Clinical trials: DBS
Parkinson Disease
Deep Brain Stimulation (DBS) Frequency Effects on Gait in Parkinson's Disease(PD)
In this study the investigators will evaluate the effect of both low and high frequency Deep Brain stimulation of the subthalamic nucleus (STN) in Parkinson's patients who have noted a change in their walking.
- Trial name
- NCT00993291
- Testing
- Frequency change to 60 Hz, Frequency change to 130 Hz
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University
Essential Tremor
directSTIM™ Deep Brain Stimulation System Post-Market Clinical Follow-up Study on Essential Tremor
This is a prospective, multi-center, single arm post-market clinical follow-up study. The present study investigates a product authorized on the European market that will be used per its intended use, and all procedures involved…
- Trial name
- NCT05795218
- Testing
- Deep Brain Stimulation
- Where
- 5 sites in Germany
- Volunteers
- 21 people
- Sponsor
- Aleva Neurotherapeutics SA
Autism Spectrum Disorder, Self-Injurious Behavior
Deep Brain Stimulation in Children With Autism
The purpose of this study is to evaluate the safety and possible effectiveness of deep brain stimulation (DBS) of the nucleus accumbens in children with autism spectrum disorder and treatment-refractory, repetitive self-injurious…
- Trial name
- NCT03982888
- Testing
- Deep Brain Stimulation, DBS
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- The Hospital for Sick Children
Dystono-dyskinetic Syndromes
Validation of a Quality of Life Assessment Tool in Adult Generalized Dystonodyskinetic Syndromes Treated by Continuous Electrical Neuromodulation
In spite of a growing interest in the evaluation of health-related quality of life in movement's disorders management, there is no tool specifically dedicated to dystonia and related syndromes that measures both the objective…
- Trial name
- DBS-QoLs (NCT05870020)
- Testing
- Questionnaire (DBS-QoLs)
- Where
- France
- Volunteers
- 33 people
- Sponsor
- University Hospital, Montpellier
Deep Brain Stimulation, Drug Resistant Epilepsy
Evaluating Modulation Effects of Temporal Interference Using SEEG
This single-center prospective study aims to investigate the electrophysiological mechanisms of temporal interference (TI) in humans by analyzing clinical, imaging, and electrophysiological data from patients aged 14-60 with…
- Trial name
- NCT06663969
- Testing
- Temporal Interference
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Parkinson's Disease
Cont. of a Study to Evaluate Implanting Peripheral Nerve Grafts Into Subjects With Parkinson's Disease (PD) During DBS
This pilot study is designed to follow up on a previous, preliminary study and test the long-term safety and feasibility of the implantation of autologous peripheral nerve grafts into the substantia nigra, basal forebrain…
- Trial name
- CAPNG (NCT02369003)
- Testing
- Autologous Peripheral Nerve Graft
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Craig van Horne, MD, PhD
Parkinson's Disease, Essential Tremor
Sensory Gating Measured With Microelectrode Recording (MER) During Deep Brain Stimulation (DBS) Surgery
Deep brain stimulation (DBS) is an FDA approved, and widely used method for treating the motor symptoms of Parkinson's disease (PD), Essential Tremor (ET), Dystonia and Obsessive Compulsive disorder (OCD).
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia, Obsessive Compulsive Disorder
- Trial name
- NCT02320266
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obsessive-Compulsive Disorder
Deep Brain Stimulation for Treatment-Resistant Obsessive Compulsive Disorder
This study will evaluate the use of Deep Brain Stimulation (DBS) to reduce symptom severity and enhance the quality of life for patients with treatment-resistant obsessive compulsive disorder (OCD).
- Trial name
- NCT00057603
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Florida
Addiction
Deep Brain Stimulation of the Nucleus Accumbens and the Ventral Anterior Internal Capsule for Severe Alcohol Addiction
The main objective of this study is to assess the efficacy of bilateral deep brain stimulation (DBS) of the nucleus accumbens (NAc) and the ventral anterior internal capsule (VC) as a novel treatment in severe alcohol addiction.
