Clinical trials: DEGLUTİTİON
GERD, Acid Reflux Disease
Validation of Patient-reported Outcomes Measures for the Assessment of Gastroesophageal Reflux Disease (GERD) Symptoms
This research study is being done to gather information about how to do further clinical studies using AZD3355 as an add-on treatment to proton pump inhibitors (PPI).
- Conditions
- GERD, Acid Reflux Disease, Heartburn, Regurgitation
- Trial name
- C27 (NCT00703534)
- Testing
- AZD3355, Gelusil®
- Where
- 84 sites in United States
- Volunteers
- 478 people
- Sponsor
- AstraZeneca
Gastroesophageal Reflux
On Demand Treatment of Reflux Disease
A comparison of the effect of on demand treatment with a pectin-containing natural product (Aflurax) with that esomeprazole (Nexium)
- Trial name
- NCT00184522
- Testing
- Aflurax, esomeprazole
- Where
- 9 sites in Norway
- Volunteers
- 82 people
- Sponsor
- Norwegian University of Science and Technology
Oropharyngeal Dysphagia
Utilization of Negative Pressure Suction to Reduce Aspiration in Oropharyngeal Dysphagia
This is an investigator initiated prospective study to determine whether the use of a negative pressure suction in the hypopharynx will reduce the amount of aspiration during Video Fluoroscopic Swallowing Exam (VFSE) among…
- Trial name
- NCT03368079
- Testing
- Negative Pressure Suction Catheter
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, Davis
Barrett's Esophagus, Gastroesophageal Reflux Disease
PillCam® ESO 2 in Esophageal Pathologies
Study Hypothesis: PillCam™ ESO-2 will demonstrate equivalent accuracy parameters as compared to blinded esophagogastroduodenoscopy (EGD) in detecting suspected Barrett's esophagus, detecting and grading esophagitis.
- Trial name
- MA-76 (NCT00885469)
- Where
- 10 sites in United States
- Volunteers
- 101 people
- Sponsor
- Medtronic - MITG
Achalasia Cardia, GERD-HRQL Scale
Compare the Quality of Life of Patients With Achalasia Cardia (AC) After Laparoscopic and Open Esophagocardiomyotomy.
Study design. A randomized, prospective design study with retrospective data addition was conducted at two medical institutions between December 2017 and July 2025.
- Conditions
- Achalasia Cardia, GERD-HRQL Scale, Eckardt Scale
- Trial name
- GERD-HRQL (NCT07177222)
- Testing
- laparoscopic esophagocardiomyotomy, open surgery
- Where
- Kyrgyzstan
- Volunteers
- 38 people
- Sponsor
- Osh State University
Amyotrophic Lateral Sclerosis (ALS), Myasthenia Gravis
Innovative Measures of Speech and Swallowing Dysfunction in Neurological Disorders
This study is evaluating the use of two painless, non-invasive technologies in the assessment of muscle health over time in both healthy volunteers and patients who have diseases that affect the nervous system.
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Myasthenia Gravis, Myopathies, Stroke
- Trial name
- QUESST (NCT02118805)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Healthy
Tongue Motor Recruitment During Exercise
The prevalence of dysphagia may be as high as 22% in individuals over 50 years of age. There are few therapeutic options offered to these individuals.
- Trial name
- NCT02687737
- Testing
- Electromyography, Maximum expiratory pressure, Videofluoroscopy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Swallowing Disorder, Traumatic Brain Injury
Swallowing Disorders in Minimally Consciousness Patients (MCS)
This study aimed to characterize swallowing disorders in minimally consciousness patients after brain traumatic injury.
- Trial name
- TC-DEG (NCT03562104)
- Testing
- videofluoroscopy, Wessex Head Injury Matrix scale
- Where
- 2 sites in France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Rouen
Dysphagia, Late Effect of Stroke
Capsaicin for Post-stroke Dysphagia
Randomised, double blind, Phase 2 Trial to evaluate the efficacy of oral Capsaicin in patients with post-stroke dysphagia in the (sub-)acute setting.
- Trial name
- CADYS (NCT04470752)
- Testing
- Capsaicin 1% oral solution, InOrpha Solution
- Where
- Switzerland
- Volunteers
- 82 people
- Sponsor
- Georg Kägi, MD
Dysphagia, Sarcopenia
Masseter and Rectus Femoris Ultrasound for Dysphagia and Sarcopenia in Critically Ill Patients
Dysphagia and sarcopenia are common complications in critically ill patients and are associated with increased morbidity, prolonged hospitalization, nutritional complications, and poorer clinical outcomes.
