Clinical trials: Cytokine Levels
Apical Periodontitis, Postoperative Pain
Cryotherapy on Inflammatory Profile and Postoperative Pain Levels in Endodontic Infections
The aim of this study is to evaluate the effects of cryotherapy applications on the inflammatory cytokine and collagenase matrix metalloproteinase levels during root canal treatment and postoperative pain intensity and incidence.
- Conditions
- Apical Periodontitis, Postoperative Pain, Cytokine Levels
- Trial name
- NCT04798144
- Testing
- Distilled water irrigation kept at 2.5°C degree, Distilled water irrigation kept at room temperature
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Ischemic Stroke, Acute
Electroacupuncture on Modifying Inflammatory Levels of Cytokines and Metabolites in Stroke Patients.
The study will make an association between the diagnosis of traditional Chinese medicine that establishes that the syndrome of blood stagnation generates alteration in blood flow, vascular dysfunction, and damage to the…
- Trial name
- NCT05734976
- Testing
- electroacupuncture
- Where
- Taiwan
- Volunteers
- 17 people
- Sponsor
- China Medical University Hospital
Periodontitis, Rheumatoid Arthritis
The Effect of Non-Surgical Periodontal Therapy on Rheumatoid Arthritis
Periodontitis is a common chronic inflammatory disease characterised by the destruction of the soft and hard tissues supporting the tooth, including alveolar bone, periodontal ligament and cementum.
- Trial name
- NCT06245265
- Testing
- ELISA (Enzyme-Linked ImmunoSorbent Assay)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Biruni University
Hemorrhage
Hemostasis Achievement Reflecting Inflammatory Status of the Pulp Based on Cytokine Levels: A Cohort Study.
Assessment of pulp inflammation by hemostasis achievement after pulp exposure
- Trial name
- NCT03737682
- Testing
- ENzyme linked immunity-sorbet assays
- Where
- Egypt
- Volunteers
- 41 people
- Sponsor
- Cairo University
Acute Diarrhea, Severe Acute Malnutrition
IL6&8 in Malnourished Children With Acute Diarrhea
Cytokines, such as IL-6 and IL-8 can be used as markers of acute infections, including acute gastroenteritis. However, there have been no previous studies on the levels of IL-6 and IL-8 in malnourished children with acute…
- Conditions
- Acute Diarrhea, Severe Acute Malnutrition, Acute Gastroenteritis
- Trial name
- NCT05183789
- Testing
- Evaluation of serum levels of IL-6 and IL-8
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Total Knee Arthroplasty
The Relationship Between Preoperative Serum Cytokine Level and Lenght of Stay in Hospital, Postoperative Pain Intensity, Functional Status, Joint Position Sense and X Ray Findings
Serum cytokines was assosiated with symptoms and progression of osteoartritis. It is unknown whether these cytokines have a predictive role on severity of symptoms after total knee arthroplasty (TKA) or not.
- Trial name
- NCT04487535
- Testing
- Cytokine level
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Hacettepe University
Chronic Kidney Disease
Correlation of Urinary Kallikrein With Cytokines, Proteinuria and Renal Function in Chronic Renal Disease Patients
Urinary kallikrein excretion is known to increase in patients with nephrotic syndrome and sick cell disease, but decrease in patients with chronic kidney disease or uremia.
- Trial name
- NCT00395005
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Cytokine, Intervertebral Disc, Degenerative
CXCL2/CXCL8 Promote Intervertebral Disc Degeneration
Low back pain (LBP) is the largest cause of morbidity in the world, and about 80% of Chinese people are affected in their lifetime.
- Trial name
- NCT05976516
- Testing
- CXCL2/CXCL8
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhongda Hospital
Traumatic Brain Injury
Effects of TT301 on Cytokine Levels Post Endotoxin Challenge
This study will evaluate the effects of TT301 on cytokine levels in healthy male volunteers participating in an endotoxin challenge.
- Trial name
- NCT01357421
- Testing
- TT301
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- OPKO Health, Inc.
