Clinical trials: Decay, Dental
Dental Caries
A Clinical Study to Assess an Experimental Dentifrice in an Experimental Model of Early Stage Caries
The aim of this study is to evaluate the relative efficacy of an experimental dentifrice containing 1150 parts per million (ppm) fluoride (as sodium fluoride [NaF]) to remineralize early stage caries type lesions in an in situ…
- Trial name
- NCT06949072
- Testing
- Test Dentifrice, Reference Dentifrice, Negative Control Dentifrice
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- HALEON
Dental Caries
Clinical Evaluation of Three Dental Adhesive Systems in Class V Restorations
The purpose of this study is to compare the clinical performance of three dental adhesive systems used to bond Class V cavity fillings in adult teeth.
- Trial name
- NCT00643461
- Testing
- Adhesive A, Adhesive B, Adhesive C
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Solventum US LLC
Dental Caries
Research on the Characteristics and Application of Lactobacillus Rhamnosus X253 as Oral Probiotics
The aim of the study is to study the application of Lactobacillus rhamnosus X253 as oral probiotics by the way of a randomised, double blinded, parallel, placebo-controlled clinical trial, and to eto detect the changes in oral…
- Trial name
- NCT05123651
- Testing
- Lactobacillus rhamnosus X253
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Junlebao Dairy Group Co., Ltd.
Migraine Disorders
TREXIMA and RELPAX Gastric Scintigraphy Inside and Outside a Migraine
An evaluation of tablet disintegration and absorption and gastric transit of sumatriptan and naproxen sodium from a TREXIMA tablet and eletriptan from a RELPAX 40mg tablet.
- Trial name
- NCT00385008
- Testing
- Combination Product (sumatriptan succinate / naproxen sodium), RELPAX(eletriptan) 40mg Tablet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- GlaxoSmithKline
Elderly, Periodontal Disease
Oral Hygiene Assistance Training Program
This is an oral health study with a nursing home staff training program and product intervention.
- Conditions
- Elderly, Periodontal Disease, Gingivitis, Caries,Dental
- Trial name
- NCT07807397
- Testing
- Stannous Fluoride Toothpaste (SnF), sodium fluoride 5000 ppm, cetylpyridinium chloride (0.075%) and zinc alcohol free mouthwash
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Caries
Everybody Brush: A Community-wide Toothpaste Distribution Campaign
Dental caries (tooth decay) is a disease with significant public health implications afflicting low-income children, with marked rural disparities in disease prevalence and treatment.
- Trial name
- NCT02327507
- Testing
- Toothpaste & Telephone Support
- Where
- United States
- Volunteers
- 21,731 people
- Sponsor
- Advantage Dental Services, LLC
Tooth Decay, Hydroxyapatite
Hydroxyapatite-toothpaste and Enamel Caries in the Primary Dentition
This multicenter, non-inferiority trial randomized, double-blind, active controlled parallel group study evaluates the hypothesis that the home regular use of a toothpaste containing microcrystalline hydroxylapatite (HAP) (test…
- Conditions
- Tooth Decay, Hydroxyapatite, Tooth Demineralization, Tooth Diseases
- Trial name
- ECIPDEN17 (NCT03553966)
- Testing
- Prophylactic, Cleaning teeth, Restorative dentistry
- Where
- Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Dr. Kurt Wolff GmbH & Co. KG
Dental Caries
Effects of a Hydroxyapatite-based Mouth Gel on Calcium Content of Plaque
The aim of this pilot study is to analyze if a hydroxyapatite-containing mouth gel has an influence on the calcium content of plaque.
- Trial name
- NCT03956992
- Testing
- Mouth gel
- Where
- Indonesia
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Dr. Joachim Enax
Dental Caries
Evaluation of the Effect of Self-Assembling Peptide P11-4
Dental caries is a biofilm-mediated, sugar-driven, multifactorial, dynamic disease that results in the phasic demineralization and remineralization of dental hard tissues.
- Trial name
- NCT05667545
- Testing
- Peptide
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Egymedicalpedia
Re-mineralization
Re-mineralization Effects of Sugar Free Chewing Gum Sweetened With Different Sugar-substitutes
The purpose of this study is to evaluate the clinical effect of chewing gum containing maltitol, on re-mineralization of early caries following daily chewing for 6 months by school children, compared to a xylitol gum, gum base…
- Trial name
- NCT02468388
- Testing
- maltitol, xylitol, gum base
- Where
- China
- Volunteers
- 482 people
- Sponsor
- Roquette Management (Shanghai) Co., Ltd.
