Clinical trials: DM
Advanced Cancer
DM-CHOC-PEN Plus Radiation for Brain Tumors
4-Demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) is a polychlorinated pyridyl cholesterol carbonate that is lipophilic, electrically neural, crosses the blood brain barrier (BBB), ability to localize in intracranial…
- Trial name
- NCT03371004
- Testing
- 4-Demethyl-4-cholesteryloxycarbonylpenclomedine
- Where
- 3 sites in United States
- Volunteers
- 19 people
- Sponsor
- DEKK-TEC, Inc.
Diabetic Nephropathy
Efficacy of Telmisartan and the Combination of Telmisartan and Ramipril in type1 Diabetes Patients With Nephropathy
Hypothesis: The angiotensin receptor blocker telmisartan is effective at reduction of albumin excretion rate(AER) in patients with type1 diabetes and micro or macroalbuminuria.
- Trial name
- START1DM (NCT00738660)
- Testing
- Telmisartan, Ramipril
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Type 2 Diabetes Mellitus
Effect of Internet Therapeutic Intervention on A1C Levels in Type 2 Diabetes Mellitus (DM) on Monotherapy
This project will test the effectiveness of an Internet based glucose monitoring system on the A1C levels of patients with type 2 diabetes.
- Trial name
- NCT01044368
- Testing
- Internet Intervention
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Endocrine Research Society
Diabetes (DM), Diabetic Ketoacidosis
Phase 1 Trial of Arginine Hydrochloride for the Management of Diabetic Ketoacidosis in Type 2 Diabetes
Diabetic ketoacidosis (DKA) is increasingly recognized in adults with "ketone-prone" type 2 diabetes. In many of these patients, the pancreas can still make insulin but becomes temporarily "stunned" during severe, prolonged high…
- Conditions
- Diabetes (DM), Diabetic Ketoacidosis, Ketosis Prone Diabetes, Hyperglycaemia (Diabetic)
- Trial name
- NCT07167693
- Testing
- Arginine hydrochloride, Sodium Chloride 0.9%
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- David K Carroll
Type II Diabetes Mellitus
The Use of a Computer Program to Help Primary Care Providers Treat Patients With Type 2 Diabetes
The primary purpose of this study is to determine whether the use of CADS by primary care providers (PCPs) for their patients with type 2 diabetes (T2DM) changes the quality of care relative to a "usual care" group in terms of…
- Trial name
- CADS (NCT01648244)
- Testing
- Computer-Assisted Decision Support
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Walter Reed National Military Medical Center
Type 2 Diabetes, Diabetic Cardiomyopathy
NT-ProBNP-based Heart Failure Screening and Prevention Trial in Patients With Type 2 Diabetes: STRONG-DM Study
A pragmatic, randomized clinical trial to evaluate the effect of a heart failure (HF) risk assessment and prevention strategy incorporating HF clinical risk scores (WATCH-DM) with cardiac biomarker (NT-proBNP) paired with a…
- Conditions
- Type 2 Diabetes, Diabetic Cardiomyopathy, Heart Failure, Cardiometabolic Diseases
- Trial name
- STRONG-DM (NCT06593327)
- Testing
- Intensive Prevention Strategy
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Schizophrenia
Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Residual Schizophrenia
The objectives of this 12-week study are to evaluate the efficacy, safety, and tolerability of AVP-786 as an adjunctive treatment compared with placebo in patients with residual schizophrenia.
- Trial name
- NCT02477670
- Testing
- AVP-786
- Where
- 17 sites in United States
- Volunteers
- 145 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Gestational Diabetes, Diabetes, Gestational
Gestational Diabetes: a Cohort Study
Gestational diabetes (GDM) is the most common hormonal complication during pregnancy. Its occurrence implies an increased risk of maternal and fetal complications and, therefore, its diagnosis and treatment are extremely…
- Conditions
- Gestational Diabetes, Diabetes, Gestational, Diabetes Mellitus in Pregnancy, Diabetes Mellitus, Type 2
- Trial name
- NCT03307486
- Where
- Brazil
- Volunteers
- 1,400 people
- Sponsor
- University of Sao Paulo General Hospital
Myositis
Investigating Genes in Patients With Polymyositis and Dermatomyositis
Polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM)belong to a group of inflammatory muscle disorders, of unknown cause, that are characterised by skeletal muscle inflammation and progressive muscular…
- Trial name
- UKMYONET (NCT01171573)
- Testing
- Venepuncture
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Northern Care Alliance NHS Foundation Trust
Chronic Obstructive Pulmonary Disease, Type 2 Diabetes
Interactive Tool to Support Self-management Through Lifestyle Feedback, Aimed at Physical Activity of COPD/DM Patients
Rationale: Physical activity is an important factor for a healthy lifestyle. Although physical activity can delay complications and decrease the burden of the disease in chronically ill persons, their level of activity is often…
- Trial name
- RCTIt'sLiFe! (NCT01867970)
- Testing
- Tool, Self-management Support Program
- Where
- Netherlands
- Volunteers
- 240 people
- Sponsor
- Maastricht University Medical Center
Type 2 Diabetes
Financial Incentives And Nurse Coaching to Enhance Diabetes Outcomes (FINANCE-DM)-1
The objective of this protocol is to answer the questions: 1) Are financial incentives layered upon nurse education and home telemonitoring superior to nurse education and home telemonitoring alone in improving metabolic control…
- Trial name
- FINANCE-DM (NCT04203173)
- Testing
- FINANCE-DM, Active Comparator
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- State University of New York at Buffalo
NAFLD
HOMA-IR as a Screening Test in NAFLD
The aim of this study is to evaluate the role of HOMA-IR in diagnosis of NAFLD in patients with type 2 DM.
- Trial name
- NCT04084925
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Fayoum University
Dermatomyositis (DM), Juvenile Dermatomyositis (JDM)
FAST for DM - Fatty Acid Supplementation Trial (FAST) for Dermatomyositis (DM)
Dermatomyositis (DM) is a rare autoimmune disease that causes muscle weakness, skin rashes, and other symptoms. Researchers think both genetic and environmental factors play a role in this disease.
- Trial name
- NCT07111065
- Testing
- FISH OIL 500MG OMEGA-3 SOFT GEL MINIS
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Type 2 Diabetes
Dynamic Responsiveness of Insulin Secretory Parameters To Sitagliptin and Glimeperide Administration in Type 2 DM
A multi-year clinical study to improve tools for measuring the function of insulin-producing beta cells in people with type 2 diabetes mellitus.
- Trial name
- NCT02443922
- Testing
- Glimepiride, Sitagliptin, Metformin
- Volunteers
- 100 people
- Sponsor
- Foundation for the National Institutes of Health
Periodontitis Stage III, Periodontitis Stage IV
Blood Glucose Screening in Patients With Advanced Periodontits: the Role of Specialist Periodontal Care in Identifying Hyperglycaemia and Supporting Patient Centered Treatment
Periodontitis is a chronic inflammatory disease and individuals with advanced periodontitis have an increased risk of hyperglycaemia.
- Conditions
- Periodontitis Stage III, Periodontitis Stage IV, Diabetes (DM), Prediabetes
- Trial name
- NCT07426224
- Testing
- Selective screening of blood glucose/HbA1c
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Folktandvården Stockholms län AB
Primary Total Hip Arthroplasty
Retrospective Observational Cohort Study of SYMBOL CUP DM 1
This is a single-center retrospective observational cohort study of consecutively operated patients who underwent primary total hip arthroplasty with a SYMBOL CUP DM HA hemispherical dual mobility acetabular implant.
- Trial name
- SYMCOR-1 (NCT04209374)
- Testing
- THA with SYMBOL CUP DM HA
- Where
- France
- Volunteers
- 59 people
- Sponsor
- Dedienne Sante S.A.S.
Diabetes Mellitus, Type 2
RF Vapor Ablation Retreatment of Duodenal Mucosa in Non-responders With Type-2 Diabetes Mellitus
The purpose of this study is to test the hypothesis that re-treatment of the duodenal mucosa with RF vapor ablation will result in improvement in glycemic parameters, without complications (bleeding/ stricture / perforation)…
- Trial name
- NCT06724822
- Testing
- RF Vapor Ablation
- Where
- Chile
- Volunteers
- 12 people
- Sponsor
- Aqua Medical, Inc.
Type2 Diabetes Mellitus
SGLT-2 Inhibitor and Myocardial Perfusion, Function and Metabolism in T2 DM Patients at High Cardiovascular Risk
Patients with type 2 diabetes (T2 DM) have a markedly increased risk of heart disease and it is estimated that, in the danish population, up 80% percent of patients with type 2 diabetes die from heart disease.
- Trial name
- SIMPLE (NCT03151343)
- Testing
- Empagliflozin
- Where
- Denmark
- Volunteers
- 92 people
- Sponsor
- Caroline M Kistorp
SGLT2 Inhibitors, First Time Use, Type2 Diabetes
First-time Usage of SGLT2 Inhibitors in Type 2 Diabetic Patients Who Are Fasting During Ramadan: Safety and Efficacy
All healthy Muslim adults are required to observe the Ramadan fast, which is one of Islam's five pillars. People with Type 2 Diabetes Mellitus frequently fast throughout Ramadan (T2DM).
- Conditions
- SGLT2 Inhibitors, First Time Use, Type2 Diabetes, Fasting in Ramadan
- Trial name
- NCT06370247
- Testing
- HbA1c, serum creatinine, eGFR urine analysis and serum electrolyte Na and K
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Limbal Stem-cell Deficiency, Congenital Aniridia
Treatment of LSCD With DM
Limbal Stem Cell Deficiency (LSCD) is a blinding disease that accounts for an estimated 15-20% of corneal blindness worldwide. Current treatments are limited.
- Trial name
- NCT05909735
- Testing
- transplantation of a Descemet's Membrane corneal onlay, partial LSCD, transplantation of a Descemet's Membrane corneal onlay, total/near-total LSCD
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Minnesota