Undernutrition
Supplementation With Nutrients Modulating IGF-1 and Cytokines in Elderly People at Risk of Undernutrition
The purpose of this study was to determine the improvement in nutritional status, especially in the level of insulin-like growth factor-1 (IGF-1) and its relationship with changes in the circulating cytokine levels, after…
- Trial name
- NCT02656186
- Testing
- Pre-intervention, Liquid nutritional supplement
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Overweight and Obesity, Cardiometabolic Risk Factors
Effect of Vitamin K2 Over Osteocalcin, Leptin, Cytokines, and Cardiovascular Risk in Young Adults With Overweight and Obesity
The goal of this clinical trial is to compare de effect of vitamin K2 in young adults with overweight or obesity. The main questions to answer are: What is the effect of Vitamin K2 supplementation on methylation, serum…
- Trial name
- NCT05995522
- Testing
- Vitamin K2, Cornstarch
- Where
- Mexico
- Volunteers
- 51 people
- Sponsor
- University of Guadalajara
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive
Changes in Cytokine Levels During an Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine whether there is a statistical association between changes in sputum serial levels of two cytokines, interleukin (IL)-17 and IL-6, during the treatment course of a severe acute…
- Trial name
- NCT00281242
- Testing
- blood draw
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Michigan
Apical Periodontitis, Retreatment
Biomarkers in Apical Periodontitis
Aim: To evaluate the effects of three different irrigation activation techniques-conventional syringe irrigation (CSI), ultrasonic irrigation (UI), and SWEEPS (Shock Wave Enhanced Emission Photoacoustic Streaming)-on the levels…
- Conditions
- Apical Periodontitis, Retreatment, Biomarkers, Cytokine
- Trial name
- NCT07504861
- Testing
- laser activation, PUI, CSI
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Hypertension, Dyslipidemias
Exploring the Effects of Antihypertensive and Lipid-Lowering Drugs on Inflammatory Cytokine Levels
This study investigates the causal relationships between antihypertensive and lipid-lowering drugs and inflammatory cytokines using a drug-targeted Mendelian randomization approach.
- Conditions
- Hypertension, Dyslipidemias, Inflammatory Response, Chronic Inflammation
- Trial name
- MRDLT (NCT06622304)
- Where
- China
- Volunteers
- 250,736 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
COVID-19
Eucalyptus Oil as Adjuvant Therapy for Coronavirus Disease 19 (COVID-19)
Background : Based on several clinical trials, eucalyptus oil can suppress edema formation and reduce inflammation, where the effect of 1,8-cineole is due to the inhibition of cytokine secretion by T lymphocytes.
- Trial name
- NCT05398965
- Testing
- Eucalyptus Oil, Standard COVID medication
- Where
- Indonesia
- Volunteers
- 54 people
- Sponsor
- Hasanuddin University
Depression - Major Depressive Disorder
Measurement of Serum Inflammatory Markers in Patients Treatment-resistant Depression Given Psilocybin
About one in three people with major depression respond poorly to standard antidepressant treatments. This kind of depression is called treatment-resistant depression, and it can lead to long-term disability, financial…
- Trial name
- NCT07164755
- Where
- United Kingdom
- Volunteers
- 46 people
- Sponsor
- King's College London
COPD
The Efficacy of Fluticasone Furoate/Vilanterol/Umeclidinium Compared With Vilanterol/Umeclidinium in Reducing Air Trapping and Airway and Blood Cytokine Levels in COPD
This study aims to demonstrate the effects of triple therapy (ICS/LABA/LAMA) and dual bronchodilators (LAMA/LABA) on air trapping in the lungs' COPD patients and inflammatory mediators
- Trial name
- NCT06474039
- Testing
- Trelegy or Anoro
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Mahidol University
Female Infertility
Observational Prospective Study of the Success of Single Embryo Transfer Implantation Related to Level of Follicular Fluid Cytokines Expression in Low Responders Infertile Patients Treated With r-hLH add-on Therapy in a Second Controlled Ovarian Stimulation Cycle.
The objective of our observational prospective study will be to compare, for women treated for infertility and included in a ICSI program, the implantation rate and delivery rate obtained after the transfer of a single blastocyst…
- Trial name
- NCT02640261
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Centro di Procreazione Assistita Demetra
Periodontal Diseases, Saliva
GCF and Saliva Levels of IL-36α in Periodontal Disease
Interleukin-36 (IL-36), recently identified and members of the IL-1 family, have been reported to be important regulators of host defense against pathogens in the oral mucosa.
- Conditions
- Periodontal Diseases, Saliva, Gingival Crevicular Fluid, Cytokine
- Trial name
- NCT07497828
- Testing
- Collection of fluid samples
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ordu University
Peri-implant Mucositis
Effect of Repeated Removal and Re-placement of Abutments Around Dental Implants
Repeated removal and re-placement of healing and prosthetic abutments result in frequent injuries to the soft tissues. The purpose was to evaluate the effect of repeated removal and re-placement of laser microgrooved and…
- Trial name
- NCT04415801
- Testing
- Repeated removal and re-placement of healing and prosthetic abutments
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza