Clinical trials: Death
Venous Thromboembolism
High-Risk Factors for VTE Death
Study population and characteristics This retrospective cohort study initially screened 105,168 consecutive hospitalized patients at Shihezi People's Hospital from February 2022 to June 2025.
- Trial name
- NCT07767279
- Testing
- comorbidity, Respiratory Failure, Sepsis
- Where
- China
- Volunteers
- 105,168 people
- Sponsor
- China International Neuroscience Institution
Hypertrophic Cardiomyopathy
Efficacy of Risk Assessment for Sudden Cardiac Death in Patients With Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is a heart disease characterized by hypertrophy of the left ventricular myocardium and is most often caused by mutations in sarcomere genes.
- Trial name
- NCT04402268
- Testing
- Cardioverter-defibrillator
- Where
- Poland
- Volunteers
- 252 people
- Sponsor
- Poznan University of Medical Sciences
COVID-19 Disease
Systematic Assessment of SARS-CoV-2 Neurotropic Capacity in Modestly and Critically Ill Patients, and Patients Who Died From COVID-19
This study is to analyze the microglia reaction or direct neurotropic effects of CNS COVID-19 in pathogenesis and brain stem dysfunction in critically ill patients.
- Trial name
- NCT04472013
- Testing
- Data collection from lumbar puncture, Data collection from blood draw, CNS magnetic resonance imaging (MRI) imaging
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University Hospital, Basel, Switzerland
Cancer, Depression
Spirituality, Religiosity, and Immune Functioning
The purpose of this study is to determine whether religiosity and spirituality are related to immune functioning, as measured by interleukin-6 blood plasma level, among terminally ill cancer patients.
- Conditions
- Cancer, Depression, Dying Process
- Trial name
- NCT00066924
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Inflammation, Heart Failure
Beer, Marathon, Genetics, Inflammation and the Cardiovascular System: Be-MaGIC-Trial
The purpose of the study is to determine the myocardial function and vascular adaptation after strenuous exercise in association with consumption of polyphenols.
- Conditions
- Inflammation, Heart Failure, Sudden Cardiac Death
- Trial name
- Be-MaGIC (NCT00933218)
- Testing
- polyphenols (non-alcoholic beer), beverage without polyphenols
- Where
- Germany
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Lower Respiratory Infection, Anemia
Risk Factor for Readmission and Death of Lower Respiratory Infections in Older Adults
Lower respiratory tract infection(LRTI) is a prevalent disease that threatens the health of older people worldwide. Anemia is also a common disorder in the elderly, and its prevalence increases significantly with age.
- Conditions
- Lower Respiratory Infection, Anemia, Readmission, Death
- Trial name
- NCT05355324
- Testing
- no intervention
- Volunteers
- 215 people
- Sponsor
- Beijing Tongren Hospital
Atrial Fibrillation, Stroke, Acute
Characterization and Prediction of Atrial Fibrillation-caused Adverse Events After Hospital Discharge for Cardiac Surgery
The purpose of the research is to identify the frequency and severity of adverse events related to atrial fibrillation that occur after discharge from hospital where the patient underwent cardiac surgery.
- Conditions
- Atrial Fibrillation, Stroke, Acute, Death
- Trial name
- MATRICeS (NCT03466125)
- Testing
- Cardiac surgery
- Where
- United States
- Volunteers
- 25,000 people
- Sponsor
- Brigham and Women's Hospital
Asymptomatic Cirrhosis, Clinically Significant Portal Hypertension
Effect of Long-term Carvedilol to Prevent Decompensation or Death in Patients With Asymptomatic Child-Pugh A5 to B8 Cirrhosis and Clinically Significant Portal Hypertension: a Multicenter Double-blind Randomized Control Trial
Decompensation of cirrhosis is a turning point in cirrhosis course, as associated with a marked decrease in life expectancy. Thus, prevention of decompensation is crucial.
- Trial name
- CARVECIR (NCT06263816)
- Testing
- Experimental group: Patients will be treated with carvedilol.
- Where
- 24 sites in France
- Volunteers
- 290 people
- Sponsor
- University Hospital, Tours
Non-Small Cell Lung Cancer
A Study of Atezolizumab in Participants With Programmed Death-Ligand 1 (PD-L1) Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) [FIR]
This multicenter, single-arm study will evaluate the efficacy and safety of atezolizumab (MPDL3280A) in participants with PD-L1-positive locally advanced or metastatic NSCLC.
- Trial name
- NCT01846416
- Testing
- Atezolizumab (MPDL3280A) [TECENTRIQ], an engineered anti-PDL1 antibody
- Where
- 31 sites in United States, Belgium and 3 more
- Volunteers
- 138 people
- Sponsor
- Genentech, Inc.
End Stage Liver Diseases
Analysis of Respiratory System Mechanics and Inflammatory Response During Orthotopic Liver Transplantation (SPPLIT Trial)
During orthotopic liver transplantation (OLT), respiratory system function may be severely impaired for several reasons including anaesthesia effects, hyperdynamic volume state with fluid overload and ischemia reperfusion injury.
