Clinical trials: DEGLUTİTİON
Dysphagia
The Impact of Intermittent Nutritional Tube Supplementation in Elderly Patients With Dysphagia
This is a prospective, randomized controlled clinical trail involved Elderly Patients With Dysphagia.The goal of this clinical trial is to compare the clinical effect of Intermittent Oro-esophageal Tube Feeding in Elderly…
- Trial name
- NCT06362109
- Testing
- Routine rehabilitation, Intermittent Oro-esophageal Tube Feeding
- Volunteers
- 80 people
- Sponsor
- Zhao Song Ling
Dysphagia
Nutrition Tubes on Sleep Quality in Stroke-related Dysphagia
Palliation to stroke-related dysphagia continues to be a challenge. Although nasogastric tube feeding (NGT) has been adopted widely, the weaknesses have yet to be improved by another enteral nutrition support mode.
- Trial name
- NCT06662344
- Testing
- Intermittent Oral-esophageal Tube Feeding, Nasogastric Tube Feeding, comprehensive rehabilitation therapy
- Volunteers
- 140 people
- Sponsor
- Babujinaya Cela
Laryngopharyngeal Reflux
Fosamprenavir for Laryngopharyngeal Upper Airway Tissue Treatment and Enzyme Reduction
Laryngopharyngeal Reflux (LPR) is a common condition that causes symptoms like chronic cough, throat clearing, hoarseness, and trouble swallowing.
- Trial name
- FLUTTER (NCT04383262)
- Testing
- Fosamprenavir Calcium
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Medical College of Wisconsin
Patients Receiving Radiotherapy for Nasopharyngeal Carcinoma Diagnosis, Ultrasonography and Shear Wave Elastography
Evaluation of Swallowing Muscles Using Ultrasonography and Shear Wave Elastography in Patients Receiving Radiotherapy for Nasopharyngeal Carcinoma Diagnosis
The aim of this study is to evaluate the mylohyoid, geniohyoid and digastric muscles in patients with radiotherapy-induced dysphagia due to nasopharynx cancer using ultrasonography and shear wave elastography (SWE).
- Conditions
- Patients Receiving Radiotherapy for Nasopharyngeal Carcinoma Diagnosis, Ultrasonography and Shear Wave Elastography, Evaluation of Swallowing Muscles
- Trial name
- NCT06934837
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Konya Beyhekim Training and Research Hospital
Gastroesophageal Reflux
Validation of RDQ Questionnaire
The primary objective of this study is to determine the accuracy of the Reflux Disease Questionnaire (RDQ) as a diagnostic test for gastroesophageal reflux disease.
- Trial name
- NCT00291746
- Testing
- Esomeprazole, Bravo technique
- Where
- 30 sites in Canada, Denmark and 4 more
- Volunteers
- 350 people
- Sponsor
- AstraZeneca
Spatial Neglect, Dysphagia
Identifying and Treating Arousal Related Deficits in Neglect and Dysphagia
The purpose of this study is to examine how stroke can alter arousal, alertness, neglect and dysphagia, and whether a medication, modafinil, can improve arousal.
- Trial name
- NCT01085903
- Testing
- Modafinil, Baseline, CPS
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Arkansas
Down Syndrome
Effects of Orofacial Therapy and Therapeutic Yoga in Children With Down Syndrome
The study aims to compare the effects of orofacial therapy and therapeutic yoga on swallowing, sleep habits, and quality of life in children with Down syndrome.
- Trial name
- NCT06352151
- Testing
- Routine Physiotherapy Group, Orofacial Treatment Group, Therapeutic Yoga Group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hasan Kalyoncu University
Deglutition Disorders
Effect of Oral Menthol on the Swallow Response of Patients With Oropharyngeal Dysphagia Associated With Neurological Diseases and Aging
Oropharyngeal dysphagia (OD) is the most frequent digestive disorder in older people (>70 years) and has been recently recognized as a geriatric syndrome.
- Trial name
- NCT03050957
- Testing
- menthol
- Volunteers
- 38 people
- Sponsor
- Hospital de Mataró
Dysphagia
Translation of the Sydney Swallow Questionnaire and Validation of the German Version
Translation of a validated questionnaire (SSQ) from english to german and validation of the german version. The SSQ consists of 17 well-structured questions for the assessment and quantification of patient reported difficulties…
- Trial name
- NCT01965964
- Testing
- Questionnaire
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Refractory Chronic Cough
Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough
This research study is evaluating the effectiveness of escalating doses of Amitriptyline and Duloxetine in reducing cough frequency in patients with refractory chronic cough (RCC)
- Trial name
- MACS-1 (NCT05110144)
- Testing
- Duloxetine 30 MG, Duloxetine 60 MG, Amitriptyline 25 MG
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Achalasia, GORD
vMII for Measurement of Oesophageal Bolus Transport and Reflux
Recent work at St. Thomas' has validated an innovative new design of a multichannel intraluminal impedance (MII) catheter that is sensitive to variation in oesophageal volume in healthy volunteers and patients.
