Clinical trials: Cytotoxicity
Dermatomyositis, Polymyositis
Methimazole to Treat Polymyositis and Dermatomyositis
This study will test the safety and effectiveness of the drug methimazole in treating polymyositis and dermatomyositis-inflammatory muscle diseases causing weakness and muscle wasting.
- Trial name
- NCT00001421
- Testing
- methimazole
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
B-Cell Chronic Lymphocytic Leukemia, Non-Hodgkin's Lymphoma
Pilot Study of Autologous T Lymphocytes With ADCC in Patients With CD20-Positive B-Cell Malignancies
Despite advancement in chemotherapy, radiotherapy and haematopoietic stem cell transplant (HSCT), and the recent introduction of more targeted therapies, a substantial proportion of patients with B-cell malignancies, such as…
- Trial name
- NCT02315118
- Testing
- T-cell therapy + Rituximab + IL-2
- Where
- Singapore
- Volunteers
- 18 people
- Sponsor
- National University Hospital, Singapore
Pancreatic Adenocarcinoma, Pancreatic Cancer
AdV-tk Therapy With Surgery and Chemoradiation for Pancreas Cancer (PaTK01)
The purpose of this Phase 1 study is to evaluate the safety and potential efficacy of Gene Mediated Cytotoxic Immunotherapy for pancreatic cancer.
- Trial name
- PaTK01 (NCT00638612)
- Testing
- AdV-tk, Valacyclovir
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Candel Therapeutics, Inc.
Immune Function
Effect of Fruit and Vegetable Consumption on Immune Function in the Elderly
The immune system undergoes a range of changes as individuals become elderly. These may manifest as an increasing susceptibility to infection or a tendency to develop autoimmune or malignant disease.
- Trial name
- ADIT (NCT00858728)
- Testing
- 5 portions, 2 portions
- Where
- United Kingdom
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Breast Cancer
Comparison of the Effect of Total Intravenous Anesthesia and Inhalation Anesthesia on Cancer Cell Cytotoxicity, Micrometastasis and Recurrence of Tumor in Patients Undergoing Breast Tumor Resection
The purpose of this study is to compare the effect of total intravenous anesthesia and inhalation anesthesia on cancer cell cytotoxicity, micrometastasis and recurrence of tumor in patients undergoing breast tumor resection.
- Trial name
- NCT02089178
- Testing
- intravenous anesthesia, inhalation anesthesia, propofol-remifentanil
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Yonsei University
Pulmonary Inflammation, Cytotoxicity
Pulmonary and Systemic Effects of Exposure to Wood Smoke
This is study is to assess pulmonary and systemic effects of exposure to wood smoke. Healthy volunteers will be expose under two different occasion to wood smoke and filtered air under two separated occasions with an interval of…
- Trial name
- NCT03302117
- Testing
- Wood smoke exposure
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Umeå University
Healthy, Cytotoxicity
Cytotoxicity of Yellow Fever Specific CD8 T Cells Following YF-17D Vaccination
Investigating cytotoxicity of yellow fever specific CD8 T cells following YF-17D vaccination and the following licensing of these epitope-specific CD8 T cells
- Conditions
- Healthy, Cytotoxicity, Yellow Fever Vaccination Reaction
- Trial name
- CYF-8 (NCT04083430)
- Testing
- Yellow Fever Vaccine
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Non-small Cell Lung Cancer (NSCLC)
A Study to Determine Safety of Durvalumab After Sequential Chemo Radiation in Patients With Unresectable Stage III Non-Small Cell Lung Cancer
This is a Phase II, open-label, multi-centre study to determine the safety of a fixed dose of Durvalumab (MEDI4736) (1500 mg) every 4 weeks [q4w] in participants with unresectable Stage III Non-Small Cell Lung Cancer (NSCLC), who…
- Trial name
- NCT03693300
- Testing
- Durvalumab
- Where
- 28 sites in United States, France and 4 more
- Volunteers
- 117 people
- Sponsor
- AstraZeneca
Chronic Hepatitis C
Effect of Boceprevir on HCV-specific T Cell Responses
Analysis of HCV-specific T cell responses in patients treated with boceprevir to assess whether therapy can induce restoration of the T cell function and to what extent this recovery can be achieved
- Trial name
- Boce-Par (NCT01403181)
- Testing
- Boceprevir
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
HIV Infections, HIV Seronegativity
ALVAC-HIV vCP1452 Alone and Combined With MN rgp120
The purpose of this study is to test how the body's immune system responds to the vaccine ALVAC-HIV vCP1452 and to determine if the vaccine is safe when given alone and with MN rgp120.
