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Heart ArrestNCT02007499

Pre-arrival Instructions Effect on Bystander Cardiopulmonary Resuscitation (CPR).

An observational study of Heart Arrest and Cardiac Arrest, run by Medical College of Wisconsin at 1 site in United States.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The investigators hypothesized that pre-arrival instructions would increase the likelihood of bystanders performing Cardiopulmonary Resuscitation (CPR). Read more about this study

Who is it for?
Ages 21 years and older
What is being tested?
Pre-Arrival Instructions
How many people
274 participants
Where
1 siteUnited States
Study dates
1 Jan 2009to 31 Dec 2013
Phase
Observational
Are there results?
Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 21 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Study population: The population of this study will be all patients with OHCA (absence of a detectable pulse, unresponsiveness, and apnea) occurring in the select communities, from January 1, 2009, to December 31, 2013 (five years).

Who may be able to join

  • Patients 21 years old or older
  • Presumed cardiac origin as indicated on the Milwaukee County Emergency Medical Services (MCEMS) report
  • Non-Emergency Medical Services (EMS) witnessed arrest

Who cannot join

  • Patients younger than 21 years old
  • Patients who are "obviously dead" (decomposition, rigor mortis, decapitation, or other)
  • Trauma victims, including hanging and burns
  • Patients with cardiac arrests clearly of other non-cardiac origin including drug overdose, carbon monoxide poisoning, drowning, exsanguination, electrocution, asphyxia, hypoxia related to respiratory disease, cerebrovascular accident and documented terminal illness
  • Patients determined to be a do-not-resuscitate (DNR) upon arrival of Emergency Medical Services (EMS) providers
  • Cardiopulmonary Resuscitation (CPR) by someone other than Emergency Medical Services (EMS) who is a trained first responder or health care provider with a predetermined duty to provide care.

Trial locations and contacts

1 site in 1 country.

United States1 site
  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226

Other trials in United States

About this study

Official title: The Effect of Pre-arrival Instructions on the Rate of Bystander Cardiopulmonary Resuscitation (CPR) for Patients in "Out of Hospital Cardiac Arrest (OHCA)".

The investigators hypothesized that pre-arrival instructions would increase the likelihood of bystanders performing Cardiopulmonary Resuscitation (CPR).

Read the detailed description

The City of Milwaukee and surrounding communities combine to form Milwaukee County covering 241 square miles and serving approximately 959,521 people. Milwaukee County includes 19 separate municipalities. Community demographics and other characteristics have remained largely stable for the past decade.

The study will take place in Milwaukee County from 2009 - 2013 in the communities providing Cardiopulmonary Resuscitation (CPR) pre-arrival instructions: West Allis and Oak Creek.

In Milwaukee County Basic Live Support (BLS) shall be started on all patients in cardiac arrest with the exception of victims with: decapitation; rigor mortis; evidence of tissue decomposition; dependent lividity; presence of a valid Do-Not-Resuscitate (DNR) or Physician Orders for Life-Sustaining Treatment (POLST); fire victim with full thickness burns to 90% or greater body surface area; hypothermic patients with signs of frozen tissue, rigid airway, ice formation in mouth, or chest noncompliant for Cardiopulmonary Resuscitation (CPR). The system standard is: Cardiopulmonary Resuscitation (CPR) will be provided whenever patient is pulseless; compressions at least 100/minute; hands on chest more than 75% of time; minimum compression depth of 2 inches in adults 75% of the time.

Therefore, the investigators will analyze data to assess how Cardiopulmonary Resuscitation (CPR) pre-arrival instructions may have affected the probability of receiving bystander Cardiopulmonary Resuscitation (CPR).

Being tested
Pre-Arrival Instructions
Keywords
Prehospital emergency care, Out of hospital cardiac arrest, Cardiopulmonary resuscitation, CPR, Heart arrest, Outcome, Bystander
Medical subject headings
Heart Arrest, Out-of-Hospital Cardiac Arrest, Death, Sudden, Cardiac

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Pre-Arrival InstructionsOther

    Out of Hospital Cardiac Arrest (OHCA) Pre-Arrival Instructions (PAI)

Study groups in NCT02007499
Study groupRoleWhat they receive
Community 1 BeforePre-arrival Cardiopulmonary Resuscitation (CPR) instruction for bystander Before Intervention Group in Community 1
Community 1 AfterPre-arrival Cardiopulmonary Resuscitation (CPR) instruction for bystander After Intervention Group in Community 1
Receives: Other: Pre-Arrival Instructions
Community 2 BeforePre-arrival Cardiopulmonary Resuscitation (CPR) instruction for bystander Before Intervention Group in Community 2
Community 2 AfterPre-arrival Cardiopulmonary Resuscitation (CPR) instruction for bystander After Intervention Group in Community 2
Receives: Other: Pre-Arrival Instructions

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Incidence of Bystander Cardiopulmonary Resuscitation (CPR) in Out of Hospital Cardiac Arrest (OHCA)

    The overall goal of this study is to determine the rate of bystander Cardiopulmonary Resuscitation (CPR) before and after implementation of Cardiopulmonary Resuscitation (CPR) pre-arrival instructions program in Milwaukee County

    Measured: Up to 2 years prior to intervention and up to 2 years post intervention

Secondary outcomes (1)
  1. Survival to Hospital Discharge or to December, 31 2013 Whichever Comes First

    Explore any relationship to age and gender of the patient, location of arrest, time of year, and other indicators known to affect survival on the overall difference in patient discharge.

