Clinical trials: DNA Damage
Cancer
Study for the Liquid Chromatography-mass Spectrometry (LC-MS/MS) Assessment of Oxidative DNA Damage in Relation to Antioxidant Usage
The purpose of this study is to evaluate the basis for the reported good effects of antioxidant supplementation. A blood test using Mass Spectrometry will measure DNA damage which is expected to decrease with antioxidant…
- Trial name
- NCT01038024
- Testing
- 1 tablet composed of antioxidants and minerals
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
DNA Damage, Inflammation
The Effects of Foods on Cell Damage Study
Studies have shown that certain compounds inside vegetables can reduce the risk of cancer. Carrots in particular have an association with reduced incidence of colorectal, bladder and breast cancer.
- Trial name
- NCT02696811
- Testing
- White carrots, Oat biscuits
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Silicosis
DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone)
Silicosis is well-known occupational disease caused by free crystalline silica (silicon dioxide) and is marked by inflammation and pulmonary fibrosis.
- Trial name
- NCT01329003
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Ultraviolet Rays; Injury, DNA Adduct Formation
Quantification of DNA Repair Products in the Urine After Ultraviolet Radiation of the Skin
Purpose of the experiment The investigators know that DNA damage is formed in the skin by sun exposure of the thymine-dimer type. Many of these injuries are repaired and excreted through the urine.
- Conditions
- Ultraviolet Rays; Injury, DNA Adduct Formation, DNA Damage, Radiation Induced, DNA Damage
- Trial name
- NCT05277961
- Testing
- Ultraviolet radiation
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Liver Health
Dietary Intervention Study on Liver Health in Young Adults
This prospective randomized dietary intervention study investigates the effects of two dietary approaches on liver health in young adults over a 12-week period.
- Trial name
- NCT07786831
- Testing
- Mediterranean Diet Intervention, General Healthy Diet Intervention
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hochschule Campus Wien (University of Applied Sciences Campus Vienna)
Oxidative Stress, DNA Damage, Radiation Induced
Multi-Nutrient Supplement for Radio-Protection
Exposure to radiation, such as during routine CTs, bone scans, or X-rays, causes oxidative stress which can damage the DNA (your genetic material) within your white blood cells.
- Conditions
- Oxidative Stress, DNA Damage, Radiation Induced, Radiation Exposure
- Trial name
- MNSRP (NCT04781868)
- Testing
- Multi-nutrient supplement
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
DNA Damage, Other Complications Associated With Artificial Fertilization
Polscope Sperm: A Non-invasive Method to Assess DNA Damage in Individual Sperm
The purpose of this study is to find a non-invasive way to discover DNA (deoxyribonucleic acid, which is the genetic material inside your cells) alterations in the sperm's head, in the near future leading us to choose the "good…
- Trial name
- NCT01461395
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Cardiovascular Function, Genotoxicity
Health Effects of Occupational Exposure to Combustion Particles - a Study on Volunteers Performing as Train Conductors
Ambient air pollution is a complex mixture of gaseous pollutants and particulate matter (PM). PM has a recognized important role in human health.
- Trial name
- BioTrack (NCT03104387)
- Testing
- Electric train, Diesel train
- Where
- Denmark
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Chronic Fatigue
High-dose Ascorbic Acid Intravenous Injection Decreases Mitochondrial DNA Damage in Chronic Fatigue Patients: Randomized-controlled Study
Reactive Oxygen Species (ROS) can cause oxidative damage, resulting in oxidation of lipids, proteins and DNA. In fatigue patients, there are some evidences of oxidative damage to DNA.
- Trial name
- NCT01926132
- Testing
- ascorbic acid 10g/20ml, Normal Saline 150ml
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yonsei University
DNA Damage
Assessment of the Cytotoxic and Genotoxic Effect of Toothpastes With Different Forms of Fluoride on the Buccal Mucosa
The remarkable therapeutic anticaries effect of fluoride is well recognized, but in recent years, toxic effects on the oral mucosa have been discussed.