- Trial name
- SPPLIT (NCT02119585)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
Palliative Care, Advanced Cancer
A Feasibility Study of Death Education Intervention for Family Caregivers of Advanced Cancer Patients
Advanced cancer is the leading cause of death in the world and China. Family caregivers, as the closest individuals to advanced cancer patients, suffer from a range of psychological and spiritual issues due to patients' impending…
- Conditions
- Palliative Care, Advanced Cancer, Family Caregivers
- Trial name
- NCT07367984
- Testing
- Death education intervention for family caregivers of advanced cancer patients
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Preterm Delivery, Obstetrical Complications
Aspirin Dose Escalation for the Prevention of Recurrent Preterm Delivery Trial
This is a phase-III multi-center double-blind randomized clinical trial of 1,800 individuals with a history of prior preterm birth at less than 35 weeks gestation who are randomized to either 162 mg aspirin or 81 mg aspirin…
- Trial name
- ADEPT (NCT06980025)
- Testing
- 162mg Aspirin, 81mg Aspirin
- Where
- 14 sites in United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Advance Care Planning, Vulnerable Populations
Using an End-of-life Conversation Game to Engage Underserved Communities in Advance Care Planning
This national project will provide an effective, evidence-based intervention for advance care planning (ACP) to 50 underserved US communities, those with poor access to healthcare systems due to economic, cultural or other…
- Conditions
- Advance Care Planning, Vulnerable Populations, Advance Directives, Terminal Illness
- Trial name
- NCT03456921
- Testing
- End-of-life conversation game called "Hello"
- Where
- United States
- Volunteers
- 1,122 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
End of Life Care, Critical Illness
Palliative Care Protocol for Adult Patients Hospitalized in Critical Care Units.
The goal of this clinical trial is to determine the effectiveness of a palliative care protocol in improving the quality of care of adult patients at high risk of dying hospitalized in the critical care unit.
- Conditions
- End of Life Care, Critical Illness, Palliative Care
- Trial name
- NCT06483958
- Testing
- palliative care protocol
- Where
- Chile
- Volunteers
- 248 people
- Sponsor
- University of Chile
Sickle Cell Anemia, Pulmonary Hypertension
Heart Disease in Sickle Cell Anemia
This study will explore what may cause people with sickle cell anemia to have heart problems and an increased risk of sudden death. People 18 years of age and older with sickle cell anemia may be eligible for this study.
- Trial name
- NCT00113152
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Heart Arrest, Cardiac Arrest
Pre-arrival Instructions Effect on Bystander Cardiopulmonary Resuscitation (CPR).
The investigators hypothesized that pre-arrival instructions would increase the likelihood of bystanders performing Cardiopulmonary Resuscitation (CPR).
- Conditions
- Heart Arrest, Cardiac Arrest, Cardiopulmonary Arrest, Out of Hospital Cardiac Arrest
- Trial name
- NCT02007499
- Testing
- Pre-Arrival Instructions
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Medical College of Wisconsin
Cardiovascular Risk Assessment
Prognosis of Type 2 Diabetic Patients
The study will include 1200 patients with type 2 diabetes and angiographically documented coronary artery disease and 600 matched non-diabetic patients without type 2 diabetes.
- Trial name
- ARTEMIS (NCT01426685)
- Where
- Finland
- Volunteers
- 1,880 people
- Sponsor
- University of Oulu
Sudden Cardiac Death, Sudden Cardiac Arrest
Wearable Cardioverter Defibrillator in Hemodialysis Patients (WED-HED) Study
A multi-center, prospective, randomized controlled clinical trial with 1:1 assignment of treatment and control. This study will evaluate the impact of wearable cardioverter defibrillator use on sudden cardiac death in incident…
- Trial name
- WED-HED (NCT02481206)
- Testing
- Wearable Cardioverter Defibrillator
- Where
- 31 sites in United States
- Volunteers
- 66 people
- Sponsor
- Zoll Medical Corporation
Colorectal Neoplasms
Neoadjuvant Chemoradiotherapy Plus Tislelizumab Followed by TME for LARC.
Long course radiotherapy plus neoadjuvant chemotherapy followed by resection total mesorecta excision has accepted widespread recognized in the treatment of locally advanced rectal cancer (LARC).
- Trial name
- NCT04911517
- Testing
- long course radiotherapy + capecitabine + PD-1 monoclonal antibody treatment combinations
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Beijing Friendship Hospital
Breast Cancer, Triple Negative Breast Cancer
Abraxane With or Without Tigatuzumab in Patients With Metastatic, Triple Negative Breast Cancer
Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer deaths in American women. Metastatic disease including metastatic breast cancer unfortunately remains incurable.
- Conditions
- Breast Cancer, Triple Negative Breast Cancer, Stage IV Breast Cancer, Metastatic Breast Cancer
- Trial name
- NCT01307891
- Testing
- Abraxane alone, Abraxane + Tigatuzumab
- Where
- 10 sites in United States
- Volunteers
- 64 people
- Sponsor
- University of Alabama at Birmingham