Clinical trials: DNA Sequencing
Magnetic Resonance Imaging
Feasibility of Regional Lung Ventilation Imaging Using 3T MR Imaging With Ultrashort Echo Time (UTE) Pulse Sequences
Structural lung and airway alterations in CF lead to focal or heterogeneous abnormalities in regional lung ventilation. The quantitative assessment of structural and functional alterations in the lung is of great importance for…
- Trial name
- PULMOREM (NCT02786056)
- Testing
- Lung MRI examination
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Systemic Mycotic Infection
Study to Evaluate the Pharmacokinetic Properties of SYP-1018 (Voriconazole-loaded PNP) and Voriconazole (Vfend)
The purpose of this study is to evaluate the pharmacokinetic properties and safety of SYP-1018 (Voriconazole-loaded PNP) and Voriconazole (Vfend).
- Trial name
- NCT01657201
- Testing
- SYP-1018 200mg, Voriconazole 200mg
- Where
- South Korea
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Samyang Biopharmaceuticals Corporation
OIC
TD-1211 IV/Oral Mass Balance Study
The purpose of this study is to determine TD-1211 is processed by the body.
- Trial name
- NCT01702194
- Testing
- TD-1211 IV [C14], TD-1211 PO [C14]
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Glycyx Therapeutics
Drug-drug Interaction
A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib
This study is being done to look at how tucatinib could affect the way other drugs work. This study will look at healthy volunteers and how tucatinib affects their liver enzymes.
- Trial name
- NCT03723395
- Testing
- tucatinib, itraconazole, rifampin
- Where
- 2 sites in United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Seagen Inc.
Healthy Participants
Relative Bioavailability Study of a Modified-Release Formulation of PF-06865571 in Healthy Adult Participants
This study is an open-label, randomized, single-dose, 4-period, 4-sequence, crossover study in a single cohort of approximately 12 healthy adult participants.
- Trial name
- NCT04044053
- Testing
- PF-06865571 400 mg Immediate Release (IR) in Fed State, PF-06865571 50 mg Modified Release (MR) in Fed State, PF-06865571 400 mg MR in Fed State
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Multiple Sclerosis
Simultaneous T2-FLAIR and T1 Brain MRI With ENRAGED FLAIR in Multiple Sclerosis
This study will evaluate a new brain MRI technique called ENRAGED FLAIR in patients with multiple sclerosis. MRI is central in the diagnosis and follow-up of multiple sclerosis because it can show inflammatory lesions in the…
- Trial name
- ENRAGED FLAIR (NCT07687693)
- Testing
- ENRAGED FLAIR MRI
- Where
- Sweden
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Non-cystic Fibrosis Bronchiectasis、Chronic Sinusitis Without Nasal Polyps、Chronic Obstructive Pulmonary Disease
Study on Drug Interactions Affecting the Pharmacokinetics of RSS0343 Tablet
This study is a single-center, single-sequence, self-controlled, open design, aiming to investigate the effects of rifampicin and clarithromycin on the pharmacokinetics of RSS0343 in humans.
- Trial name
- NCT07696091
- Testing
- RSS0343 Tablet; Rifampicin Capsules, RSS0343 Tablet; Clarithromycin Tablets
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Reistone Biopharma Company Limited
Healthy Participants
A Sub Study to Evaluate the Study Medication (Etrasimod) Using Wearable Sensors in Healthy Participants
The purpose of this study is to look at how healthy adults process Etrasimod when assessed by wearable sensors. Etrasimod is taken without food and assessments taken by site staff and then by participants after training.
- Trial name
- NCT06140290
- Testing
- Etrasimod Immediate Release (IR)
- Where
- Belgium
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Pfizer
Degeneration of Spine and Osteoarticular
New MRI Sequences in Spine and Joint
Low back pain and osteoarticular degeneration or injury is the leading worldwide cause of years lost to disability, accounting for 17 % of all patients with disabilities and its burden is growing alongside the increasing and…
- Trial name
- NMSSJ (NCT04647279)
- Testing
- Dual-emission X-ray Absorptiometry
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Healthy
Bioequivalence Study of Metoprolol Succinate ER Tablets, 200 mg Under Fasting Conditions
The purpose of this study is to monitor adverse events, safety and tolerance Metoprolol Succinate Extended-Release Tablets 200 mg under fasting conditions
- Trial name
- NCT01673997
- Testing
- Metoprolol Succinate
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dr. Reddy's Laboratories Limited
Healthy
Drug-drug Interaction Study with GLPG4716 and Nintedanib and Pirfenidone in Healthy Subjects
The main aim of this study is to investigate the possible effect of GLPG4716 on the pharmacokinetics (PK) of pirfenidone and nintedanib.