- Trial name
- NCT01658592
- Testing
- Deep brain stimulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Guodong Gao
Epilepsy, Essential Tremor
Human Cognition During Surgery: Stimulation-based and Cholinergic Modulation
This is a research study to determine how COBENFY KarXT (FDA approved), a drug which has been approved for treatment of certain disorders, affects brain activity and cognitive tasks which may be regulated by the cholinergic…
- Conditions
- Epilepsy, Essential Tremor, Seizures, Memory Consolidation
- Trial name
- NCT07721272
- Testing
- Cobenfy KarXT pill (50/20 mg)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas Southwestern Medical Center
Intraoperative Awareness
Comparison of Combined Dexmedetomidine and Ketamine (Ketodex) Versus Dexmedetomidine Alone in Awake Mapping for Deep Brain Stimulation: A Randomized Controlled Trial
Adult patients undergoing awake Deep Brain Stimulation (DBS) surgery for movement disorders (e.g., Parkinson's Disease, Essential Tremor).
- Trial name
- NCT07513935
- Testing
- Ketodex, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Essential Tremor, Parkinsons Disease (PD)
Effects of Microelectrode-based Brain Stimulation in Humans
The currently available treatments of Parkinson's disease (PD) and Essential Tremor (ET) are inadequate and accompanied by adverse side effects making the treatment much less effective.
- Trial name
- HDBS (NCT07820189)
- Testing
- High Definition Brain Stimulation (HDBS)
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Lund University
Obsessive-Compulsive Disorder, OCD
Personalized DBS for OCD Guided by Stereoencephalography Mapping
This is a double-blinded, randomized, crossover study design for SEEG-guided 4-lead DBS for treatment-refractory OCD, followed by open label stimulation for an additional 6 months.
- Trial name
- NCT06347978
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Andrew Moses Lee, MD, PhD
Obsessive Compulsive Disorder
Unilateral Deep Brain Stimulation (DBS) of the Nucleus (Nucl.) Accumbens (Acc.) in Patients With Treatment Resistant Obsessive Compulsive Disorder (OCD)
The purpose of the study was to evaluate whether a unilateral Deep Brain Stimulation of the right Nucleus Accumbens could lead to a more than 35% reduction of symptoms in patients with a treatment resistant Obsessive Compulsive…
- Trial name
- NCT00724490
- Testing
- Deep Brain Stimulation
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- University of Cologne
Obsessive-Compulsive Disorder
Cortical Stimulation to Treat Obsessive Compulsive Disorder
The purpose of this study is to identify abnormal brain signals associated with Obsessive Compulsive Disorder (OCD) and psychiatric symptoms and to investigate novel therapeutic stimulation sites.
- Trial name
- NCT04958096
- Testing
- Standard Therapeutic Deep Brain Stimulation, Cortical Stimulation for PFC, Cortical Stimulation for ACC
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Andrew Moses Lee, MD, PhD
Parkinson's Disease
Short Pulse Width DBS in Parkinson's Disease
The aim of this investigation is to explore the effect of reducing conventional pulse width of stimulation on known adverse effects of Subthalamic nucleus Deep Brain Stimulation (STN DBS) treatment such as; slurring of speech…
- Trial name
- NCT03417271
- Testing
- Deep brain stimulation
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University College, London
Healthy Volunteers
Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.1
In its totality, this grant aims to develop a line of research using temporal interference (TI) electrical neurostimulation technology to understand the causal role of deep brain structures in cognition.
- Trial name
- NCT07215299
- Testing
- Temporal Interference (TI) Electrical Stimulation - NAcc TI Active, Temporal Interference (TI) Electrical Stimulation - NAcc No-TI Active
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Essential Tremor, Deep Brain Stimulation
Probabilistic Targeting of the VIM
After having included the most improved patients by DBS among those implanted in Bordeaux Hospital University, and having defined the most active plots on tremor by its prospective grading on Fahn-Tolosa-Marin (FTM) scale and…
- Trial name
- PROBA-VIM (NCT03696420)
- Testing
- Coordinates of active plots and VIM landmarks calculation
- Where
- France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Bordeaux
Isolated Cervical Dystonia, Complex Dystonia
Functional MRI and DTI in the Preoperative Assessment of Dystonia
The aim of this study is to evaluate the organization of the motor circuit in a group of patients suffering from dystonia compared with a group of healthy controls.
- Conditions
- Isolated Cervical Dystonia, Complex Dystonia, Spasticity
- Trial name
- IRMF-DIFF (NCT02877836)
- Testing
- magnetic resonance imaging (fMRI)
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Parkinson's Disease
Effect of Deep Brain Stimulation on Depression and Quality of Life in Parkinson's Patients
We will evaluate the effect of deep brain stimulation on the depression and quality of life in Parkinson's disease. We aim to compare depression pre-operatively and post-operatively in Parkinson's patients with deep brain…
- Trial name
- NCT00179101
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Vanderbilt University