Clinical trials: DNA
HPV Infection, HPV 16 Infection
Evaluation of the Q-Pad hrHPV Test System for Identifying Precancer
The EQUIP Study is testing whether high-risk human papillomavirus (hrHPV), the virus that causes most cervical cancers, can be accurately detected from menstrual blood collected at home.
- Conditions
- HPV Infection, HPV 16 Infection, High Risk HPV, Cervical Cancer Screening
- Trial name
- EQUIP (NCT07281599)
- Testing
- Q-Pad hrHPV Test System
- Where
- 3 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Qurasense
Oropharynx Cancer
Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer
This is a trial studying patients with human papilloma virus (HPV) positive oropharyngeal cancer with tumors that can be removed via transoral surgery.
- Trial name
- NCT05388773
- Testing
- therapeutic conventional surgery, laboratory biomarker analysis, quality-of-life assessment
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Heath Skinner
Mitochondrial DNA, Quality of Life
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes
The goal of this pilot clinical trial is to learn if a subtle energy transmission and Tao Calligraphy Mindfulness Practice works to improve mitochondrial DNA.
- Trial name
- NCT07261111
- Testing
- Mindfulness practice with Tao Art (Calligraphy and Song Greatest Love)
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sha Research Foundation
Esophageal Cancer, Recurrence
Predicting Early Tumor Recurrence in Patients With Esophageal Squamous Cell Carcinoma
The prognosis of patients with esophageal squamous cell carcinoma (ESCC) who develop post-operative early tumor recurrence is often relatively poor.
- Conditions
- Esophageal Cancer, Recurrence, DNA Methylation
- Trial name
- NCT06476067
- Testing
- Surgery
- Where
- 2 sites in Japan
- Volunteers
- 150 people
- Sponsor
- City of Hope Medical Center
Esophageal Squamous Cell Carcinoma, Chemotherapy Effect
Predicting Postoperative Chemotherapy Efficacy in Patients With Esophageal Squamous Cell Carcinoma
Esophageal cancer remains a disease with a poor prognosis. Chemotherapy is an important part of its treatment, but there are cases in which chemotherapy is ineffective.
- Conditions
- Esophageal Squamous Cell Carcinoma, Chemotherapy Effect, DNA Methylation
- Trial name
- NCT06490003
- Testing
- Fluoro Uracil
- Where
- Japan
- Volunteers
- 150 people
- Sponsor
- City of Hope Medical Center
Colorectal Cancer (Diagnosis), Non-cancer Controls
Epigenetic Signature for CRC Early Detection
The epiCED is a noninvasive blood-based assay designed for early detection of colorectal cancer (CRC) using circulating cell-free DNA (cfDNA) 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) epigenetic markers.
- Conditions
- Colorectal Cancer (Diagnosis), Non-cancer Controls, DNA Methylation, Cell Free DNA
- Trial name
- epiCED (NCT07224854)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Febrile Seizures, Oxidative Stress
8-OHdG and Oxidative Stress in Febrile Seizures
This prospective case-control study investigates whether serum 8-hydroxy-2'-deoxyguanosine (8-OHdG), an established biomarker of reactive oxygen species-mediated DNA oxidation, is elevated in children with febrile seizures…
- Conditions
- Febrile Seizures, Oxidative Stress, Oxidative DNA Damage
- Trial name
- NCT07660003
- Testing
- Group 1 Health Controls, Group 2 SFC, Group 3 CFC
- Where
- Turkey (Türkiye)
- Volunteers
- 156 people
- Sponsor
- Kayseri City Hospital
Fanconi Anemia, Anemia, Hypoplastic, Congenital
Prenatal Transplantation for Fetuses With Fanconi Anemia
The investigators aim to evaluate the safety and efficacy of in utero hematopoietic stem cell transplantation (IUHSCT) for the treatment of fetuses diagnosed with Fanconi anemia (FA) during pregnancy.
- Conditions
- Fanconi Anemia, Anemia, Hypoplastic, Congenital, Congenital Bone Marrow Failure Syndromes, Bone Marrow Failure Disorders
- Trial name
- NCT07408583
- Testing
- IUHSCT for FA-affected fetuses
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Agnieszka Czechowicz
Epigenetics, DNA Methylation
Methylated Biomarkers of Smoking as a Selection Tool in Participants for Lung Cancer Screening
The MET-SELS study aims to revolutionize how we identify individuals for lung cancer screening by moving beyond the limitations of self-reported smoking history.
- Conditions
- Epigenetics, DNA Methylation, Lung Cancer Screening, Risk Stratification With Biomarker
- Trial name
- MET-SELS (NCT07631624)
- Testing
- DNA-methylation in saliva
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Sperm DNA Fragmentation, Sperm DNA Impact on ART Outcomes
Clinical Thresholds of Double-strand Breaks in Sperm's DNA in ART
The goal of this prospective observational study is to learn about the impact of double-strand sperm DNA fragmentation (dsSDF) on assisted reproductive technology (ART) outcomes and to derive clinically relevant threshold values…
- Trial name
- DSBs (NCT07621991)
- Testing
- LensHooke X12 Device
- Where
- 2 sites in India
- Volunteers
- 484 people, healthy volunteers welcome
- Sponsor
- Indira IVF Hospital Pvt Ltd
DNA Damage, Immune System Disorder
Thinking Zinc: a Study of Zinc Supplements on the Navajo Nation
This is a study to assess the effect of dietary zinc supplementation to mitigate biomarkers of metal toxicity in exposed tribal populations.