- Trial name
- NCT00011037
- Testing
- ALVAC(2)120(B,MN)GNP (vCP1452), MN rgp120/HIV-1
- Where
- 4 sites in Brazil, Haiti and 2 more
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Plaque, Dental, Antimicrobial
Anticariogenic Effect of Moringa Oleifera Mouthwash Compared to Chlorhexidine Mouthwash
Moringa oleifera (MO) is an extraordinary nutritious vegetable tree with high medicinal value for its antibacterial properties. Formulation of various natural dental remedies from this plant and their testing for their…
- Conditions
- Plaque, Dental, Antimicrobial, Mouthwash, Cytotoxicity
- Trial name
- NCT04575948
- Testing
- Moringa Oleifera, Chlorhexidine mouthwash, Base formula
- Volunteers
- 90 people
- Sponsor
- Misr International University
Chronic Myeloid Leukemia (CML), Pancreatic Ca
Natural Killer Cells and Bortezomib to Treat Cancer
Natural killer (NK) cells are white blood cells that have a limited ability to kill cancer cells. This ability might be enhanced if they are given 24 hours after an injection of the drug bortezomib.
- Conditions
- Chronic Myeloid Leukemia (CML), Pancreatic Ca, Colon/Rectal Ca, Multiple Myeloma
- Trial name
- NCT00720785
- Testing
- Bortezomib, NK cells
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
DNA Damage
In Vivo Assessment of Geno- and Cytotoxicity of Fluoridated Toothpastes and Mouthrinses on Buccal Epithelial Cells
Buccal cells represent the first barrier to the oral hygiene products' potential toxic effect. The usual concentration of fluoride in toothpastes is 1000/1100 parts per million (ppm F); toothpastes with higher (1500 ppm F) and…
- Trial name
- NCT04801576
- Testing
- Flouride in mouthrinses
- Where
- Croatia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Cancer, Chronic Stress
Can You Breathe Your Way To Better Health?
The purpose of this clinical trial is to explore the effects of either a 2-week high-intensity interval training (HIIT) or breath training intervention on measures of overall health, circulating biomarkers of stress, and immune…
- Conditions
- Cancer, Chronic Stress, Autonomic Dysfunction
- Trial name
- NCT06829836
- Testing
- Hight intensity interval training, Cyclic Hyperventilation with Retention
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Northern Colorado
Carcinoma, Hepatocellular
Cytotoxicity Induced by Tumor Lysate Pulsed Dendritic Cells Against Autologous Hepatocellular Carcinoma Cells
Hepatoma ranks the first on the cancer mortality list in Taiwan, and there are currently no other effective treatment options for advanced HCC.
- Trial name
- NCT00327496
- Testing
- DC vaccine
- Volunteers
- 10 people
- Sponsor
- Mackay Memorial Hospital
Gastric Cancer
ADCC Against Gastric Cancer Cells
Peripheral blood will be taken from the enrolled patients at National University Hospital and from healthy volunteers. ADCC assay will be performed for evaluating efficacy of new medicine candidates.
- Trial name
- NCT02078362
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- National University Hospital, Singapore
Multiple Myeloma
Autologous Memory-like NK Cell Therapy With BHV-1100 and Low Dose IL-2 in Multiple Myeloma Patients
This is an open-label single center Phase 1a/1b study with the primary objective of establishing the safety and exploring the efficacy of infusing the ex vivo combination product of BHV-1100 plus cytokine induced memory-like…
- Trial name
- NCT04634435
- Testing
- BHV-1100 plus cytokine induced memory-like (CIML) NK cells plus IVIG and low dose IL-2
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Biohaven Pharmaceuticals, Inc.
Cytotoxicity
Study Evaluating Occupational Exposure to Antineoplastic Drugs
The multicenter study involves comparing two groups (an exposed group and a control group). The exposed group is selected from workers who perform their activities in drug handling areas (DH) or units for antineoplastic…
- Trial name
- BRIC (NCT06343103)
- Testing
- Workers exposed, Workers not exposed
- Where
- 5 sites in Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- European Institute of Oncology
Malignant Glioma, Glioblastoma Multiforme
Phase 1b Study of AdV-tk + Valacyclovir Combined With Radiation Therapy for Malignant Gliomas
This phase I study evaluated a Gene Mediated Cytotoxic Immunotherapy approach for malignant gliomas, including glioblastoma multiforme and anaplastic astrocytoma.
- Conditions
- Malignant Glioma, Glioblastoma Multiforme, Anaplastic Astrocytoma
- Trial name
- BrTK01 (NCT00751270)
- Testing
- AdV-tk, Valacyclovir
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Candel Therapeutics, Inc.
Prostate Cancer
Phase 3 Study of ProstAtak® Immunotherapy With Standard Radiation Therapy for Localized Prostate Cancer
The purpose of this study is to evaluate the effectiveness of ProstAtak® immunotherapy in combination with radiation therapy for patients with intermediate-high risk localized prostate cancer.
- Trial name
- PrTK03 (NCT01436968)
- Testing
- Aglatimagene besadenovec + valacyclovir
- Where
- 73 sites in United States, Puerto Rico
- Volunteers
- 711 people
- Sponsor
- Candel Therapeutics, Inc.