Clinical trials: Cytoreductive Surgery
Peritoneal Carcinomatosis, Gastric Cancer
Clinical Trial at Neoadjuvant Peritoneal and Systemic Chemotherapy Plus HIPEC in Gastric Carcinomatosis
Implementation of a curative strategy of treatment in peritoneal carcinomatosis of gastric cancer. The goal is to get 1C level of evidence (patient died with "standard" treatment, with this treatment some of them survive) in…
- Trial name
- HIPEC (NCT01342653)
- Testing
- Intraperitoneal and systemic chemotherapy plus maximum cytoreduction plus HIPEC
- Where
- 3 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Ovarian Cancer, Intraperitoneal Chemotherapy
Intensive Intraperitoneal Therapy in Advanced Ovarian Cancer
Clinicians postulate that it may be interesting to combine the two IntraPeritoneal (IP) treatments associated with a significant improvement of OC overall survival i.e.
- Trial name
- INTENS-IP (NCT04282356)
- Testing
- Intraperitoneal chemotherapy during surgery
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Metastatic Breast Cancer
Intensive Combo Chemo With Autologous BM Rescue for Metastatic Breast Cancer
To determine the therapeutic efficacy of high-dose cyclophosphamide and BCNU with autologous bone marrow transplantation after initial tumor cytoreduction for patients with receptor-negative metastatic breast carcinoma and to…
- Trial name
- NCT00584766
- Testing
- High-dose chemotherapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Oklahoma
Hepatocellular Carcinoma
Cytoreductive Surgery and Transarterial Chemoembolization (TACE) Versus TACE for Hepatocellular Carcinoma
The aim of this study is to compare the surgical outcomes of cytoreductive surgery followed by Transarterial Chemoembolization (TACE) with TACE alone in patients with MNHCC so as to establish a treatment standard for MNHCC.
- Trial name
- TACE (NCT00820157)
- Testing
- Cytoreductive Surgery, TACE
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Epithelial Ovarian Cancer
To Evaluate Plasmajet in Achieving Complete Cytoreduction of Advanced EOC- Initial Feasibility Study
Surgery for ovarian cancer involves a big cut on your tummy (abdomen) followed by removal of pelvic organs (womb, tubes and ovaries), abdominal organs (fat tissue {omentum}, appendix) and any other tissues involved with cancer.
- Trial name
- PJEOC (NCT02376231)
- Testing
- Surgery for EOC with trial (PJ) device (PlasmaJet)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Dr Thumuluru Kavitha Madhuri
Ovarian Cancer, Hyperthermic Intraperitoneal Chemotherapy
HIPEC in the Treatment of Stage IIc-IV Epithelial Ovarian Cancer After CRS (HIPECOC)
This study evaluate the Hyperthermic Intraperitoneal Chemotherapy(HIPEC) in the treatment of Stage IIc-IV epithelial Ovarian Cancer after primary Cytoreductive Surgery (CRS).Half participants will receive HIPEC twice with one…
- Trial name
- NCT04280185
- Testing
- Hyperthermic Intraperitoneal Chemotherapy
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
FIGO Stage III and IV Ovarian Cancer, Fallopian Tube Cancers
CATALINA-4: A Study to Investigate the Safety and Efficacy of TORL-1-23 With Chemotherapy Given Before Initial Surgery in Women With Advanced Stage Ovarian Cancer
A Phase 1B/2 Study to Investigate the Safety and Efficacy of TORL-1-23 with Chemotherapy Given Before Initial Surgery in Women with Advanced Stage Ovarian Cancer
- Conditions
- FIGO Stage III and IV Ovarian Cancer, Fallopian Tube Cancers, Primary Peritoneal Cancer
- Trial name
- NCT07322094
- Testing
- TORL-1-23 and paclitaxel, TORL-1-23 and carboplatin, TORL-1-23, paclitaxel, and carboplatin
- Where
- 7 sites in United States
- Volunteers
- 60 people
- Sponsor
- TORL Biotherapeutics, LLC
Colorectal Cancer Metastatic
Quality of Life After Cytoreductive Surgery and Intraperitoneal Chemotherapy
Cytoreductive surgery with intraperitoneal chemotherapy is one of the most important treatments for patients with colorectal cancer and peritoneal metastasis.
- Trial name
- NCT03503071
- Testing
- Cytoreductive surgery and intraperitoneal chemotherapy
- Where
- South Korea
- Sponsor
- Kyungpook National University Hospital
Ovarian Cancer, Low Anterior Resection Syndrome
Assessment of Quality of Life After Low Anterior Resection During Cytoreductive Surgery for Advanced Ovarian Cancer
This study aims to evaluate the incidence of low anterior resection syndrome and quality of life after cytoreductive surgery for advanced ovarian cancer patients.
- Conditions
- Ovarian Cancer, Low Anterior Resection Syndrome, Quality of Life
- Trial name
- LAPSODY (NCT05431530)
- Testing
- Cytoreductive surgery
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Seoul National University Hospital
Colorectal Cancer Metastatic, Cancer Metastatic to the Peritoneal Cavity
Severe Neutropenia After HIPEC Using Mitomycin-C
Mitomycin-C (MMC) is the most commonly used chemotherapeutic agent for hyperthermic intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery (CRS) to treat colorectal cancer patients with peritoneal metastases.
