Clinical trials: Death, Cardiac
Sudden Cardiac Death
POWER (Pulse Width Optimized Waveform Evaluation Trial)
The objective of this study is to compare the ULV (Upper Limit of Vulnerability)/DFT (Defibrillation Threshold) efficacy between the 2.5, 3.5 and 4.5 ms membrane time constant based biphasic defibrillation waveforms.
- Trial name
- NCT00311181
- Testing
- Implantable Cardioverter Defibrillator (ICD), Cardiac Resynchronization Therapy (CRT-D)
- Where
- 2 sites in United States
- Volunteers
- 217 people
- Sponsor
- Abbott Medical Devices
Sudden Cardiac Death
TroponinT After Subcutaneous Cardioverter-Defibrillator Implantation
Serum Troponin levels pre- and postoperatively will be compared in patients receiving an entirely subcutaneous cardioverter-defibrillator.
- Trial name
- TROPIC (NCT03526302)
- Where
- Germany
- Volunteers
- 43 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Brugada Syndrome, Sudden Death
The Response To Ajmaline Provocation in Healthy Subjects
Standard, high lead and sodium channel provoked electrocardiograms of a healthy volunteers will be performed to observe the various ECG changes.
- Trial name
- NCT02933437
- Testing
- Ajmaline
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Sudden Cardiac Death
Long Term Integrity Follow-up Evaluation
To document the performance of the Guidant ENDOTAK EZ and the RELIANCE defibrillation leads over 5 years.
- Trial name
- LEAD LIFE (NCT00848835)
- Testing
- defibrillation lead (ENDOTAK EZ and RELIANCE)
- Volunteers
- 372 people
- Sponsor
- Guidant Corporation
Abdominal Aortic Aneurysm, Coronary Heart Disease
Ethnicity and Onset of Cardiovascular Disease: A CALIBER Study
Specific cardiovascular diseases, such as stroke and heart attack, have been shown to vary by ethnic group. However, less is known about differences between ethnic groups and a wider range of cardiovascular diseases.
- Conditions
- Abdominal Aortic Aneurysm, Coronary Heart Disease, Sudden Cardiac Death, Intracerebral Haemorrhage
- Trial name
- NCT02176174
- Volunteers
- 1,068,318 people, healthy volunteers welcome
- Sponsor
- University College, London
Syncope
Ambulatory Post-Syncope Arrhythmia Protection Feasibility Study
The purpose of this study is to conduct an observational investigation of a novel care path used to manage emergency department (ED) presenting syncope patients on an outpatient basis.
- Trial name
- ASAP (NCT02188147)
- Testing
- Short Term Wearable Defibrillator
- Where
- 6 sites in United States
- Volunteers
- 39 people
- Sponsor
- Zoll Medical Corporation
Patient Transfer to Intensive Care Unit (Procedure), Respiratory Arrest (Disorder)
Evaluation of the Patient Deterioration Warning System
The overall goal of the project is to reduce the number of unexpected patient deteriorations by 50% at Emergency Departments (ED) by investigating if the novel Patient Deterioration Warning Systems (PDWS), can improve clinicians'…
- Conditions
- Patient Transfer to Intensive Care Unit (Procedure), Respiratory Arrest (Disorder), Cardiac Arrest (Disorder), Patient Died in Hospital (Finding)
- Trial name
- PDWS (NCT03375658)
- Testing
- PDWS Intervension
- Where
- 2 sites in Denmark
- Volunteers
- 6,500 people
- Sponsor
- University of Southern Denmark
Parkinson's Disease
Domperidone and Risk of Sudden Cardiac Death
The purpose of this study is to assess the risk of serious cardiac events, specifically ventricular tachyarrhythmia and sudden cardiac death (VT/SCD), associated with the use of domperidone in a population of patients with…
- Trial name
- NCT02500108
- Testing
- Domperidone
- Where
- Canada
- Volunteers
- 214,962 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Death, Sudden, Cardiac, Ventricular Fibrillation
Failure of Chronically Implanted Defibrillator Leads -Incidence and Management
Comparison of two different approaches to address the problem of malfunctioning ICD-leads. These leads consist of two parts. One that is used for detection of arrhythmias(and pacing if required) (Pace/Sense) and a second part…
- Trial name
- NCT00614718
- Where
- 3 sites in Germany, Switzerland
- Volunteers
- 1,317 people
- Sponsor
- University Hospital, Basel, Switzerland
Heart Failure, Ventricular Dysfunction
Austrian Wearable Cardioverter Defibrillator Registry
Background: The wearable cardioverter defibrillator (WCD) is an established treatment option for patients at high risk for ventricular tachycardia / ventricular fibrillation (VT/VF), either in whom this risk may only be…
- Conditions
- Heart Failure, Ventricular Dysfunction, Sudden Death, Sudden Cardiac Arrest
- Trial name
- NCT02816047
- Testing
- Registry
- Where
- Austria
- Volunteers
- 450 people
- Sponsor
- Medical University of Graz
Unexpected Hospital Mortality, Death, Sudden, Cardiac
Prevention of Serious Adverse Events in Acute Care Hospitals by Afferent Limb and Response Method Intervention - the ALARM Intervention Study.
