Clinical trials: Cytotoxicity
Relapsing Remitting Multiple Sclerosis
Reduced Oligodendrocyte-specific Cytotoxicity and Ofatumumab Treatment
In this study the investigators wish to test the hypothesis that the repertoire of solutes secreted by leukocytes isolated from patients with relapsing-remitting forms of Multiple Sclerosis (MS) following 6 months of treatment…
- Trial name
- NCT05171972
- Testing
- Ofatumumab
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Leukemia, Lymphocytic
Human IL-15 (rhIL-15) and Obinutuzumab for Relapsed and Refractory Chronic Lymphocyte Leukemia
Background: Chronic lymphocytic leukemia (CLL) is a blood cancer. Recombinant human interleukin 15 (IL-15) is a manmade protein. Obinutuzumab is a protein made to deactivate cancer cells.
- Conditions
- Leukemia, Lymphocytic, Chronic, B-Cell
- Trial name
- NCT03759184
- Testing
- rhIL-15, Obinutuzumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Cancer Institute (NCI)
HER2 Positive Gastric Cancer, Colorectal Cancer
FATE-NK100 as Monotherapy and in Combination With Monoclonal Antibody in Subjects With Advanced Solid Tumors
This is a Phase 1, single-dose, open-label, dose-escalation study. The study will be conducted in three parts (i.e. regimens) in an outpatient setting as follows: Regimen A: FATE-NK100 as a monotherapy in subjects with advanced…
- Conditions
- HER2 Positive Gastric Cancer, Colorectal Cancer, Head and Neck Squamous Cell Carcinoma, EGFR Positive Solid Tumor
- Trial name
- NCT03319459
- Testing
- FATE-NK100, Cetuximab, Trastuzumab
- Where
- 4 sites in United States
- Volunteers
- 44 people
- Sponsor
- Fate Therapeutics
Colorectal Cancer
Autologous Antigen-activated Dendritic Cells in the Treatment of Patients With Colorectal Cancer
The purpose of this work: to assess the tolerability and effectiveness of the autogemotherapy method on the basis of autologous antigen-activated dendritic cells in the treatment of patients with colorectal cancer.
- Trial name
- NCT03214939
- Testing
- Immunotherapy based on dendritic cells
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Research Institute of Fundamental and Clinical Immunology
Melanoma, Kidney Cancer
Determining the Lymphokine Activated Killer (LAK) Cytotoxicity Present in Patients Undergoing Interleukin-2 Therapy
Therapy with Interleukin-2 stimulates lymphocytes in humans to become Lymphokine-activated Killer cells (LAK). This study will determine if these killer cells are able to kill certain standard cell-lines in the laboratory.
- Trial name
- LAK (NCT01068470)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Loma Linda University
Metastatic Breast Cancer
Effects of Granulocyte Colony-stimulating Factor (G-CSF), Trastuzumab, and Vinorelbine on Immune Cell Function
Trastuzumab or Herceptin is an antibody directed against Her-2. Her-2 is a growth factor receptor which is present on the tumors of 25% of patients with breast cancer.
- Trial name
- NCT00169104
- Testing
- G-CSF, trastuzumab, vinorelbine
- Volunteers
- 23 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Urothelial Carcinoma
EGCG Modulate the Cytotoxic Effects of Chemotherapeutic Agents in Human Urothelial Carcinoma Cells
Urothelial carcinoma (UC) is the most common cancer of urinary tract. Patients with metastatic UC are usually treated with systemic chemotherapy.
- Trial name
- NCT01993966
- Where
- 2 sites in Taiwan
- Volunteers
- 25 people
- Sponsor
- National Taiwan University Hospital
HER2-positive Breast Cancer, Operable Breast Cancer
Impact of Pegfilgrastim on Trastuzumab Anti-tumor Effect and ADCC in Operable HER2+ Breast Cancer Breast Cancer
First preclinical data suggest that pegfilgrastim could constitute a potent adjuvant for immunotherapy with mAb possessing ADCC/ADCP properties as trastuzumab.
- Trial name
- BREASTIMMU02 (NCT03571633)
- Testing
- Trastuzumab + Paclitaxel, Pegfilgrastim
- Where
- 9 sites in France
- Volunteers
- 90 people
- Sponsor
- Centre Leon Berard
PreDiabetes
Effect of Melatonin and Metformin on Glycemic Control Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes
Melatonin is a hormone that regulates the circadian cycle in addition to having an antioxidant effect. Patients with prediabetes state, has a deregulation of glucose metabolism and an overproduction of reactive oxygen species…
- Trial name
- NCT03848533
- Testing
- melatonin, metformin
- Where
- Mexico
- Volunteers
- 42 people
- Sponsor
- University of Guadalajara
Adult T-Cell Lymphoma/Leukemia, Sezary Syndrome
Phase I Study of Recombinant Human IL-15 (rhIL-15) and Mogamulizumab for People With Refractory or Relapsed Adult T-Cell Leukemia and Mycosis Fungoides/Sezary Syndrome
Background: Adult T-cell leukemia/lymphoma (ATLL) and mycosis fungoides/Sezary syndrome (MF/SS) are cancers that form in the T cells, a type of white blood cell that helps with the body's immune response.