Cavities of Teeth, Dental Decay
Scotchbond Universal Plus Compared to Scotchbond Universal for Posterior Class I & II Restorations With Filtek Universal
This research study is looking at a new bond-promoting substance (a dental adhesive called 3M™ Scotchbond™ Universal Plus Adhesive) used between the tooth and dental restoration (filling).
- Trial name
- NCT05248204
- Testing
- Scotchbond™ Universal Plus Adhesive, Scotchbond™ Universal Adhesive
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Solventum US LLC
Dental Caries
Efficacy Of A PVP-I Fluoride Varnish
The purpose of the study is to determine the efficacy of Advantage Anti-Caries Varnish. Single-center, double-blind, controlled Phase 2 study with parallel groups of children.
- Trial name
- NCT03082196
- Testing
- Test varnish, Standard varnish
- Where
- Micronesia
- Volunteers
- 284 people
- Sponsor
- Advantage Dental Services, LLC
Enamel Lesions, Demineralization, Tooth
Evaluation of the Anti-cavity Efficacy of Three Dentifrices Using an Intra-oral Enamel Demineralization - Remineralization In-Situ Model
Clinical study to evaluate the anti-cavity efficacy of three dentifrices using an intra-oral enamel Demineralization - Remineralization In-Situ Model. This is a Phase III, single-center, triple-blind with a crossover design.
- Conditions
- Enamel Lesions, Demineralization, Tooth, Remineralization, Dental Cavity
- Trial name
- REPAIR (NCT06732518)
- Testing
- Fluoride Toothpaste, Fluoride free toothpaste in a chalk base, Fluoride free toothpaste in a PCC/RNCC base
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Caries
A Phase 2 Study to Evaluate the Microbiology, Safety and Tolerability of C16G2 Varnish and Strip in Adolescent and Adult Subjects
An open-label and single-blind phase 2 study to evaluate the oral microbiology, safety and tolerability of multiple C16G2 Varnish and Strip applications in male and female dental subjects 12-75 years of age.
- Trial name
- C3J17-206-00 (NCT03196219)
- Testing
- C16G2
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Armata Pharmaceuticals, Inc.
Demineralization, Remineralization
Clinical Study to Evaluate the Anti-cavity Efficacy of Three Dentifrices: An In Situ Model
Clinical study to evaluate the anti-cavity effectiveness of three dentrifices using an intra-oral enamel Demineralization and Remineralization In-Situ Model.
- Conditions
- Demineralization, Remineralization, Dental Cavity, Enamel Lesions
- Trial name
- NCT07134231
- Testing
- Fluoride free toothpaste in a chalk base, Fluoride Toothpaste, Fluoride free toothpaste in a PCC/RNCC base
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Caries
A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children
The objective of this study is to assess the safety and to evaluate the anti-caries efficacy of COL101 (arginine) non-fluoride dentifrices compared to a 0.24% sodium fluoride dentifrice in 10-14 year-old children over a one year…
- Trial name
- NCT04750902
- Testing
- 0.24% Sodium Fluoride Dentifrice, 1.5% Arginine Dentifrice, 4.0% Arginine Dentifrice
- Where
- 9 sites in United States, Puerto Rico
- Volunteers
- 2,025 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Caries
Comparative Study of Experimental Dental Adhesive With and Without Phosphoric Acid Pretreatment
The intent of this study is to evaluate the clinical performance of an experimental dental bonding agent for use with dental restorative composites with and without pretreatment of the tooth dentin and enamel using phosphoric…
- Trial name
- NCT02071953
- Testing
- Experimental adhesive w/out phosphoric acid in post. rest., Experimental adhesive with phosphoric acid in post. rest.
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Dentsply International
Dental Caries in Children
Pharmacokinetics of Advantage Arrest in Healthy Children 13-Months to 13-Years of Age
The purpose of this study is to further characterize basic pharmacokinetic (PK) parameters in healthy children to contribute to evidence for the safety of silver diamine fluoride (SDF; Advantage Arrest).
- Trial name
- NCT05670743
- Testing
- 38% silver diamine fluoride
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Advantage Silver Dental Arrest, LLC
Dental Caries
Evaluation of Plaque Fluid Fluoride Retention From Fluoride Toothpastes
The purpose of this study is to investigate the efficacy of different sodium fluoride (NaF) containing toothpastes in prevention of dental caries.
- Trial name
- NCT00708305
- Testing
- Sodium Fluoride (NaF)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Caries
Pharmacokinetics of Advantage Arrest in Children
The purpose of this study is to characterize basic PK parameters (Cmax, t1/2, AUC) in healthy children to contribute to evidence for the safety of Advantage Arrest, consistent with Guidance for Industry--Exposure--Response…
- Trial name
- NCT04186663
- Testing
- Silver Diamine Fluoride
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Advantage Silver Dental Arrest, LLC