Clinical trials: DNA Damage
Periodontitis (Stage 3), Smoking
Determination of RNA/DNA Damage Associated With Oxidative Stress in Periodontitis Patients
This study looked at whether a type of gum disease called Stage III periodontitis and cigarette smoking are linked to higher levels of "oxidative stress." Oxidative stress can damage DNA and RNA, which are important parts of our…
- Trial name
- NCT07279896
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Zehra Hasgül
Polycystic Ovary Syndrome, Chronic Periodontitis
Chronic Periodontitis and Polycystic Ovary Syndrome
Background: The aim of this study was to investigate the levels of malondialdehyde (MDA), total antioxidant status (TAS), 8-hydroxy-2´- deoxyguanosine (8-OHdG) in blood serum and saliva samples in female patients with chronic…
- Trial name
- NCT02954120
- Testing
- no intervention provided
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Infertility
Reduction of Sperm DNA Fragmentation by Oral Ginger
This study is a randomized, double blind, controlled clinical trials assess the efficacy of the ginger oral treatment on sperm DNA fragmentation, sperm parameters and male hormones.
- Trial name
- NCT02032251
- Testing
- oral administration of ginger
- Where
- Iran
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Royan Institute
Healthy Men, Healthy Women
Garlic Intake And Biomarkers Of Cancer Risk
This study is being done to study the healthful benefits of eating garlic. Previous studies suggest that garlic may help prevent cancer.
- Trial name
- NCT01293591
- Testing
- Control, Garlic treatment
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- USDA Beltsville Human Nutrition Research Center
Covid19
DNA Damage and Oxidative Stress in Hospitalized COVID-19 Patients
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic challenging health systems worldwide.
- Trial name
- ABCD (NCT04784468)
- Testing
- No intervention
- Where
- Austria
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Precancerous Condition, Prostate Cancer
Study of Blood Samples From Older Patients at High Risk of Developing Prostate Cancer and From Healthy Male Participants
RATIONALE: Studying samples of blood in the laboratory from patients who are at high risk of developing prostate cancer may help doctors identify biomarkers related to cancer.
- Trial name
- NCT00898274
- Testing
- immunoenzyme technique, laboratory biomarker analysis
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Healthy Adult Participants
Multilevel Exercise Response in Rowers
This observational study aims to evaluate multilevel physiological, molecular, metabolic, intestinal, immunological, and psychophysiological responses to rowing-specific exercise in elite rowers.
- Trial name
- NCT07613619
- Testing
- 2000-m rowing ergometer test, 6000-m rowing ergometer test
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Coronary Atherosclerosis
DNA Damage & Repair Proteins In Patients With Atherosclerotic Coronary Artery Disease
The purpose of this study is: 1. To examine the association between stable and unstable coronary artery disease (CAD) with markers of DNA damage and repair, 2.
- Trial name
- DECODE (NCT02335086)
- Where
- 2 sites in United Kingdom
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Cardiovascular Function, Genotoxicity
Health Effects of Occupational Exposure to Combustion Particles - a Study on Volunteers Performing as Train Conductors
Ambient air pollution is a complex mixture of gaseous pollutants and particulate matter (PM). PM has a recognized important role in human health.
- Trial name
- BioTrack (NCT03104387)
- Testing
- Electric train, Diesel train
- Where
- Denmark
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
DNA Damage, Immune System Disorder
Thinking Zinc: a Study of Zinc Supplements on the Navajo Nation
This is a study to assess the effect of dietary zinc supplementation to mitigate biomarkers of metal toxicity in exposed tribal populations.
- Trial name
- NCT03908736
- Testing
- Zinc Picolinate 15 Mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Smoking, Cigarette Smoking
e-Cigarette - DNA Adducts
This study will examine the level of toxicity of e-cigarette use compared to smokers and nonsmokers including inflammation markers, toxicant and carcinogen exposure.
