Clinical trials: DEGLUTİTİON
Dysphagia
Standardizing Swallow Pressure Measurements
This study aims to directly compare and contrast swallowing pressure and impedance measurements obtained from two high-resolution manometry (HRM) systems: the Laborie LMT Pharyngeal System and the Medtronic ManoScan ESO HRM…
- Trial name
- NCT07475091
- Testing
- Laborie LMT Pharyngeal System (3.7 mm catheter), Medtronic ManoScan ESO HRM System (4.2 mm catheter)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Deglutition Disorders, Lateral Medullary Syndrome
Cortical Function Changes During Swallowing in Patients With Dysphagia in Lateral Medullary Syndrome
The goal of this observational study is to detect the alteration of cortical activation and functional connectivity during swallowing in patients with Lateral Medullary Syndrome (LMS) dysphagia by functional near infrared…
- Trial name
- NCT06208020
- Testing
- Functional near-infrared spectroscopy (fNIRS) detection
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Barrett's Esophagus, GERD
Barrett's Esophagus & Gastroesophageal Reflux Disease
This is a study of Barrett's Esophagus (BE) and Gastroesophageal Reflux Disease (GERD). It aims to look at the long term efficacy of evidence-based cutting edge diagnostic and therapeutic algorithms and techniques such as…
- Trial name
- NCT00513331
- Testing
- Endoscopy, Radiofrequency ablation protocol, Endoscopic mucosal resection protocol
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Valley Health System
Gastroesophageal Reflux Disease
Prevalence of EED and Quality of Life Evaluated by Gastroesophageal Reflux Disease (GERD)-Q in Korean GERD Patients
The purpose of this study is to asses the EED symptom prevalence in Koran GERD patients with typical reflux symptom and to evaluate quality of life with the scales including Gerd Q.
- Trial name
- Preedom (NCT00768196)
- Where
- 4 sites in South Korea
- Volunteers
- 2,000 people
- Sponsor
- AstraZeneca
Laryngeal Carcinoma, Bilateral Vocal Cord Paresis
Thulium Contact Laser of Laryngotracheal Stenosis
The purpose of the study is to compare results of the treatment of tumorous and non-tumorous laryngotracheal stenosis using thulium contact laser versus carbon dioxide laser used in the past.
- Conditions
- Laryngeal Carcinoma, Bilateral Vocal Cord Paresis, Subglottic Stenosis
- Trial name
- NCT02587546
- Testing
- laryngeal carcinoma, bilateral vocal cord paralysis, subglottic stenosis
- Where
- Czechia
- Volunteers
- 31 people
- Sponsor
- University Hospital Ostrava
Gastroparesis, Gastroesophageal Reflux
Domperidone for Gastroparesis in Solid Organ Transplantation
The purpose of this study is to examine the clinical response to domperidone in solid organ transplant recipients with gastroparesis.
- Trial name
- NCT00552422
- Testing
- domperidone
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- David J. Lederer, M.D.
Toothless
TOngue/Palate Interactions Study
The project aims to assess the effect of a complete denture of new denture wearers on speech production using sensors placed inside a duplicate of the prosthesis according to the technique described in the PRESLA system.
- Trial name
- EEXPLORE (NCT03966131)
- Testing
- Tongue pressure recordings with the PRESLA prothesis for the Arm1 (patients wearing the complete denture for the first time), Tongue pressure recordings with the PRESLA prothesis for the Arm2 (patients used to wear the complete denture)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Gastroesophageal Reflux Disease
Symptom Assessment for GERD Patients Receiving H. Pylori Eradication
Background: Rebound acid hypersecretion and acid-related symptoms after discontinuation of proton-pump inhibitor has been reported in previous studies.
- Trial name
- NCT01249482
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Dysphagia, NeuroMuscular Electrical Stimulation
Effectiveness of Transcutaneous NMES as an Adjunct for Swallowing Disorders in Tracheotomized Patients
Dysphagia can reach a prevalence of up to 80% in intensive care patients. The implementation or prolonged presence of medical devices such as the intubation tube, tracheostomy, or nasogastric tube alters the physiology of…
- Trial name
- SWALEC (NCT07529210)
- Testing
- Neuromuscular Electrical Stimulation (NMES)
- Volunteers
- 238 people
- Sponsor
- Hopital Forcilles
Omentopexy, Sleeve Gastrectomy
De Novo Gastroesophageal Reflux Disease After Sleeve Gastrectomy With and Without Omentopexy
The goal of this clinical trial is to compare the effects of sleeve gastrectomy with and without omentopexy on gastroesophageal reflux disease (GERD) in patients with obesity.
