Clinical trials: DNA Methylation, active
Rare Disease, Undiagnosed Disease
EpiSign International: Expanding Epigenomic Testing in Rare Disease
The purpose of this study is to assess the utility of EpiSign software and an integrated DNA methylation and copy number variant (CNV) microarray technology in helping to diagnose individuals with rare diseases.
- Conditions
- Rare Disease, Undiagnosed Disease, Genetic Diseases, Inborn, Congenital Abnormalities
- Trial name
- NCT07839754
- Testing
- Integrated EPIC/CNV microarray with EpiSign analysis, EpiSign analysis with EPIC DNA methylation microarray
- Where
- United Kingdom
- Volunteers
- 192 people
- Sponsor
- University of Manchester
Uterine Cervical Neoplasms, HIV I Infection
Cervical Pre-cancer Treatment Failure Among Women Living With HIV in Zimbabwe
The goal of this observational study is to improve cervical pre-cancer treatment outcomes among women living with HIV (WLWH), particularly in low and middle income countries (LMICs), by generating the evidence needed for…
- Conditions
- Uterine Cervical Neoplasms, HIV I Infection, HPV Infection
- Trial name
- NCT07202936
- Where
- Zimbabwe
- Volunteers
- 168 people
- Sponsor
- University of Bern
Uterine Cervical Neoplasm, Uterine Cervical Dysplasia
Developing a Combined Molecular Screening and Triage Test for Cervical Cancer in Self-samples
The goal of the COMBISCREEN project is to develop a fully molecular cervical screening and triage approach that is applicable on self-samples, which are an easily accessible and non-invasive source of biomarkers.
- Conditions
- Uterine Cervical Neoplasm, Uterine Cervical Dysplasia, Human Papilloma Virus, HPV-Related Cervical Carcinoma
- Trial name
- COMBISCREEN (NCT06598176)
- Testing
- Colli-Pee 20mL device with UCM, Evalyn Brush
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universiteit Antwerpen
Colorectal Cancer Screening, Lynch Syndrome
DYNAMICS-LYNCH：DNA Methylation Analysis in Stool for Screening of Lynch Syndrome-Associated Colorectal Cancer
Colorectal cancer (CRC) has high incidence and mortality rates globally. Over 1 million new cases are diagnosed annually, and about 600,000 people die from the disease each year.
- Trial name
- NCT06772844
- Testing
- fecal DNA methylation testing
- Volunteers
- 400 people
- Sponsor
- Sun Yat-sen University
Gastric (Stomach) Cancer
Fecal DNA Methylation and Helicobacter Pylori SNPs Tests for Gastric Cancer
Based on the detection technology of methylation sites in feces, combined or not combined with Helicobacter pylori gastric cancer susceptibility gene detection, an early diagnosis and detection system for gastric cancer is…
- Trial name
- NCT07312500
- Testing
- Diagnostic Test: fecal methylation site-based testing and fecal Helicobacter pylori gastric cancer susceptibility gene-based testing
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fudan University
Colorectal Neoplasms
The Predictive Value of Guangzhou Panel for Recurrence in Early-stage Colorectal Cancer
This study aims to evaluate the predictive value of a four-gene methylation assay called Guangzhou Panel in early-stage colorectal cancer. Patients will be divided into two groups: high risk group and low risk group.
- Trial name
- NCT03923335
- Testing
- DNA methylation detection
- Where
- China
- Volunteers
- 287 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Cardiovascular Diseases (CVD), Type 2 Diabetes
Epigenetics and NCD Prevention in Kazakhstan: Personalized Approaches and Biological Age Prediction
This study aims to enhance personalized and preventive care for non-communicable diseases (NCDs) in Kazakhstan by examining epigenetic factors, predicting biological age and reproductive function using machine learning, and…
- Conditions
- Cardiovascular Diseases (CVD), Type 2 Diabetes, Chronic Respiratory Diseases, Obesity (Disorder)
- Trial name
- NCT06953180
- Testing
- Genetic: DNA analysis
- Where
- Kazakhstan
- Volunteers
- 6,720 people, healthy volunteers welcome
- Sponsor
- Asfendiyarov Kazakh National Medical University
Neuroendocrine Neoplasms
Collection of Liquid Biopsy Samples of Neuroendocrine Neoplasms (NEN) Patients - Collection of NET (CollectNET) 2.0, a Study by the BE-FORCE Consortium
The CollectNET 2.0 by BE-FORCE is a prospective, multicentric, interventional study in which liquid biopsies will be collected from neuroendocrine neoplasms (NEN) patients to create an extensive biobank that will be used for…
- Trial name
- BE-FORCE (NCT06541080)
- Testing
- Shallow Whole Genome Sequencing (sWGS)-GIPXplore, methylation-sensitive restriction enzymes (MSRE)-Single-molecule molecular inversion probes (smMIP)-seq assay
- Where
- 8 sites in Belgium
- Volunteers
- 550 people
- Sponsor
- University Hospital, Antwerp
Cervical Cancer, Papillomavirus Infections
DNA Methylation and the Increased Risk of Cervical Cancer Development
This study aims to investigate the correlation between reproductive tract microbiota and DNA methylation in cervical epithelial cells, as well as its impact on the development of cervical cancer, through a paired case-control…
- Trial name
- NCT06859151
- Testing
- Reproductive tract microbiota
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
PMDD, Premenstrual Dysphoric Disorder (PMDD)
Identification and Validation of Epigenetic Biomarkers of PMDD
This research is being done to examine epigenetic markers and mood changes across the menstrual cycle, particularly in premenstrual dysphoric disorder (PMDD).