- Conditions
- Smoking, Cigarette Smoking, Electronic Cigarettes
- Trial name
- NCT03284632
- Where
- United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
DNA Damage, Other Complications Associated With Artificial Fertilization
Polscope Sperm: A Non-invasive Method to Assess DNA Damage in Individual Sperm
The purpose of this study is to find a non-invasive way to discover DNA (deoxyribonucleic acid, which is the genetic material inside your cells) alterations in the sperm's head, in the near future leading us to choose the "good…
- Trial name
- NCT01461395
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of South Florida
DNA Damage, Inflammation
The Effects of Foods on Cell Damage Study
Studies have shown that certain compounds inside vegetables can reduce the risk of cancer. Carrots in particular have an association with reduced incidence of colorectal, bladder and breast cancer.
- Trial name
- NCT02696811
- Testing
- White carrots, Oat biscuits
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Infertility Unexplained, Infertility, Male
Impact of DNA Fragmentation in Sperm on Pregnancy Outcome After Intra-uterine Insemination in a Spontaneous Cycle
Infertility affects about 10% of all couples and is defined by a failure to achieve a clinical pregnancy within a year of regular unprotected sexual intercourse.
- Conditions
- Infertility Unexplained, Infertility, Male, DNA Damage
- Trial name
- NCT03319654
- Testing
- DNA fragmentation by TUNEL assay
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Skin Cancer, Heat Tolerance
Title: ICARUS - Psycho-physiological Profiling of Low and High Heat-resilient Individuals
The escalating environmental heat-stress associated with global warming is a societal challenge with large and potential harmful consequences for humans.
- Conditions
- Skin Cancer, Heat Tolerance, Heat-related Illness, Hyperthermia
- Trial name
- ICARUS (NCT07510061)
- Testing
- Controlled Heat and Ultraviolet Radiation Exposure Protocol
- Where
- 2 sites in Denmark, Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Phantom Limb
Study to Identify the Genetic Variations Associated With Phantom Limb Pain
The purpose of this study is to determine if there is a genetic component to phantom limb pain. DNA will be analyzed for single nucleotide polymorphisms (SNPs) between the control and phantom limb pain group.
- Trial name
- NCT01462448
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 726 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Oxidative Stress, DNA Damage, Radiation Induced
Multi-Nutrient Supplement for Radio-Protection
Exposure to radiation, such as during routine CTs, bone scans, or X-rays, causes oxidative stress which can damage the DNA (your genetic material) within your white blood cells.
- Conditions
- Oxidative Stress, DNA Damage, Radiation Induced, Radiation Exposure
- Trial name
- MNSRP (NCT04781868)
- Testing
- Multi-nutrient supplement
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Coronary Arterial Disease (CAD)
The Effect of Cardiac Rehabilitation on Oxidative DNA Damage and Inflammation in Patients With Coronary Artery Disease
The objective of this study was to determine the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), an indicator of oxidative stress, and to demonstrate oxidative DNA damage in cardiac rehabilitation treatment in patients with…
- Trial name
- NCT06867926
- Testing
- Cardiac rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Cancer
Study for the Liquid Chromatography-mass Spectrometry (LC-MS/MS) Assessment of Oxidative DNA Damage in Relation to Antioxidant Usage
The purpose of this study is to evaluate the basis for the reported good effects of antioxidant supplementation. A blood test using Mass Spectrometry will measure DNA damage which is expected to decrease with antioxidant…
- Trial name
- NCT01038024
- Testing
- 1 tablet composed of antioxidants and minerals
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Oral Cancer, Smoking
Prevention of Oral DNA Damage by Black Raspberries
The purpose of this voluntary research study is to learn about the potential effects that black raspberry (BRB) lozenges may have on reducing the damage caused from cigarette smoke in mouth cells in adult smokers, which may be…
- Conditions
- Oral Cancer, Smoking, DNA Damage, Oxidative Stress
- Trial name
- NCT04372914
- Testing
- BRB Lozenges
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center