Clinical trials: Cytoreductive Surgery
Colon Cancer
The Influence of Perioperative Administration of Dexmedetomidine on Inflammation Response and Postoperative Outcomes in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Cytoreductive Surgery; Double Blind Randomized Controlled Trial
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) has been reported to be an effective treatment approach for peritoneal cancer, however, the stress response to HIPEC is major neuroendocrine and…
- Trial name
- NCT03370588
- Testing
- dexmedetomidine, Normal saline
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Yonsei University
Gastric Cancer, Peritoneal Carcinomatosis
Efficacy of HIPEC Combined With Systemic Chemotherapy and CRS on Peritoneal Metastases From Gastric Cancer
This project is a multi-center, prospective, randomized controlled clinical observation the safety and efficacy that stage IV limited peritoneal metastasis of gastric cancer patients accept hyperthermic intraperitoneal…
- Trial name
- NCT03179579
- Testing
- HIPEC with neoadjuvant chemotherapy, Systemic chemotherapy
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Shu-Zhong Cui
Gastric Cancer, Peritoneal Carcinomatosis
Complete Cytoreduction Followed by IP and Systemic Chemotherapies for Gastric Cancer With Peritoneal Carcinomatosis
Background: Approximately 15% of gastric adenocarcinoma patients presents with peritoneal carcinomatosis (PC) at the first encounter and is regarded as an unresectable and end-stage disease.
- Trial name
- CRS-IP (NCT04547725)
- Testing
- CRS followed by IP and systemic chemotherapies
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- National Taiwan University Hospital
Gynecologic Cancer, Gynecologic Neoplasms
Intravenous and Intraperitoneal Paclitaxel and Oral Nilotinib for Peritoneal Carcinomatosis
Background: Tumors that have spread to the lining of the abdomen from other cancers, such as cancer of the appendix, colon, or ovary, are called peritoneal carcinomatosis. In most cases, outcomes are poor.
- Conditions
- Gynecologic Cancer, Gynecologic Neoplasms, Peritoneal Carcinomatosis, Peritoneal Neoplasms
- Trial name
- NCT05185947
- Testing
- Paclitaxel, Nilotinib, ECG
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Ovarian Carcinoma
Phase II Study of Intraperitoneal NanoPac® in Patients With Ovarian Cancer
This study will evaluate NanoPac® administered intraperitoneally (IP) immediately post-cytoreductive surgery, followed by standard of care (SOC) intravenous (IV) chemotherapy, in women with ovarian cancer.
- Trial name
- NCT03029585
- Testing
- NanoPac® 100 mg/m2, NanoPac® 200 mg/m2, NanoPac® 300 mg/m2
- Where
- 7 sites in United States
- Volunteers
- 10 people
- Sponsor
- NanOlogy, LLC
Advanced Ovarian Carcinoma, Fallopian Tube Clear Cell Adenocarcinoma
Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial
This phase III trial compares minimally invasive surgery (MIS) to laparotomy in treating patients with stage IIIC-IV ovarian, primary peritoneal, or fallopian tube cancer who are receiving chemotherapy before and after surgery…
- Conditions
- Advanced Ovarian Carcinoma, Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Tumor, Fallopian Tube Serous Neoplasm
- Trial name
- NCT04575935
- Testing
- Chemotherapy, Laparotomy, Minimally Invasive Surgery
- Where
- 19 sites in United States, Canada and 3 more
- Volunteers
- 580 people
- Sponsor
- M.D. Anderson Cancer Center
Colon Tumors, Rectum Tumors
Treatment of a Cancerous Disease of the Peritoneum With Complete Cytoreductive Surgery and Intraperitoneal Chemohyperthermia
The purpose of this study is to evaluate the treatment of a cancerous disease of the peritoneum with complete cytoreductive surgery with intraperitoneal chemohyperthermia using oxaliplatin plus irinotecan.
- Conditions
- Colon Tumors, Rectum Tumors, Appendix Tumors, Peritoneum Tumors
- Trial name
- NCT00180960
- Testing
- Oxaliplatin and irinotecan
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Pain
Intra-Peritoneal Local Anaesthesia After Cytoreductive Surgery
Can perioperative administration of intra-peritoneal local anaesthetics further reduce postoperative pain, inflammation and outcome in patients undergoing major abdominal surgery (cytoreductive surgery) and managed with thoracic…
- Trial name
- IPLA (NCT02256228)
- Testing
- Ropivacaine, Saline
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Göteborg University
Colorectal Cancer, Colorectal Carcinoma
Chemokine-Modulatory Regimen for Recurrent Resectable Colorectal Cancer
Determine the safety of a combination of IFN, celecoxib, and rintatolimod for patients with recurrent colorectal cancer. This will also test whether the above combination can help the immune system to fight the tumors.
- Conditions
- Colorectal Cancer, Colorectal Carcinoma, Colorectal Tumors, Neoplasms, Colorectal
- Trial name
- NCT01545141
- Testing
- Chemokin Modulatory Regimen (5 MU/m2), Chemokin Modulatory Regimen (10 MU/m2), Chemokin Modulatory Regimen (20 MU/m2)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Roswell Park Cancer Institute
Lymphoma
Rituximab and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Large Cell Lymphoma
RATIONALE: Monoclonal antibodies such as rituximab can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells.
