Clinical trials: Cytology
Adenocarcinoma of Lung
The Detection of EGFR Mutations in Liquid Based Cytology Samples
This study will investigate whether liquid based cytology specimens are a feasible alternative to formalin-fixed paraffin embedded histology samples for detection of epidermal growth factor receptor (EGFR) mutations in lung…
- Trial name
- NCT04086680
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Royal Cornwall Hospitals Trust
Lesion Sampled for Cytology
Simple Technique to Improve Diagnostic Yield in EUS-FNA
Endoscopic ultrasound and fine needle aspiration are useful tools for the diagnosis and staging of pancreatic cancer. One potential limitation is contamination when needle traverses the gastrointestinal tract under continuous…
- Trial name
- NCT01995474
- Testing
- Twisted Syringe, Conventional Technique
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical College of Wisconsin
Low Back Pain
Study of Cells From Spinal Cavity of Patients With Low Back Pain
The purpose of this study to determine if cells collected give us information about what is causing a patient pain can be detected and connected with epiduroscopy images (pictures taken with a small fiber optic scope).
- Trial name
- NCT01089491
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Bladder Cancer
Measuring Urinary Nano Particles and Metallic Compounds in TCC Patients
In many of urothelial carcinoma patients, one does not find common risk factors such as smoking. The medical center is located in an industrial city with known air and water pollution.
- Trial name
- NCT02811952
- Testing
- without intervention
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Carmel Medical Center
Kidney Neoplasms
Evaluation of Diagnostic Value of Molecular Markers in Renal Cancer
Renal cancer is frequent and its diagnosis mainly dependant on imaging. More than 50% of renal tumors are currently diagnosed without symptoms.
- Trial name
- CMM (NCT00491621)
- Testing
- surgery or biopsy of the kidney tumor
- Where
- 7 sites in France
- Volunteers
- 74 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cervical Intraepithelial Neoplasia, Human Papillomavirus
A Comparison Study of Two Community Outreach-Based Approaches to Increase Participation of Women Living in the Mississippi Delta in Cervical Cancer Screening
Background: The Mississippi Delta (which includes the counties along the Mississippi River) is one of the poorest areas in the United States.
- Trial name
- NCT01058148
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Cancer Institute (NCI)
HIV-1 Infection
HPV Test-and-Treat-Strategy Versus Cytology-based Strategy for Prevention of CIN2+ in HIV-Infected Women
Women sometimes develop cancer in an area called the cervix, which is the opening to the uterus, or womb. Women who have HIV are more likely to get this kind of cancer than women who do not have HIV.
- Trial name
- NCT01315353
- Testing
- Cervical Cryotherapy, Loop Electrosurgical Excision Procedure (LEEP)
- Where
- 13 sites in Botswana, Haiti and 5 more
- Volunteers
- 467 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Eosinophilic Esophagitis, Diagnoses Disease
Pilot Study of Esocheck in Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is a prevalent chronic inflammatory condition of the esophagus characterized by esophageal eosinophilia that can lead to inflammation and stricture formation.
- Trial name
- EoE (NCT04311970)
- Testing
- EsoCheck
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Pennsylvania
Lung Cancer
Sputum Cytology in Screening Heavy Smokers For Lung Cancer
RATIONALE: Screening tests, such as sputum cytology, may help doctors find tumor cells early and plan better treatment for lung cancer.
- Trial name
- NCT00103363
- Testing
- cytology specimen collection procedure, physiologic testing, annual screening
- Where
- United States
- Volunteers
- 3,270 people
- Sponsor
- University of Colorado, Denver
Cervical Cytology, PAP
Techcyte SureView Cervical Cytology System Clinical Validation Study
The clinical study is a multi-center, retrospective, blinded, matched-pair, two-arm clinical study in which one test assessment and a control assessment of liquid-based cytology (LBC) pap tests are performed and compared to a…
- Trial name
- NCT06767111
- Testing
- Digital cervical cytology slide imaging system with artificial intelligence (AI) algorithm in vitro diagnostic (IVD) device
- Where
- United States
- Volunteers
- 4,596 people, healthy volunteers welcome
- Sponsor
- Techcyte, Inc.
Endometrial Neoplasms, DNA Methylation
Cervical Cytology DNA Methylation for Endometrial Lesion Screening and Follow-up
The goal of this observational study is to evaluate the accuracy of a novel molecular test for screening and monitoring endometrial lesions in women at medium-to-high risk for endometrial cancer.
