Clinical trials: DEGLUTİTİON
Achalasia
Peroral Endoscopic Myotomy (POEM) for Esophageal Motility
The investigators wish to monitor the adoption of a new, incisionless approach to performing a Heller myotomy for the surgical treatment of achalasia.
- Trial name
- POEM (NCT02314741)
- Testing
- POEM Procedure
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Consciousness Disorders, Severe Acquired Brain Injury
Cross-cultural Adaptation and Multicenter Validation of the Italian Versions of the Brief Evaluation of Receptive Aphasia (BERA) and SWallowing Assessment in Disorders of Consciousness (SWADOC)
Patients with severe acquired brain injury may evolve from coma into prolonged disorders of consciousness. In these patients, residual language comprehension and swallowing abilities are difficult to evaluate because standard…
- Trial name
- NCT07711119
- Testing
- Italian SWallowing Assessment in Disorders of Consciousness (SWADOC), Italian Brief Evaluation of Receptive Aphasia (BERA)
- Where
- 4 sites in Italy
- Volunteers
- 79 people
- Sponsor
- Alfonso Magliacano
Head and Neck Cancer
Acute and Longlasting Side Effects Caused by Radiotherapy in the Head and Neck Area
The purpose of this clinical investigation is to evaluate acute and longlasting side effects in patients undergoing radiotherapy for cancer treatment in the head and neck area.
- Trial name
- NCT00995319
- Where
- Norway
- Volunteers
- 58 people
- Sponsor
- Norwegian University of Science and Technology
Gastroesophageal Reflux Disease
Cognitive Behavioral Therapy for Insomnia (CBTI) in GERD Patients With Insomnia
This study will enroll patients with persistent reflux symptoms despite proton-pump inhibitor therapy and chronic insomnia. Participants that are eligible for the study and agree to participate will receive cognitive behavioral…
- Trial name
- NCT03904472
- Testing
- Web-based CBTI
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Michigan
Esophageal Achalasia
Snare-assisted POEM for Treatment of Esophageal Achalasia
POEM is a new intervention for the treatment of achalasia and has been reported to relieve the dysphagia symptom effectively. Although the cost of POEM method is less than the method of Laparoscopic Heller Myotomy and…
- Trial name
- NCT02999451
- Testing
- snare-assisted POEM, knife-assisted POEM
- Where
- China
- Volunteers
- 75 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Gastroesophageal Reflux Disease (GERD)
Partial Response to Proton Pump Inhibitors (PPI) Treatment: The Cost to Society and the Burden to the Patient - a Study in the US
The purpose of this study is to describe common treatment pathways, to collect health care utilization data and to assess symptom load as well as impact of symptoms on daily life in GERD patients who are partial-responders to PPI…
- Trial name
- REMAIN (NCT00795093)
- Where
- 53 sites in United States
- Volunteers
- 552 people
- Sponsor
- AstraZeneca
Gastro Oesophageal Reflux Disease
Influence of Wrap Fixation Technique on the Results of Fundoplication
Patients who underwent anti-reflux surgery were divided into two groups. In the I group Nissen fundoplication was supplemented with suturing wrap to the crura or the body of stomach using two non-absorbable stitches on each side.
- Trial name
- NCT04335734
- Testing
- Nissen Fundoplication with wrap fixation, Nissen Fundoplication without wrap fixation
- Volunteers
- 138 people
- Sponsor
- Grubnik Volodymyr
Pharyngeal Dysphagia, Dysphagia
External Pharyngeal Exerciser for Dysphagia
Pharyngeal muscle weakness and dysphagia is common in individuals post-stroke or with Parkinson's disease and in individuals with head/neck cancer who have undergone surgery and/or radiation therapy.
- Conditions
- Pharyngeal Dysphagia, Dysphagia, Oral Pharyngeal Dysphagia
- Trial name
- NCT05267314
- Testing
- pharyngeal exerciser + standard therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Southern California
Barrett Esophagus, GERD
Non-endoscopic Esophageal Sampling to Detect Barrett's Esophagus and Esophageal Cancer in Veterans
This study seeks to incorporate non-endoscopic detection method (Esocheck/Esoguard) in primary care practice and test whether this screening modality increases the positive predictive value of upper endoscopy and increases the…
- Conditions
- Barrett Esophagus, GERD, Obesity, Esophageal Cancer
- Trial name
- NCT05210049
- Testing
- Esocheck/Esoguard
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Louis Stokes VA Medical Center
Gastro Esophageal Reflux Disease, Dyspepsia
Spirulina Platensis for PPI Withdrawal
Background: Rebound acid hypersecretion after proton pump inhibitors (PPIs) discontinuation may be accompanied by dyspepsia. Aim: To assess whether Spirulina platensis, by its anti-inflammatory properties, could minimize rebound…
- Conditions
- Gastro Esophageal Reflux Disease, Dyspepsia, Rebound Acid Hypersecretion
- Trial name
- SpAReDPPI (NCT04988347)
- Testing
- Spirulina platensis
- Volunteers
- 45 people
- Sponsor
- Universidade de Passo Fundo
Reflux Disease, Gastro-Esophageal
Breathing Exercises in Patients With Gastroesophageal Reflux
The aim of this study was to examine the effects of diaphragmatic breathing exercises combined with relaxation exercises on patient-reported reflux symptoms, quality of life, anxiety, and depression levels in patients diagnosed…
- Trial name
- NCT06812650
- Testing
- Medical treatment, Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Karabuk University
Gastroesophageal Reflux Disease
Antireflux Ablation of the Cardia Mucosa vs Placebo for the Treatment of Gastroesophageal Reflux Disease
The ARMA technique improves GORD-related quality of life with a low proportion of adverse effects.