- Conditions
- Adult T-Cell Lymphoma/Leukemia, Sezary Syndrome, Mycosis Fungoides
- Trial name
- NCT04185220
- Testing
- Recombinant human Interleukin-15 (rhIL-15), Mogamulizumab
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Cancer Institute (NCI)
Multiple Myeloma
Study of SGN-40, Lenalidomide, and Dexamethasone in Patients With Multiple Myeloma
This is a Phase I, open-label, multi-dose trial to define the MTD and tolerability of a regimen including lenalidomide, dexamethasone, and intravenous SGN-40 in patients with relapsed multiple myeloma.
- Trial name
- NCT00525447
- Testing
- SGN-40, lenalidomide, dexamethasone
- Where
- 9 sites in United States
- Volunteers
- 36 people
- Sponsor
- Seagen Inc.
DNA Damage
Assessment of the Cytotoxic and Genotoxic Effect of Toothpastes With Different Forms of Fluoride on the Buccal Mucosa
The remarkable therapeutic anticaries effect of fluoride is well recognized, but in recent years, toxic effects on the oral mucosa have been discussed.
- Trial name
- NCT05596149
- Testing
- Toothpaste without fluoride, Toothpaste with sodium fluoride, Toothpaste with sodium monofluorophosphate
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
PreDiabetes
Effect of Phytoecdysterone Administration in Subjects With Prediabetes
Prediabetes is the term used for people whose glucose levels do not meet the criteria for diabetes but are too high to be considered normal.
- Trial name
- NCT03906201
- Testing
- Ecdysterone
- Where
- Mexico
- Volunteers
- 34 people
- Sponsor
- University of Guadalajara
Cytotoxicity
In-Vitro Cytotoxicity Assessment of INOX (Nanoksa G Plus) Polymer Discs
This study aims to evaluate the cytotoxicity of INOX (Nanoksa G Plus) high-performance polymer discs on cell cultures using standardized in-vitro assays.
- Trial name
- NCT07381153
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Malocclusion, Cytotoxicity
Evaluate Cytotoxicity, Leaching, and Structural Conformation of Clear Aligners
The aim is to evaluate clear aligners' cytotoxicity, leaching, and structural properties and compare them with four cleaning tools. The null hypothesis is the cleansers have no impact on the properties tested.
- Trial name
- NCT06503029
- Testing
- Invisalign Cleaning Crystals, Fittey Dent Cleaning Tablet, Listeren Mouthwash
- Where
- Saudi Arabia
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Cytotoxicity
Biological Evaluation of Orthopedic Materials: An In Vitro Study Using Patient-Derived Human Samples
The anterior cruciate ligament (ACL) is the primary stabilizer of the knee joint, and ACL injuries are highly prevalent, particularly among physically active and athletic individuals.
- Trial name
- RAISE (NCT07671521)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Stefano Zaffagnini
Breast Cancer
Evaluation of Changes in the Immunological Microenvironment Surrounding Subcutaneous Breast Cancer Metastases After Liquid Nitrogen Cryotherapy
Cryotherapy is a cold ablation technique used in many tumor locations. The destruction of tissues by cryoablation preserves proteins and in particular anti-tumor antigens, which could induce the stimulation of an immune response.
- Trial name
- CRIMCAS (NCT05825547)
- Testing
- Cryotherapy treatment
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Melanoma
Study of DS-8273a With Nivolumab in Unresectable Stage III or Stage IV Melanoma
The purpose of this study is to evaluate the safety profile, tolerability, and immunoregulatory (pharmacodynamic; PD) activity of DS-8273a administered in combination with nivolumab (anti-PD-1 antibody) to subjects with…
- Trial name
- NCT02983006
- Testing
- DS-8273a, Nivolumab
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- NYU Langone Health
NK Cell Mediated Immunity, NK Cell Cytokine Production
Cellular Immunity and Renal Cell Cancer
Renal cell cancer (RCC) is one of the most important urogenital tumors because of it's high mortality and increasing incidence. RCC, which accounts about 3% of all malignant tumors in the adults, is the most lethal urogenital…
- Conditions
- NK Cell Mediated Immunity, NK Cell Cytokine Production, Kidney Cancer
- Trial name
- NCT04377113
- Where
- Croatia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Center Rijeka
HIV-1-infection
Optimising DNA Vaccinations in Healthy Volunteers
This is a two part study to evaluate the immunogenicity and tolerability of DNA-C CN54ENV plasmid DNA (CN54ENV) administered with electroporation (EP), with and without DNA encoding recombinant interleukin-12 (GENEVAX® IL-12).
- Trial name
- DNAVAC001 (NCT03663998)
- Testing
- CN54ENV DNA, GENEVAX® IL-12 DNA
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Imperial College London