- Trial name
- NCT04971746
- Testing
- Pirfenidone, GLPG4716, Nintedanib
- Where
- Germany
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Lakefront Biotherapeutics NV
Anesthesia, Medical Education
Mental Visualization as a Learning Tool in Anesthesia
The purpose of this study is to evaluate the benefit of adding mental visualization to a training program in medical education. Undergraduate medical students will be randomized before participating in a training program on…
- Trial name
- NCT04159389
- Testing
- Mental visualization
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Grenoble Alps
Healthy Adult Subjects
A Drug-drug Interaction Trial to Evaluate the Pharmacokinetics Effect of Rifampicin on Famitinib
The primary objective of the study was to assess the effect of repeated oral doses of Rifampicin on the pharmacokinetic profile of a single dose of Famitinib.
- Trial name
- NCT04494659
- Testing
- Famitinib capsule, Rifampicin capsule
- Where
- China
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Healthy Volunteers
Drug-drug-interaction Study of Candesartan, Amlodipine and Atorvastatin
Study to determine the potential pharmacokinetic interaction of candesartan cilexetil, atorvastatin as atorvastatin calcium trihydrate and amlodipine as amlodipine besilate at steady state after a multiple oral administration and…
- Trial name
- NCT04245046
- Testing
- Candesartan, Amlodipine, Atorvastatin
- Where
- Jordan
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Midas Pharma GmbH
Bioequivalence
A Bioequivalence Study Between Fluticasone Propionate 100 mcg and Salmeterol Xinafoate 50 mcg Inhalation Powder/Respirent Pharmaceuticals vs. ADVAIR DISKUS® 100/50 Inhalation Powder/GSK in Healthy Volunteers
Bioequivalence study between two inhaler products of fixed dose combination of fluticasone propionate and salmeterol xinafoate inhalation powder
- Trial name
- NCT03975166
- Testing
- Test Product, Reference Product
- Where
- Greece
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Respirent Pharmaceuticals Co Ltd.
Drug-drug Interaction
A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib on Metformin
This study is being done to look at how tucatinib might affect the way another drug (metformin) works. It will look at healthy volunteers and how tucatinib affects how the body absorbs metformin.
- Trial name
- NCT03826602
- Testing
- Tucatinib, Metformin, Iohexol
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Seagen Inc.
Healthy
Interaction Study of Clopidogrel 300/75 mg Given Alone or Concomitantly With Pantoprazole 80 mg in Healthy Subjects
Primary objective: Assess the effects of clopidogrel (300 mg loading dose followed by 4 days 75 mg/day) on Adenosine diphosphate (ADP)-induced platelet aggregation when given concomitantly with pantoprazole 80 mg/day compared to…
- Trial name
- NCT01129427
- Testing
- Clopidogrel, Pantoprazole
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Sanofi
Hyperlipidemias
A Study to Evaluate the Safety and Pharmacokinetics of AD-221 Compared to Coadministration of AD-221A and AD-221B
Primary endpoint of this study is to evaluate the pharmacokinetic characteristics of AD-221 in healthy male subjects.
- Trial name
- NCT05202405
- Testing
- AD-221, AD-221A and AD-221B
- Where
- South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Addpharma Inc.
Bioequivalence, Healthy Subjects
Bioequivalence Study of 8 mg Perindopril Tert-butylamine / 2.5 mg Indapamide Tablets Versus 10 mg Perindopril Arginine / 2.5 mg Indapamide Film-coated Tablets in Healthy Volunteers
The present study is a comparative bioavailability study performed to assess bioequivalence between a Test medication (PERINDOPRES® DUO, 8 mg perindopril tert-butylamine / 2.5 mg indapamide tablets manufactured by PrJSC…
- Trial name
- NCT05464745
- Testing
- PERINDOPRES® DUO 8 mg perindopril tert-butylamine / 2.5 mg indapamide tablets, Noliterax® 10 mg/2.5 mg 10 mg perindopril arginine / 2.5 mg indapamide film-coated tablets
- Where
- Jordan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Darnitsa Pharmaceutical Company
Healthy Volunteers
A Drug-Drug Interaction Study To Estimate The Effect Of Tafamidis On Rosuvastatin Pharmacokinetics
Each subject will be given a single oral dose of rosuvastatin on Day 1 in Period 1. In Period 2, after a washout period of at least 5 days, each subject will receive oral doses of tafamidis twice daily (BID) on days 1 and 2…
- Trial name
- NCT04253353
- Testing
- tafamidis, rosuvastatin
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
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