Clinical trials: Dark Therapy
Glaucoma, Intraocular Pressure
the Pops-titration Versus the Slow-coagulation Cyclophotocoagulation in Treatment of Refractory Glaucoma
Transcleral cyclophotocoagulation (TSCPC) has long been used as refractory glaucoma management and is very easy to learn and easy to perform.
- Trial name
- NCT01774227
- Testing
- The pops-titration group, The slow-coagulation group
- Where
- Thailand
- Volunteers
- 98 people
- Sponsor
- Prince of Songkla University
Bipolar, Manic
Effect of Blue Light Blocking on Reducing Manic Symptoms in Bipolar Disorder
This study will be a randomized controlled trial (RCT) measuring the efficacy of wearing blue-blocking glasses (orange glasses) on manic symptoms in a population of patients suffering from Bipolar Disorder (BD), hospitalized for…
- Conditions
- Bipolar, Manic, Bipolar Disorder (BD), Dark Therapy
- Trial name
- BLUME (NCT06748716)
- Testing
- Blue-blocking glasses, Clear glasses
- Where
- Switzerland
- Volunteers
- 96 people
- Sponsor
- Rayan NASSERDINE
Hyperpigmentation, Dark Spots
A 16-week Clinical Study Investigating a Dark Spot Corrector Serum in Women With Moderate Discrete Hyperpigmentation
This was a single-center, double-blinded, randomized, controlled cosmetic clinical trial to investigate the efficacy and tolerance of dark spot corrector serum and regimen skincare products when used over the course of 16 weeks…
- Trial name
- NCT07468175
- Testing
- Cosmetic dark spot corrector serum
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Periorbital Hyperpigmentation
Efficacy of Platelet-rich Plasma (PRP) in the Treatment of Dark Circles Under the Eyes
10 ml of blood from each patient will be drawn. This blood specimen will be centrifuged in a specific way to get 1 ml of platelet rich plasma (PRP). PRP will be injected into the the skin under the eyes.
- Trial name
- NCT03114514
- Testing
- PRP
- Where
- Syria
- Volunteers
- 40 people
- Sponsor
- Damascus University
Ischemic Stroke, Acute, Treatment Outcome
Effect of Early Versus Late Initiation of Edaravone Dexborneol on Neural Function in Patients With Acute Ischemic Stroke
The primary objective of this study was to evaluate the efficacy and safety of initiation of edaravone dextivel therapy compared with placebo in patients with acute ischaemic stroke (early and late) and to explore the optimal…
- Trial name
- EARLYS (NCT05885919)
- Testing
- Edaravone Dexborneol Concentrated Solution for injection
- Where
- 3 sites in China
- Volunteers
- 212 people
- Sponsor
- Xiangya Hospital of Central South University
Hyperbaric Oxygen Therapy
Effect of Hyperbaric Oxygen Therapy on Microcirculation
Previous studies shoes that hyperoxia alters microcirculation.The investigators hypothesize that hyperbaric may restore microcirculation integrity.
- Trial name
- MICROHB (NCT03980210)
- Testing
- Hyperbaric oxygen therapy
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Periorbital Hyperpigmentation (Dark Circles)
A Study to Determine the Safety & Efficacy of Autologous Human Platelet Lysate (HPL) in Treatment of Dark Circles
This is a multicentre, open label, randomized, pilot study to evalute safety and efficacy of Human Platelet Lysate (HPL) in subjects with Periorbital Hyperpigmentation.
- Trial name
- NCT01644448
- Testing
- Autologous Human Platelet Lysate, Standard Therapy
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Kasiak Research Pvt. Ltd.
Retinitis Pigmentosa
A First-in-human, Proof of Concept Study of CPK850 in Patients With RLBP1 Retinitis Pigmentosa
The purpose of this first-in-human study is to explore the maximum tolerated dose (MTD) of CPK850 as determined by the single ascending dose ranging portion of the study.
- Trial name
- NCT03374657
- Testing
- CPK850
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Novartis Pharmaceuticals
Skin Ageing, Facial Wrinkles
Clinical Study Evaluating the Safety and Effectiveness of the NIRA Laser M2.1 for the Treatment of Full-Face Wrinkles
This clinical trial evaluated the safety and effectiveness of the NIRA Laser M2.1, with or without a topical treatment, for the treatment of full-face wrinkles in adults.
- Conditions
- Skin Ageing, Facial Wrinkles, Acne, Skin Elasticity
- Trial name
- NCT07572331
- Testing
- NIRA Laser M2.1, Topical
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- NIRA Innovations Inc.