- Trial name
- NCT04711655
- Testing
- ARMA (antireflux ablation of the cardiac mucosa), upper digestive endoscopy
- Where
- 9 sites in Spain
- Volunteers
- 64 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Obesity
Study of Stomatognathic System of the Obese Subjects
The aim is to identify differences in the stomatognathic system, mastication and deglutition functions between obese and normal weight subjects.
- Trial name
- SSSCDFO (NCT00868049)
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Deglutition, Healthy Swallowing
Physiological Flow of Liquids in Healthy Swallowing
Thickened liquids are commonly used as an intervention for people with dysphagia (swallowing impairment). However, the field currently lacks a proper understanding of how this intervention works.
- Conditions
- Deglutition, Healthy Swallowing, Aging
- Trial name
- NCT04114617
- Testing
- Starch-thickened liquids, Xanthan-gum thickened liquids, Barium concentration
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Pharyngeal Cancer, Swallowing Disorder
Evaluation of the French Translation of Swallowing (SOAL-VF) Patient Reported Outcomes (PRO) After Total PharyngoLaryngectomy
A monocentric study to evaluate the french translation of Swallowing (SOAL-VF) Patient Reported Outcomes (PRO) after Total PharyngoLaryngectomy
- Conditions
- Pharyngeal Cancer, Swallowing Disorder, Larynx Cancer
- Trial name
- SOAL-VF (NCT05497947)
- Where
- France
- Volunteers
- 225 people
- Sponsor
- Centre Hospitalier de Valence
Patient Satisfaction, Relapse
Long-term Follow-up After Surgical Treatment for GERD (Gastroesophageal Reflux Disease)
10 years of follow-up with SF-36 global (Quality of Life issues), GSRS (Gastrointestinal Symptom Rating Scale) and two reflux specific questionnaires.
- Conditions
- Patient Satisfaction, Relapse, Dysphagia, Bloating
- Trial name
- NCT04182178
- Testing
- 10 years follow up
- Where
- Sweden
- Volunteers
- 307 people
- Sponsor
- Karolinska Institutet
Gastroesophageal Reflux, Obesity
Laparoscopic Roux-en-Y Gastric Bypass and Gastro-esophageal Reflux
Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) is considered the weight loss procedure of choice for patients suffering of gastro-esophageal reflux (GER).
- Trial name
- NCT02618044
- Volunteers
- 86 people
- Sponsor
- University of Turin, Italy
Achalasia, Gastroesophageal Reflux
ARAT for Reflux Disease After Peroral Endoscopic Myotomy in Patients With Achalasia
The peroral endoscopic myotomy for the treatment of achalasia is associated with a higher incidence of gastroesophageal reflux disease compared with Heller's myotomy.
- Trial name
- ARAT (NCT04065516)
- Testing
- ARAT technique
- Where
- Mexico
- Volunteers
- 44 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Gastro-Esophageal Reflux, Fundoplication
Health, Economic Analysis and Clinical Aspects of Patients With Neurological Disabilities in Enteral Nutrition With Dedicated Formula. The Role of Nissen's Fundoplication in the Management of Gastroesophageal Reflux
Nutritional difficulties are common in children with neurodisabilities and can be associated with malnutrition and gastrointestinal diseases, such as gastro-esophageal reflux disease (GERD) and constipation.
- Trial name
- NCT05068089
- Testing
- Nissen fundoplication, Enteral nutrition
- Where
- Italy
- Volunteers
- 360 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Gastroesophageal Reflux Disease, Gastrointestinal Infections
LGG for Prevention of Infectious Complications During PPI Treatment in Children
Background: Proton pump inhibitors (PPI) are effective for treating gastroesophageal reflux disease (GERD). However, they may be associated with an increased risk of gastrointestinal and respiratory tract infections.
- Conditions
- Gastroesophageal Reflux Disease, Gastrointestinal Infections, Respiratory Tract Infections
- Trial name
- NCT01782118
- Testing
- Lactobacillus GG
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Medical University of Warsaw
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