Clinical trials: Deafness, Perception
Hearing Loss, Idiopathic Sudden Sensorineural
Efficacy and Safety of AM-111 as Acute Sudden Sensorineural Hearing Loss Treatment
The primary objective of the trial is the confirmation of the efficacy of AM-111 in the recovery of severe to profound idiopathic sudden sensorineural hearing loss (ISSNHL).
- Trial name
- ASSENT (NCT02809118)
- Testing
- AM-111 0.4 mg/ml, AM-111 0.8 mg/ml
- Where
- 51 sites in United States, Canada and 1 more
- Volunteers
- 56 people
- Sponsor
- Auris Medical, Inc.
Hearing Impaired (Partially)
Optimization of Perceived Sound Quality for Music Listening in Hearing Aid Users With Hearing Loss.
This study aims to optimize music listening quality for 66 hearing aid users (33 musicians and 33 non-musician music enthusiasts) by developing a dedicated "Music Program" based on individual frequency preference profiles.
- Trial name
- OPTIMMUSIC (NCT07677748)
- Testing
- Musical listening quality preference test
- Volunteers
- 66 people
- Sponsor
- Institut Pasteur
Obstructive Sleep Apnea, Sudden Hearing Loss
OSA and Sudden Sensorineural Hearing Loss
This study studies the prevalence between obstructive sleep apnea syndrome and sensorineural hearing loss. We recruit patients who have been treated for sudden sensorineural hearing loss in Poitiers' University Hospital between…
- Trial name
- SAS-SB (NCT03747874)
- Testing
- ventilatory polygraphy
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Poitiers University Hospital
Hearing Loss, Sensorineural
Speech Perception in Bimodal Hearing
The protocol has two aims; Aim 1 involves two experiments and Aim 2 involves three experiments. Under Aim 1, the investigator will identify that the frequency and time ranges of consonants produce consonant enhancement (i.e.…
- Trial name
- NCT05599165
- Testing
- signal processing on consonant recognition
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Baylor University
Sudden Sensorineural Hearing Loss
Comparison of the Effectiveness of Oral and Intratympanic Corticosteroid Treatments in Patients Diagnosed With Sudden Sensorineural Hearing Loss
The goal of this clinical trial is to learn which one works to treat better in patients with sudden sensorineural hearing loss, oral or intratympanic corticosteroid treatment.
- Trial name
- NCT06968507
- Testing
- Methylprednisolone (drug), Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 214 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Intratympanic Steroid Injection, Idiopathic Sudden Sensorineural Hearing Loss
Comparing Topical Tetracaine Drops to Topical Focal Phenol for Local Anesthesia During Intratympanic Steroid Injection
Intratympanic steroid injections are an accepted treatment for Meniere's disease and idiopathic sudden sensorineural hearing loss. This treatment is typically performed using local topical anesthesia.
- Conditions
- Intratympanic Steroid Injection, Idiopathic Sudden Sensorineural Hearing Loss, Meniere Disease
- Trial name
- NCT04794842
- Testing
- Tetracaine 5% drops, Phenol 90% concentration
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Our Lady of the Lake Hospital
Seneorineural Deafness, Sudden Sensorineural Hearing Loss
A Phase 1b/2a, Study Evaluating the Safety, PK/PD and Efficacy of NS101 in Healthy Volunteers and SSNHL Patients
The goal of this 2 step-up, exploratory study is to test safey, tolerability and PK/PD profiles in healthy volunteers and safety, tolerability and efficacy in sudden sensorineural hearing loss patients as an early salvage…
- Trial name
- NCT06249919
- Testing
- NS101
- Where
- 16 sites in South Korea
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Neuracle Science Co., LTD.
Cochlear Implants
Pitch Perception and Memory: Deficits and Training
Pitch perception and memory are central in auditory cognition, in particular for sound source segregation and recognition, speech prosody and music processing.
- Trial name
- Pitch_Train (NCT03707691)
- Testing
- Listening tests. Pitch training protocol, visuo-spatial training protocol, EEG/MEG/MRI recordings.
- Where
- France
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Sensorineural Hearing Loss
Status Telemetry for Cochlear Implantations
Cochlear implants (CIs) are well-established neuroprosthesis used to restore hearing for patients with partial or complete deafness.
- Trial name
- PATHOS (NCT06223724)
- Testing
- STOP, MAESTRO
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Sensory Hearing Loss
Evaluation of a Binaural Beamformer (StereoZoom) in a Virtual Acoustic Environment and in Real Life
The goal of the study is to determine the benefit in speech intelligibility of the BBF and the MBF compared to an omni-directional microphone in different noise conditions.