- Trial name
- NCT00005631
- Testing
- filgrastim, rituximab, carboplatin
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Infection;Post Surg Procedure, Peritoneal Cancer
Post Splenectomy Infections After Surgery for Peritoneal Malignancies (OPSI)
The spleen is involved in maintaining immunity and plays an important role in the elimination of encapsulated bacteria and parasites.
- Trial name
- OPSI (NCT05718726)
- Testing
- Questionnaire, interview or observation study
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Hampshire Hospitals NHS Foundation Trust
Ileus
Phase 2 RCT of Alvimopan vs. Placebo After CRS/HIPEC
The purpose of this study is to investigate the ability of alvimopan to reduce the time to return of bowel function in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.
- Trial name
- ILEUS (NCT03352414)
- Testing
- Alvimopan
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of California, San Diego
Leukemia, Lymphoma
Combination Chemotherapy and Bone Marrow Transplantation in Treating Patients With Leukemia or Myelodysplastic Syndrome
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with bone marrow transplantation may allow the doctor to give higher doses of…
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
- Trial name
- NCT00002502
- Testing
- busulfan, cyclophosphamide, cytarabine
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer, Ovarian Carcinoma
Intraperitoneal LSTA1 in CRS-HIPEC
This Study is designed to test an investigational product (IP) called LSTA1 (Study drug). LSTA1 is a drug designed to improve the delivery of anti-cancer treatments, such as chemotherapy.
- Conditions
- Colorectal Cancer, Ovarian Carcinoma, Appendix Cancer, Peritoneal Metastases
- Trial name
- NCT06216561
- Testing
- CRS-HIPEC + LSTA1, CRS-HIPEC alone
- Where
- United States
- Sponsor
- University of California, San Diego
Haematological Abnormality
Coagulation Profile of Patients Undergoing CRS(Cytoreductive Surgery) and Hyperthermic Intraperitoneal Chemotherapy
To study the changes in coagulation profile in patients undergoing cytoreductive surgery and Hyperthermic intraperitoneal chemotherapy.
- Trial name
- NCT03137745
- Testing
- thromboelastography
- Volunteers
- 60 people
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India
Stage III Fallopian Tube Cancer, Stage III Ovarian Cancer
IGFBP-2 Vaccine and Combination Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Undergoing Surgery
This phase II trial studies how well pUMVC3-IGFBP2 plasmid deoxyribonucleic acid (DNA) vaccine (IGFBP-2 vaccine) and combination chemotherapy work in treating patients with stage III-IV ovarian, fallopian tube, or primary…
- Conditions
- Stage III Fallopian Tube Cancer, Stage III Ovarian Cancer, Stage III Primary Peritoneal Cancer, Stage IIIA Fallopian Tube Cancer
- Trial name
- NCT03029611
- Testing
- Carboplatin, Gynecological Surgical Procedure, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Washington
Ovarian Cancer
Restrictive or Individualized Goal-Directed Fluid Replacement Strategy in Ovarian Cancer Cytoreductive Surgery
This is a single center prospective randomized controlled study comparing the postoperative outcome after cytoreductive surgery in ovarian cancer patient after using restrictive or individualized goal-directed fluid replacement…
- Trial name
- RIGoROCS (NCT03519165)
- Testing
- EV1000(FloTrac System 4.0)
- Where
- India
- Volunteers
- 145 people
- Sponsor
- Tata Medical Center
Stomach Neoplasms, Colorectal Neoplasms
Surgery Plus Intraoperative Peritoneal Hyperthermic Chemotherapy (IPHC) to Treat Peritoneal Carcinomatosis
OBJECTIVES: Determine response and survival of patients with peritoneal carcinomatosis treated with cytoreductive surgery plus intraoperative peritoneal hyperthermic chemotherapy with cisplatin and mitomycin Assess the quality of…
- Conditions
- Stomach Neoplasms, Colorectal Neoplasms, Neoplasm Metastasis, Mesothelioma
- Trial name
- IPHC (NCT00454519)
- Testing
- cytoreductive surgery, intraoperative peritoneal hyperthermic chemotherapy with cisplatin and mitomycin
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wuhan University
Appendix Cancer, Colorectal Cancer
ICARuS Post-operative Intraperitoneal Chemotherapy (EPIC) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) After Optimal Cytoreductive Surgery (CRS) for Neoplasms of the Appendix, Colon or Rectum With Isolated Peritoneal Metastasis
This is the first randomized trial comparing Early post-operative intraperitoneal chemotherapy (EPIC) and hyperthermic intraperitoneal chemotherapy (HIPEC) for appendiceal and colorectal cancer.
- Trial name
- ICARuS (NCT01815359)
- Testing
- Cytoreductive Surgery, HIPEC with Mitomycin-C, EPIC with FUDR and Leucovorin
- Where
- 9 sites in United States
- Volunteers
- 292 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Metastatic Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma
Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial
This phase III trial compares the effect of adding surgery to a standard of care immunotherapy-based drug combination versus a standard of care immunotherapy-based drug combination alone in treating patients with kidney cancer…
- Conditions
- Metastatic Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma, Stage IV Renal Cell Cancer AJCC v8
- Trial name
- PROBE (NCT04510597)
- Testing
- Cytoreductive Nephrectomy, Active Comparator
- Where
- 387 sites in United States
- Volunteers
- 364 people
- Sponsor
- SWOG Cancer Research Network