Septic Shock, Vasodilatory Shock
Serum Biomarkers to Predict Response to Angiotensin II in Septic Shock
This trial will be a randomized controlled single-center pilot trial comparing the use of angiotensin II versus standard-of-care (SOC) vasopressor therapy in adult patients with persistent vasodilatory shock despite moderate-dose…
- Trial name
- DARK-Sepsis (NCT05824767)
- Testing
- Angiotensin II
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of New Mexico
Under-eyes Dark Circles
Efficacy and Tolerance Evaluation of an Injective Treatment for the Area Around the Eyes
Efficacy and tolerance evaluation of an intradermal injective HA and aminoacids based treatment for the area around the eyes
- Trial name
- NCT03881189
- Testing
- SUNEKOS® 200
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Derming SRL
Age-related Macular Degeneration
Dark Adaptation as an Early Indicator of Response to Statin Therapy for Intermediate AMD
interventional trial for off label use of high dose atorvastatin 80 mg in intermediate AMD patients and correlate recovery response measured by dark adaptation recovery time with drusen volume reduction measured by SD-OCT
- Trial name
- DELPHI (NCT04735263)
- Testing
- Atorvastatin 80mg
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Hyperpigmentation, Skin Ageing
Evaluation of the Safety and Tolerability of a Brightening Treatment Paired With a Skincare Regimen
A12-week single-center, open-label, clinical study is being conducted to assess the efficacy and tolerability of the Brightening Treatment paired with a skincare regimen on healthy female subjects aged 20-65 years with…
- Conditions
- Hyperpigmentation, Skin Ageing, Post Inflammatory Hyperpigmentation, Skin Roughness
- Trial name
- NCT07501000
- Testing
- Brightening Treatment
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Sepsis
Sidestream Dark-Field (SDF) Imaging of the Intestinal Microcirculation
Sepsis is the most frequent cause of death in critically ill patients in non-coronary care Intensive Care Units in the developed world.
- Trial name
- NCT00883597
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Nova Scotia Health Authority
Meniere's Disease, Stress
Stress Management Therapy for Meniere's Disease
Attacks in Meniere's disease, characterized by vertigo and hearing loss, are well known to occur repeatedly under stressed environment.
- Trial name
- SMT (NCT01099046)
- Testing
- Lifestyle
- Where
- Japan
- Volunteers
- 200 people
- Sponsor
- Osaka University
Periorbital Disorder
Treatment of Periorbicular Hyperchromia Comparing 10% Thioglycolic Acid Peeling Versus Pulsed Intense Light
Periorbital hyperchromia (POH) or periorbital hyperpigmentation, commonly known as "dark circles", is a relatively common condition and a frequent reason for dermatological consultation.
- Trial name
- NCT03238105
- Testing
- Thioglycolic Acid, Intense Pulsed Light
- Where
- Brazil
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Bibliotherapy, Fear of the Dark
Bibliotherapy Combined With Games to Reduce Fear of the Dark in Young Children
Intense fear of the dark is a common issue among children, which can interfere with their daily functioning at family, social, and academic levels.
- Conditions
- Bibliotherapy, Fear of the Dark, Nighttime Fears
- Trial name
- NCT07067320
- Testing
- Bibliotherapy combined with games to overcome fear of the dark
- Where
- Spain
- Volunteers
- 39 people
- Sponsor
- Universidad Miguel Hernandez de Elche
Melasma
Salicylic Acid Peels Combined With 4% Hydroquinone in the Treatment of Moderate to Severe Melasma in Hispanic Women
This study will enroll 20 adult Hispanic women. Participants will apply 4% hydroquinone cream twice daily to affected areas on the face for 14 weeks and half the face will be peeled with 20-30% salicylic acid every two weeks for…
- Trial name
- NCT00616239
- Testing
- 20-30% Salicylic Acid peels to the right side of the face, 20-30% Salicylic Acid peels to the left side of the face
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas Southwestern Medical Center
Type1diabetes
Sublingual Microcirculation in Children with Compensated T1D Using the SDF Method
The main goal of the study is to describe the sublingual microcirculation of children with type 1 diabetes mellitus (T1D) with stable and satisfactory treatment of the disease and to compare it with previously measured parameters…
- Trial name
- NCT05958264
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- Vlasta Krausová
Psoriasis Vulgaris
Narrowband UVB Light Therapy to Patients With Dark Skin Types Who Have 10% of Their Body Involved With Psoriasis Vulgaris.
This study offers narrowband UVB light therapy to patients with both light and dark skin types who have 10% of their body involved with psoriasis vulgaris.
- Trial name
- NCT00220025
- Testing
- Phototherapy
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Mary Sullivan-Whalen