- Conditions
- Colorectal Cancer Metastatic, Cancer Metastatic to the Peritoneal Cavity, Appendiceal Neoplasm, Pseudomyxoma Peritonei
- Trial name
- NCT05513183
- Testing
- Intraoperative blood and peritoneal fluid samplings during HIPEC
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Gangnam Severance Hospital
Pancreatic Adenocarcinoma, Peritoneal (Metastatic) Cancer
To Evaluate the Feasibility and Safety of Combining Surgery (Pancreatectomy and Cytoreduction) With HIPEC for Treating Pancreatic Cancer With Peritoneal Involvement.
The goal of this clinical trial is to evaluate the safety and feasibility of a combined surgical and chemotherapy approach (pancreatectomy with cytoreductive surgery and HIPEC) in patients aged 18 and older with pancreatic ductal…
- Trial name
- NCT07493421
- Testing
- Pancreatectomy, Complete Cytoreduction, Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
- Where
- 3 sites in China, Portugal
- Volunteers
- 20 people
- Sponsor
- Unidade Local de Saúde São João, Oporto
Cancer, Appendiceal, ColoRectal Cancer
Comparing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) Using Mitomycin-C Versus Melphalan for Colorectal Peritoneal Carcinomatosis
The purpose of this trial is to compare the morbidity and mortality of CRS-HIPEC using mitomycin-C versus melphalan for colorectal peritoneal carcinomatosis.
- Trial name
- NCT03073694
- Testing
- Mitomycin c, Melphalan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Kansas Medical Center
Mesothelioma
Study of Cytoreductive Surgery and Hyperthermic Intraoperative Chemotherapy With Pemetrexed and Cisplatin for MPM
Primary Objective To determine the maximum tolerated dose (MTD) of intrathoracic administration of pemetrexed when given in conjunction with cisplatin in patients with resectable malignant pleural mesothelioma MPM.
- Trial name
- NCT02838745
- Testing
- Pemetrexed, Cisplatin
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Ovarian Neoplasm, Fluid Therapy
Fluid Balance During Surgery for Ovarian Cancer
Extensive tumour debulking challenges both surgeon and anaesthesiologist but promotes survival in late-stage ovarian cancer patients.
- Trial name
- NCT03006939
- Testing
- Cytoreductive surgery
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bonn
Peritoneal Carcinosis, Peritoneal Metastases
Impact of an Omega-3 Enriched Oral Nutritional Supplement on Improving Surgical Outcomes in Patients With Peritoneal Carcinomatosis Undergoing Cytoreductive Surgery
The OMNI study is a clinical trial investigating whether a nutritional supplement with added Omega-3 fatty acids can improve surgical outcomes for patients with peritoneal carcinomatosis.
- Conditions
- Peritoneal Carcinosis, Peritoneal Metastases, HIPEC, Cytoreductive Surgery
- Trial name
- OMNI (NCT07478432)
- Testing
- ONS enriched with Omega-3, Standard ONS
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Catholic University of the Sacred Heart
Fanconi Anemia, Severe Marrow Failure
HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy
The purpose of this study is to determine whether the use of lower doses of busulfan and the elimination of cyclosporine will further reduce transplant-related side effects for patients with Fanconi Anemia (FA).
- Conditions
- Fanconi Anemia, Severe Marrow Failure, Myelodysplastic Syndrome (MDS), Acute Myelogenous Leukemia (AML)
- Trial name
- RAFA (NCT02143830)
- Testing
- Busulfan, Cyclophosphamide, Fludarabine
- Where
- 3 sites in United States
- Volunteers
- 70 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Colo-rectal Cancer
Psychological distREsS hipEc oR pelVic Exenteration
The purpose of this study is to describe type and extent of psychological distress (adverse effects) in patients undergoing surgery for colorectal cancer with peritoneal metastases and after surgery for colorectal cancer with…
- Trial name
- PRESERVE (NCT04956107)
- Where
- 3 sites in Denmark, Sweden
- Volunteers
- 225 people
- Sponsor
- University of Aarhus
Peritoneal Carcinomatosis
Peritoneal Carcinomatosis Extent Evaluation: Radiologic, Laparoscopic and Pathologic.
pathologically proved ovarian cancer patients that underwent contrast enhanced abdomino-pelvic CT and diagnostic laparoscopy before cytoreductive surgery (CRS) will be included in the study.
- Trial name
- NCT03798132
- Testing
- laparoscopy
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Shimaa Abdalla Ahmed
Stage IV Prostate Adenocarcinoma AJCC v7
Therapeutic Effect of Cytoreductive Radical Prostatectomy in Men With Newly Diagnosed Metastatic Prostate Cancer
This is a phase 2.5 international, multi-institution, randomized clinical trial to evaluate the potential therapeutic effect of CRP combined with the BST in men with mPCa prospectively.
- Trial name
- NCT03456843
- Testing
- Antiandrogen Therapy, Docetaxel, Laboratory Biomarker Analysis
- Where
- 16 sites in United States, Australia and 4 more
- Volunteers
- 190 people
- Sponsor
- Yale University
Pseudomyxoma Peritonei, Cytoreductive Surgery
What Are the Experiences of Patients With Pseudomyxoma Peritonei?
Complete cytoreductive surgery (CCRS) is an extensive, and potentially curative, procedure utilised for peritoneal malignancies including Pseudomyxoma peritonei (PMP).
- Conditions
- Pseudomyxoma Peritonei, Cytoreductive Surgery, Recovery
- Trial name
- NCT04125225
- Where
- United Kingdom
- Sponsor
- University of Southampton