- Trial name
- NCT03361527
- Testing
- binaural beamformer
- Where
- Switzerland
- Volunteers
- 4 people
- Sponsor
- Advanced Bionics AG
Sudden Sensorineural Hearing Loss (SSNHL), Tinnitus
'Inner Ear Support' Oral Capsule in Patients With Sudden Sensorineural Hearing Loss
Sudden sensorineural hearing loss (SSNHL) is a medical condition where people experience rapid hearing loss, usually in one ear, over a short period of time (typically within 72 hours).
- Trial name
- NCT06997406
- Testing
- Inner ear support
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Far East Bio-Tec Co., Ltd
Sensori-Neural Deafness, Exosomes
A Randomized Trial of Intratympanic Drug Delivery: Evaluating the Efficacy and Safety of Dexamethasone-Loaded Exosomes Versus Standard Therapy in Acute Sensorineural Hearing Loss.
Primary Objective To compare the efficacy of a single course of IT Exo-Dex versus conventional IT dexamethasone and exosome vehicle alone, as measured by the mean change in pure-tone average (PTA; 0.5, 1, 2, 4 kHz) from baseline…
- Trial name
- EXO-DEX-SNHL (NCT07568184)
- Testing
- exosomes derived from human umbilical cord mesenchymal stem cells
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kafrelsheikh University
Auditory Perception
Sound Perception Study of Hearing-impaired People With Hearing Aids
The aim of the ETERNEL project will be to study the influence of the perception of a single sound timbre on the understanding of a complex sound scene in hearing-impaired people with hearing aids.
- Trial name
- ETERNEL (NCT06691087)
- Testing
- Influence of the parameters of the sound timbre on the perception of a sound, Complex sound scene comprehension test, Complex sound scene comprehension test with hearing aids
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Sensorineural Hearing Loss
Immunity After Cochlear Implantation and Perilymph Molecular Profiles in Sensorineural Hearing Loss
Many patients receiving cochlear implant (CI) have some residual hearing prior to implantation surgery. However, approximately one third of them will lose it in next 6 months after cochlear implantation.
- Trial name
- PERILOTO (NCT05670158)
- Testing
- Blood sampling, Perilymph sampling
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Montpellier
Hearing Loss
Supplementing Hearing Aids With Computerized Auditory Training
The study is designed to examine the effectiveness of a computer-based auditory training program to improve the benefits received by individuals who wear hearing aids.
- Trial name
- LACE (NCT00727337)
- Testing
- LACE-computer, CONTROL, Lace-DVD
- Where
- United States
- Volunteers
- 279 people
- Sponsor
- VA Office of Research and Development
Ototoxic Hearing Loss, Ototoxicity, Drug-Induced
Cisplatin-induced Cochlear and Vestibular Damage in Head and Neck Cancer
The goal of this observational study is to learn about the occurrence of and to identify suitable strategies for screening and monitoring of inner ear damage in patients receiving cisplatin chemoradiotherapy for head and neck…
- Conditions
- Ototoxic Hearing Loss, Ototoxicity, Drug-Induced, Cisplatin-induced Hearing Loss, Cisplatin Ototoxicity
- Trial name
- NCT06929468
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- Simon Jäger
Sensorineural Hearing Loss
A Trial of LY3056480 in Patients With SNLH
A phase 2 trial with LY3056480 in patients with stable SNHL
- Trial name
- VESTA (NCT05061758)
- Testing
- LY3056480
- Where
- 3 sites in United States
- Sponsor
- Audion Therapeutics BV
Frequency Compression, Severe-profound Hearing Impairment
Use of Frequency Compression in Severe-profound Hearing Loss Adults
The purpose of this study is to investigate the functional benefits of frequency compression vs no frequency compression or fitted to hearing loss in severe-profound hearing impaired adults with high frequency hearing losses.
- Trial name
- FC (NCT04623112)
- Testing
- Hearing aid feature: Frequency Compression
- Volunteers
- 27 people
- Sponsor
- University College, London
Hearing Loss, Cochlear
Evaluating a Deep Neural Noise-Reduction Algorithm for Hearing Aids
This study is designed to understand how different hearing-aid noise-reduction technologies affect a listener's ability to hear speech in noisy environments.
- Trial name
- NCT07287774
- Testing
- Hearing Aid Noise Reduction - Off, Hearing Aid Noise Reduction - Low, Hearing Aid Noise Reduction - High
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Purdue University
Conductive Hearing Loss, Sensorineural Hearing Loss
Middle Ear Optical Coherence Tomography Imaging and Vibrometry in Patients With Hearing Loss
This study involves imaging ears with hearing loss with a new system that allows the user to see the middle ear bones and measure their movement in response to sound.
- Trial name
- NCT07732920
- Testing
- OCT - clear
- Where
- 2 sites in Canada
- Volunteers
- 500 people
- Sponsor
- Audioptics Medical Incorporated