    Measured: Up to 2 years prior to intervention and up to 2 years post intervention

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted10 Dec 2013 (estimated)
  2. Study start1 Jan 2009
  3. Primary completion31 Dec 2013
  4. Study completion31 Dec 2013

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Retrospective
Enrolment
274 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT02007499
Sponsor's protocol ID
PRO00021202
Status last verified
Mar 2026
First submitted
25 Nov 2013
Last updated
7 Apr 2026
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No: The study is looking for the incident of pre-instruction only there is no participant involved directly

Publications

  • Song KJ, Shin SD, Park CB, Kim JY, Kim DK, Kim CH, Ha SY, Eng Hock Ong M, Bobrow BJ, McNally B. Dispatcher-assisted bystander cardiopulmonary resuscitation in a metropolitan city: a before-after population-based study. Resuscitation. 2014 Jan;85(1):34-41. doi: 10.1016/j.resuscitation.2013.06.004. Epub 2013 Jun 17.

    PubMed 23792111
  • Nichol G, Thomas E, Callaway CW, Hedges J, Powell JL, Aufderheide TP, Rea T, Lowe R, Brown T, Dreyer J, Davis D, Idris A, Stiell I; Resuscitation Outcomes Consortium Investigators. Regional variation in out-of-hospital cardiac arrest incidence and outcome. JAMA. 2008 Sep 24;300(12):1423-31. doi: 10.1001/jama.300.12.1423.

    PubMed 18812533
  • Liu JM, Yang Q, Pirrallo RG, Klein JP, Aufderheide TP. Hospital variability of out-of-hospital cardiac arrest survival. Prehosp Emerg Care. 2008 Jul-Sep;12(3):339-46. doi: 10.1080/10903120802101330.

    PubMed 18584502
  • Nichol G, Rumsfeld J, Eigel B, Abella BS, Labarthe D, Hong Y, O'Connor RE, Mosesso VN, Berg RA, Leeper BB, Weisfeldt ML; American Heart Association Emergency Cardiovascular Care Committee; American Heart Association Council on Cardiopulmonary, Perioperative, and Critical Care; American Heart Association Council on Cardiovascular Nursing; American Heart Association Council on Clinical Cardiology; Quality of Care and Outcomes Research Interdisciplinary Working Group. Essential features of designating out-of-hospital cardiac arrest as a reportable event: a scientific statement from the American Heart Association Emergency Cardiovascular Care Committee; Council on Cardiopulmonary, Perioperative, and Critical Care; Council on Cardiovascular Nursing; Council on Clinical Cardiology; and Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2008 Apr 29;117(17):2299-308. doi: 10.1161/CIRCULATIONAHA.107.189472. Epub 2008 Apr 14.

    PubMed 18413503
  • Lateef F, Anantharaman V. Bystander cardiopulmonary resuscitation in prehospital cardiac arrest patients in Singapore. Prehosp Emerg Care. 2001 Oct-Dec;5(4):387-90. doi: 10.1080/10903120190939562.

    PubMed 11642590
  • Rea TD, Eisenberg MS, Culley LL, Becker L. Dispatcher-assisted cardiopulmonary resuscitation and survival in cardiac arrest. Circulation. 2001 Nov 20;104(21):2513-6. doi: 10.1161/hc4601.099468.

    PubMed 11714643
  • Sasson C, Magid DJ, Chan P, Root ED, McNally BF, Kellermann AL, Haukoos JS; CARES Surveillance Group. Association of neighborhood characteristics with bystander-initiated CPR. N Engl J Med. 2012 Oct 25;367(17):1607-15. doi: 10.1056/NEJMoa1110700.

    PubMed 23094722
  • Abella BS, Aufderheide TP, Eigel B, Hickey RW, Longstreth WT Jr, Nadkarni V, Nichol G, Sayre MR, Sommargren CE, Hazinski MF; American Heart Association. Reducing barriers for implementation of bystander-initiated cardiopulmonary resuscitation: a scientific statement from the American Heart Association for healthcare providers, policymakers, and community leaders regarding the effectiveness of cardiopulmonary resuscitation. Circulation. 2008 Feb 5;117(5):704-9. doi: 10.1161/CIRCULATIONAHA.107.188486. Epub 2008 Jan 14. No abstract available.

    PubMed 18195177
  • Billittier AJ 4th, Lerner EB, Tucker W, Lee J. The lay public's expectations of prearrival instructions when dialing 9-1-1. Prehosp Emerg Care. 2000 Jul-Sep;4(3):234-7. doi: 10.1080/10903120090941254.

    PubMed 10895918
  • Cummins RO, Chamberlain DA, Abramson NS, Allen M, Baskett P, Becker L, Bossaert L, Delooz H, Dick W, Eisenberg M, et al. Recommended guidelines for uniform reporting of data from out-of-hospital cardiac arrest: the Utstein Style. Task Force of the American Heart Association, the European Resuscitation Council, the Heart and Stroke Foundation of Canada, and the Australian Resuscitation Council. Ann Emerg Med. 1991 Aug;20(8):861-74. No abstract available.

    PubMed 1854070
  • Berdowski J, Berg RA, Tijssen JG, Koster RW. Global incidences of out-of-hospital cardiac arrest and survival rates: Systematic review of 67 prospective studies. Resuscitation. 2010 Nov;81(11):1479-87. doi: 10.1016/j.resuscitation.2010.08.006. Epub 2010 Sep 9.

    PubMed 20828914

Questions about this trial

What is this clinical trial studying?

An observational study of Heart Arrest and Cardiac Arrest, run by Medical College of Wisconsin at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 7 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

Yes. Results are posted in the registry (first posted 7 Apr 2026). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Incidence of Bystander Cardiopulmonary Resuscitation (CPR) in Out of Hospital Cardiac Arrest (OHCA) (time frame: Up to 2 years prior to intervention and up to 2 years post intervention). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT02007499, which also lists 11 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Apr 2026.

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