- Conditions
- Endometrial Neoplasms, DNA Methylation, Cervical Smears, Early Detection of Cancer
- Trial name
- EndoMethy-V (NCT07298707)
- Volunteers
- 3,500 people
- Sponsor
- Peking Union Medical College Hospital
Gardasil Vaccine, Stem Cell Transplant
Gardasil Vaccination in Post Stem Cell Transplant Patients
Background: Gardasil , a recently approved vaccine for the sexually transmitted human papillomavirus (HPV), provides immunity to four types of HPV that are associated with genital warts and cervical, vaginal, and vulvar precancer…
- Conditions
- Gardasil Vaccine, Stem Cell Transplant, Immunogenicity
- Trial name
- NCT01092195
- Testing
- Gardasil
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Advanced Stage Non Small Cell Lung Cancer
Erlotinib 100mg qd Versus Gefitinib 250mg qd for EGFR Mutant Nsclc
This study is a multicenter, randomized, open-label Phase II trial that compares reduced dose erlotinib 100mg daily and standard dose gefitinib 250mg daily in patients with advanced non-small cell lung cancer who harbor EGFR…
- Trial name
- NSCLC EGFR TKI (NCT01955421)
- Testing
- Erlotinib 100mg qd, Gefitinib 250mg qd
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Sun Yat-sen University
Breast Cancer, Ductal Carcinoma in Situ
Intraoperative Gamma Camera for Breast Cancer Surgery
Aim: This study aims at evaluating the performances of an intraoperative gamma camera (field of view 10X10 cm), named CarolIReS, to detect axillary drainage and to assess the removal of sentinel lymph nodes (SLN) in breast…
- Trial name
- NCT00757302
- Testing
- SLN procedure (CarolIReS camera)
- Where
- France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Strasbourg, France
Esophageal Neoplasms, Stomach Neoplasms
Early Detection of Esophageal Cancer
Esophageal cancer is a common malignancy with a very poor prognosis. The principal reason for its poor prognosis is that most tumors are asymptomatic and go undetected until they have spread beyond the esophageal wall and are…
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Endoscopy, Gastrointestinal, Digestive System Endoscopic Surgical Procedures
- Trial name
- NCT00341523
- Where
- China
- Volunteers
- 6,864 people
- Sponsor
- National Cancer Institute (NCI)
Clinical Stage IV Gastric Cancer AJCC v8, Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
Paclitaxel for the Treatment of Gastric or Gastroesophageal Cancer
This phase I trial studies the side effects and best dose of paclitaxel for the treatment of gastric or gastroesophageal cancer.
- Conditions
- Clinical Stage IV Gastric Cancer AJCC v8, Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8, Clinical Stage IVA Gastric Cancer AJCC v8, Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8
- Trial name
- NCT04220827
- Testing
- Paclitaxel
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- M.D. Anderson Cancer Center
Biliary Stricture, Jaundice, Obstructive
Multicenter RCT for BIliary Brushing: RX Cytology, BOSTON vs. Infinity®, US Endoscopy
The aim of this prospective national multicenter randomized study is to compare, during an ERCP for VBP stenosis, the sensitivity of two biliary brushes: the INFINITY® vs the RX Cytology Brush® The main objective is the…
- Trial name
- BIB (NCT04251013)
- Testing
- Biliary brushing with the RX Cytology brush, Boston Scientific, Biliary brushing with the Infinity® brush, US Endoscopy
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Société Française d'Endoscopie Digestive
Gastroesophageal-junction Cancer
Significance of Peritoneal Washing Cytology Before and After Neoadjuvant Chemotherapy in Patients With Esophagogastric-junction Cancer
Background: The prevalence of gastroesophageal-junction cancer (cancer between the distal part of the oesophagus, and proximal part of the stomach/GEJ-cancer) is increasing in Denmark with more than 400 patients per year.
- Trial name
- NCT02085564
- Testing
- Peritoneal washing cytology
- Where
- Denmark
- Volunteers
- 87 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Gastric Cancer
Feasibility Study of Intraperitoneal Paclitaxel
This is a single arm phase 2 trial evaluating the efficacy and tolerability of intraperitoneal paclitaxel with oxaliplatin and capecitabine in advanced gastric cancer patients with peritoneal metastasis and/or cancer cells on…
- Trial name
- NCT01739894
- Testing
- IP Paclitaxel
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- National University Hospital, Singapore
Cancer of the Cervix, Cervical Intraepithelial Neoplasia
Compass - Randomised Controlled Trial of Primary HPV Testing for Cervical Screening in Australia
Compass is a randomised controlled trial of primary HPV testing for cervical cancer screening in Australia. A pilot study involving 5,000 women was carried out in 2013-2014.
- Trial name
- Compass (NCT02328872)
- Testing
- Molecular testing for HPV, Liquid Based Cytology
- Where
- Australia
- Volunteers
- 76,181 people, healthy volunteers welcome
- Sponsor
- VCS Foundation