Clinical trials: Death, Sudden, Cardiac
Sudden Cardiac Death, Ventricular Fibrillation
LifeVest Post-CABG Registry
This is a multi-center prospective registry of patients with an ejection fraction (EF) ≤ 35% following coronary artery bypass graft (CABG) surgery in order to test the hypothesis that wearable defibrillators (WD) will decrease…
- Conditions
- Sudden Cardiac Death, Ventricular Fibrillation, Ventricular Tachycardia, Ventricular Dysfunction
- Trial name
- NCT01448005
- Testing
- wearable defibrillator (LifeVest)
- Where
- 5 sites in United States
- Volunteers
- 69 people
- Sponsor
- Zoll Medical Corporation
Myocardial Infarction, Heart Failure
A Critical Pathway for Implantable Cardioverter-Defibrillators in Patients With Ischemic Cardiomyopathy
The purpose of this study is to develop and implement a critical pathway to identify patients with ischemic cardiomyopathy who are candidates for an implantable cardioverter-defibrillator (ICD).
- Trial name
- CAPTURE (NCT01248702)
- Testing
- Use of the ICD Critical Pathway
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- University of British Columbia
Myocardial Infarction, Death, Sudden, Cardiac
Assessment of Noninvasive Methods to Identify Patients at Risk of Serious Arrhythmias After a Heart Attack
This study evaluates the usefulness of noninvasive tests of the structure of the heart and the nervous system controlling the heart.
- Conditions
- Myocardial Infarction, Death, Sudden, Cardiac, Death
- Trial name
- NCT00399503
- Testing
- Spectral T Wave Alternans, Modified Moving Average T Wave Alternans, Baroreceptor Sensitivity
- Where
- Canada
- Volunteers
- 350 people
- Sponsor
- University of Calgary
Cardiomyopathy
Morphological Predictors of Sudden Cardiac Death in Patients With Known Cardiomyopathies
This is a pilot study to find a correlation between MRI and ICD therapy in patients with known cardiomyopathies, aiming to determine if cardiac scarring identified by MRI correlates with ventricular arrhythmias and the occurrence…
- Trial name
- NCT00312624
- Testing
- contrast-enhanced cardiac MRI
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Stroke, Myocardial Infarctions
Letigen® and Cardiovascular Morbidity
Letigen® was a combination drug containing ephedrine, an adrenergic agonist with lipolytic and appetite-inhibiting properties. The drug was used as adjuvant treatment of obesity from 1990 and up to 2002 when it was withdrawn from…
- Conditions
- Stroke, Myocardial Infarctions, Sudden Death
- Trial name
- NCT00692666
- Volunteers
- 300,000 people
- Sponsor
- University of Southern Denmark
Epilepsy, Sudden Cardiac Death
Optimization of VNS in Epileptic Patients to Induce Cardioprotection
This study is a non-randomized, prospective study in patients with a diagnosis of epilepsy and previously implanted FDA approved Vagus Nerve Stimulation (VNS) devices.
- Trial name
- NCT04387435
- Testing
- A change or titration in the current or frequency settings of the VNS therapy system.
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, Los Angeles
Myocardial Infarction, Ventricular Tachycardia
MAgnetic Resonance Imaging-guided implanTation of Cardioverter DEFibrillators
Implantable cardioverter-defibrillators (ICD) are currently recommended for the primary prevention of sudden cardiac death (SCD) in patients with a remote (>6 weeks) myocardial infarction (MI) and a low (≤35%) left ventricular…
- Conditions
- Myocardial Infarction, Ventricular Tachycardia, Ventricular Fibrillation, Sudden Cardiac Death
- Trial name
- SMART-DEF (NCT06269692)
- Testing
- MRI screening, Implantable Loop Recorder, Implantable Cardioverter Defibrillator
- Where
- France
- Volunteers
- 1,812 people
- Sponsor
- Central Hospital, Nancy, France
Cardiovascular Diseases, Heart Diseases
Thrombogenic Factors and Recurrent Coronary Events
To determine if selected circulating blood factors that reflect enhanced thrombogenesis are associated with an increased incidence of recurrent coronary events, including cardiac death or non-fatal myocardial infarction.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Myocardial Infarction
- Trial name
- NCT00005358
- Sponsor
- University of Rochester
Death, Sudden, Cardiac, Perfusion Index
Is the Perfusion Index an Accurate Predictor of Return of Spontaneus Circulation in Out-of-hospital Cardiac Arrest
The purpose of this pilot feasibility study is to evaluate the ability of the Perfusion Index to predict the return to spontaneous circulation of the out-of-hospital cardiac arrest patient during cardiopulmonary resuscitation.
- Conditions
- Death, Sudden, Cardiac, Perfusion Index, Return of Spontaneous Circulation
- Trial name
- NCT05383885
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Brugada Syndrome
Epicardial Ablation in Brugada Syndrome
This prospective study evaluates the methodology and results of epicardial mapping/ablation in a large series of consecutive selected BrS patients and to verify if RFA could normalize the consequences of a genetic disease.