- Trial name
- NCT03908736
- Testing
- Zinc Picolinate 15 Mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Infertility (IVF Patients), Oocyte Competence
The EPIC Study: Exploring Paternal Age and the Influence on Blastocyst Culture
This study aims to assess the effect of age of the male partner and the reproductive ability of sperm prepared via sperm selection devices (Zymot) compared to routine embryologist selected sperm after density gradient…
- Conditions
- Infertility (IVF Patients), Oocyte Competence, Sperm DNA Fragmentation, Paternal Age
- Trial name
- EPIC (NCT06629766)
- Testing
- Microfluidic sperm separation device, Density grade centrifugation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Prostate Cancer Metastatic Castration-Resistant, Abnormal DNA Repair
Abiraterone/Prednisone, Olaparib, or Abiraterone/Prednisone + Olaparib in Patients With Metastatic Castration-Resistant Prostate Cancer With DNA Repair Defects
This is a biomarker preselected, randomized, open-label, multicenter, phase II study in men with metastatic castration resistant prostate cancer (mCRPC).
- Conditions
- Prostate Cancer Metastatic Castration-Resistant, Abnormal DNA Repair, Metastatic Prostate Carcinoma, Stage IV Prostate Cancer
- Trial name
- NCT03012321
- Testing
- Olaparib, Abiraterone Acetate, Prednisone
- Where
- 16 sites in United States
- Volunteers
- 70 people
- Sponsor
- Northwestern University
DNA Repair Disorder, Cockayne Syndrome
Natural History Study for DNA Repair Disorders
This will be a single-center, single-arm, non-interventional natural history study to evaluate the longitudinal clinical course, functional outcome measures, and candidate biomarkers for individuals with DNA repair disorders…
- Conditions
- DNA Repair Disorder, Cockayne Syndrome, Xeroderma Pigmentosum, Trichothiodystrophy
- Trial name
- NCT05484570
- Testing
- Interval History, Physical Examination, ECAB Assessment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Endometriosis, Infertility
Pesticides and Infertility: Oxidative Stress Via Circulating Cell-free DNA and Gut/Genital Microbiome Signatures in Women With Endometriosis
This project PestiEndoMicro aims to provide an innovative approach, studying endometriosis under the genital and gut microbiota scope.
- Conditions
- Endometriosis, Infertility, Female Fertility, Cell Free DNA
- Trial name
- PestiEndoMicro (NCT07471373)
- Testing
- Circulating DNA analysis, Vaginal microbiota analysis, Endometrial microbiota analysis
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Prostate Cancer, Metastasis
Targeted Radiotherapy in Androgen-suppressed Prostate Cancer Patients.
This multi-center, phase II trial will be conducted in men with castration resistant prostate cancer. The aim of the TRAP trial is to test whether a new precise radiotherapy technique called stereotactic body radiotherapy (SBRT)…
- Conditions
- Prostate Cancer, Metastasis, Toxicity Due to Radiotherapy, Circulating Tumour DNA
- Trial name
- TRAP (NCT03644303)
- Testing
- SBRT + ADT
- Where
- 7 sites in United Kingdom
- Volunteers
- 86 people
- Sponsor
- Royal Marsden NHS Foundation Trust
ATM Gene Mutation, BRCA1 Gene Mutation
Niraparib Before Surgery in Treating Patients With High Risk Localized Prostate Cancer and DNA Damage Response Defects
This phase II trial studies how well niraparib, when given before surgery, works in treating patients with high risk prostate cancer that has not spread to other parts of the body (localized) and alterations in deoxyribonucleic…
- Conditions
- ATM Gene Mutation, BRCA1 Gene Mutation, BRCA2 Gene Mutation, BRIP1 Gene Mutation
- Trial name
- NCT04030559
- Testing
- Niraparib, Niraparib Tosylate Monohydrate, Radical Prostatectomy
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of California, Davis
Oral Squamous Cell Carcinoma, Maxillo-facial Surgery
Epigenetic Biomarkers in the Saliva for the Diagnosis of Squamous Cells Carcinoma of the Oral Cavity
Head and neck squamous cell carcinoma (HNSCC) are malignant tumors originating from the epithelial mucosa of the upper aerodigestive tract.
- Conditions
- Oral Squamous Cell Carcinoma, Maxillo-facial Surgery, Biomarkers, Saliva
- Trial name
- EPSACO (NCT05791149)
- Testing
- saliva tube
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Herpes Zoster
Long-term Effectiveness of the Live Attenuated Herpes Zoster Vaccine
This is a multicenter retrospective cohort study to evaluate the long-term effectiveness of the live attenuated herpes zoster vaccine within 6 years after vaccination.
- Trial name
- NCT07585370
- Testing
- Attenuated Zoster Vaccine, Live
- Where
- China
- Volunteers
- 24,740 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Circulating Tumor DNA, Recurrence
Circulating Tumor DNA Based Adjuvant Chemotherapy in Stage II Colon Cancer Patients: the MEDOCC-CrEATE Trial
Patients in the Prospective Dutch ColoRectal Cancer cohort (PLCRC) with non-metastatic colon cancer that gave consent for additional blood withdrawals are enrolled in the observational PLCRC-MEDOCC substudy.
- Conditions
- Circulating Tumor DNA, Recurrence, Colon Cancer Stage II
- Trial name
- CrEATE (NCT06434896)
- Testing
- ctDNA analysis after surgery
- Where
- 29 sites in Netherlands
- Volunteers
- 1,320 people
- Sponsor
- UMC Utrecht