4P-CF (NCT05562492)
- Testing
- CamAPS FX, Standard insulin therapy with CGM
- Where
- 14 sites in United Kingdom
- Volunteers
- 128 people
- Sponsor
- University of Cambridge
Cystic Fibrosis (CF), Cystic Fibrosis-related Diabetes
Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)
This multicenter cross-sectional study will include a diverse population of adolescents and adults with CF. The overall Aim is to describe prevalence of diabetes microvascular complications and macrovascular surrogates in people…
- Conditions
- Cystic Fibrosis (CF), Cystic Fibrosis-related Diabetes, Diabetes, Retinopathy
- Trial name
- SPeCTRuM (NCT06837181)
- Testing
- observational study
- Where
- 18 sites in United States
- Volunteers
- 200 people
- Sponsor
- Jaeb Center for Health Research
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
Semaglutide in CFRD
This open label, single arm pilot study, will examine the safety and tolerability of GLP-1RA semaglutide as an add-on therapy to insulin for overweight/obese adult patients with cystic fibrosis related diabetes (CFRD).
- Trial name
- NCT05788965
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota
Cystic Fibrosis Related Diabetes, Hyperglycaemia
Investigating the Relationship Between Glycemia and Sleep in Adults With Cystic Fibrosis-Related Diabetes
The goal of this at-home, remote study is to understand the relationship between blood sugars and sleep in adults living with Cystic Fibrosis Related Diabetes (CFRD).
- Conditions
- Cystic Fibrosis Related Diabetes, Hyperglycaemia, Insomnia, Cardiometabolic Diseases
- Trial name
- NCT06700889
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Cystic Fibrosis-related Diabetes
Comparison of Meal-Time Dosing of Insulin in Cystic Fibrosis Related Diabetes
The aim of this study is to assess the utility of CGMs to determine the optimal method to dose meal-time insulin. The investigators will examine glucose excursions in patients with CF who will dose meal-time rapid-acting insulin…
- Trial name
- NCT04533646
- Testing
- Insulin, Continuous glucose monitor (CGM)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Jagdeesh Ullal
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
The Effects of a Low Glycemic Load Diet on Dysglycemia and Body Composition in Adults With Cystic Fibrosis-Related Diabetes
This study will evalute the effect of a low glycemic load (LGL diet on dysglycemia, insulin requirements, DXA-derived body composition, gastrointestinal symptoms and quality of life measures in adults with cystic fibrosis-related…
- Conditions
- Cystic Fibrosis, Cystic Fibrosis-related Diabetes, Cystic Fibrosis With Intestinal Manifestations
- Trial name
- DINE (NCT05723445)
- Testing
- Low Glycemic Load Diet
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Rhode Island Hospital