1. Summary Growing evidence suggests that a significant proportion of in-hospital patient deaths occur after serious adverse events (SAE's).
- Conditions
- Unexpected Hospital Mortality, Death, Sudden, Cardiac, Unplanned Intensive Care Unit Admission
- Trial name
- ALARM (NCT01949025)
- Testing
- ALARM intervention
- Where
- Belgium
- Volunteers
- 69,656 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Sudden Cardiac Death, Acute Myocardial Infarction
Thrombus and Inflammation Study in Sudden Cardiac DEath
Sudden death is a natural death occurring within one hour after the onset of symptoms. It remains a major public health problem and accounts for 5 to 10 % of the annual total mortality ie about 300.000 in the United States.
- Trial name
- TIDE (NCT00748111)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Non-ischemic Cardiomyopathy
Sudden Death Stratification
Sudden cardiac death (SCD) risk stratification is a challenge in non-ischemic cardiomyopathy (NICM). The underlying mechanism of monomorphic ventricular tachycardia (VT) is mostly scar related.
- Trial name
- NCT04607265
- Testing
- Cardiac MRI
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Vascular Death, Myocardial Infarction
Vascular Events In Noncardiac Surgery Patients Cohort Evaluation Study (VISION)
The investigators' study has 4 primary objectives. Among patients undergoing noncardiac surgery the investigators will determine: (1) the incidence of major perioperative vascular events; (2) the optimal clinical model to predict…
- Conditions
- Vascular Death, Myocardial Infarction, Cardiac Arrest, Stroke
- Trial name
- VISION (NCT00512109)
- Where
- 8 sites in Brazil, Canada and 5 more
- Volunteers
- 40,060 people
- Sponsor
- McMaster University
Cardiovascular Diseases, Death, Sudden, Cardiac
Diuretics, Hypertension, and Arrhythmias Clinical Trial
To determine whether hypertensive patients with ECG abnormalities and receiving hydrochlorothiazide diuretics were at increased risk of sudden death.
- Conditions
- Cardiovascular Diseases, Death, Sudden, Cardiac, Heart Arrest, Heart Diseases
- Trial name
- NCT00000525
- Testing
- hydrochlorothiazide, diet, potassium supplementation, diet, magnesium supplementation
- Volunteers
- 233 people
- Sponsor
- University of California, San Francisco
Long QT Syndrome
Mutation-specific Therapy for the Long QT Syndrome
Novel therapy for the Long QT Syndrome based on the mechanism of action of the disease-causing mutations Long QT syndrome type 2 (LQT2) accounts for ~ 35% of all LQTS cases and is difficult to manage, as beta-blockers frequently…
- Trial name
- MAST2 (NCT04581408)
- Testing
- Lumacaftor / Ivacaftor, Orkambi® Oral Tablet
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Istituto Auxologico Italiano
Sudden Cardiac Death
Development of Algorithms to Predict Hemodynamic Instability
Hemodynamic monitoring in hospitalized patients is crucial since in clinical practice unexpected deterioration of cardiovascular function remains a serious problem and an important cause of death.
- Trial name
- NCT01262508
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
Epilepsy, Sudden Cardiac Death
Optimization of VNS in Epileptic Patients to Induce Cardioprotection
This study is a non-randomized, prospective study in patients with a diagnosis of epilepsy and previously implanted FDA approved Vagus Nerve Stimulation (VNS) devices.
- Trial name
- NCT04387435
- Testing
- A change or titration in the current or frequency settings of the VNS therapy system.
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, Los Angeles
Heart Failure, Sudden Cardiac Death
Prospective Clinical Registry of Subcutaneous Implantable Cardioverter Defibrillator (S-ICD) (S-ICD Korea Registry)
S-ICD avoids the use intravascular leads and their associated risks, has been increasingly used for primary and secondary prevention of sudden death.
- Conditions
- Heart Failure, Sudden Cardiac Death, Ventricular Tachycardia
- Trial name
- NCT04127643
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Community Based Study, Cardiovascular Disease
Heart Rate, Baroreflex Sensitivity and Cardiovascular Morbidity and Mortality in the Population
The aim of the present Paris Prospective Study III (PPS3) is (1) to assess the determinants of the regulation of heart rate and blood pressure variations and carotid properties (under different physiologic stimulations) and (2)…
- Conditions
- Community Based Study, Cardiovascular Disease, Sudden Death, Blood Pressure
- Trial name
- PPSIII (NCT00741728)
- Testing
- Spider flash ECG, high-precision carotid echo-tracking, step test
- Where
- France
- Volunteers
- 10,157 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France