- Trial name
- BRUGADA_I (NCT02641431)
- Testing
- mapping/ablation, Ajmaline, ablation
- Where
- Italy
- Volunteers
- 135 people
- Sponsor
- IRCCS Policlinico S. Donato
Epilepsy, Seizures
Genetic Markers of Cardiovascular Disease in Epilepsy
Epilepsy is a common condition which affects over 3 million people in the US. Patients with uncontrolled epilepsy have a lifetime risk of sudden unexpected death (SUDEP) of 35%, which is greatest in those under 40 years of age.
- Conditions
- Epilepsy, Seizures, Syncope, Channelopathy
- Trial name
- NCT02824822
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Mayo Clinic
Angina Pectoris, Variant, Sudden Cardiac Death
Implantable Cardioverter Defibrillator Versus Optimal Medical Therapy In Patients With Variant Angina Manifesting as Aborted Sudden Cardiac Death
The purpose of this study is to determine whether ICD(Implantable Cardioverter Defibrillator) implantation on the top of optimal medical therapy in patients with variant angina manifesting as aborted sudden cardiac death reduces…
- Trial name
- VARIANT ICD (NCT02845531)
- Testing
- Implantable Cardioverter Defibrillator, Optimal Medical Therapy
- Where
- 26 sites in South Korea
- Volunteers
- 140 people
- Sponsor
- Kee-joon Choi
Long QT Syndrome, ADHD
Drug-induced Repolarization ECG Changes
Studies have shown that the risk of developing heart arrhythmias, is increased in patients receiving medication for Attention-deficit hyperactivity disorder (ADHD) and depression.
- Conditions
- Long QT Syndrome, ADHD, Depression, Death
- Trial name
- NCT03642405
- Testing
- Electrocardiogram examination, Echocardiography, Blood Samples
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital at Herlev
Schizophrenia, Schizoaffective Disorder
Changes in Heart Rhythms Associated With Antipsychotic Drug Treatment
This study is being done to look at the electrical activity of the heart. This study will help decide whether taking recordings for a 24-hour period gives more useful information than recording it for a few seconds in a doctor's…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT00538122
- Testing
- 24 Holter Monitor Recording
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Vanderbilt University
Channelopathies
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives
several genes have been associated with ion channel diseases, but a large number of families do not yet have an identified genetic cause.
- Trial name
- NCT04832126
- Testing
- Genetic analysis
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- D'Or Institute for Research and Education
Brugada Syndrome, Sudden Death
The Response To Ajmaline Provocation in Healthy Subjects
Standard, high lead and sodium channel provoked electrocardiograms of a healthy volunteers will be performed to observe the various ECG changes.
- Trial name
- NCT02933437
- Testing
- Ajmaline
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Left Ventricular Systolic Dysfunction, Congestive Heart Failure
SCD-HeFT 10 Year Follow-up
No clinical trial that has examined the role of implantable cardioverter defibrillator (ICD) therapy in the prevention of Sudden Cardiac Death (SCD) has provided outcome data for longer than a few years.
- Conditions
- Left Ventricular Systolic Dysfunction, Congestive Heart Failure, Ischemic and Non-ischemic Cardiomyopathy, Sudden Cardiac Death Primary Prevention
- Trial name
- SCD-HeFT10 Yr (NCT01058837)
- Where
- United States
- Volunteers
- 1,855 people
- Sponsor
- Seattle Institute for Cardiac Research
Myocardial Infarction, Myocardial Infarction Old
CMR Based Prediction of Ventricular Tachycardia Events in Healed Myocardial Infarction (DEVELOP-VT)
Fibrotic tissue is known to be the substrate for the appearance of scar-related reentrant ventricular arrhythmias (VA) in chronic ischemic cardiomyopathy (ICM).
- Conditions
- Myocardial Infarction, Myocardial Infarction Old, Arrhythmias, Cardiac, Ventricular Tachycardia
- Trial name
- DEVELOP-VT (NCT04599439)
- Testing
- Cardiac magnetic resonance imaging
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Centro Medico Teknon
Arrythmia, Cardiac, Sudden Cardiac Death
Arrhythmia in Hemodialysis Patients
Patients receiving dialysis for kidney failure suffer from very high rates of sudden cardiac death due to abnormal heart rhythms and perfusion defects associated with HD treatment.
- Conditions
- Arrythmia, Cardiac, Sudden Cardiac Death, Hemodialysis
- Trial name
- NCT04036695
- Testing
- Reveal LINQ insertable cardiac monitoring system
- Where
- 2 sites in Canada
- Volunteers
- 18 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Aortic Stenosis, Non-Sustained VT
Mechanisms of Excess Risk in Aortic Stenosis
Aortic stenosis (AS) is caused by narrowing of one of the main heart valves. Replacing the valve is the only treatment to prevent the heart from failing or death.
- Conditions
- Aortic Stenosis, Non-Sustained VT, Heart Failure
- Trial name
- MASTER (NCT04627987)
- Testing
- Cardiac MRI scan, Serum biomarkers (High sensitivity troponin, NT-proBNP, Implantable Loop Recorder
- Where
- United Kingdom
- Volunteers
- 192 people
- Sponsor
- University College, London