- Conditions
- Omentopexy, Sleeve Gastrectomy, Gastroesophageal Reflux Disease
- Trial name
- NCT07854613
- Testing
- Sleeve Gastrectomy With Omentopexy, Sleeve Gastrectomy Without Omentopexy
- Where
- China
- Volunteers
- 140 people
- Sponsor
- China-Japan Friendship Hospital
Cerebral Palsy
Home-Based Action Observation Training for Chewing and Swallowing Function
This study is a two-part randomized controlled trial designed to investigate the effects of home-based Action Observation Training (AOT) combined with Functional Chewing Training (FuCT) in children with Cerebral Palsy (CP) who…
- Trial name
- NCT06268223
- Testing
- Functional Chewing Exercise, Action Observation Training
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Ondokuz Mayıs University
Stroke Sequelae, Deglutition Disorders
Effects of Different-Frequency Electroacupuncture on Suprahyoid Muscles in Post-Stroke Dysphagia: Efficacy and Neural Networks
This randomized controlled study in patients with post-stroke dysphagia aims to determine the optimal stimulation frequency of electroacupuncture of the suprahyoid muscles and to elucidate the underlying neural mechanisms.
- Conditions
- Stroke Sequelae, Deglutition Disorders, Acupuncture Therapy, Electroacupuncture
- Trial name
- NCT07496762
- Testing
- Low Frequency EA, Medium Frequency EA, High Frequency EA
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Kaili Chen
Esophageal Achalasia, Esophageal Motility Disorders
POEM Versus Laparoscopic Heller Myotomy With Dor Fundoplication for Esophageal Achalasia
Achalasia is a disorder of the esophagus in which the muscular valve between the esophagus and the stomach fails to relax, and the body of the esophagus loses its normal coordinated squeezing movement.
- Conditions
- Esophageal Achalasia, Esophageal Motility Disorders, Gastroesophageal Reflux
- Trial name
- POEM-HD (NCT07814027)
- Testing
- Peroral endoscopic myotomy, Laparoscopic Heller myotomy with Dor fundoplication
- Where
- Egypt
- Volunteers
- 220 people
- Sponsor
- Minia University
Gastro Esophageal Reflux
A Placebo Controlled Trial With Baclofen for the Treatment of GERD Patients With Incomplete PPI Response
Reflux (acid and non-acid) mainly occurs during transient LES relaxations (TLESRs). The gamma-aminobutyric acid (GABA) receptor type B agonist baclofen was shown to inhibit TLESRs, thereby significantly decreasing acid reflux…
- Trial name
- NCT03835442
- Testing
- Baclofen
- Volunteers
- 60 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gastroesophageal Reflux Disease
Detection of Minimal Change Esophagitis Using Confocal Laser Endomicroscopy
This is an observational, prospective and pilot study to determine through confocal endomicroscopy diagnostic microscopic features detectable at the gastroesophageal junction of patients with non-erosive gastroesophageal reflux…
- Trial name
- NCT00954070
- Testing
- Confocal endomicroscope (Pentax Model EC3870K)
- Where
- Singapore
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Gastroesophageal Reflux, Dysphagia
Establishing Pressures at the EGJ During Diaphragmatic Breathing Using High-resolution Esophageal Manometry
The goal of this study is to determine which position, maneuvers or combination thereof generates the highest pressure at the EGJ as assessed by high-resolution esophageal manometry and thus greater or more robust contraction of…
- Conditions
- Gastroesophageal Reflux, Dysphagia, Esophageal Motility Disorders
- Trial name
- NCT06329583
- Testing
- diaphragmatic breathing
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Dysphagia
Dysphagia Following Anterior Cervical Spine Surgery; Single Dose Steroid vs Saline (DysDexVSSal)
This prospective, randomized, double blind, controlled study evaluates the effect of a single dose of perioperative IV steroid versus saline on swallowing after anterior cervical spine surgery
- Trial name
- NCT03711474
- Testing
- Dexamethasone, Saline
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Achalasia, Esophageal, Achalasia
The Use of Indocyanine Green Fluorescence (ICG) During Laparoscopic Heller- Dor
The aim this prospective observational study is to evaluate the role of Indocyanine Green Fluorescence (ICG) in patients with achalasia underwent to Heller-Dor laparoscopic.
- Conditions
- Achalasia, Esophageal, Achalasia, Indocyanine Green (ICG), Indocyanine Green
- Trial name
- NCT07181070
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Federico II University
Non Erosive Reflux Disease, GERD
Minimal Injuries From Esophagus Detected by Optical Enhancement System™ Associated to Optical Magnification HD Scopes
White light endoscopy remains the gold standard technique to evaluate gastrointestinal tract. Gastroesophageal Reflux Disease (GERD) is defined as presence of reflux symptoms (heartburn and regurgitation) associated or not with…
- Trial name
- NCT02575287
- Testing
- Optical Enhancement, Optical Enhancement with optical magnification, Optical magnification without Optical enhancement
- Where
- Ecuador
- Volunteers
- 100 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
GERD (Gastroesophageal Reflux Disease)
Evaluating Medication Adherence of Patients With Gastroesophageal Reflux Disease With Support of the Smartphone Application GERDCare
Adherence to GERD treatment, including medication, diet, and lifestyle, is essential for symptom control and complication prevention, yet adherence rates remain low due to various demographic and clinical factors.
- Trial name
- AppGERD (NCT07125521)
- Testing
- GERCCare mobile app
- Where
- Vietnam
- Volunteers
- 380 people
- Sponsor
- Institute of Gastroenterology and Hepatology, Vietnam
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