- Trial name
- NCT05596149
- Testing
- Toothpaste without fluoride, Toothpaste with sodium fluoride, Toothpaste with sodium monofluorophosphate
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Coronary Arterial Disease (CAD)
The Effect of Cardiac Rehabilitation on Oxidative DNA Damage and Inflammation in Patients With Coronary Artery Disease
The objective of this study was to determine the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), an indicator of oxidative stress, and to demonstrate oxidative DNA damage in cardiac rehabilitation treatment in patients with…
- Trial name
- NCT06867926
- Testing
- Cardiac rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Breast Cancer, Long-Term Survivors
Chemotherapy-Induced Changes to Cognition and DNA in Breast Cancer Survivors
The purpose of this study is to learn more about how chemotherapy affects an individual's thinking abilities (cognition). Some research has shown that chemotherapy can cause changes in cognition in breast cancer survivors.
- Trial name
- NCT00496613
- Testing
- Mini-Mental State Exam and Blood draw
- Where
- 3 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Aging, Obesity
Obesity and Aging: Impacts of Nutritional Counseling and Physical Exercise on Telomeres and Senescence Parameters
The study will involve 80 elderly women, 40 eutrophic and 40 obese, divided into four groups, each with n=20. 1) Eutrophic Group (EG) undergoing only nutritional counseling (NC), 2) Eutrophic Group with NC and combined training…
- Conditions
- Aging, Obesity, Nutrition, Exercise
- Trial name
- NCT07479940
- Testing
- Combined Training, Nutritional Counseling
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Healthy Volunteers
Cutaneous DNA Damage Caused by UV-A Irradiation
The DIMUVA study aims to evaluate the correlation between cutaneous phototype and the nature and quantity of damage caused to cutaneous DNA after exposure to UV-A radiation.
- Trial name
- DIMUVA (NCT00864955)
- Testing
- UVA and UVB irradiation
- Where
- 2 sites in France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Endocrine Disease, Fertility Decreased Male
Sperm DNA Damage in β-thalassemia Major: Is There a Role for Antioxidants?
Accumulation of iron in patients with beta thalassemia major causes free radical formation which leads to damage of biological membranes. Sperm DNA damage may result from these generated antioxidants.
- Conditions
- Endocrine Disease, Fertility Decreased Male, DNA Damage
- Trial name
- NCT03014882
- Testing
- L-Carnitine and N-acetyl cysteine
- Where
- 3 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Healthy Volunteer Children
Socioeconomic Determinants of the Chemical Exposome and Its Genotoxic Effects in Children
PESTIFOL will include children over 8 and under 12 years old of different socioeconomic positions (SEP), mostly living in the region of Pays de la Loire.
- Trial name
- PESTIFOL (NCT06314633)
- Testing
- Hair cut, Socio-economic questionnaires
- Where
- France
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Institut Cancerologie de l'Ouest
Focus of the Study: DNA Damage Due to Medical Diagnostic X-ray
Impact of Antioxidant Agents on the Number of DNA Double-strand Breaks After Radiation-based Cardiac Examinations
Trial with medicinal products Recent studies revealed that radiation-based procedures in patients may lead to DNA double-strand breaks in human blood lymphocytes.
- Trial name
- NCT01578395
- Testing
- Low-dose radiation exposure, High-dose radiation exposure, No radiation exposure
- Where
- Switzerland
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Occupational Exposure, Genotoxicity
Biomonitoring of Occupationally Populations Exposed to Micro and Nanoplastic
The biomonitoring study aims to evaluate genotoxic damage and other parameters of exposure in different occupational exposed populations that work directly with different plastics.
- Conditions
- Occupational Exposure, Genotoxicity, Damage Dna
- Trial name
- NCT06323603
- Testing
- Micro and nanoplastic
- Where
- 4 sites in Finland, Spain
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ricard Marcos
Oxidative Stress
Xanthohumol and Prevention of DNA Damage
The purpose of this research study is to learn if and in what amount a compound from hops, called xanthohumol (ZAN-tho-HUE-mol), prevents damage to DNA and oxidative stress.
- Trial name
- NCT02432651
- Testing
- 6 mg xanthohumol per day, 12 mg xanthohumol per day, 24 mg xanthohumol per day
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Oregon State University
Smoking, Cigarette Smoking
e-Cigarette - DNA Adducts
This study will examine the level of toxicity of e-cigarette use compared to smokers and nonsmokers including inflammation markers, toxicant and carcinogen exposure.
- Conditions
- Smoking, Cigarette Smoking, Electronic Cigarettes
- Trial name
- NCT03284632
- Where
- United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University of Minnesota