- Conditions
- PMDD, Premenstrual Dysphoric Disorder (PMDD), Premenstrual Syndrome-PMS, Premenstrual Syndrome
- Trial name
- BIO (NCT06771583)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cervical Cancer Screening
Reengineering Cervical Cancer Screening for the 21st Century: Joint Action for a Novel Up-to-date and Sustainable Screening Program
Cervical cancer screening (CCS) is important to prevent and control cervical cancer (CC). In Portugal, CCS starts with the assessment of the presence of Human Papillomavirus (HPV) in cervical-vaginal samples, collected by a…
- Trial name
- JANUS (NCT06915610)
- Testing
- Invitation of all participants to CCS according to the standard of care (active comparator), Invitation of all participants to CCS through self-sampling, Invitation of all participants to CCS, asking them to choose between self-sampling and the standard of care
- Where
- Portugal
- Volunteers
- 5,700 people, healthy volunteers welcome
- Sponsor
- Instituto de Saude Publica da Universidade do Porto
Endometrial Cancer
The Clinical Utility of DNA Methylation Testing in Patient-collected Urine and Vaginal Samples to Detect Endometrial Cancer: a Case-control Study
The goal of this observational case-control study is to investigate the use of DNA-methylation testing in patient-collected urine and vaginal samples to detect endometrial cancer.
- Trial name
- NCT06846775
- Testing
- DNA-methylation testing in patient-collected urine and vaginal samples
- Where
- 3 sites in Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Edentulism, Biological Aging
Biological Aging Following Full-Arch Implant-Supported Fixed Rehabilitation in Edentulous Patients
This study aims to investigate the association between full-arch implant-supported fixed dental rehabilitation and changes in biological aging among adults with complete tooth loss (edentulism).
- Trial name
- NCT07890753
- Testing
- Full-Arch Implant-Supported Fixed Dental Rehabilitation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Junyu Shi
Lung Nodules, Lung Cancer Screening
ctDNA Mutations and Methylation Status for Early Detection of Lung Cancer in Patients With Suspicious Lung Nodules
Lung Cancer is common in Asia and is different from lung cancer from Western countries in terms of lung cancer epidemiology and management.
- Conditions
- Lung Nodules, Lung Cancer Screening, Suspected Lung Cancer
- Trial name
- NCT07615556
- Testing
- ctDNA mutations and methylation with SPOTMAS Lung assays, Non-contrast LDCT Thorax scans
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Cancer
a PROspective Case Control Study to Develop and Validate a Blood Test FOr mUlti-caNcers Early Detection（PROFOUND）
This study is a multi-center, case-control study aiming at developing and blinded testing machine learning-based multiple cancers early detection model by prospectively collecting blood samples from newly diagnosed cancer…
- Trial name
- PROFOUND (NCT06217900)
- Where
- 8 sites in China
- Volunteers
- 16,666 people, healthy volunteers welcome
- Sponsor
- Shanghai Weihe Medical Laboratory Co., Ltd.
Carcinoma, Non-small Cell Lung Cancer
Predicting Non-small Cell Lung Cancer (NSCLC) Lymph Node Metastasis: Integrating Circulating Tumor DNA (ctDNA) Mutation/ Methylation Profiling With Positron Emission Tomography-computed Tomography (PET-CT) Scan
This is a single center, prospective and observational study conducted in three stages to predict the NSCLC lymph node metastasis based on ctDNA/specific methylation molecular features combined with PET-CT imaging features and…
- Trial name
- NCT06358222
- Testing
- Blood ctDNA + methylation + PET-CT and Postoperative pathology, MRD+ methylation (or combined with PET-CT) and Invasive mediastinoscopy /EBUS-TBNA, Intraoperative lymph node dissection
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Chest Hospital
Gall Bladder Cancer, Intrahepatic Cholangiocarcinoma (Icc)
A Cell-free DNA Methylation Blood-Based Test for Biliary Tract Cancers Screening
Biliary tract carcinoma (BTC), including gallbladder cancer, intrahepatic cholangiocarcinoma, and extrahepatic cholangiocarcinoma, ranks sixth in incidence among gastrointestinal malignancies and tenth in cancer-related mortality…
- Conditions
- Gall Bladder Cancer, Intrahepatic Cholangiocarcinoma (Icc), Extrahepatic Cholangiocarcinoma, Hilar Cholangiocarcinoma
- Trial name
- NCT07176962
- Where
- China
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Yingbin Liu, MD, PhD, FACS
Thyroid Gland Nodule
Diagnostic DNA Methylation Signature in Diagnosing Thyroid Cancer After Fine-Needle Aspiration in Patients With Thyroid Nodules
This trial studies how well the diagnostic deoxyribonucleic acid (DNA) methylation signature works in detecting thyroid cancer in patients with thyroid nodules.
- Trial name
- NCT03676647
- Testing
- Diagnostic DNA Methylation Signature
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- City of Hope Medical Center
Aging, Epigenetic Aging
Human Sperm Cryopreservation as an Alternative to the Decline of Sperm Quality With Aging
This observational study will evaluate whether sperm cryopreservation can help preserve sperm quality and molecular characteristics that may be affected by increasing paternal age.
- Conditions
- Aging, Epigenetic Aging, Infertility, Assisted Reproduction Technologies
- Trial name
- NCT07814235
- Where
- Spain
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- IVI Murcia
Nasopharyngeal Carcinoma
Diagnostic Accuracy of EBV C Promoter Methylation Kit in Nasopharyngeal Carcinoma
This clinical study aims to evaluate the diagnostic performance of a new Epstein-Barr virus (EBV) C promoter methylation detection kit.
- Trial name
- NCT06445088
- Testing
- VCA-IgA, EBNA1-IgA, and EBV-DNA, EBV C Promoter Methylation Detection in nasopharyngeal swab samples
- Where
- 5 sites in China
- Volunteers
- 908 people
- Sponsor
- Sun Yat-sen University