- Trial name
- vMII (NCT00604942)
- Testing
- Heller's Myotomy, Nissen Fundoplication, domperidone or esomeprazole (Conservative management)
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chest Pain Rule Out Myocardial Infarction
PPI's and SSRI's Therapy for the Management of NCCP
Non cardiac chest pain (NCCP) is defined as recurring, angina-like, retrosternal chest pain of non cardiac origin. Annual prevalence of NCCP in the general population of the western world ranges from 25-35%.
- Trial name
- NCCP (NCT02825342)
- Testing
- Citalopram
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Evangelismos Hospital
Scleroderma Lung
Scleroderma Lung: Role of Gastroesophageal Reflux, Microaspiration and Cough
This is a mechanistic research study to evaluate the relationship between cough, reflux, and aspiration in patients with systemic sclerosis (scleroderma).
- Trial name
- NCT01667042
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Mayo Clinic
Gastroesophageal Reflux, Dysphagia
Establishing Pressures at the EGJ During Diaphragmatic Breathing Using High-resolution Esophageal Manometry
The goal of this study is to determine which position, maneuvers or combination thereof generates the highest pressure at the EGJ as assessed by high-resolution esophageal manometry and thus greater or more robust contraction of…
- Conditions
- Gastroesophageal Reflux, Dysphagia, Esophageal Motility Disorders
- Trial name
- NCT06329583
- Testing
- diaphragmatic breathing
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Dysphagia
Effect of Oral Neuromuscular Training on Swallowing
In this randomized controlled trial the investigators wish to investigate the effect of an oral neuromuscular training device (called IQoro) on swallowing function and time until decannulation from a tracheostomy tube, in…
- Trial name
- NCT05235282
- Testing
- IQoro, Usual care for swallowing function
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- University of Aarhus
Physical Therapy
Feasibility Of Oral Sensorimotor Stimulation On Oropharyngeal Dysphagia In Children With Spastic Cerebral Palsy
Children with CP encounter swallow and feeding impairments, especially in infancy and childhood with long meal times with late development of oral motor skills resulting in poor growth.
- Trial name
- NCT04524559
- Testing
- conventional physical therapy training, oral motor training.
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Cairo University
Swallowing Disorder, Chewing Problem
Chewing and Swallowing Training Program in Coffin-Lowry Syndrome
This study will report the chewing and swallowing disorders of a Coffin-Lowry Syndrome (CLS) patient, and effects of chewing and swallowing training on chewing and swallowing function.
- Trial name
- NCT04199546
- Testing
- Chewing and swallowing rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Hacettepe University
GERD
Study of the NDO Endoscopic Plication System For the Treatment of Symptomatic Gastroesophageal Reflux Disease
The purpose of this prospective, multicenter study was to evaluate the safety and efficacy of endoscopic full-thickness plication for the treatment of symptomatic gastroesophageal reflux.
- Trial name
- NCT00587522
- Testing
- NDO Full-thickness Plicator
- Where
- 7 sites in United States, Canada
- Volunteers
- 64 people
- Sponsor
- NDO Surgical, Inc.
GERD
Nexium (Esomeprazole) in Symptom Adapted Therapy in GERD Patients
To compare the efficacy of three different long-term treatment strategies of reflux disease in primary care setting.
- Trial name
- MAESTRO (NCT00444275)
- Testing
- esomeprazole (Nexium®), Xolaam®
- Where
- France
- Volunteers
- 3,029 people
- Sponsor
- AstraZeneca
Pharmacokinetics, Cardiodynamic ECG
A Study to Investigate the Pharmacokinetics and ECG Effects of Linaprazan Glurate
This is a Phase I, single-center, double blind, placebo-controlled, parallel-group, randomized trial designed to evaluate the PK, cardiodynamic ECG effects, safety, and tolerability of single oral doses of linaprazan glurate.
- Conditions
- Pharmacokinetics, Cardiodynamic ECG, Safety, and Tolerability, GERD
- Trial name
- NCT05469854
- Testing
- Linaprazan glurate
- Where
- Sweden
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Cinclus Pharma Holding AB
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