Clinical trials: Decreased Risk of Diabetes Mellitus Type II
Type 2 Diabetes Mellitus (T2DM)
Phase III Trial of SGLT2 Inhibitor and Thiazolidinedione Fixed-Dose Combination vs. Monotherapy in Type 2 Diabetes Patients on Metformin
This clinical trial is studying whether combining two commonly used diabetes medications into a single pill works better than taking them separately for people with type 2 diabetes who are already on metformin.
- Trial name
- CONTROL (NCT07057479)
- Testing
- Fixed-dose combination of SGLT2 inhibitor and thiazolidinedione, Control Group 1 Intervention - SGLT2 inhibitor monotherapy, Control Group 2 Intervention - Thiazolidinedione monotherapy
- Where
- Brazil
- Sponsor
- Eurofarma Laboratorios S.A.
Diabetes Mellitus, Type 2, Obesity
Microclinic Social Network Behavioral Health Trial in Jordan
This 3-armed randomized controlled trial aims to evaluate the effectiveness of The Microclinic Behavioral Health Program in improving obesity and diabetes risk factors through a behavioral intervention program structured to…
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Hypertension, Hyperglycemia
- Trial name
- NCT01818674
- Testing
- Microclinic Behavioral Health Full Program (education curriculum in classroom setting, plus full social interaction program), Microclinic Behavioral Health Basic Program (education-only in classroom setting; no structured social interactions)
- Where
- 3 sites in Jordan
- Volunteers
- 914 people
- Sponsor
- Microclinic International
Lifestyle Risk Reduction, Adolescent Health
Health Without Barriers/Salud Sin Barreras- Northern Colorado
The overarching goal of this work is to address the limited access to evidence-based health behavior and lifestyle interventions for youth and families most impacted by preventable chronic diseases, including obesity and type 2…
- Conditions
- Lifestyle Risk Reduction, Adolescent Health, Family Health, Cardio-metabolic Health
- Trial name
- HWB/SSB (NCT06822387)
- Testing
- Mindfulness-Based Intervention, Parent Education, Physical Activity
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Heart Diseases, Diabetes Mellitus, Type 2
Behavior Change Intervention for Cardiovascular Risk Reduction Among People Experiencing Homelessness
This single-arm trial of the Cardiovascular Risk Reduction Among People Experiencing Homelessness (CV-Homes) intervention alone (n=8) will test the perception and feasibility of anticipated study procedures.
- Conditions
- Heart Diseases, Diabetes Mellitus, Type 2, Pre-diabetes, Hypertension
- Trial name
- CV-Homes (NCT06025721)
- Testing
- Cardiovascular Risk Homeless Support
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Katherine Vickery
Atherosclerosis, Cardiovascular Disease
A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event
The purpose of this study is to measure the change in high-sensitivity C-reactive protein (hsCRP), a marker of inflammation in the body, with clazakizumab compared with placebo in adults who have elevated hsCRP and at increased…
- Conditions
- Atherosclerosis, Cardiovascular Disease, Obesity, Hypertension
- Trial name
- CLARITY-CRP (NCT07783802)
- Testing
- Clazakizumab
- Where
- 46 sites in United States, Argentina and 2 more
- Volunteers
- 120 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Type 2
Lifestyle Intervention For Effective Diabetes Management
Chronic disease management programs are shown to reduce mortality, recurrent hospitalizations, and improve indirect societal costs among specific subgroups of the population.
- Trial name
- LIFE-DM (NCT00813930)
- Testing
- INTERxVENT lifestyle modification program
- Where
- 3 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Type 2 Diabetes
Study to Weigh the Effect of Exercise Training on BONE (SWEET-BONE) Quality and Strength in Type 2 Diabetes
Type 2 diabetes mellitus (T2DM) is associated with increased fracture risk despite normal to increased bone mass, thus suggesting poor bone quality.
- Trial name
- SWEET-BONE (NCT02421393)
- Testing
- supervised exercise training
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Metabolic Fitness Association, Italy
Risk Reduction Behavior, Diabetes Mellitus, Type 2
Corazon de la Familia (Heart of the Family)
The Corazón de la Familia study is a randomized controlled trial to examine the effects of a novel family-focused lifestyle modification intervention to reduce risk for type 2 diabetes and cardiovascular disease (CVD) among…
- Conditions
- Risk Reduction Behavior, Diabetes Mellitus, Type 2, Cardiovascular Diseases
- Trial name
- NCT03196024
- Testing
- Family-focused intervention arm, Individual-focused intervention arm
- Where
- United States
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- Gia Mudd
Reducing the Elevated Blood Pressure for Diabetic Hypertensive Patients
Metformin Versus Vildagliptin for Diabetic Hypertensive Patients
This is a controlled study to measure the efficacy of using metformin or vildagliptin for type 2 diabetic patients who suffers from hypertension to reduce cardiovascular risk resulting from both diabetes and hypertension using…
- Trial name
- NCT03253562
- Testing
- Metformin Pill, Vildagliptin 50 mg
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- MTI University
Type 2 Diabetes Risk Reduction in Young Adults
Holistic Lifestyle mHealth Intervention for Risk Reduction of Type 2 Diabetes Mellitus in Young Adults
The goal of this clinical trial (randomized controlled trial) is to examine the effectiveness of a holistic lifestyle mHealth intervention in reducing the risk of type 2 diabetes mellitus.