- Trial name
- NCT07787312
- Where
- Spain
- Volunteers
- 323 people
- Sponsor
- Sara Casanova Prieto
Idiopathic Pulmonary Fibrosis, Gastroesophageal Reflux
Treatment of IPF With Laparoscopic Anti-Reflux Surgery
This study will test the hypothesis that treatment with laparoscopic anti-reflux surgery in subjects with idiopathic pulmonary fibrosis (IPF) and abnormal gastroesophageal reflux (GER) will slow the decline of forced vital…
- Trial name
- WRAP-IPF (NCT01982968)
- Testing
- Surgery
- Where
- 5 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of California, San Francisco
Swallowing Disorder, Perinatal Asphyxia
Effect of Non-nutritive Sucking on Transition to Oral Feeding in Infants With Asphyxia
The transition period to full oral feeding in infants with perinatal asphyxia is important in predicting long-term outcomes. The transition to independent oral feeding is accepted as a discharge criterion by the American Academy…
- Conditions
- Swallowing Disorder, Perinatal Asphyxia, Feeding; Difficult, Newborn, Feeding Disorder of Infancy or Early Childhood
- Trial name
- NCT05687708
- Testing
- Non-Nutritive Sucking
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medipol University
Deglutition Disorders, Oropharynx Cancer
Physiological Flow of Liquids in Head and Neck Cancer Patients: A Pilot Study
This study is part of a larger grant, for which the overall goal is to collect measurements of liquid flow through the oropharynx (i.e., mouth and throat) during swallowing.
- Trial name
- NCT04112940
- Testing
- Starch-based Thickened Liquids, Xanthan-gum Thickened Liquids
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto
Esophageal Achalasia
Comparison Study of Conventional POEM and Hybrid POEM for Esophageal Achalasia
Peroral endoscopic myotomy (POEM) has recently been introduced as promising alternative to laparoscopic Heller myotomy for patients with idiopathic achalasia.
- Trial name
- NCT01742494
- Testing
- Water-jet POEM, Conventional POEM
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Zhongshan Hospital
Gastroesophageal Reflux Disease, Hiatal Hernia
Transoral Incisionless Fundoplication (TIF) Versus Sham for Treatment of Gastroesophageal Reflux Disease (GERD)
The study objective is to evaluate the relative merits, safety and effectiveness of transoral incisionless fundoplication (TIF) in proton pump inhibitor (PPI) dependent GERD patients compared with sham procedure.
- Trial name
- NCT01110811
- Testing
- Transoral Incisionless Fundoplication (TIF)
- Where
- 4 sites in Belgium, France and 1 more
- Volunteers
- 60 people
- Sponsor
- EndoGastric Solutions
Oropharyngeal Dysphagia
Minimal-Massive Intervention in Elderly Patients With Dysphagia
The purpose of this study is to apply a minimal-massive intervention (minimal recommendations to maximal number of patients) to elderly (>70 years) hospitalized patients with oropharyngeal dysphagia (OD).
- Trial name
- MMI (NCT02396992)
- Testing
- Minimal-Massive Intervention
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- Hospital de Mataró
Gastroesophageal Reflux
Which Supraesophageal Reflux Symptoms Reliably Respond to Proton-Pump-Inhibitor (PPI) Therapy
The investigators hypothesize that persons with the particular cluster of symptoms that are due to supraesophageal reflux (SER) will have complete resolution of those symptoms with adequate acid suppression when a PPI is…
- Trial name
- NCT00170001
- Testing
- Nexium, Sugar Pill
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Severe Stroke, Acute Stroke
Optimizing Early Nutrition Support in Severe Stroke-2
Post stroke pneumonia (PSP) is one of the common early complications of stroke. Post-stroke infections, in general, are associated with less favorable neurologic outcomes.
- Conditions
- Severe Stroke, Acute Stroke, Dysphagia
- Trial name
- NCT05998902
- Testing
- Trophic enteral feeding combined with supplemental parenteral nutrition, Full enteral feeding
- Where
- 30 sites in China
- Volunteers
- 546 people
- Sponsor
- Wen Jiang-3
Gastroesophageal Reflux Disease (GERD)
A Study to Compare PK/PD Characteristics and Safety Profiles Between AD-120 and AD-120A
Primary endpoint of this study is to evaluate the pharmacokinetic and pharmacodynamic characteristics of AD-120 in healthy subjects.
- Trial name
- NCT06916130
- Testing
- AD-120A, AD-120
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Addpharma Inc.
GERD
Anti-Reflux Endoscopic Therapy Using Argon Plasma Coagulation (AREA) in Gastroesophageal Reflux Disease (GERD) Patients: A Single Center, Randomized, Sham, Controlled Trial (The AREA Study)
Background and Rationale: Gastroesophageal reflux disease is affecting 1 in 3 US adults with half experiencing daily symptoms. Per recent data, more than 50% continue to experience daily symptoms despite taking medical therapy…
- Trial name
- AREA (NCT06641375)
- Testing
- Anti reflux endoscopic theraphy, Endoscopy
- Where
- India
- Volunteers
- 18 people
- Sponsor
- Asian Institute of Gastroenterology, India
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