- Trial name
- NCT07604012
- Testing
- Holistic mHealth Intervention
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fatima Jinnah Women University
Coronary Artery Disease, Type II Diabetes Mellitus
Innovative Strategies For Risk Reduction Following CABG
Background: Treatment targets for cardiac risk factor reduction are not being met. Therefore, there is a need for new strategies to assist patients in meeting these goals.
- Trial name
- NCT00462436
- Testing
- Consumption of Dietary Portfolio
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Unity Health Toronto
Decreased Cardovascular Risk, Decreased Risk of Diabetes Mellitus Type II
MoKaRi II Intervention Study
The proposed intervention study addresses the development and validation of nutritional concepts based on menu plans for patients with hypertriglyceridemia (triglycerides > 1.5 mmol/l) and participants with impaired glucose…
- Trial name
- MoKaRi II (NCT05382533)
- Testing
- Menu plans
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Jena
Diabetes Mellitus, Type 2, Metabolic Syndrome
Randomized Control Trial for Overweight Employees in Worksites
Impact of lifestyle intervention in at-risk Asian Indians at worksite remains largely unexplored. The aim of this study was to assess impact of the multi-component interventions on body weight, body fat patterning and…
- Conditions
- Diabetes Mellitus, Type 2, Metabolic Syndrome, Lifestyle Risk Reduction
- Trial name
- NCT03249610
- Testing
- Lifestyle intervention
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Pre-diabetes, Older Adults
Liraglutide and a Calorie Restricted Diet Augments Weight Loss and Decreases Risk of Type 2 Diabetes and CVD.
The goal of this study is to evaluate the hypothesis that the addition of liraglutide, a long-acting glucagon-like peptide 1 (GLP-1) analogue, to a calorie-restricted diet will lead to greater weight loss than will a…
- Trial name
- NCT01784965
- Testing
- liraglutide
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Stanford University
Type 2 Diabetes Mellitus
Reducing Sedentary Behaviour in Young Adults at Risk of Diabetes
Excessive periods of time spent sitting may be a risk factor for diabetes. Current lifestyles encourage large amounts of sitting (sedentary behaviour) through increasing car use, computers, and appealing screen-based home…
- Trial name
- STAND (NCT01301196)
- Testing
- Educational workshop
- Where
- United Kingdom
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Cardiovascular Diseases, Type 2 Diabetes Mellitus in Obese
Implementation of a Peer Leader-facilitated Dyadic Intervention
This Pilot Study Large Application builds upon the results of our prior work to 1) Implement and pilot test a peer leader-facilitated 12-week dyadic intervention (Community Health among Asian Indian immigrants (CHAI) Dyad study)…
- Conditions
- Cardiovascular Diseases, Type 2 Diabetes Mellitus in Obese, Hyperlipidemias
- Trial name
- NCT06643806
- Testing
- CHAI dyad study
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Cardiovascular Disease, Diabetes
The FLAVO Trial: Dietary Flavonoids and Cardiovascular Disease Risk Reduction in Postmenopausal Women With Type 2 Diabetes
The purpose of this placebo controlled trial is to determine whether a year long intervention with flavonoids (found in cocoa and soy) is more effective in reducing the risk of cardiovascular disease in postmenopausal women with…
- Trial name
- FLAVO (NCT00677599)
- Testing
- Flavonoid enrichment (cocoa / soy compounds)
- Where
- United Kingdom
- Volunteers
- 152 people
- Sponsor
- University of East Anglia
Metabolic Syndrome, Diabete Type 2
Metformin Versus Vildagliptin in Reducing Risk of Metabolic Syndrome Complications Progression
Several crosssectional and prospective studies have shown that metabolic syndrome and its related components are associated with both prevalent and incident CKD .
- Conditions
- Metabolic Syndrome, Diabete Type 2, Kidney Insufficiency
- Trial name
- NCT04485845
- Testing
- Vildagliptin, Captopril Tablets, MetFORMIN 500 Mg Oral Tablet
- Where
- Egypt
- Volunteers
- 39 people
- Sponsor
- Cairo University
Cancer, Diabetes Mellitus, Type 2
SGLT2 Inhibitors and Reducing the Risk of Cancers Among Diabetics , an Observational Study
Since the discovery of SGLT2 inhibitors, there is a great shift in diabetic treatment, so this drug is magic, this drug can reduce the blood sugar level by blocking the reabsorption of glucose in the kidney and increasing glucose…
- Conditions
- Cancer, Diabetes Mellitus, Type 2, Interleukin 6, SGLT2 Inhibitors
- Trial name
- NCT05612269
- Testing
- interleukin 6
- Where
- Saudi Arabia
- Volunteers
- 200 people
- Sponsor
- Ministry of Health, Saudi Arabia
Type 2 Diabetes
Fibre Grain Herb Trial in Type 2 Diabetes
Despite the availability of multiple medications for the treatment of Type 2 diabetes, patients often continue to have difficulty attaining blood glucose targets and managing cardiovascular disease risk factors.
- Trial name
- FIGHT (NCT02553382)
- Testing
- Dietary, Herbal, Positive Control
- Where
- 2 sites in Canada, Croatia
- Volunteers
- 104 people
- Sponsor
- Unity Health Toronto